This message contains images. If you don't see images, click here to view. Advertise in this news brief. Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 25, 2017 SLAS.org    SLAS2017    Moving? New job? Let SLAS know.       Advertisement Advertisement Advertisement Advertisement   The 2017 SLAS Technology Ten: Translating Life Sciences Innovation SLAS     Share    For the past 21 years, SLAS Technology (formerly JALA) has provided a unique forum for the presentation of new technologies that advance life sciences and biomedical research. "This tradition continues with the first SLAS Technology Ten, celebrating the best of the great work published in this journal throughout the previous year," says Edward Kai-Hua Chow, SLAS Technology editor-in-chief. "The collection represents achievements from nine countries — China, Finland, France, Germany, Japan, Sweden, Switzerland, UK, and USA." Read Chow's editorial, listen to his podcast and search for the individual papers with free access to all in January. More Advertisement Five Advance in SLAS2017 Student Poster Competition SLAS    Share    Following pre-conference evaluation against set criteria, judges have named the following five student poster authors as finalists who will be further evaluated at SLAS2017, where they will compete for three $500 cash prizes: Alice Bong (University of Queensland, Australia): Imaging Intracellular Calcium Dynamics in Breast Cancer using Automated High-Content Fluorescence Imaging Samantha Grist (University of British Columbia, Canada): Monitoring Tumor Cell Behavior and Response to Treatment under Chronic and Transient Hypoxia within a 3-D Culture Environment using a Microfluidic Platform Andrea Mazzocchi (Wake Forest Institute for Regenerative Medicine, U.S.): 3D Printing of Cancer Organoids for High-Throughput Screening Sudip Mondal (University of Texas at Austin, U.S.): Next Generation Screening Technology for High-Throughput Drug Screening using C. elegans Disease Models Bilal Zulfiqur (Griffith University, Australia): High-Throughput Phenotypic Screening Reveals Novel Pharmacologically Active Compounds for Visceral Leishmaniasis Good luck to all! More Advertisement [Promo] Get a high-content imager starting as low as $100K. US and Canada only. Learn More>> [Download eBook] The industry standard for microplate readers [Download case study] Tailor our automated microbial colony picker to meet your unique workflow demands [FREE article] Phenotypic characterization of toxic compound effects on liver spheroids Learn more about greater predictivity for compound efficacy and toxicity using 3D models SLAS ELN Reports: Making Micro-Volume Biology Work — Tools, Techniques and Secrets SLAS    Share    "The field of microfluidics has been evolving rapidly in the past few years," says SLAS2017 Session Chair Daniel Sipes of the Genomics Institute of the Novartis Research Foundation (San Diego, CA). "From the perspective of someone looking for technologies to improve high-throughput screening and compound profiling, the state of microfluidic applications is more interesting and attractive than ever." Sipes discusses eye-opening work for those involved at the single-cell level in automated and high-throughput formats in the SLAS Electronic Laboratory Neighborhood e-zine. Image courtesy of Kevin Chapman, Berkeley Lights, Inc. (Emeryville, CA). More Advertisement Rumor has it..... A lot of you have probably heard the Biomek team at Beckman Coulter Life Sciences is up to something. Rumor? Fact? Let’s shed some light on the truth. Watch Now SLAS2017 Keynote Presentation Details Now Available SLAS    Share    Jennifer Lippincott-Schwartz presents Emerging Fluorescence Technology to Study the Spatial and Temporal Dynamics of Organelles within Cells, Monday morning. She focuses on visualization technologies that are playing an increasingly important role in the study of numerous aspects of cell biology, capturing processes at the level of whole organisms down to single molecules. On Wednesday afternoon, Rachel Swaby offers From the Center of the Earth to the Stars: The Unknown History of Women in Science, exploring fascinating stories that dig into the impact women made and why it matters that others learn about them. Both sessions are open to SLAS2017 full conference registrants. More Advertisement Feb. 1: Poster Abstracts Due for 2017 SLAS Europe Compound Management Conference SLAS     Share    One week remains to submit your scientific poster abstract for the opportunity to have your work showcased at "Breaking Down Walls — Uniting Sample Management Communities to Advance Scientific Innovation," March 14-15, 2017, Berlin, Germany. SLAS Europe Compound Management Conference registrations are now being