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NEW and FREE at SLAS Discovery: Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective
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A perspective article in the March 2018 issue of SLAS Discovery from the biology group at the European Screening Centre Newhouse details how the European Lead Factory (ELF), a large publicly accessible drug discovery platform, uses microscale thermophoresis (MST) to aid in the prioritization of small molecule hits from high-throughput screening. MST measures the rate and direction of movement of biomolecules through a temperature gradient, which can change when small molecules bind to them. The authors describe the MST technology, their assay development and screening workflows, lessons learned and compare the success of MST with other common biophysical assay techniques. The article is available for free until March 20 at SLAS Discovery Online. More


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SLAS ELN Reports: The Lab Man Interviews Product Innovators at SLAS2018
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SLAS Director of Education Steve Hamilton (a.k.a. The Lab Man) spoke with 2018 SLAS New Product Award winners Paul Ventura and Tom Rawlins of FORMULATRIX (Bedford, MA), Ed Walsh of iotaSciences (Oxford, UK; also a 2018 SLAS Innovation AveNEW delegate) and Iain Russell of Labcyte (San Jose, CA). Learn how the winners replied when The Lab Man asked, "What is one of the features that led to this product winning the award?" in the individual podcasts and in the SLAS Electronic Laboratory Neighborhood e-zine. More


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Present a Poster at the 2018 SLAS Europe Conference and Exhibition
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Gain significant visibility for your research and organization by delivering a poster presentation at the inaugural 2018 SLAS Europe Conference and Exhibition to be held June 27-29 in Brussels. SUBMIT POSTER ABSTRACTS by March 30 for the opportunity to present your research and receive meaningful feedback from an extremely knowledgeable, supportive and collaborative community. Posters selected can be viewed throughout exhibition hours and specific times are scheduled for authors to present and discuss their work. APPLY TODAY: Students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) may apply for the prestigious SLAS Tony B. Academic Travel Award to reduce your travel costs to the 2018 SLAS Europe Conference and Exhibition. The travel award application deadline with poster consideration only is also March 30. More


Save the Date for 2018 SLAS Americas Sample Management Symposium
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Investigate, evaluate and participate Nov. 13-14 in Boston, MA, at the 2018 SLAS Americas Sample Management Symposium! Delve into subject matter designed to support best practices and foster potential opportunity in the evolving area of sample management. Rules are being rewritten for biological compounds and samples that require the same care and attention previously paid only to small molecule libraries. The program committee, led by Chair Susan Holland-Crimmin of GlaxoSmithKline, includes members Marybeth Burton of Merck, Jeff Chin of Bristol-Myers Squibb, Thomas Frech of Xavo, Rose Gonzales of Pfizer, Christine Glazier of Amgen and Kathi Shea of Brooks. More




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Congrats to Chadwick Davis: Winner of the SLAS Journals Video Drone at SLAS2018!
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SLAS2018 participants who volunteered to serve as manuscript reviewers for SLAS Discovery and/or SLAS Technology and who checked the OPT-IN box in their SAGEtrack user records to receive journal news (not advertisements) were entered into a prize drawing for a $500 DJI Phantom P3-STANDARD Quadcopter Drone with 2.7K HD Video Camera. The lucky winner is Chadwick Davis, Ph.D., of Recursion Pharmaceuticals in Salt Lake City, UT. Congratulations, Chadwick! We hope you'll share some of your cool videos with SLAS Facebook. More


Grab a Cup of Coffee and Relax with the SLAS2018 Poster Presentations
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Did you see these entries in the SLAS2018 poster gallery in San Diego?

Handheld GMO Biosensor
Optical Nanosensors for Monitoring 3D Oxygen Gradients in P. aeruginosa Biofilms
Sensible High-Throughput Automated Cloning
Spinach Splice Sensor: A Fluorescent Drug Discovery Platform

