This message contains images. If you don't see images, click here to view. Advertise in this news brief. Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit February 24, 2016 SLAS.org    SLAS2017    Moving? New job? Let SLAS know.       Advertisement Advertisement Advertisement Advertisement Advertisement   Advertisement Fernanda Ricci Wins 2016 JALA & JBS Art of Science Contest SLAS    Share    Congratulations to Fernanda Ricci of IIT@SEMM in Italy, top vote-getter and winner of a $500 Amazon gift card for her beautiful image — a mosaic representation of cell colonies and the resulting automated segmentation obtained with Colony Assay Toolbox (CaT, F. Ricci et al. JBS 2014). The illustrations are representative of a colony formation in a 384 multi-well format; the single wells are entirely acquired by using a 4x objective combined with a large camera in wide-field microscopy (Nikon Ti-Eclipse). All 10 finalists receive 60 days free online access to the SAGE Pharmacology & Biomedical Collection (100,000+ research reports!). More Advertisement SLAS ELN Reports: Exploring the Potential of Mass Spectrometry in Drug Discovery — A JBS Special Issue SLAS     Share    There's an element of mystery and a few myths around mass spectrometry (MS) that JBS Guest Editors Jonathan Wingfield, Ph.D., AstraZeneca (U.K.), and Ian Wilson, D.Sc., of Imperial College (U.K.), hope to dispel. "One is the idea that MS is a high-tech platform that tends to be operated by specialists," comments Wingfield. "That impression can be a potential barrier that stops people from wanting to use this type of technology. I hope this collection of papers appearing in a rigorously peer-reviewed, mainstream scientific journal will debunk some of these myths and get people interested in the potential of MS." Read more in the latest feature article in the SLAS Electronic Laboratory Neighborhood e-zine. More Advertisement Tecan booth talks at SLAS2016 are now available! FREE Access to 'Novel Acoustic Loading of a Mass Spectrometer' Presentation and JALA Special Issue on Advancing Scientific Innovation with ADE SLAS    Share    The 2015 SLAS Innovation Award-winning presentation by Jonathan Wingfield on "Novel Acoustic Loading of a Mass Spectrometer — Towards Next Generation High-Throughput MS Screening" can now be accessed for free courtesy of sponsorship by Labcyte Inc. Plus, more than 200 pages of peer-reviewed scientific reports on acoustic droplet ejection (ADE) are available for FREE at JALA Online, also courtesy of Labcyte. More Advertisement ACCELERATE YOUR SAMPLE PREP See how researchers are accelerating their research with the Agilent Bravo Automated Sample Prep Platform. SLAS Webinar: The SmartLab of the Future SLAS    Share    On March 24, Felix Lenk, Ph.D., Technische Universität Dresden, presents "The SmartLab of the Future: Benchtop Lab Automation with the PetriJet and NutriJet Platforms." Lenk describes the PetriJet platform, which provides a lab with a compact device for the automated handling of culture dishes in batches of 20 or continuously. Together with exchangeable processing stations, nearly all tasks associated with culture dishes like identification, filling and imaging can be effectively automated. NutriJet provides a lab with a fully automated solution for medium composition right from the container of the ingredient manufacturer and is fully GMP compliant. The March 24 Webinar, presented by JALA and JBS, the official journals of SLAS, is free to SLAS dues-paying members. More Advertisement FREE at JALA Online: Miniaturization Technologies for Efficient Single-Cell Library Preparation for Next-Generation Sequencing SLAS    Share    A collaborative team from University of California, San Diego and TTP Labtech share results that "indicate that the application of a nanoliter-scale liquid handling system enables automated library preparation for single-cell transcriptome sequencing at markedly lower reaction volume without compromising reproducibility, quality, or complexity of the resulting libraries. "This technical advance will significantly decrease both the cost and labor required for these studies, making analysis of hundreds to thousands of single cells feasible. The ability to carry out large-scale studies will allow for detailed studies aimed at detecting transcriptional differences between cell populations collected at multiple time points or exposed to different experimental conditions, as well as identifying rare subpopulations of cells." More Advertisement Unlimited Modes of Detection = 1 Microplate Reader With an industry-leading number of detection modes, SpectraMax i3 not only meets your application needs today, it also adapts to your changing requirements tomorrow. Read about the latest microplate reader applications like StainFree Cell Detection and ScanLater Western Blot in the Novel Microplate Reader Applications eBook. Download here >> Advertisement Welcome to RAD Source Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info. Advertisement Fully automate your genomics workflow The Fragment Analyzer INFINITY is the only parallel capillary electrophoresis instrument capable of complete integration into your robotic automation system. Fully compatible with all the high quality kits developed for the Fragment Analyzer, the Fragment Analyzer INFINITY can run over 2400 samples a day without human intervention. FREE to All at SLAS.org: 'Analyzing the Complexity of Drug Resistance in Cancer' by Michael M. Gottesman SLAS    Share    Recorded live at SLAS2016 and now freely accessible to all, this keynote presentation by Michael Gottesman, Ph.D., chief of the U.S. National Cancer Institute's Laboratory of Cell Biology, discusses the daunting complexity of resistance mechanisms in cancer cells, the Institute's approach to cell-based research and recent discoveries related to oncology. More New at SLAS.org: HT-MALDI-MS as a Complete Label-Free Drug Discovery Platform — From Target Characterization through HTS to Hit Follow-Up SLAS    Share    From the SLAS2016 Bioanalytics, Biomarkers and Diagnostics track, this recorded presentation by Scott Busby, Novartis Institutes for Biomedical Research, USA, explores the HT-MALDI-MS platform, which overcomes many previous limitations of mass spectrometry-based screening assays. This includes superior throughput to LCMS and SPE coupled ESI assays in both assay development and screening times, significantly reducing assay costs by eliminating expensive solvents and antibody reagents used in other techniques and enabling new assays that are not