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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 02, 2016    SLAS2017    Moving? New job? Let SLAS know.      








SLAS ELN Reports: Michelle Arkin — All Things are One Thing
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SLAS2016 Drug Target Strategies Track Chair Michelle Arkin, Ph.D., likes a good puzzle. Not only does she enjoy deciphering complicated connections and matching up contrasting ideas, she refers to it as her "personality super power." Even more powerful to her is the sharing of ideas between like-minded professionals in the life sciences discovery and technology community.

Read more about the associate professor in pharmaceutical chemistry and associate director of biology in the Small Molecule Discovery Center at the University of California, San Francisco and an author of several JBS papers in the SLAS Electronic Laboratory Neighborhood.


JBS March Issue: 'Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity' and More
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This University of Glasgow team review article addresses the current strategies being investigated for the inhibition of the NF-κB pathway in autoimmune diseases and considers potential future strategies for the therapeutic targeting of this crucial transcription factor. This issue of JBS also features one technical note and eight original research articles, including the SAGE Choice Article (free access to all) "New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories" from a collaborative Montana Molecular and Scintillon team.

The issue is available now to SLAS Biomolecular Sciences Section members, JBS subscribers and pay-per-view readers. Free public access becomes available one year after final publication.

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New at Development of a Platform to Enable Fully Automated Cross-Titration Experiments
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In his SLAS2016 Automation & High-Throughput Technologies Track presentation, Jason Cassaday, Merck, USA, describes how Merck's Automation and Engineering Team employed its multi-functional expertise in robotics, information technology and assay development to design an automation platform capable of performing agonist shift assays in a high-density (1536 well), high-throughput format that can test hundreds of compounds per day in cross-titration experiments.

An internally developed automation control system (Telios) integrates compound handling, compound dispensing, sample tracking, assay read instrumentation and data management. It is one of seven presentations recorded at SLAS2016 for on-demand viewing by SLAS dues-paid members and SLAS2016 full conference participants.


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FREE Kudos Functionality Now Available to SLAS Journal Authors
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Kudos is a new service that allows authors to explain, enrich and share their published papers, and then measure the impact of their efforts. Register for Kudos for free to:
  • Add a lay summary to explain your JALA or JBS paper to broader audiences
  • Add supplementary data such as podcasts and videos
  • Share your paper directly via Twitter, Facebook, LinkedIn and e-mail
  • Measure impact with citations and Altmetric scores
Authors who used Kudos in 2013 enjoyed 19% higher downloads of their published work than non-users. Register for Kudos and "claim" papers previously published in JALA and JBS.


Only 339 Days Until SLAS2017!
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For life sciences discovery and technology professionals, all roads lead to SLAS2017, Feb. 4-8, Washington, DC. Keynote speakers have been named:
  • Jennifer Lippincott-Schwartz, Section Chief of the Cell Biology and Metabolism Branch, NICHD, NIH and NIH Distinguished Investigator
  • Rachel Swaby, Author of Headstrong: 52 Women Who Changed Science and the World
Scientific tracks are in place, and SLAS begins accepting abstract proposals for podium and poster presentations in April 2016. Plan now to share your achievements and budget for a trip to the SLAS International Conference & Exhibition. Also, the SLAS2017 Exhibition is 85% sold; companies interested in exhibiting should contact Barry Sacks as soon as possible.

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Enabling Light Work in Helical Self-Assembly for Dynamic Amplification of Chirality with Photoreversibility
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Light-driven transcription and replication are always subordinate to a delicate chirality transfer. Enabling light work in construction of the helical self-assembly with reversible chiral transformation becomes attractive. Herein we demonstrate that a helical hydrogen-bonded self-assembly is reversibly photoswitched between photochromic open and closed forms upon irradiation with alternative UV and visible light, in which molecular chirality is amplified with the formation of helixes at supramolecular level. More

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Preventing Protein Unfolding    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When the body loses its ability to fold proteins into the correct shapes, the result can be irreversible and tragic. The accumulation of unfolded or misfolded proteins in the brain causes many devastating neurodegenerative diseases, including Alzheimer's, Parkinson's and amyotrophic lateral sclerosis. In order to maintain their functions, structural proteins and engineered, protein-based materials need to avoid unfolding even under large mechanical stresses. More

