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SLAS ELN: What's next for the NIH Molecular Libraries Program?
SLAS Share
   
The National Institutes of Health's Molecular Libraries Program is ending. Was it a success? Did it fail to live up to its expectations? It depends on who you ask. The new SLAS Electronic Laboratory Neighborhood feature presents various perspectives. Be sure to share how this program has affected you in the feature's comments section.
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SLAS Asia keynoter speaks at stem cell meeting
SLAS Share
Listen to a presentation by Mahendra Rao, M.D., Ph.D., NIH Center for Regenerative Medicine at the Nov. 30, 2011, Sixth Annual Scientific Symposium Stem Cell Meeting on the Mesa. Rao will present "Stem Cells for Regenerative Medicine" at the 2012 SLAS Asia Conference and Exhibition, which takes place June 19-21 in Shanghai, China.
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SLAS R&D student internship offered
SLAS Share
GlaxoSmithKline has a six-month (June to December 2012) opportunity for an undergraduate or a graduate student to work in screening and compound profiling, in the Platform Technology and Science Department at its Collegeville, Pa., location. Candidates with a background in biochemistry, cellular biology, molecular biology or engineering with an interest in drug discovery and laboratory automation are welcome to apply.
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Starfruit Software/Database Service - LTS per Study. You can control who to use a sample. Visit Store – Starfruit Library to see "Starfruit Sample Locator BIMS" |
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JBS March issue highlights
SLAS Share
"Establishment of a Stable Cell Line Coexpressing Dengue Virus-2 and Green Fluorescent Protein for Screening of Antiviral Compounds" is among the original articles featured in the March 2012 issue of JBS. Watch for your copy in the mail or access online.
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Stay connected with SLAS social media
SLAS Share
The SLAS presence on LinkedIn, Twitter and Facebook grew substantially following the excitement of SLAS2012 in San Diego. These networking tools provide a means of continuing the discussion begun there! If you have not yet joined these SLAS communities, click through the individual links under the banner, top right, at SLAS.org.
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Career Connections for laboratory science and technology jobs
SLAS Share
SLAS offers Career Connections in alliance with the National Healthcare Career Network. Whether you are looking for a job, or wishing to post an opening, consider this targeted laboratory science and technology jobs site.
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The Nexar® System optimized for Homogeneous ELISA processing is fully automated and modular. The system includes inline random access sample storage, liquid handling, incubation, and detection (< 3 minutes/384 array). Achieve high throughput processing, miniaturized reaction volumes in Array Tape™ and true walk-away operation. Contact Douglas Scientific today! MORE
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The MaxCyte® VLX™ Large Scale Transfection System is specifically designed for extremely large volume transfection and is able to transfect up to 2E11 cells in less than 30 minutes with high cell viability and transfection efficiencies. This system is ideal for rapid, gram scale production of proteins and monoclonal antibodies.
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Alpillo® microplate cushions from ALPAQUA® are designed to enhance automated precision pipetting. Integrated spring technology allows for touch-off dispensing and complete aspiration of every microliter of precious samples and reagents from SBS standard microplates. Protect your instruments & consumables and eliminate troublesome tip crashes & head contamination - all while improving pipetting consistency.
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Computational modeling of cellular signaling processes embedded into dynamic spatial contexts
Nature Methods Share
Cellular signaling processes depend on spatiotemporal distributions of molecular components. Multicolor, high-resolution microscopy permits detailed assessment of such distributions, providing input for fine-grained computational models that explore mechanisms governing dynamic assembly of multimolecular complexes and their role in shaping cellular behavior.
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If you are a scientist or researcher looking for the latest innovations in laboratory equipment–then Pittcon 2012, the world’s largest annual conference and expo for lab science, is a must attend event. Register now at www.pittcon.org
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Personalizing cancer drugs
Technology Review Share
Michael Pellini fires up his computer and opens a report on a patient with a tumor of the salivary gland. The patient had surgery, but the cancer recurred. That's when a biopsy was sent to Foundation Medicine, the company that Pellini runs, for a detailed DNA study. Foundation deciphered some 200 genes with a known link to cancer and found what he calls "actionable" mutations in three of them.
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Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin
Nature Chemical Biology Share
Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo.
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The virus station: A field lab for finding a deadly disease
Popular Science Share
A man who worked in a lead and gold mine in southwest Uganda died suddenly from a hemorrhagic fever. Concerned that it could be the beginning of an outbreak of Marburg virus, which is similar to Ebola, doctors sent a blood sample to the Uganda Virus Research Institute, where pathologists confirmed that Marburg was indeed the cause of death and alerted the World Health Organization and the Centers for Disease Control and Prevention.
