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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 21, 2015

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SLAS ELN Reports: Neglected Infectious Diseases — Making Progress, but Burden Remains
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The need for safe and effective treatments for neglected infectious diseases is only now beginning to be met, according to Julio Martin-Plaza, Ph.D., GlaxoSmithKline, Tres Cantos, Spain and Eric Chatelain, Ph.D., Drugs for Neglected Diseases initiative, Geneva, Switzerland. Martin-Plaza and Chatelain are guest editors of the open access January 2015 special issue of the Journal of Biomolecular Screening on Novel Therapeutic Approaches for Neglected Infectious Diseases. Read more in the SLAS e-zine and listen to Chatlain's video overview. More

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Five Finalists Advance in SLAS2015 Student Poster Competition
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Congratulations to the following students, selected during pre-conference judging, for a chance to be among the Top 3 student posters and win $500 each at SLAS2015 in Washington, DC.

Kathryn Champ, Johns Hopkins University
Screening for Synergy of Resveratrol and Repurposed Drugs Towards Retinoblastoma

llana Chefetz, University of Michigan
ALDH inhibition as a trigger for necroptotic cell death of Ovarian Cancer Stem Cells

Samantha Grist, University of British Columbia, Vancouver
A Microfluidic Device with Integrated Oxygen Sensors for the Cell-Based Screening of Cancer Treatments under Transient Hypoxia

Juwina Wijaya, University of California Los Angeles
Utilizing small molecules to study mitochondria presequence-degrading protease

Agnieszka Żuchowska, Warsaw University of Technology
Proliferation of MRC-5 and A549 cells on modified poly(dimethylosiloxane) (PDMS)

Additional abstracts and posters can be viewed in the SLAS2015 ePoster Gallery.
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JALA & JBS Art of Science Contest: Vote Now!
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Finalists have been selected for the 2015 JALA & JBS Art of Science Contest, and their creative work features fun cells, interesting neurons, parasites, liposomes and scaffolds — oh my! Vote for your favorite finalist today — the top vote-getter will be named the grand prize winner. View the 10 images, read a bit about them and vote today. More


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Sign up Today: Robust Mentoring Program Added to SLAS2015 Career Connections
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If one-on-one time with an established life sciences professional is appealing for career planning, you can find it at SLAS2015 in Washington, DC.

Mentoring sessions are first come, first served, and free to SLAS2015 registered attendees.

Sessions are 45 minutes and will be held Monday and Tuesday, Feb. 9 and 10.

Read about more SLAS2015 career services, including career development workshops on effective interviewing, building professional relationships, finding an industry job and choosing an academic laboratory.
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SLAS Asia Beijing Seminar this Friday, Jan. 23
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Systemic Screening of Natural Products Targeting Multiple-Targets and Discovery of Drug Candidates will be held Friday afternoon, Jan. 23, at the Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences in Beijing. The program features:

Du Guanhua, Academy of Materia Medica, Chinese Academy of Medical Science; Institute of Materia Medica, Chinese Academy of Medical Science; Chinese Pharmacological Society; The National Centre for Drug Screening (Beijing)

Ye Qizhuang, Thousand Talents Program; formerly with Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Shuyi Si, SLAS Asia Council member; Vice Chair of SLAS Asia Education Advisory Committee vice chair; National Center for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

Dai Huanqing, Institute of Microbiology, Chinese Academy of Sciences
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SLAS2015 Conference App Available
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The new and improved SLAS2015 mobile app can help you get around, connect and stay up to date. Download in advance of SLAS2015, and use it to plan your itinerary, review scientific session abstracts and speaker details, highlight companies to visit in the Exhibition and set preferences for connecting with other participants and receiving notifications of important alerts. The app is available free for both iOS and Android devices. Watch a short video to learn more about its capabilities. More

JALA & JBS Special Issue Calls for Papers
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SLAS is accepting manuscript proposals for three special issues of its journals:
  • High-Throughput Imaging Technologies (JALA manuscript proposals due April 1)
  • Advances in Mass Spectrometry within Drug Discovery (JBS proposals due April 10)
  • Micro and Nanotechnologies for Quantitative Biology and Medicine (JALA proposals due Oct. 20)
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    New 'Triggered-Release' Mechanism Could Improve Drug Delivery
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    More efficient medical treatments could be developed thanks to a new method for triggering the rearrangement of chemical particles, scientists say. The new method uses two "parent" nanoparticles that are designed to interact only when in proximity to each other and trigger the release of drug molecules contained within both. The release of the drug molecules from the "parent" nanoparticles could subsequently form a third "daughter" particle, which comprises molecules from both "parent" nanoparticles, researchers explain. More

    Exploiting Highly Ordered Subnanoliter Volume Microcapillaries as Microtools for the Analysis of Antibody Producing Cells
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The interrogation of highly diverse repertoires of heterogeneous cell populations on a single cell basis increases the likelihood that a cell with unique characteristics will be identified. We have developed a new single cell analysis system comprising millions of bundled subnanoliter volume bioincubation chambers for the identification and recovery of target specific antibody secreting cells (ASCs). More

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    Bone Stem Cells Identified that Can Regenerate Bones and Cartilage
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at Columbia University Medical Center (CUMC) say they have identified a stem cell in the bone marrow of mice that is capable of regenerating both bone and cartilage. They report their study ("Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential") in the online issue of Cell. The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. More

    Oxidation Half-Reaction of Aqueous Nucleosides and Nucleotides via Photoelectron Spectroscopy Augmented by ab Initio Calculations
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Oxidative damage to DNA and hole transport between nucleobases in oxidized DNA are important processes in lesion formation for which surprisingly poor thermodynamic data exist, the relative ease of oxidizing the four nucleobases being one such example. Theoretical simulations of radiation damage and charge transport in DNA depend on accurate values for vertical ionization energies (VIEs), reorganization energies, and standard reduction potentials. More


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    Raman Technique Reveals Protein Synthesis In Live Tissue
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A newly improved imaging method helps researchers map where cells are synthesizing and degrading proteins in live tissue. The technique, based on Raman spectroscopy, could be used to investigate how protein metabolism changes in cognitive disorders or long-term memory formation, the researchers say. To better understand how our brains learn and remember, neuroscientists want to pinpoint which neurons fire and which synapses are active when the brain encodes new information. More

    Flu Shot This Year Provides Weak Protection
    Live Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    This year's flu vaccine is not very effective at preventing the flu, particularly among adults, according to new estimates from the Centers for Disease Control and Prevention. In a study of more than 2,000 people in the United States, including both children and adults, researchers found that those who got this year's flu shot were just 23 percent less likely to go to the doctor for flu symptoms than people who didn't get a shot. More



    Global Bonds Boost Chemists' Pace of Research and Discovery
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A pair of chemistry graduate students, from Emory and Nagoya University in Japan, combined forces to demonstrate how a newer, more efficient strategy can be applied to synthesize natural compounds that hold potential medicinal benefits. The Journal of the American Chemical Society published their findings, showing how C-H functionalization speeds up synthesis of two promising marine alkaloids from a sea sponge, known as dictyodendrin A and F. More

    Eradicating Ebola: What Will It Take?
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Ebola's outbreak in 2014 became one of the biggest world health threats in recent memory. The development of the disease was exhaustively chronicled as the world watched it go from a few isolated cases in West Africa to a full-blown epidemic there. Fear reached a fevered pitch when a few infected individuals landed in the U.S., but it died down just as quickly after a few months. Unfortunately, nothing has been able to halt the spread of the virus in Guinea, Liberia and Sierra Leone. More


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