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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 18, 2017

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Last Call! Submit SLAS2017 Poster Abstracts by Jan. 23
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Take advantage of this final opportunity to present your work and receive thoughtful input from the SLAS community. Selected posters are available for viewing throughout SLAS2017 Exhibition hours, and specific times are scheduled for authors to discuss their work.

"SLAS attendees, by and large, are focused on applying novel technologies and methodology to answer both basic and clinically-relevant questions," say SLAS2017 Scientific Program Committee members John Doench of The Broad Institute and Benjamin Haley of Genentech. "One never knows what questions or suggestions may come up during a presentation, which could significantly alter the original intent or plan of the presenter. More so, presentations could stimulate collaborations between the presenter and parties interested in the described research."
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Assay Guidance Workshop for HTS and Lead Discovery at SLAS2017
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Held in conjunction with the National Institutes of Health National Center for Advancing Translational Sciences, this full-day workshop addresses a broad range of critical concepts underlying assay development for high-throughput screening and lead discovery projects.

It features presentations by several NCATS staff members and is designed to disseminate critical information about the implementation of robust assay methods and is intended to benefit the entire drug discovery community. This workshop is available to SLAS2017 registrants only and requires an additional registration fee. Learn more from The Lab Man in the SLAS e-zine.
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SLAS ELN Reports: Meet the New SLAS CEO
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Vicki Loise is on board as SLAS chief executive officer. An experienced non-profit management veteran, Loise joins the SLAS professional team with a passion for excellence and an eye toward bringing to life the refreshed SLAS Strategic Plan.

"I'm thrilled to serve as CEO of SLAS," says Loise. "With a foundation that’s firmly established and a clear vision forward thanks to the efforts of the Board of Directors, exceptional volunteers and professional team, I believe SLAS is poised for significant growth. I look forward to facilitating that growth, resulting in increased value for our membership, vendor partners and the life sciences discovery and technology community across the globe."

She looks forward to meeting many members of the community at SLAS2017.
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NEW in SLAS Technology: Rapid Prototyping of a Cyclic Olefin Copolymer Microfluidic Device for Automated Oocyte Culturing
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A collaborative team from Spain presents a rapid fabrication process for a cyclic olefin copolymer (COC) monolithic microfluidic device combining hot embossing — using a low-temperature cofired ceramic (LTCC) master — and micromilling. The microfluidic device is suitable for trapping and maturation of bovine oocytes, studied to determine their ability to be fertilized.

Another COC microfluidic device is fabricated to store sperm and assess its quality parameters over time. The study demonstrates good biocompatibility of the COC when working with gametes, and it exhibits certain advantages, such as the nonabsorption of small molecules, gas impermeability and low fabrication costs, all at the prototyping and mass production scale, taking a step further toward fully automated microfluidic devices in assisted reproductive technology. Non-members/non-subscribers may read this paper for free for a limited time.
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Explosion of Breakthrough Technologies to be Showcased at SLAS2017
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The number of exhibitors launching new products in front of the stellar SLAS2017 audience continues to grow ... and grow rapidly! Nearly 40 products are now on tap to be unveiled at SLAS2017, Feb. 4-8 in Washington, DC.

Among the latest are the AcouTrap benchtop research platform for non-contact acoustic cell trapping from AcouSort AB (SLAS2017 Innovation AveNEW participant), NMP 03 micro gas pump for portable devices from KNF Neuberger, Inc., xxpress qPCR machine from Nova Biostorage Plus, LLC, and MASS-2 molecular affinity screening system from Sierra Sensors GmbH.
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Late Night with LRIG: Rapid-Fire Innovation Session Participants Named
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Get ready for a fast-paced presentation of the latest and greatest innovations in technology products and services. 17 companies have six minutes each to tell participants how their product excels and then address questions from the audience for another couple of minutes. Late Night with LRIG moderators are Andy Zaayenga of SmarterLab, Sanj Kumar of Axol Bioscience and David Pechter, independent technology consultant and SLAS Technology podcast editor.

This always popular session takes place at SLAS2017 on Monday, Feb. 6, beginning at 6 p.m. Come early to ensure a seat; light appetizers and drinks are provided.
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SLAS2017 Short Course Spotlight: Lead Generation: A Critical Discussion of Hypothesis & Empirical Strategies
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The course provides a framework for discussing drug discovery screening strategies with an emphasis on effectively using and integrating phenotypic-based and target-based screening approaches. The goal of the course is to provide a broader context of the drug discovery process and to help understand how to best utilize existing knowledge, tools and technologies. Course instructors are David C. Swinney of the Institute for Rare and Neglected Diseases Drug Discovery and Jonathan Lee of Eli Lilly.

