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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 25, 2017

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The 2017 SLAS Technology Ten: Translating Life Sciences Innovation
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For the past 21 years, SLAS Technology (formerly JALA) has provided a unique forum for the presentation of new technologies that advance life sciences and biomedical research.

"This tradition continues with the first SLAS Technology Ten, celebrating the best of the great work published in this journal throughout the previous year," says Edward Kai-Hua Chow, SLAS Technology editor-in-chief. "The collection represents achievements from nine countries — China, Finland, France, Germany, Japan, Sweden, Switzerland, UK, and USA."

Read Chow's editorial, listen to his podcast and search for the individual papers with free access to all in January.
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Five Advance in SLAS2017 Student Poster Competition
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Following pre-conference evaluation against set criteria, judges have named the following five student poster authors as finalists who will be further evaluated at SLAS2017, where they will compete for three $500 cash prizes:

Alice Bong (University of Queensland, Australia): Imaging Intracellular Calcium Dynamics in Breast Cancer using Automated High-Content Fluorescence Imaging

Samantha Grist (University of British Columbia, Canada): Monitoring Tumor Cell Behavior and Response to Treatment under Chronic and Transient Hypoxia within a 3-D Culture Environment using a Microfluidic Platform

Andrea Mazzocchi (Wake Forest Institute for Regenerative Medicine, U.S.): 3D Printing of Cancer Organoids for High-Throughput Screening

Sudip Mondal (University of Texas at Austin, U.S.): Next Generation Screening Technology for High-Throughput Drug Screening using C. elegans Disease Models

Bilal Zulfiqur (Griffith University, Australia): High-Throughput Phenotypic Screening Reveals Novel Pharmacologically Active Compounds for Visceral Leishmaniasis

Good luck to all!
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SLAS ELN Reports: Making Micro-Volume Biology Work — Tools, Techniques and Secrets
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"The field of microfluidics has been evolving rapidly in the past few years," says SLAS2017 Session Chair Daniel Sipes of the Genomics Institute of the Novartis Research Foundation (San Diego, CA). "From the perspective of someone looking for technologies to improve high-throughput screening and compound profiling, the state of microfluidic applications is more interesting and attractive than ever."

Sipes discusses eye-opening work for those involved at the single-cell level in automated and high-throughput formats in the SLAS Electronic Laboratory Neighborhood e-zine. Image courtesy of Kevin Chapman, Berkeley Lights, Inc. (Emeryville, CA).
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SLAS2017 Keynote Presentation Details Now Available
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Jennifer Lippincott-Schwartz presents Emerging Fluorescence Technology to Study the Spatial and Temporal Dynamics of Organelles within Cells, Monday morning. She focuses on visualization technologies that are playing an increasingly important role in the study of numerous aspects of cell biology, capturing processes at the level of whole organisms down to single molecules.

On Wednesday afternoon, Rachel Swaby offers From the Center of the Earth to the Stars: The Unknown History of Women in Science, exploring fascinating stories that dig into the impact women made and why it matters that others learn about them.

Both sessions are open to SLAS2017 full conference registrants.
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Feb. 1: Poster Abstracts Due for 2017 SLAS Europe Compound Management Conference
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One week remains to submit your scientific poster abstract for the opportunity to have your work showcased at "Breaking Down Walls — Uniting Sample Management Communities to Advance Scientific Innovation," March 14-15, 2017, Berlin, Germany.

SLAS Europe Compound Management Conference registrations are now being accepted, and the program features leading scientists from AstraZeneca, Evotec, Lead Discovery Center and Pivot Park Screening Centre to name a few.
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SLAS Discovery: Evaluation of Parameters Impacting Drug Susceptibility in Intracellular Trypanosoma cruzi Assay Protocols
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Featured on the front cover of the February issue of SLAS Discovery is a report by a collaborative team from Leishmania Research Laboratory (Republic of Korea), Yonsei University (Republic of Korea) and Drugs for Neglected Diseases initiative (Switzerland) that examines the differences between widely used colorimetric and image-based screening assays by evaluating the activities of a set of reference compounds.

The team finds significant variation in compound effectiveness between assays, indicating discrepancies resulting primarily from cell seeding schemes and compound incubation times. Other factors, such as strain type and readout method, only result in minor variations within their experimental setup.

"Our findings are of general interest to the scientific community investigating Chagas disease drug discovery since they provide insights into the development of intracellular T. cruzi assays and interpretation of assay results," according to the paper. "These findings also underscore the need for multiple, independent assessments of the activity of potential compounds."
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SLAS2017 Short Course Spotlight: An Introduction to Mass Spectrometry and its Applications within Drug Discovery
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Course instructors Jonathan Wingfield and Ian Sinclair of AstraZeneca Discovery Sciences (U.K.) help participants to better understand the principles of mass spectrometry and its diversity of instruments and ionization techniques, where mass spectrometry can be applied in drug discovery and how recent developments in mass spectrometry have magnified its impact.

