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SLAS
A new collection of reviews and original research in February’s SLAS Technology illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development. This special collection illustrates how the human iPS cells and 3D cell culture technology provide powerful approaches to the development of novel and more effective therapies.This issue, sponsored by Corning Life Sciences, is free to access and includes:
- Editorial Introduction: Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery by Guest Editor Richard M. Eglen, Ph.D., Corning Life Sciences (Tewksbury, MA, USA)
- Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization
- Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids and Disease Modeling
- Original Research: Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy
- Original Research: Full Factorial Microfluidic Designs and Devices for Parallelizing Human Pluripotent Stem Cell Differentiation
- Original Research: A Single-Step Self-Assembly Approach for the Fabrication of Aligned and Multilayered Three-Dimensional Tissue Constructs Using Multidomain Peptide Hydrogel
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SLAS
 The ten finalists for this year’s SLAS Innovation Award have been announced. Each presenter will be competing for a $10,000 cash prize to be awarded after the closing keynote on the final day of SLAS2019. These podium presentations were selected due to their outstanding innovations and contributions to the exploration of advancing technologies in the lab and include topics such as high-throughput organ-on-chip drug screening in immuno-oncology, microfluidic functional screening and live-cell gene imaging. Read on for a list of this year’s finalists, their presentations and complete judging and scoring criteria.
VIEW THE 2019 FINALISTS
SLAS
SLAS2019 Conference Co-Chair John Doench, Ph.D., has a passion for collaborative science. And that passion is why he’s dedicated to working with others to foster ideas and connections that enable scientists to make a difference. “Getting people to buy into the idea of collaborative science is a challenge,” Doench says. “So much of how we think about science is about the individual.” Read more about Doench, how he got into biology as a history major, his wide-ranging daily interactions and success stories with CRISPR, and how he adapted his collaborative science approach to make sure attendees of SLAS2019 walk away with new tools and ideas they can use to continue their success.
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SLAS
You now have until Feb. 11 to save €125 off registration for the SLAS Europe Sample Management Symposium in Berlin. Join your colleagues from sample and compound management academia and industry, March 11-12, for presentations and discussions on quality, process efficiency, metadata and miniaturization among other topics. In addition, exhibit and sponsorship opportunities are still available.
VIEW FULL MEETING DETAILS
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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SLAS
SLAS2019 International Conference and Exhibition
Feb. 2-6
Washington, DC, USA
Friday, Feb. 1: Advance registration discounts end
Saturday, Feb. 2: Short Courses Begin. Onsite registration rates apply!
Sponsorship opportunities still available!
SLAS Journals Special Issues Call for Papers
SLAS Discovery: Advances in Cellular Target Engagement and Target Deconvolution
March 1: Proposals due
July 1: Invited submissions due
SLAS Technology: Flexible Analytical Devices for Point-of-Care Testing
March 1: Proposals due
July 1: Invited submissions due
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1: Proposals due
Aug. 10: Invited submissions due
Save These 2019 Dates!
SLAS 2019 European Sample Management Symposium
Early Bird Registration Discount Ends February 11!
March 11-12
Berlin, Germany
SLAS Europe 2019 Conference and Exhibition
June 26-28
Barcelona, Spain
Feb. 11: Super Early Bird Registration Rate Ends
Feb. 18: Podium Abstract Submission Deadline
Exhibit and Sponsorship Opportunities Still Available!
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SLAS
 Just register before Feb. 1, that’s it! Here are some other numbers that may catch your attention: In just ten days, SLAS2019 will host 144 scientific presentations from ten different tracks, 22 pre-conference Short Courses, more than 300 exhibitors, 40 Exhibitor Tutorials, 23 Spotlight Solution sessions, two dynamic keynote speakers, one amazing Tuesday Night Party and so much more that we can’t fit into this small article. Secure your spot in Washington, DC by registering now instead of onsite and save $200 off full conference rates.
