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Announcing the 2018 SLAS Journal Achievement Award Honorees
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SLAS Discovery and SLAS Technology celebrate honorees in three categories — Readers Choice, Authors Choice and Reviewer Excellence. The 2018 SLAS Journal Achievement Awards reflect popularity of published articles with readers and authors throughout 2017 and exceptional volunteer service in 2017.
All articles are now freely available at SLAS Discovery Online and SLAS Technology Online.
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Welcome to New SLAS President Sabeth Verpoorte
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SLAS welcomes Sabeth Verpoorte, who began her term as SLAS president at SLAS2018 in San Diego, CA. "As I begin my term as SLAS President, I want to assure you that the Board and Professional Team are committed to serving your evolving needs as life sciences professionals," said Verpoorte. "While we are pleased with our current programming and services, we feel that SLAS can be even more valuable to you in the years to come. Please know that we are wholly committed to providing you the information, education and connections you need to distinguish yourself in an ever-changing field." Verpoorte welcomes three new members to the SLAS Board of Directors at SLAS2018 — Emilio Diez Monedero, Peter Simpson and SeverineTamas-Lhoustau — and thanked outgoing members Scott Atkin, Michele Cleary and Susan Lunte. She looks forward to serving the SLAS global community in her new role.
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Special Issue Call for Papers: Academic Screening Centers Showcase
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SLAS Discovery Associate Editor Marc Bickle of the Technology Development Studio of the Max Planck
Institute of Molecular Cell Biology and Genetics in Dresden, Germany seeks original research papers, technical notes and reviews that focus on science in the context of academic screening endeavors. An in-depth editorial will describe each laboratory and its operational model.
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2018 SLAS Europe Conference and Exhibition: Transforming Research
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Register now for the inaugural 2018 SLAS Europe Conference and Exhibition, June 27-29, 2018, in Brussels, Belgium. Early bird registration rates save participants €140 and expire on Friday, March 30.
Scientific tracks for this premier event for the European life sciences discovery and technology community include:
Emerging Investigative Biology — examining topics such as Biological Mechanisms Involved in Aging and Degenerative Disease, Exploring Target Biology and The Impact of New Technologies on the Treatment of Rare Diseases;
Technology — focusing on subject matter such as Organoids and Other Complex Biological Systems in Drug Discovery and Development, Revolutions in Phenotypic Screening for Modern-Day Drug Discovery and Next Generation Analytics; and
Discovery — investigating areas such as Bringing Biology and Technology Together to Enable the Early Drug Discovery Pipeline, Future SAR Screening and Late-Stage Discovery.
The conference also includes poster presentations focusing on thought-provoking research and a multinational exhibition and sessions that explore opportunities in business and technology careers.
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Collaborative Sparks Fly in SLAS Ignite Academic Theater!
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Six selected researchers tapped into the experience, insights and capabilities of peers and complementary organizations via the SLAS Ignite Academic Theater, an accelerant for collaborative partnerships and contract relations. The inaugural class of speakers offered 10-minute presentations followed by Q&A as they discussed topics from mass spectroscopy and disulfide trapping to identifying new drug targets, combinatorial drug discovery and high-content screening.
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS2018 in San Diego Ends Today
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The Feb. 3-7 event attracted life sciences discovery and technology professionals from all around the globe. With 144 podium sessions, 230-plus poster presentations and 300-plus multinational exhibitors, in addition to Short Courses, Exhibitor Tutorials, Special Interest Group meetings, career services, SLAS author services and a memorable Tuesday Evening Celebration in Old Town San Diego, the SLAS International Conference and Exhibition set a new bar of science education excellence. Watch SLAS Social Media — SLAS Facebook, SLAS Twitter and SLAS LinkedIn — for photos from the event as well as announcement of the 2018 SLAS Innovation Award winner named in today's closing keynote presentation. Mark your calendar now for SLAS2019, Feb. 2-6, Washington, DC.
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5 Good Reasons Your Employer Should Reward You for Publishing in the SLAS Journals
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SLAS Technology (Translating Life Sciences Innovation) and SLAS Discovery (Advancing Life Sciences R&D) offer essential ways to navigate the ever-increasing volume of peer-reviewed research for life sciences discovery and technology professionals. Visit these rich resources regularly to:
1. Find answers, ideas and inspiration by searching the scientific archives of SLAS Technology, SLAS Discovery and other SAGE journals with keywords and author names. Save searches and/or sign up to receive custom search alerts via e-mail.