Solute Carrier Proteins: Unlocking the Gene-Family for Effective Therapies
New York Academy of Sciences     Share    Share on FacebookTwitterShare on LinkedinE-mail article
The New York Academy of Sciences (NYAS) is bringing together world leaders in the field April 26 to discuss recent breakthroughs in integral membrane proteins' structural biology, cellular engineering and metabolomics, which hold the promise of "unlocking" the gene family. Speakers include:
  • Dax Fu, Johns Hopkins School of Medicine
  • Kathleen M. Giacomini, UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation
  • Matthias A. Hediger, University of Bern
  • Avner Schlessinger, Icahn School of Medicine at Mount Sinai
  • Giulio Superti-Furga, Austrian Academy of Sciences
  • Ming Zhou, Baylor College of Medicine
You can attend the event in person in New York City or via live webinar.

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Researchers Build Powerful 3-D Microscope
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
UT Southwestern Medical Center researchers have designed and built a microscope capable of creating high-resolution, 3-D images of living cancer cells in realistic, controllable microenvironments. "There is no microscope that allows us to look at living cells with this resolution and precision in a controlled microenvironment. We can now create 3-D images of cancer cells and record how they interact with their microenvironment via signaling," said Dr. Gaudenz Danuser. More

Forensic Chemistry and Ambient Mass Spectrometry: A Perfect Couple Destined for a Happy Marriage?
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Ambient mass spectrometry has been demonstrated, via various proof-of-concept studies, to offer a powerful, rather universal, simple, fast, nondestructive, and robust tool in forensic chemistry, producing reliable evidence at the molecular level. Its nearly nondestructive nature also preserves the sample for further inquiries. This feature article demonstrates the applicability of ambient mass spectrometry in forensic chemistry and explains the challenges that need to be overcome for this technique to make the ultimate step from the academic world into forensic institutes worldwide. More


Tiny Enzyme Tweak Expands Substrate Palette
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
To be used industrially, enzymes usually need to undergo some surgery before they can become chemical workhorses. It may take a nip here, or a tuck there, to sculpt their active site into a shape that will accept a range of chemical substrates. But the alterations that allow an enzyme to be more promiscuous can also cripple its chemical activity or make it much less stable. Researchers have now given a particularly picky enzyme a makeover so that it can handle a wide range of aldol reaction substrates without any loss in performance. More

Ladder Polymers Stand Apart
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Polymer chemists at Agency for Science, Technology and Research, Singapore, have synthesized materials with intrinsic, microscale porosity that are well suited for reusable gas and liquid separations because of their robust, ladder-like frameworks. Polymers tend to pack tightly together in the solid state, easily filling any voids with their flexible chain structure. Recently, however, polymers of intrinsic microporosity have emerged that use rigid, fused organic ring structures to open up tiny voids in the plastic material. More

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Gene Signatures for Deadliest Prostate Cancers and Basal Stem Cells Overlap
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Prostate basal cells are intrinsically enriched in gene sets normally associated with stem cells, report researchers based at The University of Texas MD Anderson Cancer Center. These researchers also found that the basal cell gene signature was "enriched" in the gene signatures that characterize the most aggressive prostate cancer subtypes. These findings not only speak to a controversy over the role of stem cells in prostate cancer, they also suggest strategies for treating aggressive and therapy-resistant forms of prostate cancer. More

New Twist in Addiction Crisis: Deadly Painkiller Impostors
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Authorities are sounding the alarm about a new and deadly twist in the country's drug-addiction crisis in the form of a potent painkiller disguised as other medications. Tennessee officials say they've seen two dozen cases in recent months of pills marked as the less potent opiates oxycodone or Percocet that turned out to contain fentanyl, a far more powerful drug. One official likened the danger to users playing Russian roulette each time they buy a pill on the street. More



Principal Scientist, Cell Biology & Imaging
BioTek Instruments, Inc.
US – VT – Burlington

Physician-Principal Investigator
US – AZ – Tempe

UK/Nordic Sales and Business Development Manager
Switzerland – Schlieren

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