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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 17, 2018

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Six Minutes to Sell It: Late Night with LRIG at SLAS2018
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In six minutes or less, the 17 companies participating in the Late Night with LRIG Rapid-Fire Innovation Session will tell the audience how their products excel and field a few questions. The popular session returns to SLAS2018 on Monday, Feb. 5 at 6 p.m. with a sampling of top technologies and innovations that include an affordable automated imaging and analysis system, modern informatics for life sciences R&D, standardization in tissue banking and functional characterization of neurons and heart cells with MEA, and more.

Moderators Andy Zaayenga of SmarterLab, LRIG San Diego Chair Mike Biros of Cellerynt Group, and LRIG Board Member Steve Rees of AstraZeneca keep the fast-paced open discussion among exhibitors and attendees moving with brisk precision. SLAS2018 registered attendees should come early to ensure a seat and enjoy light appetizers and drinks.
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Achtung! Feb. 4 is the Deadline for 2018 SLAS Europe Compound Management Conference Registration Discounts
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Register now for the 2018 SLAS Europe Compound Management Conference, March 8-9, 2018 in Berlin, Germany. Early bird registration rates save participants up to £120 and expire on Sunday, Feb. 4. This premier forum is designed exclusively for compound and sample management professionals, from bench scientists to senior managers. Compound libraries in the drug discovery community, both in industry and academia, are critical to the discovery process.

Learn about emerging trends and technologies, applications of process and quality control, effective library design, the challenges of data and information management and examples of successful collaboration with external and internal resources.
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New and FREE at SLAS Discovery: A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities
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A fast, sensitive and robust methodology for screening small molecule inhibitors against CD73/Ecto-5'-Nucleotidase, a promising target for developing anti-cancer drugs, is the focus of a new original research article available FREE from SLAS Discovery Online. The methodology described by authors Gejing Deng (Sanofi) et al., uses multiple stable isotope-labeled substrates for carrying out CD73 reactions followed by sample pooling then simultaneously quantifying multiple reaction products using ultra-fast RapidFire-MS/MS.

In contrast to other optical based methodologies, this methodology allows identifying molecules with diverse inhibition modalities and characterizing inhibitors using both recombinant CD73 and CD73+ cells.
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SLAS ELN Reports: Growing Impact of Biologics in Drug Discovery and Therapeutics
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"Biologics make up an estimated 25 to 30 percent of therapeutic agents on the market today," says Daniel Sipes, M.S., director of automation at Genomics Institute, Novartis Research Foundation, (San Diego, CA). "This demand for therapeutic biologics has exceeded what can be provided by traditional manual laboratory methods and has opened the door for the development of automation and miniaturization to accelerate the discovery process and offer new therapeutic opportunities." Read more about these opportunities from Sipes and Rob Howes, Ph.D., director of reagents and assay development at AstraZeneca (Gothenburg, Sweden). Sipes and Howes are co-chairs of the SLAS2018 Biologics Discovery track. More


Opportunity Knocks: Sign up to Meet the Editors-in-Chief
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The editors-in-chief of SLAS Discovery and SLAS Technology invite SLAS2018 attendees to register for 15-minute one-on-one personal consultations. Share your ideas, discuss your work, ask about publication options and learn more about how the SLAS journals can help you make a bigger splash in life sciences. Appointments are being accepted on a first-come, first-served basis — contact nhallock@slas.org.

SLAS2018 attendees also can publicly meet the editors-in-chief at the SLAS Journals Information Station (Aisle 200 of the SLAS2018 Exhibition). SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D. (National University of Singapore) will greet visitors on Monday, Feb. 5, from 12:30-1 p.m.; and SLAS Discovery Editor-in-Chief Robert M. Campbell, Ph.D. (Eli Lilly, Indianapolis, IN) will visit with guests on Tuesday, Feb. 6, from 12:30-1 p.m. Volunteer to serve as a reviewer and/or opt-in to receive journal news during your visit to the Station and you'll earn an entry to win a video drone ($500 value).
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SLAS Welcomes New Corporate Member: Intense Engineering
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SLAS welcomes the Society's latest corporate member, Intense Engineering (Madison, WI). Intense Engineering designs, develops and builds turnkey automated systems, custom equipment and products for life science companies. The company supports research, development and production groups by collaborating with customers and following a rigorous, GAMP5 V-model, problem-focused process.

