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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit January 31, 2018

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Announcing the 2018 SLAS Technology Ten: Translating Life Sciences Innovation
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"The 2018 SLAS Technology Ten represent some of the most innovative scientific achievements that were featured in SLAS Technology in the past 12 months," says Editor-in-Chief Edward Kai-Hua Chow, Ph.D., (National University of Singapore). "SLAS is proud and appreciative that the 83 authors who contributed to the 2018 SLAS Technology Ten for their hard work, ingenuity, and willingness to stretch the boundaries of what is possible in life sciences and biomedical technology." Read more about the 10 honorees in Chow's editorial in the February 2018 issue. More


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SLAS ELN: Meet the New SLAS Board Members, Champions of Collaboration
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Passion and persistence exemplify the three new leaders joining the SLAS Board of Directors in 2018. Emilio Diez Monedero, Peter Simpson and Severine Tamas-Lhoustau share a base in Europe and an overwhelming desire to share their talents and experience for the good of the Society during their three-year terms on the Board. They join six members continuing their terms tasked with leading an organization devoted to professionals who thrive at the intersection of applied and basic life sciences discovery and technology. More


NEW and FREE at SLAS Discovery: Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules that Exhibit Functional Synergy with Potentiators and Correctors
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In the February 2018 issue of SLAS Discovery, Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA) describe a phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity. From their screen, the authors discover a novel class of investigational compounds that they call amplifiers. The amplifiers target the inefficiencies of early CFTR biosynthesis and produce more immature protein, independent of a particular mutation in CFTR. Amplifiers have been shown in vitro to synergize with other CFTR modulators to provide greater than additive activity. More


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Congratulations to the Five SLAS Student Poster Competition Finalists!
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Five up-and-coming thought leaders were selected as finalists in the SLAS2018 Student Poster Competition. Final judging, awards and interviews with The Lab Man start at 4 p.m., Monday, Feb. 5 in the SLAS Booth in the SLAS2018 Exhibition (Aisle 200). The final five include:

  • John Hickey, Johns Hopkins University
    High Throughput Enrichment and Identification of Rare Antigen-specific CD8+ T cells
  • Ramila Joshi, The University of Akron
    Microengineered Stem Cell Niches Reveal Compounding Effect of Colony Size on Neural Differentiation
  • Xiao Wang: BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School
    Squeeze & Chemotax: A High-throughput Microfluidic Assay for Probing the Effect of Deformation on Leukocyte Chemotaxis
  • Arnaud Nicolas: Leiden University / Mimetas
    High-throughput and Automated Analysis of Organ-on-a-Chip Neuronal and Glial Model Using Calcium Imaging
  • Sri Teja Mullapudi, Max Planck Institute for Heart and Lung Research
    In Vivo Screening to Identify Insulin-Independent Modulators of Metabolism Identifies Novel Candidates

  • Explore all of SLAS2018's poster abstracts!
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    Meet the Head of the Class at SLAS: Graduate Education Fellowship Grant Recipients Share Tips at Student Mixer
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    Meet Eric Werner and Julea Vlassakis — the first two recipients of the SLAS Graduate Education Fellowship Grant — at the Student and Early Career Professional Mixer from 5-6 p.m. Monday, Feb. 5 in the SLAS Booth in the SLAS2018 Exhibition (Aisle 200). Werner, the 2016 grant recipient, is a graduate student and Ph.D. candidate from the University of California, Irvine, and the 2017 grant recipient Vlassakis, a graduate student and Ph.D. candidate from the University of California, Berkeley, visit with participants, exchange ideas and share how to apply to be the next SLAS student researcher. Learn more about activities at SLAS2018 specifically designed by and geared towards students and early career professionals! More




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    Make a List, Check it Twice: MORE New Products at SLAS2018
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    Visit the SLAS2018 New Product Announcements page to see daily additions leading up to SLAS2018 in San Diego. The list of now more than 40 products includes: Aurora Biomed (Vancouver, BC, Canada) rolling out the VERSA automated liquid handler liquid biopsy workstation; Benchling (San Francisco, CA; an SLAS Innovation AveNEW participant at SLAS2018) introducing its Benchling cloud-based informatics platform for life science R&D; Insphero (Schlieren, Switzerland and Brunswick, ME) presenting the Akura Flow discovery "body-on-a-chip" platform; and SCREEN Holdings Co. (Rolling Meadows, IL) unveiling the Cell3iMager Estier, an optical coherence tomography imaging system. SLAS2018 exhibitors: Click here to add your new product launch to the list! More


    What's 'Appening? Log into the NEW SLAS2018 Conference App
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    Always up-to-date, always available and oh-so all-inclusive! The official SLAS2018 Conference App puts the entire SLAS International Conference and Exhibition at your fingertips: the conference schedule, abstracts, e-poster gallery and exhibitor directory, as well as maps of the convention center and exhibition. The app automatically updates any program changes and sends notifications. Connect with other attendees, exhibitors and participate in social media conversations (#SLAS2018). Search and meet potential collaboration partners via the SLAS Ignite Partnership Program part of the app. Download the app today by searching "SLAS Events" in your favorite app store. More




