This message contains images. If you don't see images, click here to view. Advertise in this news brief.    Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 21, 2015 SLAS.org    SLAS2015    Moving? New job? Let SLAS know.     Advertisement Advertisement Advertisement Advertisement Advertisement Totally automated. Highly interactive. Boost your career or find the perfect candidate. SLAS Career Connections offers both online and in-person career services.   Advertisement SLAS ELN Reports: Neglected Infectious Diseases — Making Progress, but Burden Remains SLAS    Share    The need for safe and effective treatments for neglected infectious diseases is only now beginning to be met, according to Julio Martin-Plaza, Ph.D., GlaxoSmithKline, Tres Cantos, Spain and Eric Chatelain, Ph.D., Drugs for Neglected Diseases initiative, Geneva, Switzerland. Martin-Plaza and Chatelain are guest editors of the open access January 2015 special issue of the Journal of Biomolecular Screening on Novel Therapeutic Approaches for Neglected Infectious Diseases. Read more in the SLAS e-zine and listen to Chatlain's video overview. More Advertisement Five Finalists Advance in SLAS2015 Student Poster Competition SLAS    Share    Congratulations to the following students, selected during pre-conference judging, for a chance to be among the Top 3 student posters and win $500 each at SLAS2015 in Washington, DC. Kathryn Champ, Johns Hopkins University Screening for Synergy of Resveratrol and Repurposed Drugs Towards Retinoblastoma llana Chefetz, University of Michigan ALDH inhibition as a trigger for necroptotic cell death of Ovarian Cancer Stem Cells Samantha Grist, University of British Columbia, Vancouver A Microfluidic Device with Integrated Oxygen Sensors for the Cell-Based Screening of Cancer Treatments under Transient Hypoxia Juwina Wijaya, University of California Los Angeles Utilizing small molecules to study mitochondria presequence-degrading protease Agnieszka Żuchowska, Warsaw University of Technology Proliferation of MRC-5 and A549 cells on modified poly(dimethylosiloxane) (PDMS) Additional abstracts and posters can be viewed in the SLAS2015 ePoster Gallery. More Advertisement Generate and analyze 3D multicellular spheroids in the same microplate Corning® BioCoat™ High Content Imaging Microplates provide enhanced performance for cell-based assays Reduce sample loss with Axygen® Maxymum Recovery® technology Comparison of Axygen® 96-well half-skirt microplates with competitors reveal consistent and comparable functionality Effectively and efficiently isolate PCR contaminants using Axygen® AxyPrep Mag PCR Clean-up kit JALA & JBS Art of Science Contest: Vote Now! SLAS    Share    Finalists have been selected for the 2015 JALA & JBS Art of Science Contest, and their creative work features fun cells, interesting neurons, parasites, liposomes and scaffolds — oh my! Vote for your favorite finalist today — the top vote-getter will be named the grand prize winner. View the 10 images, read a bit about them and vote today. More Advertisement AUTOMATE MICROSCALE FlOW CHEMISTRY AND BIOLOGY CONTROL YOUR EXPERIMENT WITH THE LABSMITH uPROCESS™ AUTOMATION PLATFORM THAT INCLUDES PUMPS, VALVES, PRESSURE SENSORS, BREADBOARDING, AND CONTROL SOFTWARE. MODULAR, INTEGRATED, AUTOMATED. WWW.LABSMITH.COM Advertisement It's All About Your Data During SLAS, visit CDD (Booth 1155) to see how you can effortlessly store, analyze, & mine your biological study data & chemical structures with CDD Vault®. Finally, a modern approach to drug research informatics. Click here! Sign up Today: Robust Mentoring Program Added to SLAS2015 Career Connections SLAS    Share    If one-on-one time with an established life sciences professional is appealing for career planning, you can find it at SLAS2015 in Washington, DC. Mentoring sessions are first come, first served, and free to SLAS2015 registered attendees. Sessions are 45 minutes and will be held Monday and Tuesday, Feb. 9 and 10. Read about more SLAS2015 career services, including career development workshops on effective interviewing, building professional relationships, finding an industry job and choosing an academic laboratory. More Advertisement SLAS Asia Beijing Seminar this Friday, Jan. 23 SLAS     Share    Systemic Screening of Natural Products Targeting Multiple-Targets and Discovery of Drug Candidates will be held Friday afternoon, Jan. 23, at the Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences in Beijing. The program features: Du Guanhua, Academy of Materia Medica, Chinese Academy of Medical Science; Institute of Materia Medica, Chinese Academy of Medical Science; Chinese Pharmacological Society; The