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JALA & JBS Art of Science Contest Winner: Tomasz Koprowski
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Tomasz Koprowski, of the Institute for Chemical and Bioengineering in Zurich, Switzerland, is the top online vote-getter and grand prize winner of a $500 Amazon gift card. His image, "The Tree of Life," shows C.elegans worms on a chunk of agar.
Koprowski's image was one of nine finalists from six countries selected by SLAS from 60 entries. The other finalists each received a $25 Amazon gift card and all finalists received 60 days free access to the SAGE Pharmacology & Biomedical Collection. Start thinking about your entry for the 2015 JALA & JBS Art of Science Contest, and watch SLAS.org for announcements.
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SLAS ELN Reports: SLAS President Daniel Sipes Talks Community
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"It's always invigorating to start a new year off on a high note, and so far, mine has been resounding!" says new SLAS President Daniel G. Sipes, in his first "From the SLAS President" column in the SLAS Electronic Laboratory Neighborhood e-zine.
"It was with honor and gratitude that I accepted the SLAS president's gavel from Jeff Paslay, and it was with pleasure that I spent five days with about 5,800 of some of the smartest and most inspiring people on the face of this earth — my many friends and colleagues at SLAS2014."
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SLAS Webinar: Challenging Targets for Drug Discovery
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The March 18 SLAS Webinar at 11:30 am ET reviews a site-directed fragment-based discovery approach, disulfide-trapping, that is well-suited to probing targets of biomedical interest that do not have useful small molecule starting points.
The presenter is James A. Wells, Ph.D., a leader in therapeutic sciences and technology development for protein engineering and small molecule drug discovery. Wells is a professor and chair of the Department of Pharmaceutical Chemistry at the University of California, San Francisco.
This SLAS Webinar is the first in the three-webinar series, "Protein-Protein Interactions as Small Molecule Drug Targets," and is free to dues-paid SLAS members.
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Tips for Successful Scientific Publishing
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At SLAS2014, JALA Deputy Editor-in-Chief Edward Chow, Ph.D., University of Singapore, led the popular "JALA & JBS Author Workshop: How to Get Your Work Published."
The presentation is now available for free at SLAS.org. Chow offers instruction for central message design, journal selection and proper manuscript composition. Originality, citations and the peer review process also are covered.
Read the Northeastern Section of the American Chemical Society NESACS blog for attendee Dan Eustace's recap of the workshop.
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SLAS2015 Keynote Speaker Discusses Synthetic Biology
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Laurie Garrett, journalist and global health authority, is one of three keynote speakers at SLAS2015, Feb. 7-11 in Washington, D.C. Read her article, "Biology's Brave New World: The Promise and Perils of the Synbio Revolution," published late 2013 in Foreign Affairs, a publication of the Council on Foreign Relations.
It discusses the controversies and concerns surrounding dual-use research in synthetic biology, highlighting J. Craig Venter's contributions, and subsequent reactions from academic, industry and government participants.
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NEW at JBS Online: Cell-Based Fluorescence Assay
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A team from the University of Bern in Switzerland has developed and validated a sensitive and reproducible cell-based fluorescence assay suitable for the identification of compounds that specifically modulate DMT1 transport activity.
Read the manuscript from Nicolas Montalbetti, Alexandre Simonin, Marianela G. Dalghi, Gergely Kovacs and Matthias A. Hediger, available at JBS Online only to SLAS Biomolecular Sciences Section members and JBS subscribers ahead-of-print.
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SLAS Phenotypic Drug Discovery SIG Uses LinkedIn to Share Scientific Articles
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The 1,000 members of the SLAS Phenotypic Drug Discovery Special Interest Group LinkedIn subgroup have been using this SLAS forum to continue discussions from SLAS2014 in San Diego. Among the recent posts:
- Any suggested review articles on impact (or non-impact) of biomarker discovery efforts toward clinical work/drug label?
- Recent paper (Hay 2014) reports that success rate in clinical trial development remains low
- New Papers: Activity Database Mining and Biological MOA
Join the discussion in this SLAS LinkedIn subgroup or one of the 17 others.
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Scientists Invent Advanced Approach to Identify New Drug Candidates from Genome Sequence
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In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
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Editing the Human Genome One Letter at a Time
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Researchers at the Gladstone Institutes say they found a way to edit the human genome one letter at a time. They add that this finding will not only boost the ability to model human disease, but will also pave the way for improved gene therapy approaches. Writing in Nature Methods, the team described how to efficiently and accurately capture rare genetic mutations that cause disease — as well as how to fix them.
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Extraordinary Stem Cell Method Tested in Human Tissue
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Talk about speedy work. Hot on the heels of the news that simply dipping adult mouse cells in acid could turn them into cells with the potential to turn into any cell in the body, it appears that the same thing may have been done using human cells. A picture, given to New Scientist by Charles Vacanti at Harvard Medical School, is said to be an image of the first human "STAP cell" experiments.
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Latest Advancements in Brain Cancer R&D
By Rosemary Sparacio Share
 Promising research and development is being accomplished all throughout the oncology field. This includes advances in brain cancer research, which can be seen in areas as diverse as boosting the immune system to innovative surgery. Patients with one of the most aggressive brain cancers — glioblastoma — typically have a survival rate beyond five years of less than 5 percent. But several recent studies have shown advancements in the treatment of this deadly cancer.
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Synthesized Sponge Chemical Shows Promise for Cancer
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A promising compound for cancer treatment has been synthesized in a laboratory by an RMIT University researcher during his PhD research. Dr Dan Balan, from the School of Applied Sciences at RMIT, said 15-aza-Salicylihalamide A analogue had demonstrated potent activity against several leukemia cell lines. Salicylihalamide A is cytotoxic — or a toxin which is known to destroy cells and which also provides a defense for the sea sponge.
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Gene Links Brain Structure to Intelligence
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For the first time, scientists at King's College London have identified a gene linking the thickness of the grey matter in the brain to intelligence. The study is published in Molecular Psychiatry and may help scientists understand biological mechanisms behind some forms of intellectual impairment. The researchers looked at the cerebral cortex, the outermost layer of the human brain.
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Role of the Metal in the Bonding and Properties of Bimetallic Complexes Involving Manganese, Iron, and Cobalt
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A multidentate ligand platform is introduced that enables the isolation of both homo- and heterobimetallic complexes of divalent first-row transition metal ions such as Mn(II), Fe(II), and Co(II). By means of a two-step metalation strategy, five bimetallic coordination complexes were synthesized with the general formula M1M2Cl(py3tren), where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)amine.
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Confusion Over Scientific Nomenclature is Par for the Chemistry Course
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Graduate students with Brent L. Iverson on their thesis committees know better than to mention "π-stacking" during their candidacy exam. Department lore makes clear that the University of Texas chemist will grill anyone who dares invoke the term. "I always ask, 'What do you mean by that?' " Iverson says, which inevitably leads to a heated back-and-forth. Iverson wins every time, though, because "the student realizes that they've been making assumptions that they shouldn't," he says.
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SLAS Point-to-Point
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