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    SLAS Quest: Join the Hunt, Win $100
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    Join the fun as it unfolds at SLAS2018 with a new way to win: SLAS Quest, an epic scavenger hunt through the Exhibition. Participants use the SLAS2018 Conference App to scan QR codes and answer trivia questions at different locations to earn points and track progress on the leader board. New locations added each day remain available for the duration of the game. Lucky winners named daily after total points are tallied at 5:30 p.m. on Monday, Feb. 5 and Tuesday, Feb. 6 and at 12 p.m. on Wednesday, Feb. 7. Winners receive $100 Visa gift cards and must be present to win. Good luck on your Quest! More


    How to Prepare a Manuscript for Successful Publication
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    Learn how to design and write scientific research papers more clearly and effectively to improve chances for publication on Wednesday, Feb. 7 from 8-9:15 a.m. in room 17A (San Diego Convention Center). SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D. (National University of Singapore) and SLAS Discovery Editor-in-Chief Robert M. Campbell, Ph.D. (Eli Lilly, Indianapolis, IN) will explain what editors want, what they don't want, common mistakes, insider tips and how reviewers evaluate manuscripts. Continental breakfast will be served immediately preceding the workshop from 7:30 to 8 a.m. More




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    Explore the Latest Festo Innovations

    Join Festo as we kick off the new year at SLAS in San Diego, CA. Discover our latest products and innovative technologies for laboratory automation at booth 637. Stop by and speak with our experts to help find a solution for your laboratory challenges.

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    Stem Cells Made by Modifying the Epigenome with CRISPR
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    A form of CRISPR that activates rather than cuts DNA can convert embryonic mouse cells to induced pluripotent stem cells, researchers reported in Cell Stem Cell. "This paper demonstrates the ability of CRISPR effectors to go beyond turning on a single gene and completely rewire the transcriptional state of the cell," Neville Sanjana, a bioengineer at the New York Genome Institute who did not participate in the study, writes in an email to The Scientist. More


    Drug-Releasing Transplants Combat Rejection in Mice
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    Dressed in shorts and a mustard-colored Hawaiian shirt, Robert R. Kane of Baylor University started his presentation at the inaugural Atlantic Basin Conference on Chemistry in Cancun, Mexico by showing a classic image of human anatomy. Labels on the diagram pointed to major organs that sometimes require replacement. "Y'all are all familiar with transplantation, and we're pretty good at it," he said. More




    Decoding the DNA Repair Process
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    Researchers at The University of Kansas Cancer Center are working to fill the knowledge gap between DNA damage and cancer, including developing approaches to manipulate the DNA damage response to treat and prevent disease. Their research on an integral DNA repair protein was recently highlighted in the scientific journal, Nature Communications. Carcinogens, in the form of environmental hazards such as UV radiation and tobacco smoke, can cause mutations and/or breaks in our DNA. More


    Chemical Bypass of General Base Catalysis in Hedgehog Protein Cholesterolysis Using a Hyper-Nucleophilic Substrate
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Proteins in the hedgehog family undergo self-catalyzed endoproteolysis involving nucleophilic attack by a molecule of cholesterol. Recently, a conserved aspartate residue (D303, or D46) of hedgehog was identified as the general base that activates cholesterol during this unusual autoprocessing event; mutation of the catalyzing functional group (D303A) reduces activity by >104-fold. Here we report near total rescue of this ostensibly dead general base mutant by a synthetic substrate, 3β-hydroperoxycholestane (3HPC) in which the sterol −OH group is replaced by the hyper nucleophilic −OOH group. More


    Stem Cells: On Your Mark, Get Set, Don't Go
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Like overeager runners at the starting line, stem cells sometimes jump the gun, disqualifying themselves and losing the chance to enter the winner's circle. For would-be therapeutic stem cells, the winner's circle is a transplantation site. It can be reached only if stem cells pace themselves and avoid differentiating too soon. To keep stem cells from differentiating prematurely, scientists based at the University of British Columbia have developed a drug that helps regulate the transition between activated, proliferating stem cells and differentiation-primed, poorly engrafting progenitors. More


    Artificial Sweetener Could Offer Superior Cancer Treatments
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    Artificial sweeteners are used in diet drinks and foods but also could someday be used as treatments targeting carbonic anhydrase IX, a protein associated with aggressive cancers. Although several drugs have been approved that target similar forms of CA, they aren’t selective and may cause side effects, including vomiting and fatigue. Now researchers report in ACS' Journal of Medicinal Chemistry that an artificial sweetener could lead to development of a more selective therapy. More


    Scientists Get Better Numbers on What Happens When Electrons Get Wet
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    There's a particular set of chemical reactions that governs many of the processes around us — everything from bridges corroding in water to your breakfast breaking down in your gut. One crucial part of that reaction involves electrons striking water, and despite how commonplace this reaction is, scientists still have to use ballpark numbers for certain parts of the equation when they use computers to model them. More


    'Chemical Net' Could Be Key to Capturing Pure Hydrogen
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Hydrogen is one of the most abundant elements on Earth and an exceptionally clean fuel source. While it is making its way into the fuel cells of electric cars, busses and heavy equipment, its widespread use is hampered by the expensive gas-separation process required to produce pure hydrogen. But that process could soon become more efficient and cost-effective thanks to a discovery by an international team of researchers, led in the U.S. by Drexel University. More


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    Merck
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    Eli Lilly & Co.
    US - CA - San Diego

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    Transnetyx
    US - TN - Memphis

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