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SLAS2017 Presentations Available On Demand
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Keynote speaker Jennifer Lippincott-Schwartz's SLAS2017 presentation, "Emerging Fluorescence Technology to Study the Spatial and Temporal Dynamics of Organelles within Cells," discusses emerging visualization technologies that allow cell biologists to capture processes from whole organisms down to single molecules.

Six SLAS2017 scientific podium presentations also are available, including 2017 SLAS Innovation Award winner Elodie Sollier-Christen's overview of Vortex Bioscience's new VTX-1 platform to isolate and collect intact circulating tumor cells directly from whole blood in less than 1.5 hours. SLAS members can access the presentations (synched audio and slides) at any time; non-members have access until April 30.
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Just Announced! Special Issue on Enabling Technology in Cell-Based Therapies
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SLAS Technology Guest Editors Christopher Puleo, Brian Davis, Reginald Smith and Nichole Wood of GE Global Research US seek original scientific reports and reviews about technologies that are enabling the translation of cell-based therapies.

Areas of interest include but are not limited to technologies for cell manufacturing automation, clinical automation and cell administration, and in vivo programming of therapeutic cells. Manuscript proposals (abstracts) are due June 1.
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SLAS ELN Reports: The Lab Man Interviews Product Innovators
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SLAS Director of Education Steve Hamilton (a.k.a. The Lab Man) spoke with SLAS2017 New Product Award winners Ariane Jonetz-Mentzel and Ian Hanegraaff of Analytik Jena US; Rich Cote of Avidien Technologies; and Jonathon Prinz and Vincent Lemaitre of infinitesimal (also an SLAS2017 Innovation AveNEW delegate).

The Lab Man asked each product innovator, "What was it about your technology that you believe earned this award?" Learn more in the individual podcasts and in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS2017 Labware Leachables SIG Meeting Presentation Now Online
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David A. Weil, Ph.D., presented "Identification of Potential Bioactive Leachables and Extractables from Plastic Lab Ware by Using GC and LC Separation Methods Linked with MS Detection" at the Labware Leachables Special Interest Group meeting at SLAS2017.

The senior applications scientist with Agilent Technologies covered bioactive compounds; plastic or glass labware; leachables and sample loss; challenges of extractable and leachable (E and L) analysis; commonly found impurities; and Agilent E and L solutions. Weil's presentation can be accessed at SLASshare and the SLAS Labware Leachables SIG forum on LinkedIn.
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Call for Papers: Statistical Applications in Knowledge and Drug Discovery
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SLAS Discovery invites special issue manuscript proposals (abstracts) on topics related to experimental design and statistical analysis for traditional and high-throughput applications used in drug discovery, including but not limited to biomarker discovery, assay development, screening, target validation, chemical biology, personalized medicine, image analysis, high-throughput and high-content screening, robotics and automation, kinetic profiling, library generation, 'omics technologies, flow cytometry and immunocytochemistry. Proposal due date is April 1. More




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Mark Your Calendar for SLAS2018, Feb. 3-7 in San Diego
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The SLAS2018 Scientific Program Committee is reviewing feedback from SLAS2017 participants and moving forward with early program planning. Keynote presenters are Benjamin F. Cravatt, enzymes researcher at The Scripps Research Institute, and Marc Abrahams, founder of the Ig Nobel Prize. The 10 scientific program educational tracks are:
  • Assay Development and Screening
  • Automation and High-Throughput Technologies
  • Advances in Bioanalytics, Biomarkers and Diagnostics
  • Biologics Discovery (NEW!)
  • Cellular Technologies
  • Chemical Biology (NEW!)
  • High Definition Biotechnology (NEW!)
  • Data Analysis and Informatics
  • Drug Target Strategies
  • Micro- and Nanotechnologies
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How Can Researchers Solve the Issue of Reproducibility?
By Suzanne Mason    Share    Share on FacebookTwitterShare on LinkedinE-mail article
At SLAS 2017, the annual international conference and exhibition from the Society for Laboratory Automation and Screening, the topic of reproducibility was center stage. Panelists in a special session discussed the challenges and solutions that both industry and academia have when it comes to reproducibility. "This really isn't an industry vs. academia issue. It's an issue for science and how we do science," said panelist Cathy Tralau-Stewart. More


