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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 10, 2018

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SLAS2018 Keynote Cravatt Discusses Profiling Proteins
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During his keynote presentation Monday, Feb. 5 at SLAS2018, Benjamin F. Cravatt, Ph.D., discusses the role that enzymes play in physiological and pathological processes, especially as it pertains to the nervous system and cancer. Cravatt’s team in the Department of Molecular Medicine at The Scripps Research Institute (La Jolla, CA), where he is a professor and co-chair, discovered chemical proteomic technologies that globally profile the functional state of proteins in native biological systems.

Prominent among these methods is activity-based protein profiling (ABPP), which uses chemical probes to map the activity state of large numbers of proteins in parallel. Cravatt describes the application of ABPP to discover and functionally annotate proteins in mammalian physiology and disease. The functional annotation of the uncharacterized proteins found in eukaryotic and prokaryotic organisms promise to enrich life science’s knowledge of the biochemical pathways that support human physiology and disease. They also lead to the discovery of new therapeutic targets.
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FREE in SLAS Discovery Ahead of Print: Nanofractionation Platform with Parallel Mass Spectrometry for Identification of Cytochrome CYP1A2 Inhibitors in Metabolic Mixtures
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A fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures is the highlight of one of the latest original research articles available ahead-of-print at SLAS Discovery Online.

The methodology, presented by Barbara M. Zietek et al., centers around an at-line nanofractionation platform in which a metabolic mixture is chromatographically separated followed by parallel on-line mass spectrometric (MS) analysis and at-line nanofractionation on high-density microtiter well plates that are then directly exposed to a bioassay.
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Don't Miss the Date: SLAS2018 Poster Abstracts Due Jan. 22
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Gain significant visibility for your research and organization by delivering a poster presentation at SLAS2018. Submit your poster abstract by Jan. 22 for the opportunity to present your research and receive meaningful feedback from an extremely knowledgeable, supportive and collaborative community.

Posters selected can be viewed throughout SLAS2018 exhibition hours and specific times are scheduled for authors to present and discuss their work. Please note that presenters must be registered as full-conference attendees. After the conference, posters remain accessible online in the SLAS2018 e-Poster Gallery.
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Share the Wealth: Invite a Colleague to SLAS2018!
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Let others know what's waiting for them at the 2018 SLAS International Conference and Exhibition: 144 podium sessions, 20 short courses, 230-plus poster presentations, 300-plus multinational exhibitors, a menu of personalized career services and an abundance of intelligent network-building activities.

Look for the blue Invite-A-Colleague button at the top of the page at SLAS2018.org to connect with colleagues. You need only enter your name, e-mail address, personal message and the first name, last name and e-mail of recipients.
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Call for Papers: Make a Bigger Splash in Life Sciences with the SLAS Journals
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Thousands of researchers, scientists and engineers count on the rigorously peer-reviewed SLAS Discovery (Advancing Life Sciences R&D) and SLAS Technology (Translating Life Sciences Innovation) to advance their research and their careers. Backed by the high-quality education standards of SLAS. MEDLINE: PubMed-indexed. NO article processing charges (APCs for regular publication. Open access options available. WATCH THE VIDEOS



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Use SLAS2018 Video Previews to Plan Your Conference Experience
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To help SLAS2018 participants plan their conference agendas, new videos have been added to SLAS2018.org. Session chairs and subject matter experts offer quick snapshots of their upcoming presentations in these helpful, informative videos.

Among the new additions are thoughts by 2017 SLAS Graduate Education Fellowship Grant winner Julea Vlassakis of the University of California, Berkeley. Also a 2018 SLAS Innovation Award nominee, Vlassakis shares her research in the design of electrophoretic assays that separate protein complexes from up to thousands of single cells. Her podium presentation, "Electrophoretic Cytometry Isolates Cytoskeleton Molecular Complexes of Single Cancer Cells," is one of four in the High-Definition Technology Platforms for Single Cell Analysis session in the High-Definition Biotechnology track and will be delivered on Tuesday, Feb. 6.
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Scalable Method to Make Tissue Engineering Material
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To help restore damaged bone, researchers are developing polymer scaffolds that can be implanted in the body to support the growth of new tissue. Poly(propylene fumarate), or PPF, is one of the few materials available for tissue engineering that is both compatible with three-dimensional printing and can be completely absorbed by the body. But applications for this material have been limited by a lack of production methods suitable for commercial-scale 3-D printing, says Matthew L. Becker of the University of Akron. More




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Tuberculosis Drugs Work Better with Vitamin C
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Studies in mice and in tissue cultures suggest that giving vitamin C with tuberculosis drugs could reduce the unusually long time it takes these drugs to eradicate this pathogen. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. In the study, the investigators treated Mycobacterium tuberculosis-infected mice with anti-tuberculosis drugs or vitamin C alone, or the drugs and vitamin C together. More


Pfizer to Halt Alzheimer's and Parkinson's Drug Research
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U.S. pharmaceutical corporation Pfizer announced plans to abandon research of new drugs to treat Alzheimer's and Parkinson's diseases. The decision will result in about 300 layoffs in the company's neuroscience discovery and early development programs, which are located in Massachusetts and Connecticut, according to a statement emailed to journalists. More




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Explore the Latest Festo Innovations

Join Festo as we kick off the new year at SLAS in San Diego, CA. Discover our latest products and innovative technologies for laboratory automation at booth 637. Stop by and speak with our experts to help find a solution for your laboratory challenges.


10 Great Health and Science Books From 2017
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Is your New Year's resolution to read more? We here at STAT have you covered. This year saw the publication of some page-turning memoirs, deeply researched works of nonfiction, and fascinating stories of the history of science — among many others. So as we turn the page on 2017, we asked our readers and staff for their picks of the best health and science books that came out this year. More


Cancer Immunotherapy Resistance Related to Chromatin Remodeling Genes
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Despite its encouraging successes, cancer immunotherapy mostly fails against cancer. If cancer immunotherapy is to succeed more widely, its failures will have to be scrutinized for mechanisms of resistance — mechanisms that can then be recognized as drug targets. One mechanism of cancer resistance has been uncovered by two recent studies — one a preclinical study, the other a clinical study of patients with kidney cancer. More




Carbon Nanotubes Devices May Have a Limit to How 'Nano' They Can Be
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Carbon nanotubes bound for electronics not only need to be as clean as possible to maximize their utility in next-generation nanoscale devices, but contact effects may limit how small a nano device can be, according to researchers at the Energy Safety Research Institute (ESRI) at Swansea University in collaboration with researchers at Rice University. More


Glucagon Receptor Structure Offers New Opportunities for Type 2 Diabetes Drug Discovery
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Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 diabetes. These receptors consist of an extracellular domain (ECD) and a transmembrane domain (TMD), both of which are required to interact with their cognate peptide ligands and to regulate downstream signal transduction. Due to difficulties in high-quality protein preparation, determination of the structure of full-length class B GPCRs remains a challenge, thus limiting the understanding of molecular mechanisms of receptor action. More


White Blood Cells Launch DNA 'Webs' to Warn of Invaders
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Think of it as communicating with Silly String. When some of our white blood cells detect viruses or other microbes that have invaded our bodies, they may alert other cells to the threat by spraying out some of their DNA. This unexpected warning system, described in a study, could hasten the body's response to pathogens. "It might be a new way for immune cells to detect infections and get rid of them," says innate immunologist Paul Kubes of the University of Calgary, who isn't connected to the study. More


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OBGYN Clinician-Investigator
Mayo Clinic
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