accepted, and the program features leading scientists from AstraZeneca, Evotec, Lead Discovery Center and Pivot Park Screening Centre to name a few. More Advertisement Get the perfect fit and improved ergonomics with FlexFit® Technology. Leave no sample behind with our naturally low retentive X-Resin® Technology. Are your tips low retention? Watch this video to see the difference now! Using a Rainin LTS pipette? xTIP® Pipette Tips feature innovation beyond ergonomics. Learn more! Biotix vs Rainin. Who will reign supreme in "The Pressure Test"? Watch now! SLAS Discovery: Evaluation of Parameters Impacting Drug Susceptibility in Intracellular Trypanosoma cruzi Assay Protocols SLAS     Share    Featured on the front cover of the February issue of SLAS Discovery is a report by a collaborative team from Leishmania Research Laboratory (Republic of Korea), Yonsei University (Republic of Korea) and Drugs for Neglected Diseases initiative (Switzerland) that examines the differences between widely used colorimetric and image-based screening assays by evaluating the activities of a set of reference compounds. The team finds significant variation in compound effectiveness between assays, indicating discrepancies resulting primarily from cell seeding schemes and compound incubation times. Other factors, such as strain type and readout method, only result in minor variations within their experimental setup. "Our findings are of general interest to the scientific community investigating Chagas disease drug discovery since they provide insights into the development of intracellular T. cruzi assays and interpretation of assay results," according to the paper. "These findings also underscore the need for multiple, independent assessments of the activity of potential compounds." More Advertisement Accelerate your NGS Success Fast, accurate sequencing begins with automated NGS Sample Prep from Agilent. SLAS2017 Short Course Spotlight: An Introduction to Mass Spectrometry and its Applications within Drug Discovery SLAS    Share    Course instructors Jonathan Wingfield and Ian Sinclair of AstraZeneca Discovery Sciences (U.K.) help participants to better understand the principles of mass spectrometry and its diversity of instruments and ionization techniques, where mass spectrometry can be applied in drug discovery and how recent developments in mass spectrometry have magnified its impact. 2015 SLAS Innovation Award Winner Wingfield and Sinclair were guest editors for the February 2016 SLAS Discovery (formerly JBS) Special Issue on Advances in Mass Spectrometry within Drug Discovery. An Introduction to Mass Spectrometry and its Applications within Drug Discovery is one of 20 Short Courses to be held at SLAS2017. More Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models Journal of the American Chemical Society    Share    Vesosomes are nested liposomal structures with high potential as advanced drug delivery vehicles, bioreactors and artificial cells. However, to date no method has been reported to prepare monodisperse vesosomes of controlled size. Here we report on a multistep microfluidic strategy for hierarchically assembling uniform vesosomes from dewetting of double emulsion templates. The control afforded by our method is illustrated by the formation of concentric, pericentric and multicompartment liposomes. More Scientists Develop Micromotors That Neutralize Gastric Acid and Release Drugs Depending on pH Phys.org    Share    Tiny "submarines" that speed independently through the stomach, use gastric acid for fuel (while rapidly neutralizing it), and release their cargo precisely at the desired pH: Though it may sound like science fiction, this is a new method for treating stomach diseases with acid-sensitive drugs introduced by scientists in the journal Angewandte Chemie. The technique is based on proton-driven micromotors with a pH-dependent polymer coating that can be loaded with drugs. More Advertisement 3D culture platform for HTS ORGANOGENIX and MBL International together provide NanoCulture Plate for innovative drug discovery and HTS screening. NCP that has artificial scaffold which mimics the ECM structure achieve scaffold type 3D cell culture regardless of non-coating. NCP has several features which are high reproducibility, operability and observability for 3D HTS. A 'Strand' of DNA as Never Before Bioscience Technology    Share    In a carefully designed polymer, researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences have imprinted a sequence of a single strand of DNA. The resulting negative remained chemically active and was capable of binding the appropriate nucleobases forming a genetic code. The polymer matrix — the first of its type in history — thus functioned