Swinney and Lee detail considerations for choosing a screening strategy including the differentiation from competitor's compounds/standards of care, integration of available knowledge/technologies/screening tools and the activities required to move a screening hit forward to clinical proof of concept. Lead Generation: A Critical Discussion of Hypothesis & Empirical Strategies is one of 20 Short Courses to be held at SLAS2017.
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China Opens Unique Free Electron Laser Facility
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China is joining the elite club of countries that have equipped researchers with the potent sources of high-energy photons called free electron lasers (FELs). The Dalian Coherent Light Source, whose completion was announced in Beijing, has a twist that makes it unique: It is the only large laser light source in the world dedicated to the particular range of short-wavelength light called vacuum ultraviolet, which makes it "a new tool for the detection and analysis of molecules undergoing chemical reactions," says Alec Wodtke, a physical chemist at the University of Göttingen in Germany. More


Transforming Next-Generation Sequencing
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Next-Generation Sequencing (NGS) technologies and techniques have improved the productivity and accuracy of DNA sequencers. The benefits of Moore's Law are reducing the cost of the High Performance Computing (HPC) capabilities needed to perform the alignment and other workflow steps on the outputs from NGS sequencing machines. These two trends deliver tremendous benefit to advancing personalized medicine, pharmaceutical discovery, and innovations in life science research by continually lowering the overall cost of genomics. More


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Meet KMC Systems - SLAS Booth#1601
KMC Systems is a leading provider of engineering services and contract manufacturing for the development, design and production of medical and life sciences instrumentation. We specialize in developing mechanized processes for tightly controlled and highly automated systems and manufacturing complex, highly-regulated instruments for the clinical environment. Visit KMC at Booth#1601.
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Chemist Develops New Theory for Explaining the Function of Proteins
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A University of Arkansas chemist and his collaborator at North Carolina State University have developed a new theory for explaining how proteins and other biomolecules function based on movement and change of shape and structure rather than content. Proteins are considered the workhorse molecules of cells. They are responsible for nearly all tasks in cellular life, including product manufacture, waste cleanup, and routine maintenance. More


Stem Cells Broaden Potential If Deprived of miRNA
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
By losing a single microRNA (miRNA), pluripotent stem cells may accomplish a rare feat: they may become totipotent. That is, they may give rise not only to all the tissues of a developing embryo, but also to extraembryonic tissues—the placenta and yok sac. In short, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) may acquire the developmental potential of a zygote, or fertilized egg. More




Interfaces Select Specific Stereochemical Conformations: The Isomerization of Glyoxal at the Liquid Water Interface
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Interfacial chemistry involving glyoxal at aerosol surfaces is postulated to catalyze aerosol growth. This chemistry remains speculative due to a lack of detailed information concerning the physicochemical behavior of glyoxal at the interface of atmospheric aerosols. Here, we report results from high-level electronic structure calculations as well as both classical and Born–Oppenheimer ab initio molecular dynamics simulations of glyoxal solvation at the air/liquid water interface. More


FAST: Size-Selective, Clog-Free Isolation of Rare Cancer Cells from Whole Blood at a Liquid-Liquid Interface
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Circulating tumor cells (CTCs) have great potential to provide minimally invasive ways for the early detection of cancer metastasis and for the response monitoring of various cancer treatments. Despite the clinical importance and progress of CTC-based cancer diagnostics, most of the current methods of enriching CTCs are difficult to implement in general hospital settings due to complex and time-consuming protocols. More


Bacterial Protein Acts as Prion in Yeast and E. coli
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Researchers at Harvard Medical School used software to run through roughly 60,000 bacterial genomes in search of proteins that, in yeast, would be predicted to behave as prions — that is, become misfolded in a way that passes on the errant structure to like proteins. In doing so, they identified a version of the global regulator Rho encoded in the genome of Clostridium botulinum, the causative agent of botulism. When they injected Cb­-Rho into E. coli to examine the protein's function, they found that the protein misfolded in a prion-like manner, rendering it nonfunctional and allowing genes normally suppressed by Rho to be expressed. More


3-D Printing Could Transform Future Membrane Technology
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Researchers at the University of Bath suggest developments in 3-D printing techniques could open the door to the advancement of membrane capabilities. This work is part of the University's Centre for Advanced Separations Engineering (CASE) and is the first time the properties of different 3-D printing techniques available to membrane fabrication have been assessed. More


Career


Staff Scientist
National Institute on Deafness and Other Communication Disorders (NIH)
US – MD – Bethesda

Sr. Research Scientist
Sappi North America
US – ME – Westbrook

Postdoctoral Fellowship in Primate Neurophysiology and Motor Learning
University of Pittsburgh
US – PA – Pittsburgh

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