possible with conventional TR-FRET assays. It is one of seven presentations recorded at SLAS2016 for free on-demand viewing by SLAS dues-paid members and full conference participants. More Advertisement Important factors to Consider for Thermal Shift Assays Download the Overcoming Technical Challenges in Cell-Based High Throughput Screens Whitepaper Scientists Find Popular Stem Cell Techniques Safe Lab Manager    Share    A new study led by scientists at The Scripps Research Institute and the J. Craig Venter Institute shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients. The research, published in the journal Nature Communications, is an important step in assessing patient safety in the rapidly developing field of stem cell therapies. More Chemistry Trick Paves Way for Safer Diabetes Medication Science Daily    Share    Knud J. Jensen is a professor at the University of Copenhagen's Department of Chemistry. Together with Technical University of Denmark and Novo Nordisk researchers, he has published Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron (II) and Zink (II) Ions at Distinct Sites" in the journal, Angewandte Chemie. "We have discovered an entirely new method of modifying a molecule — Insulin — that is important for 35 million diabetes patients. We are incredibly happy with that," says Professor Jensen. More Advertisement Become a Lab Superhero! The Mantis will revolutionize your workflow for applications including NGS sample prep, qPCR, assay development, and cellular assays. Automation made simple. Advertisement Cloud, Consulting, and Custom Services, All In One. Scigilian is a software company specializing in offering solutions to the problems encountered in pharmaceutical research, biotechnology, and contract research. Trusted, from large pharma to small CRO. Why Do Our Cell's Power Plants Have Their Own DNA? Science Magazine    Share    It's one of the big mysteries of cell biology. Why do mitochondria — the oval-shaped structures that power our cells — have their own DNA, and why have they kept it when the cell itself has plenty of its own genetic material? A new study may have found an answer. Scientists think that mitochondria were once independent single-celled organisms until, more than a billion years ago, they were swallowed by larger cells. More Study Reveals Mechanism Behind Enzyme That Tags Unneeded DNA Phys.org    Share    Researchers have discovered the two-step process that activates an essential human enzyme, called Suv39h1, which is responsible for organizing large portions of the DNA found in every living cell. For any particular cell, such as a skin or brain cell, much of this genetic information is extraneous and must be packed away to allow sufficient space and resources for more important genes. Failure to properly pack DNA jeopardizes the stability of chromosomes and can result in severe diseases. More Advertisement Whole-Genome Study Allays Cancer Fears Surrounding Stem Cell Techniques Genetic Engineering & Biotechnology News    Share    Cell-replacement therapies that depend on induced pluripotent stem cells inspire hope and fear — hope that cells derived from iPSCs will actualize regenerative medicine; fear that the very same cells will bring cancer-causing mutations to patients. The fear lingers even though several studies have already suggested that iPSCs can be considered safe. These studies were conducted because iPSCs are created only after they have endured the rigors of reprogramming, stresses thought to be capable of introducing deleterious mutations. More Protein Structure Illuminates How Viruses Take Over Cells Bioscience Technology    Share    Using cutting-edge imaging technology, Salk Institute and Harvard Medical School researchers have determined the structure of a protein complex that lets viruses similar to the human immunodeficiency virus establish permanent infections within their hosts. Contrary to previous assumptions, the newly detailed viral protein complex structure indicates that this type of molecular architecture differs across retroviruses. More Advertisement KMC Systems Engineering & Manufacturing KMC Systems provides contract engineering and manufacturing services to leading and emerging OEMs. As a trusted outsourcing partner for 35 years, KMC Systems develops, designs and manufactures cutting-edge, full-system instrumentation for the medical and life science markets. Visit us online and download our brochure to learn more about KMC Systems. Advertisement The Concept Is Simple We work with scientists to design and develop new, innovative tools for biological, chemical, and materials research, both in basic studies and pharmaceutical and industrial applications. We know research, we know assay development, and we know tools development. Learn More Advertisement Sample Screening from your Compound The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound management or screening system. Same Gene, Different Functions The Scientist    Share    The human genome contains roughly 20,000 protein-coding genes, yet the number of proteins in human cells is thought to be more like 100,000. Researchers from three institutions in North America have now shown that at least some of the diversity of proteins' functions in the cell may be due to the widely diverging roles of protein isoforms — structurally similar variants produced as a result of slight differences during the translation of a single gene. More Enzyme Inhibitors Block Ebola Chemical & Engineering News    Share    The 2014 Ebola epidemic drew the world's attention to the virus, which multiplies rapidly inside human tissues, destroying entire organs within days. Although antibodies have proved helpful in treating Ebola, no drugs block the virus. In many cases, all doctors can do is treat the symptoms and wait for the immune system to work. Now, researchers have engineered a group of small molecules that inhibit key cellular proteins, blocking Ebola's ability to infect mouse cells and offering a new approach for battling the deadly virus. More Advertisement Laboratory Automation Engineer/Associate Scientist or Sr. Engineer/Scientist, Process Development Genentech US – CA – South San Francisco Research Technician Drexel University College of Medicine Department of Pharmacology US – PA – Philadelphia Sr. Scientist II, Cell Based Discovery The Coca-Cola Company US – GA – Atlanta Search Jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues Feb. 17, 2016 Feb. 10, 2016 Feb. 3, 2016 Jan. 27, 2016 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063