Learn more about the posters presented at SLAS2018 in the SLAS2018 e-Poster Gallery! The functional tool offers options to browse posters, "bookmark" your favorites, attach notes and create a personalized summary of the material that interests you. Plus, a new video on the SLAS YouTube channel promotes poster presenters and what they learned from the SLAS International Conference and Exhibition.
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New CRISPR-Cas9 Tool Edits Both RNA and DNA Precisely, U-M Team Reports
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A tool that has already revolutionized disease research may soon get even better, thanks to an accidental discovery in the bacteria that cause many of the worst cases of meningitis. Called CRISPR-Cas9, the tool acts as molecular scissors — able to cut DNA at exactly the spot it's asked to. But it can't cut the other kind of genetic material found in cells, called RNA. Now, researchers at the University of Michigan have discovered a single protein that can perform CRISPR-style, precise programmable cutting on both DNA and RNA. More


Body's Own Stem Cells Could Serve as Cancer Vaccine
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Induced pluripotent stem cells, or iPS cells, are a keystone of regenerative medicine. Outside the body, they can be coaxed to become many different types of cells and tissues that can help repair damage due to trauma or disease. Now, a study in mice from the Stanford University School of Medicine suggests another use for iPS cells: training the immune system to attack or even prevent tumors. The results suggest it may one day be possible to vaccinate an individual with his or her own iPS cells to protect against the development of many types of cancer. More




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Explore the Latest Festo Innovations

Join Festo as we kick off the new year at SLAS in San Diego, CA. Discover our latest products and innovative technologies for laboratory automation at booth 637. Stop by and speak with our experts to help find a solution for your laboratory challenges.


Distinctive Three-Step Hysteretic Sorption of Ethane with In Situ Crystallographic Visualization of the Pore Forms in a Soft Porous Crystal
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Over the past two decades, a large number of porous metal organic frameworks (MOFs) have been reported to show potential for catalysis as well as the storage and separation of gases. Numerous MOFs display impressive gas uptake capacities owing to their large specific surface areas and pore volumes. Because of the wide variety of potential building blocks, MOFs have a distinct advantage over conventional porous materials such as activated carbons and zeolites. More


Machine Learning Identifies Potential Inorganic Complexes for Switches and Sensors
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Machine learning, in which computers train on large data sets to make predictions, can be a fast way to find promising molecules for various applications, but it’s only as good as the data it trains on. A new strategy could make the method more useful for identifying leads among inorganic complexes, for which reliable data can be harder to come by. Heather J. Kulik and colleagues at Massachusetts Institute of Technology wanted to use machine learning to find new inorganic compounds with a small energy gap between their high- and low-electron-spin states. More




Engineers Test Drug Transfer Using Placenta-On-a-Chip
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Researchers at the University of Pennsylvania's School of Engineering and Applied Science have demonstrated the feasibility of their "organ-on-a-chip" platform in studying how drugs are transported across the human placental barrier. Some maternally-administered medications can enter the fetal bloodstream, but how the placenta determines which molecules can get through is still poorly understood. The ways of testing this process are limited. More


Hepatitis B Infects Organ-on-a-Chip Platform
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For the first time, a real pathogen has instigated a real disease process in an artificial organ, and scientists are really, really pleased. As far as scientists are concerned, the whole point of an artificial organ — in this case, a liver-on-a-chip platform — is to simulate a real organ's physiology, and that includes pathophysiology. By using an artificial liver to model the interactions between human tissue and an infectious agent — in this case, hepatitis B — scientists have opened a new front in disease research and, potentially, the development of new drugs. More


First Blood Test for Concussion Approved by FDA
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The U.S. Food and Drug Administration recently approved the first blood-based screening test for concussions. The diagnostic, which measures the abundance of the proteins UCH-L1 and GFAP, can help identify which patients should be sent for a CT scan to confirm any brain damage. "This is going to change the testing paradigm for suspected cases of concussion," Tara Rabin, a spokesperson for the FDA, tells The New York Times. More


Physicists Create New Form of Light
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Try a quick experiment: Take two flashlights into a dark room and shine them so that their light beams cross. Notice anything peculiar? The rather anticlimactic answer is, probably not. That's because the individual photons that make up light do not interact. Instead, they simply pass each other by, like indifferent spirits in the night. But what if light particles could be made to interact, attracting and repelling each other like atoms in ordinary matter? More


Career


DNA-Encoded Library Technology (DELT)
Merck & Co.
US – NJ – Kenilworth

Software Engineer
BioTek Instruments, Inc.
US – VT – Burlington

Senior Software Engineer
BioSoft Integrators LLC
US – CA – San Diego

Search Jobs at SLAS Career Connections


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