National Centre for Drug Screening (Beijing) Ye Qizhuang, Thousand Talents Program; formerly with Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shuyi Si, SLAS Asia Council member; Vice Chair of SLAS Asia Education Advisory Committee vice chair; National Center for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Dai Huanqing, Institute of Microbiology, Chinese Academy of Sciences More Advertisement Upcoming Tutorials at SLAS2015 Achieving Massive Throughput and Quality Gains via Acoustic-dispensing Technology: Genentech’s New Workflow for Mammalian Genotyping Increasing Productivity, At Reduced Cost, Across a Range of Assay Platforms with the Echo® Liquid Handler Echo® Combination Screen Software: Quickly Create and Manage Combinatorial Screens Register NOW SLAS2015 Conference App Available SLAS    Share    The new and improved SLAS2015 mobile app can help you get around, connect and stay up to date. Download in advance of SLAS2015, and use it to plan your itinerary, review scientific session abstracts and speaker details, highlight companies to visit in the Exhibition and set preferences for connecting with other participants and receiving notifications of important alerts. The app is available free for both iOS and Android devices. Watch a short video to learn more about its capabilities. More JALA & JBS Special Issue Calls for Papers SLAS    Share    SLAS is accepting manuscript proposals for three special issues of its journals: High-Throughput Imaging Technologies (JALA manuscript proposals due April 1) Advances in Mass Spectrometry within Drug Discovery (JBS proposals due April 10) Micro and Nanotechnologies for Quantitative Biology and Medicine (JALA proposals due Oct. 20) More Advertisement Cloud Solutions Designed with Scientists in Mind Save time and money with    Acquire™ lab supplies    management software. Streamline compound    management with Store™ Make internal and external    compounds and assays    accessible to all project    teams with Request™ Visualize™ enables    securely sharing compound    and biological assay results. Advertisement Overcoming the challenges of phenotypic screening TTP Labtech’s acumen® Cellista has played a pivotal role in the miniaturization and optimization of physiologically relevant cell-based 2D and 3D assays to make them amenable for the screening of high-impact compound libraries. Learn more at our SLAS workshop “Evaluating Cancer Drug Candidates Using High-Throughput 3D Cell Culture Models” on 10th February at 12:30. Advertisement Best Fragments Moving Forward? Having difficulties selecting the best fragment hits? Get reliable affinity and kinetic data directly from primary screens using Pioneer FE with hit-selection software from SensiQ. Pioneer FE optimizes workflows by providing the fastest time to first results available on any SPR biosensor. More Confidence. Better Decisions. Pioneer FE. New 'Triggered-Release' Mechanism Could Improve Drug Delivery Science Daily    Share    More efficient medical treatments could be developed thanks to a new method for triggering the rearrangement of chemical particles, scientists say. The new method uses two "parent" nanoparticles that are designed to interact only when in proximity to each other and trigger the release of drug molecules contained within both. The release of the drug molecules from the "parent" nanoparticles could subsequently form a third "daughter" particle, which comprises molecules from both "parent" nanoparticles, researchers explain. More Exploiting Highly Ordered Subnanoliter Volume Microcapillaries as Microtools for the Analysis of Antibody Producing Cells Analytical Chemistry    Share    The interrogation of highly diverse repertoires of heterogeneous cell populations on a single cell basis increases the likelihood that a cell with unique characteristics will be identified. We have developed a new single cell analysis system comprising millions of bundled subnanoliter volume bioincubation chambers for the identification and recovery of target specific antibody secreting cells (ASCs). More Advertisement Bone Stem Cells Identified that Can Regenerate Bones and Cartilage Genetic Engineering & Biotechnology News    Share    Scientists at Columbia University Medical Center (CUMC) say they have identified a stem cell in the bone marrow of mice that is capable of regenerating both bone and cartilage. They report their study ("Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential") in the online issue of Cell. The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. More Oxidation Half-Reaction of Aqueous Nucleosides and Nucleotides via Photoelectron Spectroscopy Augmented by ab