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Discussions and musings focused on the engaging field of laboratory science and technology.
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The Lab Man Interviews SLAS2014 New Product Award Recipients
SLAS Share
   
Learn about the celebrated products in three new podcasts from The Lab Man. Ranger Technology from Coastal Genomics; switchSENSE Analyzer DRX 2400 from Dynamic Biosensors; and Gavi from Planet Innovation were selected for SLAS New Product Award Designations at SLAS2014, where more than 45 new products were launched.
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JBS Special Issue Call for Papers: Novel Therapeutic Approaches for Neglected Infectious Diseases
SLAS Share
Manuscript proposals (abstracts) are due March 10 for this JBS special issue.
Guest Editors Drs. Julio Martin and Eric Chatelain request articles related to approaches undertaken — both technological and strategic — to discover and advance new chemical entities for the treatment of neglected tropical diseases, including novel methods, success stories and lessons learned.
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SLAS ELN Reports: Christine Brideau — An Early Adopter to Change
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Christine Brideau, B.S., describes her ascent in research as a journey filled with continual change, including a move just last month to accept an offer from Wuxi AppTec to set up an in vitro biology assay development laboratory in New Jersey.
This is a first for the contract research organization based in Shanghai, China. Read more about the Canadian native in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS Webinar Series Begins March 18: Protein-Protein Interactions as Small Molecule Drug Targets
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SLAS delivers world-class education and information to your desktop again this spring. Register today for:
Webinars are FREE to dues-paid SLAS members.
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SLAS Membership Offers Great Value
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Are you having trouble accessing the member's only pages of SLAS.org? Did you miss the February issue of the Journal of Biomolecular Screening or the Journal of Laboratory Automation? Your SLAS membership may have expired. Renew today and continue to receive all that your membership has to offer, including FREE access to upcoming spring webinar series, Protein-Protein Interactions as Small Molecule Drug Targets. Questions? Contact Manager of Member Services Mary Geismann.
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Francis Collins Blog: DNA Barcodes Interrogate Cancer Cells
SLAS Share
A challenge of antibody cancer therapy has been to identify target proteins in cancer tissues.
The SLAS2015 keynote speaker and National Institutes of Health director posted last week about a technique developed at the Center for Systems Biology, Massachusetts General Hospital using DNA-tagged (i.e. "barcode") antibodies as a method to reveal the identities as well as quantity of proteins on cell surfaces.
Editor's note: If this is your area of interest, be sure to contribute to the call for papers for the JBS special issue, Therapeutic Antibody Discovery and Development. Manuscript proposals (abstracts) are due April 25.
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SLAS2014 Photo Gallery: The Many Faces of SLAS
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More than 300 photos capture the excitement and energy of SLAS2014, the Society's Third Annual Conference and Exhibition.
From the opening keynote session featuring SLAS board members and Dr. Eric Topol through the closing session with Radiolab's Robert Krulwich and Jad Abumrad, SLAS2014 was a great showing of community spirit.
Explore the photo gallery today.
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Aptamer Binding to Celiac Disease-Triggering Hydrophobic Proteins: A Sensitive Gluten Detection Approach
Analytical Chemistry Share
Celiac disease represents a significant public health problem in large parts of the world. A major hurdle in the effective management of the disease by celiac sufferers is the sensitivity of the current available methods for assessing gluten contents in food. In response, we report a highly sensitive approach for gluten analysis using aptamers as specific receptors. Gliadins, a fraction of gluten proteins, are the main constituent responsible for triggering the disease.
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SpectraMax® i3 Multi-Mode Detection Platform is a flexible plate reader that evolves to fit your application needs. This system offers one-of-a kind ScanLater™ Western Blot Detection, SpectraMax® MiniMax™ Imaging Cytometer, as well as built in absorbance, fluorescence, and luminescence detection modes while the patented cartridge design allows FP, HTRF, and AlphaScreen® field upgrades – all on a single detection platform. View video and learn more →
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Scientists Transform Skin Cells into Functioning Liver Cells
Bioscience Technology Share
The power of regenerative medicine now allows scientists to transform skin cells into cells that closely resemble heart cells, pancreas cells and even neurons. However, a method to generate cells that are fully mature — a crucial prerequisite for life-saving therapies — has proven far more difficult. But now, scientists have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own.
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Microparticles Show Molecules Their Way: 3-Dimensional Structures Using 3 Chemically Different Patches
Science Daily Share
A team of researchers of Karlsruhe Institute of Technology and the University of Michigan/USA has produced novel microparticles, whose surface consists of three chemically different segments. These segments can be provided with different (bio-) molecules. Thanks to the specific spatial orientation of the attached molecules, the microparticles are suited for innovative applications in medicine, biochemistry, and engineering. The researchers now report about their development in the journal Angewandte Chemie.
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MIT Team Develops Urine Test for Cancer
Genetic Engineering & Biotechnology News Share
Scientists at MIT say they have developed a simple, cheap paper test that could be used to improve cancer diagnosis rates and help people get treated earlier. The diagnostic, which works much like a pregnancy test, reportedly could reveal within minutes, based on a urine sample, whether a person has cancer. This approach has helped detect infectious diseases, and the new technology allows noncommunicable diseases to be detected using the same strategy.
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Tapping Solar Power With Perovskites
Chemical & Engineering News Share
Every now and again, a well-studied research topic explodes with new life. Long after carbon materials filled chapters of dated textbooks, for example, that field's soul was reenergized around 1990 after buckyballs and carbon nanotubes were discovered. It happened again in that field about a half-dozen years ago when graphene took the world by storm. It's happening now in photovoltaics.
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Discovery of Light-Responsive Ligands through Screening of a Light-Responsive Genetically Encoded Library
ACS Chemical Biology Share
Light-responsive ligands are useful tools in biochemistry and cell biology because the function of these ligands can be spatially and temporally controlled. Conventional design of such ligands relies on previously available data about the structure of both the ligand and the receptor. In this paper, we describe de novo discovery of light-responsive ligands through screening of a genetically encoded light-responsive library.
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Using Computers to Speed Up Drug Discovery
Phys.org Share
Okinawa Institute of Science and Technology researcher uses a computational approach in identifying proteins that will interact with potential drugs to speed up the process of drug discovery. One of the major problems in today's society is the efficiency and cost of developing medicines to treat disease. The advancements in pharmaceutical science have been phenomenal, but the price of these advances remains prohibitively high.
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Latest Research Offers Promise in Detection of Pancreatic Cancer
By Rosemary Sparacio Share
 Pancreatic cancer causes more than 38,000 deaths in the U.S. each year, and is the fourth-most common cause of cancer deaths in the western world. No routine screening methods for pancreatic cancer are available, due to the subtle differences among cancerous, atypical and healthy tissue. Recently, however, two studies have identified biomarkers that show potential as a method for early detection of pancreatic cancer.
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Fine-Tuning Salmonella-Based Vaccines
Lab Manager Share
In a new study, lead author Karen Brenneman and her colleagues at Arizona State University's Biodesign Institute propose an improved method of screening salmonella vaccines in small animal studies and enhancing their effectiveness in humans. The new research demonstrates a system for improving the ability of salmonella vaccine strains to survive the hostile environment of the stomach, where high acid concentrations are typically lethal for invasive bacteria.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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