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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit February 25, 2015

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SLAS ELN President's Message: Come Transform Research
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"SLAS is a collaborative community — the power is its people," says SLAS President Dean Ho in his first message in the SLAS Electronic Laboratory Neighborhood e-zine. He highlights the new SLAS Graduate Education Fellowship Grant Program announced at SLAS2015.

"This $1,000,000 is in addition to the more than $150,000 that's already allocated annually to underwrite SLAS student programs and services. These commitments emphasize why SLAS is well known worldwide as THE organization for emerging scientific innovators and their innovations."
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March 10 SLAS Webinar: How Circulating Tumor Cells Can Help Identify Targets for New Cancer Drugs
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Dr. Martin Fleisher, director of the Biomarker Discovery Laboratory and attending clinical chemist in the Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center, is internationally recognized as an expert in the use of biomarkers for detecting and monitoring cancer. In the SLAS Webinar, he shares how the use of circulating tumor cells as biomarkers can be predictive of tumor sensitivity to specific drugs with the potential to provide a snapshot of the molecular makeup of an individual patient's metastatic tumor.

Such a "liquid biopsy," he says, can help clinicians in patient management and aid in understanding tumor growth biology throughout the course of the disease. SLAS Webinars are free to dues-paid SLAS members. Not yet a member? Join today.
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JBS Open Access: Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids
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The Malaria Box, assembled by the Medicines for Malaria Venture, is a structurally diverse set of 200 druglike and 200 probelike compounds distilled from more than 20,000 antimalarial hits from corporate and academic libraries. This JBS manuscript describes the screening of the Malaria Box and triaging of the identified hits against kinetoplastids responsible for human African trypanosomiasis, Chagas disease and visceral leishmaniasis.

The in vitro and in vivo profiling of the most promising active compounds with respect to efficacy, toxicity, pharmacokinetics, and complementary druggable properties are presented and a collaborative model used as a way to accelerate the discovery process discussed. This manuscript is available online for free to everyone courtesy of the Drugs for Neglected Diseases initiative.
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  • Now Online: SLAS2015 JALA & JBS Author Workshop: How to Get Your Work Published
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    JALA Editor-in-Chief Edward Kai-Hua Chow, Ph.D., of National University of Singapore shared step-by-step advice on how to design and write scientific research papers more clearly and effectively to improve their chances for successful publication at the recently held conference in Washington, DC.

    Learn what editors want, what they don't want and how reviewers evaluate manuscripts by reviewing slides from the session.
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    SLAS2015 Encore Presentations Available On Demand
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    The following SLAS2015 podium presentations were recorded for on demand access to dues-paid SLAS members. SLAS2015 Full Conference attendees also are being granted access to these encore presentations for a limited time. Questions on how to access? Contact SLAS Membership Manager Mary Geismann at mgeismann@slas.org.

    Shashi G. Amur: Biomarker Qualification at CDER, FDA

    Jarie Bolander: Real Time Predictive Modeling of Clinical Samples in Transit to Ensure Sample Viability

    Marie-Elena Brett: Droplet-Based Three Dimensional Cell Migration Assay with Flow Cytometry Based Automated Analysis

    David Evans: Spheroid Culture Screening in Anti-cancer Drug Discovery

    David J. Guckenberger: An Automated Open Platform for Exclusion-based Sample Preparation: Getting More Information from Limited Patient Samples

    Thomas Lundbäck: Screening for Novel Inhibitors of Thymidylate Synthase Using CETSA – a High Throughput Target Engagement Assay

    Lorenz M. Mayr: Precise Genome Editing and Stem Cell Technologies - Novel Tools for Novel Medicines

    Stephen Trowbridge: From Brackets to Body Parts - How 3D Printing Is Changing the Way We Work

    Fabien Vincent: The Phenotypic Screening “Rule of 3”: Developing More Predictive Assays

    Jonathan Wingfield: Novel Acoustic Loading of a Mass Spectrometer – Towards Next Generation High Throughput MS Screening
    2015 SLAS Innovation Award winner

    Not an SLAS member? Join today.
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    Welcome New SLAS Corporate Members
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    Two companies became SLAS Corporate Members during SLAS2015. Hettich Automation, family owned and operated for more than 100 years, is headquartered in Tuttlingen, Germany. Hettich is a clinical and research centrifuge manufacturer.

