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JBS Special Issue Call for Papers: Therapeutic Antibody Discovery and Development
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Guest Editors Rob Howes and Joseph G. McGivern are looking for manuscript proposals related to all aspects of the discovery and development of therapeutic antibodies with an emphasis on biochemical, cell-based and analytical assays. Submit abstracts by April 25 for consideration; invited authors will be notified by May 1, and final manuscripts will be due August 1. More

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SLAS2014 On Demand Sessions Now Available
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"The Convergence of the Digital Era and Medicine" keynote presentation by Dr. Eric J. Topol and the Special Session on Disruptive Technologies featuring Daniel Sipes, Jordan Miller, Keith Wood, Christopher Brown and Michael Bandell are ready for viewing at SLAS.org. SLAS provides these videotaped presentations free-of-charge as a service to the life sciences R&D community.

Completing a short registration form is the only requirement for access. SLAS thanks these esteemed presenters for allowing their presentations and expertise to be shared freely.
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SLAS ELN Reports: JALA and JBS Cover Author Spotlights
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Learn more about the JALA and JBS February issue cover authors, Daniel T. Kamei and Simon J. Gruber respectively, in the SLAS Electronic Laboratory Neighborhood e-zine.

Kamei authored the review article, "Modeling Mass Transfer from Carmustine-Loaded Polymeric Implants for Malignant Gliomas." Gruber is lead author for "Discovery of Enzyme Modulators via High-Throughput Time-Resolved FRET in Living Cells."
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The SLAS2014 Poster Gallery Still Open for Browsing
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No worries if you did not get the chance to visit all of the nearly 400 posters presented at SLAS2014 last month. In the SLAS2014 Poster Gallery, you can search online by poster number, presentation date, review thumbnails, read abstracts, bookmark favorites and more.

Access to the gallery is free-of-charge for everyone.
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Robust Activity at SLAS Career Connections
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With the excitement surrounding SLAS2014, the SLAS Career Connections program at SLAS.org has experienced a burst of new job notices.

Companies recently posting job openings include Biodirect-The LabSquad, BioNex Solutions, Bristol-Myers Squibb, Fibrogen, Fluid Imaging Technologies, Genentech, GlaxoSmithKline Pharmaceuticals, Merck & Company, Novartis Institutes for BioMedical Research, Parker Precision Fluidics, Thermo Fisher Scientific, University of Michigan-Dearborn, University of Minnesota and Vertex Pharmaceuticals.
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SLAS Channel on YouTube Posts 10 Videos in January
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Many new videos have been posted to the SLAS channel on YouTube. SLAS2014 participants can relive the excitement from San Diego, while those unable to attend can get a quick snapshot of how some laboratory science and technology professionals are transforming research. More

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NIH, Industry Launch $230 Million Translational Drugs, Diagnostics Push
GenomeWeb Daily News     Share    Share on FacebookTwitterShare on LinkedinE-mail article
The National Institutes of Health said Feb. 4 it plans to spend nearly $230 million in a partnership with 10 pharmaceutical firms and several non-profit groups to jumpstart efforts to find targets for new drugs and diagnostics. NIH created the Accelerating Medicines Partnership as a new model for spurring development of drugs toward US Food and Drug Administration approval, a process which has a failure rate of 95 percent and which can take a decade and cost more than $1 billion. More

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Eyes on Excipients
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When it comes to drugs, most of the attention goes to the active pharmaceutical ingredient. But typically the vast majority of what's in a tablet, capsule, or liquid isn't the active ingredient. A drug is formulated with many other compounds, called excipients, that play an essential role in delivering the active ingredient to the patient. Lubricants, for example, make a bulk material easier to handle in a manufacturing facility. More

First Glimpse of How HIV Swamps the Gut's Immune Cells
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We've been given the first glimpse of HIV in attack mode in the gut, shedding light on how the virus hijacks immune cells, multiplies and spreads throughout the body. A team of biochemists have used electron tomography microscopes to capture the first high-resolution, 3-D images of the HIV virus lurking in the intestines of "humanized" mice, whose immune systems are made up largely of human cells. More


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To find out how to feature your company in the SLAS eNewsletter and other advertising opportunities, Contact James DeBois at 469-420-2618.
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Implantable Nanosensors: Toward Continuous Physiologic Monitoring
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Continuous physiologic monitoring would add greatly to both home and clinical medical treatment for chronic conditions. Implantable nanosensors are a promising platform for designing continuous monitoring systems. This feature reviews design considerations and current approaches toward such devices. More

Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Over 100 protease inhibitors are currently used in the clinics, and most of them use blockage of the active site for their mode of inhibition. Among the protease drug targets are several enzymes for which the correct multimeric assembly is crucial to their activity, such as the proteasome and the HIV protease. Here, we present a novel mechanism of protease inhibition that relies on active-site-directed small molecules that disassemble the protease complex. More

Chemical Products on a Renewable Basis
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A breakthrough in the use of renewable raw materials in chemical production has been achieved by Karlsruhe Institute of Technology and its industrial partner AVA Biochem: In January this year, a facility at AVA Biochem in Muttenz (Switzerland) has started production of 5-(hydroxymethyl)furfural. The KIT has developed an innovative hydrothermal method to obtain the organic compound from biomass. Being a platform chemical, 5-HMF can serve as a precursor for various materials. More

Testosterone Again Linked to Heart Risks
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For some men, taking testosterone may triple the risk of having a heart attack, according to a new study. Researchers looked at medical records of more than 48,500 men ages 65 and younger who were taking testosterone (in forms of gels, patches or injections), and followed them for three months. The results showed that among men with a history of heart disease, 15 men per 1,000 had a heart attack during the three months after they started taking testosterone compared with five men per 1,000 before testosterone was prescribed. More



New Theory May Lead to More Efficient Solar Cells
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A new theoretical model developed by professors at the University of Houston and Université de Montréal may hold the key to methods for developing better materials for solar cells. Eric Bittner, a John and Rebecca Moores Professor of Chemistry and Physics at UH, and Carlos Silva, an associate professor at the Université de Montréal, say the model could lead to new solar cell materials made from improved blends of semiconducting polymers and fullerenes. More

The Impact of FDA's Social Media Guidance for Pharmaceutical Companies
By Pamela Lewis Dolan    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Food and Drug Administration took a significant step forward in clarifying the responsibilities pharmaceutical companies have concerning social media activity in the recent release of a draft guidance document. As uncertainties still remain, the impact this guidance will have on pharmaceutical companies embracing this new venue of communication is unclear. The guidance gives pharmaceutical companies reassurance that they would not be held responsible for comments left by third parties on social media sites. But, as one expert points out, this should not be considered a reason to ignore the opportunities social media presents to engage with patients. More


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  • Career


    Senior Research Scientist – High-Throughput Screening
    Vertex Pharmaceuticals, Inc.
    US – CA – San Diego

    Assistant Professor in Bioengineering
    University of Michigan-Dearborn
    US – MI – Dearborn

    Scientific Associate II/Scientist I
    Novartis Institutes for BioMedical Research
    US – CA – Emeryville

    More jobs at SLAS Career Connections


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