exactly like a sequence of real DNA. More Step Closer to Safe Stem Cell Therapies Science Daily    Share    A new compound could help rid stem cell samples of potentially tumorigenic cells, making them safer for regenerative therapies. Stem cells derived from adult cells, called human induced pluripotent stem cells (hiPSCs), have great potential for basic research and regeneration therapies. But for clinical samples to be safe, these cells need to completely differentiate into their target cells. Any remaining undifferentiated cells in the sample have the potential to form tumors, so must be selectively eliminated. More Advertisement Digilab Identity Raman Plate Reader Digilab has combined advancements in the miniaturization of spectrometers, data storage, robotics & automation, to develop the Digilab Identity Raman Plate Reader, enabling fast sample measurement into microtiter plates or slides, with the flexibility of low-to-high throughput for many industry specific applications. Why settle for less with your research investment? Advertisement Meet KMC Systems - SLAS Booth#1601 KMC Systems is a leading provider of engineering services and contract manufacturing for the development, design and production of medical and life sciences instrumentation. We specialize in developing mechanized processes for tightly controlled and highly automated systems and manufacturing complex, highly-regulated instruments for the clinical environment. Visit KMC at Booth#1601. Advertisement Specialized Lab-on-a-Chip solutions Micronit creates added value for our customers by offering a unique combination of: 1. Microfluidics expertise from design through prototyping to manufacturing. 2. Materials, from glass to polymers, silicon or hybrid combinations. 3. Customer application know-how, which together enable our customers to develop winning products, both now and in the future. Super-Resolution Imaging Offers Fast Way to Discern Fate of Stem Cells Lab Manager    Share    Scientists funded by the National Institutes of Health have developed a new way to identify the state and fate of individual stem cells earlier than previously possible. Stem cells are undifferentiated, serving as building blocks for the various tissues and organs of the body. Understanding a stem cell's fate — the type of cell it will eventually become — and how far along it is in that process can help scientists better manipulate cells for therapies. More Big Data Technique Predicts 12% of Unknown Protein Structures Chemical & Engineering New    Share    In a milestone achievement for computer-based prediction of protein structure, researchers have reported the three-dimensional conformations of 12% of the protein families that still have unknown structure. The cohort of 600 newly determined protein family structures includes 100 protein folds not found in the Protein Data Bank and 200 membrane proteins. A team led by David Baker of the University of Washington modeled the structures of these proteins using its Rosetta algorithm on a distributed network of volunteer computers. More Study: Hidden Conflicts of Interest Permeate Medicine The Scientist    Share    The pharmaceutical industry's influence extends to as patient advocacy groups, Twitter feeds, and guidelines submitted to federal agencies, according to a series of studies published Jan. 17 in JAMA Internal Medicine. Susannah Rose of the Office of Patient Experience at the Cleveland Clinic surveyed roughly 300 patient advocacy groups and found that 67 percent of these groups received money from for-profit companies in the past year. Among the groups that got industry money, 12 percent received more than half their funding from industry. More Amsterdam to Host Europe's First 'Forensic Cemetery' Science Magazine    Share    A vacant lot near a Kentucky Fried Chicken franchise in Amsterdam will soon host research that might make you lose your appetite. Amsterdam's Academic Medical Center (AMC) announced that it has obtained a permit to open Europe's first taphonomical cemetery, a place where scientists can study the decomposition of human corpses under natural conditions. Such research can help forensic investigators, for instance when they're trying to determine how long ago a body was buried. More Lab Automation Scientist Transcriptic US – CA – Menlo Park Rosetta Commons Research Experience for Undergraduates Johns Hopkins University Institute for Nanobiotechnology US – MD – Baltimore Postdoctoral Fellowships in Rodent Neurophysiology of Learning and Executive Function US – FL – Gainesville Search Jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues Jan. 18, 2017 Jan. 11, 2017 Jan. 4, 2017 Dec. 28, 2016 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063