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SLAS
The SLAS Technology Ten is out. This annual list showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months and highlights a number of areas that are recognized as important emerging technologies for life sciences laboratories and the clinic. Featured topics include technology that automates and improves isolation of subsets of cells with applications ranging from liquid biopsies to cell therapy manufacturing, technologies that improve isolation and propagation of desired cells, improvements in ways to analyze these cells through both improved hardware and software solutions and improved automation approaches for a wide range of assays with implications for everything from drug development to forensic science.
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SLAS
For a limited time, access is available to February's SLAS Discovery which features a new review by researchers from the University of Calabria (Italy) exploring OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research for improving drug delivery and predicting drug-drug interactions. OCTNs mediate the flux of physiological organic cations through the plasma membrane of cells and include three members in its sub-family, two of which are still present in humans.
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SLAS
Submit your original research abstract for a chance to present at SLAS Europe 2019, June 26-28, in Barcelona, Spain. Research scientists, engineers, academics and business leaders from academia, government and industry are invited to submit and entries from graduate students, post-doctoral associates and junior faculty are strongly encouraged. Showcase your work to fellow colleagues and future collaborators on the global stage! Apply for a Tony B Academic Travel Award to help cover the costs of your participation in the conference.
ABSTRACT SUBMISSION DETAILS
COMPLETE SLAS EUROPE 2019 DETAILS
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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SLAS
Final reminder: The National Center for Advancing Translational Sciences (NCATS) will host a two-day symposia, The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium, Feb. 7-8 in Bethesda, MD. Sessions will take an in-depth look at the challenges and opportunities of the discovery and development process for addiction- and pain-related medications in the pre-competitive preclinical stage and include a focus on current successes and failures and what's next in pain and addiction therapeutic discovery.
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SLAS
Just two more days until SLAS2019 begins in Washington, DC. Our boxes have shipped from headquarters, Pocket Guides are printed and we're ready to present the most dynamic scientific and technology content available. If you're attending, make sure to download the SLAS2019 Conference App to get the latest event information and plan your onsite schedule, view the poster gallery and abstracts, play Quest and access the SLAS Ignite Partnership Tool. Registration for the Short Courses and full conference is still available. Reserve your spot now and save up to $200 off on-site pricing. Registration for the Exhibition Only is free.
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VIEW THE CONFERENCE WEBSITE
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
Welcome to Funai Electric Co., Ltd., the latest SLAS Corporate Member. Funai Electric Co., Ltd. is a designer and manufacturer of innovative consumer electronics and OEM products. Their diverse product and technology portfolios include televisions, Blu-ray players, thermal inkjet modules, digital microfluidics dispensers and electric vehicle modules. They also distribute a vast array of products under multiple brand names with distribution throughout the world.
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SLAS
SLAS2019 International Conference and Exhibition
Feb. 2-6, 2019
Washington, DC, USA
Friday, February 1, 2019: Advance registration discounts end in two days!
Saturday, February 2: Short Courses Begin. Onsite registration rates apply!
SLAS Journals Special Issues Call for Papers
SLAS Discovery: Advances in Cellular Target Engagement and Target Deconvolution
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Flexible Analytical Devices for Point-of-Care Testing
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1, 2019: Proposals due
Aug. 10, 2019: Invited submissions due
Save These 2019 Dates
SLAS 2019 European Sample Management Symposium
Early Bird Registration Discount Ends February 11!
March 11-12, 2019
Berlin, Germany
SLAS Europe 2019 Conference and Exhibition
June 26-28, 2019
Barcelona, Spain
Monday, February 11: Super Early Bird Registration Rate Ends
Monday, February 18: Podium Abstract Submission Deadline
Exhibit and sponsorship opportunities available!
COMPLETE LIST OF 2019 SLAS CONFERENCES AND SYMPOSIA
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Monolith NT.Automated is the system that so many scientists choose as their primary tool to quickly identify true hits in single-dose screens and rank the strongest binders in their affinity-based screens. Learn more.
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Explore the best combination of kits and instruments to ensure gentle and fast isolation of primary cells for your drug discovery and in vitro assays. Curious? Join our lunch seminar and demo on high-throughput cell isolation using the MultiMACS™ X Cell Separator for maximum efficiency and reproducibility.