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3 innovative products launched at SLAS Booth 914:
• arktic: compact automated biobanking
• aequus: non-contact liquid level monitoring
• mosquito HV: cost-saving serial dilutions. |
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India rising
Science Magazine Share
At the Indian Science Congress, Prime Minister Manmohan Singh pledged to hike R&D expenditures from around $3 billion last year to $8 billion in 2017. The windfall is meant to turbocharge initiatives to create elite research institutions, bring expatriate Indian scientists home, enrich science education and equip smart new laboratories.
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Tryptophan 2,3-dioxygenase inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators
Journal of Medicinal Chemistry Share
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase, an unrelated hepatic enzyme also catalyzing the first step of tryptophan degradation, is also expressed in many tumors and that this expression prevents tumor rejection by locally depleting tryptophan.
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Coaxing the heart to heal itself
New Scientist Share
It starts slowly, with a faint discomfort that grows until it feels like a vice is tightening around your chest. The pain radiates to your left arm and shoulder, and to the back of your neck. You feel sick, dizzy and short of breath. When the pain passes, you wonder what on earth just happened. In one way, you can consider yourself lucky: you have just survived a heart attack.
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Obama announces funding for breakthroughs in natural gas and biofuels
Lab Manager Share
President Barack Obama recently announced new funding to catalyze breakthrough technologies for two key alternative fuels — natural gas and biofuels — as part of his all-of-the-above energy strategy to reduce our reliance on foreign oil and provide American families new choices for vehicles that do not rely on conventional gasoline.
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Whether your lab is manual, semi-automated or fully automated, FlexLink has flexible conveyor systems and solutions that fit perfectly where space is limited and close machine interface is required. MORE |
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High abundance of genetic Bacteroidetes markers for total fecal pollution in pristine alpine soils suggests lack in specificity for feces
Journal of Microbiological Methods Share
Two frequently applied genetic Bacteroidetes markers for total fecal pollution (AllBac and BacUni) were found in high numbers in pristine soil samples of two alpine catchment areas casting doubt on their value as fecal indicators. This finding underlines the necessity to evaluate assays locally and against non-intestinal samples before application.
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Bird flu, swine flu ... and now bat flu?
Live Science Share
Scientists have found a new influenza virus that infects bats. But don't pull out the hand sanitizer leftover from the H1N1, or swine flu, pandemic just yet. When asked about the implications of this discovery for human health, one of the researchers, Ruben Donis, said: "It's still too early to tell."
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Immune response markers for cancer vaccines paint a clearer picture
Genetic Engineering & Biotechnology News Share
A key hurdle in the development of cancer immunotherapies has been the absence of biomarkers that indicate the efficacy and kinetics of antitumor immune responses. The identification of immune response biomarkers may also predict which patients are most likely to benefit from active immunotherapies.
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New molecule has potential to help treat genetic diseases and HIV
The University of Texas Share
Chemists at The University of Texas at Austin have created a molecule that's so good at tangling itself inside the double helix of a DNA sequence that it can stay there for up to 16 days before the DNA liberates itself, much longer than any other molecule reported. It's an important step along the path to someday creating drugs that can go after rogue DNA directly.
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Agilent Technologies’ RapidFire is an SPE-based solution that enables detection of native compounds by mass spec. Requiring no labels or surrogates, it enables the screening of intractable or challenging targets which are not amenable to fluorescence or luminescence. Sample throughput is 10x faster than conventional MS screening methods. MORE
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Labcyte released a novel software algorithm that enables a greater range of fluid types to be automatically transferred with acoustic energy. Dynamic Fluid Analysis™ enables the Echo® liquid handling systems to adapt to fluid properties changes such as surface tension and viscosity, and adjusts sound energy in real time with no operator intervention required.
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Focused on Outsourced Materials Management and Sample Preparation Services, FSSI supports Compound Management, Research and Discovery Screening, and Chemistry. FSSI performs Sample Reformatting and Full Repository Services with on-demand 24-48 hour delivery. FSSI offers diversity screening libraries, pre-weighed building blocks in custom aliquots, full preparative purification, and high-throughput analysis.
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EasyHandling makes Mechatronics easier and faster than ever, with high-performance mechanical technologies and our new EasyWizard programming tool. Cut engineering time, effort & cost by up to 80%. EasyHandling is perfect for Lab applications—ranging from test tube pick-and-place and medical product packaging to hands-off inspection of hazardous materials.
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Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.
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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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For supporting the unique requirements of bio molecular lab systems, UNIConnect delivers what others can’t.
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13 of 20 top pharma/biotech companies have chosen Titian’s modular Mosaic™ software to control their sample storage/preparation. Find out why.
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Discussions and musings focused on the engaging field of laboratory science and technology.
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The SLAS Market Place offers access to new and existing technology products and services for your laboratory.
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