REGISTER NOW
VIEW THE COMPLETE SLAS2019 SCHEDULE
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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Lab Manager
By combining deep learning algorithms and statistical methods, investigators from the Institute of Evolutionary Biology (IBE), the Centro Nacional de Análisis Genómico (CNAG-CRG) of the Centre for Genomic Regulation (CRG), and the Institute of Genomics at the University of Tartu have identified, in the genome of Asiatic individuals, the footprint of a new hominid who cross bred with its ancestors tens of thousands of years ago.
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Genetic Engineering & Biotechnology News
Scientists at UCLA have developed a technique for coaxing pluripotent stem cells, which can be grown indefinitely in the lab, into becoming mature T cells capable of killing tumor cells. The method uses artificial thymic organoids, which work by mimicking the environment of the thymus, the organ in which T cells develop from blood stem cells.
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Phys.org
Research at the University of Arkansas on membrane proteins could lead to better development and testing of drugs. Chemistry researchers studied a type of membrane protein that expels drugs from a cell, contributing to drug resistance. They found that the lipid composition of the cell membrane has an effect on the behavior of these proteins, which should be taken into account when testing drugs that target membrane proteins. Their results are available open-access in the journal ACS Central Science.
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Monolith NT.Automated is the system that so many scientists choose as their primary tool to quickly identify true hits in single-dose screens and rank the strongest binders in their affinity-based screens. Learn more.
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Explore the best combination of kits and instruments to ensure gentle and fast isolation of primary cells for your drug discovery and in vitro assays. Curious? Join our lunch seminar and demo on high-throughput cell isolation using the MultiMACS™ X Cell Separator for maximum efficiency and reproducibility.
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Laboratory Equipment
If you step on a tack, neurons in your brain will register two things: that there's a piercing physical sensation in your foot, and that it's not pleasant. Now, a team of scientists at Stanford University has identified a bundle of brain cells in mice responsible for the latter — that is, the negative emotions of pain.
Pain research has traditionally focused on the neurons and molecules at the front line of pain perception — the cells in nerves that process stings, cuts, burns and the like — and ultimately convey a physical threat message.
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"Small Molecule screening with assays for calcium, sodium and potassium that are convenient and easy from ION. To view the latest technology visit us at IonIndicators.com " MORE
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Science Daily
Scientists have managed to grow perfect human blood vessels as organoids in a petri dish for the first time. The breakthrough engineering technology dramatically advances research of vascular diseases like diabetes, identifying a key pathway to potentially prevent changes to blood vessels — a major cause of death and morbidity among those with diabetes.
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Charles River invites you to discover the value of the right HTS partner. Flexible price models, smart guidance from our scientists, thorough results and data, fast data delivery. Schedule a consult with our scientists during the SLAS2019 conference and exhibition. Times filling up quickly, make your requests soon.
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Chemical & Engineering News
In August 2017, attendees at the American Chemical Society national meeting in Washington, DC, crowded into a ballroom, buzzing with questions about the newest addition to the chemistry publishing world: preprint servers. Two online sites that would post scientific manuscripts for free prior to peer review had launched just weeks earlier. ChemRxiv was initially launched by ACS, with guidance from the Royal Society of Chemistry, the German Chemical Society, and other scientific organizations and publishers. And ChemRN was Elsevier’s latest offering in its sprawling SSRN repository.
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Laboratory Equipment
Our body's cells are constantly changing. But which of these changes are healthy developments and which lead to serious diseases? This is what LifeTime, a new transnational and interdisciplinary initiative of leading European researchers, aims to discover. The consortium is jointly coordinated by the Max Delbrück Center in Berlin and the Institut Curie in Paris, with the Helmholtz Association and the CNRS.
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New Scientist
The researcher who secretly created gene-edited babies in China has been fired by his university after a preliminary investigation concluded he “illegally conducted the research in the pursuit of personal fame and gain.” In November, the world was shocked when He Jiankui claimed that two gene-edited babies had already been born and that a woman was pregnant with another.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
High Content Imaging Specialist — Senior Research Scientist
Memorial Sloan Kettering Research Institute
US – NY – New York City
Research Bioinformatician I – Heart Institute
Cedars-Sinai
US – CA – Los Angeles
Research Scientist – HTP Biology, Inflammation or IO
Gilead Sciences, Inc.
US – CA – Foster City
Search Jobs at SLAS Career Connections
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