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Journal of the American Chemical Society
Designing macrocycles with appropriate molecular recognition features that allow for the integration of suitable external stimuli to control host–guest processes is a challenging endeavor which enables molecular containers to solubilize, stabilize, and separate chemical entities in an externally controllable manner. Herein, researchers introduce photo- and thermal-responsive elements into a semi-rigid tetracationic cyclophane, OPVEx2Box4+, that is composed of oligo(p-phenylenevinylene) pyridinium units and the biphenylene-bridged 4,4-bipyridinium extended viologens and adopts a rectangle-like geometry.
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Chemical & Engineering News
Researchers at Broad Institute of MIT and Harvard and the National Institutes of Health have expanded the CRISPR gene-editing toolbox. The team has engineered a CRISPR-associated enzyme called Cas12b that they think might be a good way to edit human genes via viral delivery due to its small size. CRISPR-Cas12b joins its larger cousins Cas9 and Cas12a as tools researchers can use to fix gene mutations or to introduce new genetic sequences into genomes.
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"Small Molecule screening with assays for calcium, sodium and potassium that are convenient and easy from ION. To view the latest technology visit us at IonIndicators.com " MORE
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Phys.org
A key to materials synthesis is the ability to control the process of reduction kinetics and nucleation (phase transition) in materials. Understanding the reduction dynamics during the initial stage of material synthesis is limited due to the difficulty of investigating chemical reactions at the atomic scale. This is mainly because the chemical precursors used to synthesize materials can degrade when exposed to electron beams that are typically used to image compounds at atomic resolution.
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Genetic Engineering & Biotechnology News
Much like the dawning of social networks, it's very likely the next great transformation in healthcare started in a university dorm — Dawson Hall, part of Queen Mary University of London. For it is here, in the summer of 2013, that the first handful of workers for a new entity funded by the UK Department of Health called Genomics England began to lay the groundwork for the 100,000 Genomes Project.
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Charles River invites you to discover the value of the right HTS partner. Flexible price models, smart guidance from our scientists, thorough results and data, fast data delivery. Schedule a consult with our scientists during the SLAS2019 conference and exhibition. Times filling up quickly, make your requests soon.
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Laboratory Equipment
The accumulation of amyloid beta (Aβ) plaques and tangles of a protein, called tau, in the brain are hallmarks of Alzheimer's disease. Much effort has focused on the former, with many attempts made to prevent, slow or even reverse the presence of Aβ — and thus ameliorate the development of AD.
To date, results have been mixed.
In a new paper, researchers focused on the alternative therapeutic target: tau.
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Science Daily
Imagine a waterproof computer. It's not going to happen tomorrow, but it may no longer be a pipedream since a McGill-led international research team has shown for the first time that it is possible to form strong, stable attractions between some of the heavier elements in the periodic table. A recent article in Nature Communications provides the first experimental and theoretical proof that heavy, large atoms of an increasingly metallic nature — such as arsenic or even antimony — can be used to create new materials called cocrystals by using halogen bonds.
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Science Magazine
When parents pass their genes down to their children, they give the kids remixed versions of their own chromosomes. And that remixing of chromosomes can increase the chances that the child's DNA will also mutate in certain locations, according to a high-precision study of the DNA of more than 150,000 people. The data in this study may be helpful for understanding mutation rates in humans and measuring how quickly we are evolving.
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The Scientist
Chinese scientists have cloned five gene-edited macaque monkeys, the researchers reported in two papers in National Science Review.
These clones were made though the somatic cell nuclear transfer method that was used to produce the first primate clones, also macaques, announced roughly a year ago. But in the new report, the monkeys' genomes were first edited using CRISPR-Cas9 to show symptoms of sleep disorders by knocking out BMAL1, an important gene for circadian regulation.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Process Automation Engineer
Personalis Inc.
US – CA – Menlo Park
High Content Imaging Specialist - Senior Research Scientist
Memorial Sloan Kettering Research Institute
US – NY – New York City
Scientist I, High Throughput Mass Spectrometry
Nurix Therapeutics
US – CA – San Francisco
Search Jobs at SLAS Career Connections
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