Gene Therapy to Fight a Blood Cancer Succeeds in Major Study
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An experimental gene therapy that turns a patient's own blood cells into cancer killers worked in a major study, with more than one-third of very sick lymphoma patients showing no sign of disease six months after a single treatment, its maker said. In all, 82 percent of patients had their cancer shrink at least by half at some point in the study. Its sponsor, California-based Kite Pharma, is racing Novartis AG to become the first to win approval of the treatment, called CAR-T cell therapy, in the U.S. It could become the nation's first approved gene therapy. More


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How Protein Misfolding May Kickstart Chemical Evolution
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Alzheimer's disease, and other neurodegenerative conditions involving abnormal folding of proteins, may help explain the emergence of life — and how to create it. Researchers at Emory University and Georgia Tech demonstrated this connection in two new papers published by Nature Chemistry: "Design of multi-phase dynamic chemical networks" and "Catalytic diversity in self-propagating peptide assemblies." More


An Efficient Single-Nucleotide Editing CRISPR
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Since the discovery of the genome-editing tool CRISPR/Cas9, scientists have been looking to utilize the technology to make a significant impact on correcting genetic diseases. Technical challenges have made it difficult to use this method to correct disorders that are caused by single-nucleotide mutations, such as cystic fibrosis, sickle cell anemia, Huntington's disease and phenylketonuria. However now, researchers from the Center for Genome Engineering, within the Institute for Basic Science in Korea, have used a variation of CRISPR/Cas9 to produce mice with single-nucleotide differences. More


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Versatile Self-Adapting Boronic Acids for H-Bond Recognition: From Discrete to Polymeric Supramolecules
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Because of the peculiar dynamic covalent reactivity of boronic acids to form tetraboronate derivatives, interest in using their aryl derivatives in materials science and supramolecular chemistry has risen. Nevertheless, their ability to form H-bonded complexes has been only marginally touched. Herein we report the first solution and solid-state binding studies of the first double-H-bonded DD·AA-type complexes of a series of aromatic boronic acids that adopt a syn–syn conformation with suitable complementary H-bonding acceptor partners. More


Novel Amyloid Structure Could Lead to New Types of Antibiotics
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The highly pathogenic Staphylococcus aureus bacteria is one of the five most common causes of hospital-acquired infections. In the U.S. alone, approximately 500,000 patients at hospitals contract a staph infection. It is the bacteria responsible for MRSA, for which there is no vaccine. But all that could change, thanks to groundbreaking findings published in Science by a Technion-Israel Institute of Technology team led by assistant professor Meytal Landau of the Faculty of Biology. More




The Unexpected Supramolecular Chemistry of Nitrate Anions
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team of researchers with Dr Tiddo J. Mooibroek of the University of Amsterdam's Van 't Hoff Institute of Molecular Sciences (HIMS) argue that the nitrate anion (NO3¯) can display a counterintuitive Lewis acidity. Their findings, reported in Nature Communications, may serve as a (retrospective) guide to interpret data involving the chemical behavior of nitrate anions, which are ubiquitous in nature. More


Computers Predict Molecules' Scent From Their Structures
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A team of researchers and volunteers from across the globe have trained computers to predict the way a molecule will smell based on its structure. The feat may help scientists unravel the still-mysterious relationship between molecular structure and odor perception. This achievement in machine learning could also be a boon to the fragrance industry, saving time and money that would otherwise be spent on laborious human sniff testing. It even suggests that computers might one day identify molecules by their odor. More


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Henry Rutgers Professorship and Director of Rutgers Addiction Research Center
Rutgers Brain Health Institute
US – NJ – Piscataway

Senior Scientist/Associate Director
HD Biosciences
China – Shanghai

Director and Worldwide Head of Bioassets
GSK
United States

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