2015 SLAS Innovation Award Winner Wingfield and Sinclair were guest editors for the February 2016 SLAS Discovery (formerly JBS) Special Issue on Advances in Mass Spectrometry within Drug Discovery. An Introduction to Mass Spectrometry and its Applications within Drug Discovery is one of 20 Short Courses to be held at SLAS2017.
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Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models
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Vesosomes are nested liposomal structures with high potential as advanced drug delivery vehicles, bioreactors and artificial cells. However, to date no method has been reported to prepare monodisperse vesosomes of controlled size. Here we report on a multistep microfluidic strategy for hierarchically assembling uniform vesosomes from dewetting of double emulsion templates. The control afforded by our method is illustrated by the formation of concentric, pericentric and multicompartment liposomes. More


Scientists Develop Micromotors That Neutralize Gastric Acid and Release Drugs Depending on pH
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Tiny "submarines" that speed independently through the stomach, use gastric acid for fuel (while rapidly neutralizing it), and release their cargo precisely at the desired pH: Though it may sound like science fiction, this is a new method for treating stomach diseases with acid-sensitive drugs introduced by scientists in the journal Angewandte Chemie. The technique is based on proton-driven micromotors with a pH-dependent polymer coating that can be loaded with drugs. More




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A 'Strand' of DNA as Never Before
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In a carefully designed polymer, researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences have imprinted a sequence of a single strand of DNA. The resulting negative remained chemically active and was capable of binding the appropriate nucleobases forming a genetic code. The polymer matrix — the first of its type in history — thus functioned exactly like a sequence of real DNA. More


Step Closer to Safe Stem Cell Therapies
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A new compound could help rid stem cell samples of potentially tumorigenic cells, making them safer for regenerative therapies. Stem cells derived from adult cells, called human induced pluripotent stem cells (hiPSCs), have great potential for basic research and regeneration therapies. But for clinical samples to be safe, these cells need to completely differentiate into their target cells. Any remaining undifferentiated cells in the sample have the potential to form tumors, so must be selectively eliminated. More


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Meet KMC Systems - SLAS Booth#1601
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Super-Resolution Imaging Offers Fast Way to Discern Fate of Stem Cells
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Scientists funded by the National Institutes of Health have developed a new way to identify the state and fate of individual stem cells earlier than previously possible. Stem cells are undifferentiated, serving as building blocks for the various tissues and organs of the body. Understanding a stem cell's fate — the type of cell it will eventually become — and how far along it is in that process can help scientists better manipulate cells for therapies. More


Big Data Technique Predicts 12% of Unknown Protein Structures
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In a milestone achievement for computer-based prediction of protein structure, researchers have reported the three-dimensional conformations of 12% of the protein families that still have unknown structure. The cohort of 600 newly determined protein family structures includes 100 protein folds not found in the Protein Data Bank and 200 membrane proteins. A team led by David Baker of the University of Washington modeled the structures of these proteins using its Rosetta algorithm on a distributed network of volunteer computers. More




Study: Hidden Conflicts of Interest Permeate Medicine
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The pharmaceutical industry's influence extends to as patient advocacy groups, Twitter feeds, and guidelines submitted to federal agencies, according to a series of studies published Jan. 17 in JAMA Internal Medicine. Susannah Rose of the Office of Patient Experience at the Cleveland Clinic surveyed roughly 300 patient advocacy groups and found that 67 percent of these groups received money from for-profit companies in the past year. Among the groups that got industry money, 12 percent received more than half their funding from industry. More


Amsterdam to Host Europe's First 'Forensic Cemetery'
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A vacant lot near a Kentucky Fried Chicken franchise in Amsterdam will soon host research that might make you lose your appetite. Amsterdam's Academic Medical Center (AMC) announced that it has obtained a permit to open Europe's first taphonomical cemetery, a place where scientists can study the decomposition of human corpses under natural conditions. Such research can help forensic investigators, for instance when they're trying to determine how long ago a body was buried. More


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Lab Automation Scientist
Transcriptic
US – CA – Menlo Park

Rosetta Commons Research Experience for Undergraduates
Johns Hopkins University Institute for Nanobiotechnology
US – MD – Baltimore

Postdoctoral Fellowships in Rodent Neurophysiology of Learning and Executive Function
US – FL – Gainesville

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