    Micronic America is a global supplier of traceable sample storage solutions headquartered in Lelystad, The Netherlands. The company has been dedicated to the design and production of innovative solutions for more than 30 years.
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    Fueling the Fear: Global Health Crisis and Mass Media
    By Jessica Taylor    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Laurie Garrett, author, journalist and authority on global health issues, closed out SLAS2015 by discussing critical issues in global healthcare — particularly mass hysteria over diseases in the U.S. Garrett, who has written several best-selling books on disease and outbreak, started her discussion by stating that her familiarity and knowledge of diseases goes back through many years. As she went through the history of epidemic diseases throughout the world, she showcased how hospitals were always in chaos. More

    Distant Polypharmacology among MLP Chemical Probes
    ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Small molecules are essential tool compounds to probe the role of proteins in biology and advance toward more efficient therapeutics. However, they are used without a complete knowledge of their selectivity across the entire proteome, at risk of confounding their effects due to unknown off-target interactions. Current state-of-the-art computational approaches to predicting the affinity profile of small molecules offer a means to anticipate potential nonobvious selectivity liabilities of chemical probes. More

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    Aromaticity for All
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Aromaticity is one of chemistry's oldest concepts to describe the behavior of molecules. Chemists created it 150 years ago to help visualize and explain the bonding, structure and reactivity of benzene. Many chemists today hold aromaticity sacred and defend using the concept only for benzene, its many derivatives and related heterocyclic compounds. Others believe the concept is so fundamental to chemistry that it should also be used to help explain the bonding, structure and reactivity in any type of molecule, including fleeting inorganic compounds. More

    Monoamine Oxidase A Inhibitor-Near-Infrared Dye Conjugate Reduces Prostate Tumor Growth
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Development of anti-cancer agents with high tumor-targeting specificity and efficacy is critical for modern multidisciplinary cancer research. Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines. Recent evidence suggests a correlation between increased MAOA expression and prostate cancer (PCa) progression with poor outcomes for patients. MAOA induces epithelial–mesenchymal transition (EMT) and augments hypoxic effects by producing excess reactive oxygen species. More


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    New Nanogel for Drug Delivery
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    To help overcome that obstacle, MIT chemical engineers have designed a new type of self-healing hydrogel that could be injected through a syringe. Such gels, which can carry one or two drugs at a time, could be useful for treating cancer, macular degeneration, or heart disease, among other diseases, the researchers say. The new gel consists of a mesh network made of two components: nanoparticles made of polymers entwined within strands of another polymer, such as cellulose. More

    New Catalyst to Create Chemical Building Blocks From Biomass
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    University of Tokyo researchers have developed a novel selective catalyst that allows the creation of several basic chemicals from biomass instead of petroleum. This discovery may lead to the use of plant biomass as a basic feedstock for the chemical industry. The new catalyst developed by Professor Kyoko Nozaki's research group at the Graduate School of Engineering enables selective cleaving (hydrogenolysis) of carbon-oxygen (C-O) single bonds in phenols and aryl methyl ethers, two of the main components of lignin. More



    Silver Electrocatalysts May Help Enable Long-Term Space Travel
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Despite continuous advances, major obstacles remain before manned missions can set off for destinations like Mars. A primary concern is how people will breathe. Long-duration space flights would travel far away from Earth and take years. Oxygen tanks can't be shuttled out to resupply the astronauts, so the air must be recycled. Yet state-of-the-art systems are only about 50 percent efficient at recovering used oxygen from carbon dioxide. More

    Mutation Order Reveals What Cancer Will Do Next
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    It is well known that cancers can develop from mutations in DNA — but now we've seen for the first time that a person's fate may depend on the order in which they occur. In every cancer, there are hundreds of mutations, but some have more of an effect on the disease than others. It has now been shown that a cancer's path changes depending on which of these "driver mutations" comes first. This affects how the cancer develops, and which treatments are likely to work best. More

    Stem Cells From Teeth May Restore Sight to the Blind
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at the University of Pittsburgh working with mice showed how stem cells harvested from teeth extracted during routine dental procedures can potentially be used to restore sight in those suffering from corneal blindness. They published their study ("Dental Pulp Stem Cells: a New Cellular Resource for Corneal Stoma Regeneration") in Stem Cells Translational Medicine. Corneal blindness afflicts millions of individuals worldwide. More

    Career


    Manager, Engineering
    Genentech
    US – CA – Oceanside

    R&D Chemist
    Enzymatic Deinking Technologies (EDT)
    US – GA – Norcross

    Endowed Professorship in Pediatric Clinical Pharmacology
    Washington University School of Medicine
    US – MO – St. Louis

    Search jobs at SLAS Career Connections


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