Initio Calculations Journal of the American Chemical Society    Share    Oxidative damage to DNA and hole transport between nucleobases in oxidized DNA are important processes in lesion formation for which surprisingly poor thermodynamic data exist, the relative ease of oxidizing the four nucleobases being one such example. Theoretical simulations of radiation damage and charge transport in DNA depend on accurate values for vertical ionization energies (VIEs), reorganization energies, and standard reduction potentials. More Advertisement Clear Choice for Lysate Clearance! Why limit recovery or capacity to clarify cellular debris from your sample? For a variety of integrated pre-filter options tailored to your research needs, visit Pall Laboratory website. Advertisement Explore the latest innovations in motion and fluidics. Parker Precision Fluidics offers laboratory solutions enabling precise motion and fluidics control for instrument accuracy. RoHS compliant products optimized for stability, long life, and efficiency. For more information visit www.parker.com/precisionfluidics or email ppfinfo@parker.com. Raman Technique Reveals Protein Synthesis In Live Tissue Chemical & Engineering News    Share    A newly improved imaging method helps researchers map where cells are synthesizing and degrading proteins in live tissue. The technique, based on Raman spectroscopy, could be used to investigate how protein metabolism changes in cognitive disorders or long-term memory formation, the researchers say. To better understand how our brains learn and remember, neuroscientists want to pinpoint which neurons fire and which synapses are active when the brain encodes new information. More Flu Shot This Year Provides Weak Protection Live Science    Share    This year's flu vaccine is not very effective at preventing the flu, particularly among adults, according to new estimates from the Centers for Disease Control and Prevention. In a study of more than 2,000 people in the United States, including both children and adults, researchers found that those who got this year's flu shot were just 23 percent less likely to go to the doctor for flu symptoms than people who didn't get a shot. More Global Bonds Boost Chemists' Pace of Research and Discovery Phys.org    Share    A pair of chemistry graduate students, from Emory and Nagoya University in Japan, combined forces to demonstrate how a newer, more efficient strategy can be applied to synthesize natural compounds that hold potential medicinal benefits. The Journal of the American Chemical Society published their findings, showing how C-H functionalization speeds up synthesis of two promising marine alkaloids from a sea sponge, known as dictyodendrin A and F. More Eradicating Ebola: What Will It Take? Bioscience Technology    Share    Ebola's outbreak in 2014 became one of the biggest world health threats in recent memory. The development of the disease was exhaustively chronicled as the world watched it go from a few isolated cases in West Africa to a full-blown epidemic there. Fear reached a fevered pitch when a few infected individuals landed in the U.S., but it died down just as quickly after a few months. Unfortunately, nothing has been able to halt the spread of the virus in Guinea, Liberia and Sierra Leone. More Advertisement Meet KMC Systems - SLAS Booth#1416 As a leading provider of world-class contract manufacturing and engineering services for medical and biotechnology instrumentation, KMC Systems partners with leading and emerging medical device companies to successfully bring in-vitro diagnostic, surgical, therapeutic, life science and laboratory automation products to market. ISO 13485 Certified. FDA Registered. SLAS Booth #1416. Advertisement NEW! Cytation 5 Cell Imaging Reader Cytation™ 5 is a modular, upgradable multi-mode reader that combines automated digital imaging and conventional microplate detection. Cytation 5 includes both filter- and monochromator-based detection; the imaging module provides up to 60x magnification in fluorescence, brightfield, H&E and phase contrast. Incubation to 65 °C, shaking and Gen5 software are standard. Advertisement Sample Screening from your Compound The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound management or screening system. Senior Automation Engineer Counsyl US – CA – South San Francisco Senior Software Engineer Tecan US US – NC – Raleigh Scientist Assay Automation Janssen Prevention Center Johnson & Johnson The Netherlands – Leiden Search jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues Jan. 14, 2015 Jan. 7, 2015 Dec. 31, 2014 Dec. 24, 2014 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063