2. Sign up for citation tracking alerts.
3. Sign up to be alerted when new reports publish online ahead-of-print.
4. See what's trending in the Most Read and Most Cited monitors.
5. Get to know the people behind the science by listening to the SLAS Technology Podcast Series.
NEW: Meet Elodie Sollier-Christen of Vortex Biosciences, the latest interview in the podcast series, as she talks about the groundbreaking technology that earned her the 2017 SLAS Innovation Award.
MORE SLAS Technology / MORE SLAS Discovery
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Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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You Can Teach an Old Drug New Tricks
Lab Manager Share
This ERBB4 receptor, a member of the receptor tyrosine kinase family, is of increasing interest for science and medicine. Mutations in ERBB4 have been linked in recent studies to melanoma and lung cancer, and altered expression of ERBB4 has been observed in breast cancer, neuroblastoma, colon cancer, and non-small cell lung cancer, though the receptor has not received sufficient study to date.
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Alarm Sounds for Gene Therapy Toxicity, But Was the Concern Legitimate?
Chemical & Engineering News Share
A controversial new study by veteran gene therapy scientist James Wilson at the University of Pennsylvania is rousing concerns about the safety of high-dose gene therapy trials. It disclosed that a therapy designed to treat a muscle-wasting disease called spinal muscular atrophy given to monkeys and piglets resulted in severe toxicity in the animals, which had to be euthanized.
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Join Festo as we kick off the new year at SLAS in San Diego, CA. Discover our latest products and innovative technologies for laboratory automation at booth 637. Stop by and speak with our experts to help find a solution for your laboratory challenges.
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Scientists Develop New Chemical Tool to Study RNA Structures Inside Cells
Science Daily Share
University of California, Irvine scientists have created a new chemical tool that can analyze RNA structures within living cells. The technique could facilitate a better grasp of how RNA structures fold and form in cells, as well as help in the design of drugs targeting RNA. Researchers describe their study results in an advance online publication on the Nature Chemical Biology website.
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One-Shot Multiple Borylation toward BN-Doped Nanographenes
Journal of the American Chemical Society Share
One-shot double, triple, and quadruple borylation reactions of triarylamines were developed through a judicious choice of boron source and Brønsted base. With the aid of borylation reactions, a variety of BN-doped nanographenes were synthesized in two steps from commercially available starting materials. An organic light-emitting diode device employing BN-doped nanographene as an emitter exhibited deep pure-blue emission at 460 nm, with CIE coordinates of (0.13, 0.11), and an external quantum efficiency of 18.3%.
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Scientists Identify Fleeting Quantum Jitters that Drive Mutation Rate in DNA
Genetic Engineering & Bioctechnology News Share
Scientists in the U.S. have described how the DNA double helix contains an intrinsic timer that determines how often mutations might occur spontaneously. The team used a technique known as nuclear magnetic resonance relaxation dispersion to recognize how the bases in a double-stranded helix of DNA undergo fleeting changes in their shape — lasting just a thousandth of a second — which allow polymerase enzymes to insert the wrong base during DNA replication.
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Researchers Develop Potential Blood Test for Alzheimer's Disease
The Scientist Share
Researchers in Japan and Australia have developed the first blood test to detect amyloid-β protein buildup in the brain, one of the earliest hallmarks of Alzheimer's disease. The findings, published in Nature, show that measurements of the protein and its precursors in the blood can predict neural amyloid-β deposition and could pave the way for a cheap and minimally invasive screening tool for the disease.
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A 3-D Approach to Stop Cancer in Its Tracks
Phys.org Share
Every day, roughly 100 billion new cells are created inside the human body. These cells join trillions of older cells to form the tissues and organs we rely on to stay alive. Sometimes when a cell is created, a mutation occurs within its DNA, transforming the cell into something defective and potentially dangerous to the body's internal environment. Usually, a cell will recognize its own defects and quickly terminate itself.
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Researchers Uncover Mechanism Behind Common Parkinson's Mutation
Bioscience Technology Share
Northwestern Medicine investigators have discovered how a gene mutation results in buildup of a toxic compound known to cause Parkinson's disease symptoms, defining for the first time the mechanism underlying that aspect of the disease.
The study, published in Neuron, points to a potential novel therapeutic pathway using drugs originally intended to treat another condition, Gaucher's disease, according to senior author Joseph Mazzulli, PhD.
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