"Our clients expect us to be subject matter experts. Membership in SLAS is one tool we use to enable our engineers to have access to the latest industry trends and technology," says Jodi Hoeser, account manager in business development for the company. "Our membership allows us to collaborate with industry experts and clients ensuring we have access to the latest innovations which we implement into our custom designed automated laboratory equipment and devices."
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Quantum Leap: Computational Approach Launches New Paradigm in Electronic Structure Theory
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A group of Michigan State University researchers specializing in quantum calculations has proposed a radically new computational approach to solving the complex many-particle Schrödinger equation, which holds the key to explaining the motion of electrons in atoms and molecules. By understanding the details of this motion, one can determine the amount of energy needed to transform reactants into products in a chemical reaction, or the color of light absorbed by a molecule, and ultimately accelerate the design of new drugs and materials, better catalysts and more efficient energy sources. More




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Photoelectrochemistry of Photosystem II in Vitro vs in Vivo
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Factors governing the photoelectrochemical output of photosynthetic microorganisms are poorly understood, and energy loss may occur due to inefficient electron transfer (ET) processes. Here, we systematically compare the photoelectrochemistry of photosystem II (PSII) protein-films to cyanobacteria biofilms to derive: (i) the losses in light-to-charge conversion efficiencies, (ii) gains in photocatalytic longevity, and (iii) insights into the ET mechanism at the biofilm interface. More


Neuronal Circuits Reportedly Mapped More Comprehensively Than Ever Before
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the Francis Crick Institute say they have devised a novel method that maps electrical circuits in the brain far more comprehensively than ever before. Their approach overcomes previous limitations and has enabled them to map out all 250 cells that make up a microcircuit in part of a mouse brain that processes smell, something that has never been achieved before, according to the research team who believe their technique can be used by scientists to reveal the architecture of different parts of the brain. More




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Explore the Latest Festo Innovations

Join Festo as we kick off the new year at SLAS in San Diego, CA. Discover our latest products and innovative technologies for laboratory automation at booth 637. Stop by and speak with our experts to help find a solution for your laboratory challenges.


Scientists Make Cells That Enable the Sense of Touch
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Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell-based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body. More


Biologists' New Peptide Could Fight Many Cancers
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MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia and breast cancer, need to survive. The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced by DNA damage. By blocking Mcl-1, the peptide can force cancer cells to undergo programmed cell death. More




Nanosurfactants Create Droplet-Sized Reaction Flasks
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By adding a suit of nanoparticle surfactant armor to otherwise dull droplets, chemists in South Korea have created tiny reaction flasks that they can maneuver and modify using magnets, lasers, and electrical fields. The droplets offer a new way to do microscale chemical reactions that avoids some of the pitfalls associated with microfluidics, such as difficulty mixing solutions and limitations on the types of solvents that can be used. More


Antibody-Templated Assembly of an RNA Mimic of Green Fluorescent Protein
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One of the most intriguing ways through which nature achieves regulation of biological pathways encompasses the coordination of noncovalent interactions that bring biomolecules to be colocalized in a designated restricted space. Inspired by this mechanism, we have explored the possibility of using antibodies as bivalent biomolecular substrates for the templated assembly of a functional RNA structure. More


Career


Senior Director, Development Sciences Quality
BioMarin
US - CA - San Rafael

Director / Associate Director, Development Sciences Quality, TMF and Records Management
BioMarin
US - CA - San Rafael

Assistant Professor, Biomedical Engineering
University of Arizona
US - AZ - Tucson

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