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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 5, 2014

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2014 Laboratory Products Trends Report Details Challenges
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The more than 800 respondents to the annual Laboratory Products Association North American Survey of Laboratory Purchasing Trends report anticipate a slightly smaller workforce to handle an increased workload this year.

Learn more about how laboratories across North America are planning to invest in equipment, staffing and facilities in 2014 and use that information to your strategic advantage.

Dues-paid SLAS members have access to the full 182-page report.
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Have You Renewed Your Membership for 2014 Yet?
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If not, you no longer will receive print copies of JALA or JBS, and you won't have free access to the JALA or JBS Online archives; live and on-demand webinars; SLAS Membership Directories; 2014 Laboratory Products Trends Report; conference registration discounts; FIRST Team Grants; members-only EndNote discounts; and MORE. More

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SLAS ELN Reports: Stem Cell Technologies — 3D Culture is 'Next Wave' for Drug Discovery
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"The future of therapy is a molecule/cell therapy combination," says Sitta Sittampalam, Ph.D., senior scientific officer and project manager at the US National Institutes of Health's National Center for Advancing Translational Sciences, and co-chair of the SLAS Stem Cells and 3D Microtissues Special Interest Group.

"In 20 years, if you have a failing kidney, you won't just get a pill and hope it works; you will receive an injection of stem cells and a drug that makes those stem cells go to your kidney to rebuild it."

Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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JBS March Issue Now at JBS Online
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Driven by the World Health Organization plan to control or eliminate 10 neglected tropical diseases (NTD) by 2020, scientists from the Liverpool School of Tropical Medicine in the United Kingdom published a review article in the latest issue of JBS.

"Overcoming the Challenges of Drug Discovery for Neglected Tropical Diseases: The A•WOL Experience" highlights the challenges of this directive while also providing an example of a drug discovery and development program for NTD's onchocerciasis and lymphatic filariasis.

Lead author Mark Taylor also is featured in the SLAS Electronic Laboratory Neighborhood e-zine Cover Author Spotlight.
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Andy Zaayenga's Pick of the Month from the LabAutopedia Book List
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In Napoleon's Buttons: How 17 Molecules Changed History, Penny Le Couteur and Jay Burreson study interesting — and not often explored — impacts of chemistry on the course of history.

For example, what caused Napoleon's defeat in Russia? The authors pin it on the tin buttons of Napoleon's army.

View more interesting titles on the book list on LabAutopedia, SLAS's online scientific wiki.
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Laurie Garrett Outlines Synthetic Biology Advancements
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SLAS2015 keynote presenter Laurie Garrett provides a few examples of the good — and the potentially dangerous — work being done in synthetic biology globally in a video posted by Foreign Affairs.

Among potential upsides are the "possibility of taking care of certain human health problems that are now either insurmountable or so expensive that they're only affordable and available to a small elite of the planetary population," she states in the interview.
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Reminder: March 10 Deadline for JBS Special Issue
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A few days remain to submit manuscript proposals (abstracts) for the JBS Special Issue: Novel Therapeutic Approaches for Neglected Infectious Diseases.

Novel methods? Success stories? Lessons learned? Submit your laboratory's work to discover and advance new chemical entities for the treatment of neglected tropical diseases.
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Imaging Dynamics of Small Biomolecules Inside Live Cells
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Researchers at Columbia University have made a significant step toward visualizing small biomolecules inside living biological systems with minimum disturbance, a longstanding goal in the scientific community. In a study published March 2 in Nature Methods, Assistant Professor of Chemistry Wei Min's research team has developed a general method to image a broad spectrum of small biomolecules, such as small molecular drugs and nucleic acids, amino acids, lipids for determining where they are localized and how they function inside cells. More

Tracking Genes on the Path to Genetic Treatment
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Before doctors like Matthias Kretzler can begin using the results of molecular research to treat patients, they need science to find an effective way to match genes with the specific cells involved in disease. As Kretzler explains, finding that link would eventually let physicians create far more effective diagnostic tools and treatments. More

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Single Particle Inductively Coupled Plasma Mass Spectrometry: A Powerful Tool for Nanoanalysis
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Single particle inductively coupled plasma mass spectrometry is an emergent ICPMS method for detecting, characterizing, and quantifying nanoparticles. Although the number of applications reported to date is limited, the relatively simple instrumental requirements, the low number concentration detection levels attainable, and the possibility to detect both the presence of dissolved and particulate forms of an element make this methodology very promising in the nanoscience related areas. More

From The Lab To The Production Plant
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
If there were any doubts about the importance of chemistry to the pharmaceutical industry, the new drug approvals of 2013 should put them to rest. Of the 27 drugs cleared for marketing by the Food & Drug Administration, 24 were small molecules. For all the hype in the pharmaceutical world about monoclonal antibodies and other fruits of biotechnology, good old-fashioned medicinal chemistry continues to be a major source of pharmaceutical innovation. More


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Collisions of Sodium Atoms with Liquid Glycerol: Insights into Solvation and Ionization
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The reactive uptake and ionization of sodium atoms in glycerol were investigated by gas–liquid scattering experiments and ab initio molecular dynamics simulations. A nearly effusive beam of Na atoms at 670 K was directed at liquid glycerol in vacuum, and the scattered Na atoms were detected by a rotatable mass spectrometer. More

Pancreatic Cancer's Killer Trick Offers Treatment Hope
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Pancreatic cancer's deadliest trick could be its undoing. Despite each person's tumors having very different genetic mutations, they all cause the same metabolic changes that help it grow. What's more, drugs already exist that can block the process. Pancreatic cancer is the most lethal of all common cancers — 95 percent of people die within five years of diagnosis. One reason it is so deadly is that no two cases are genetically the same. More



New Research Reveals Role of Methionine in Enzyme Catalysis
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first convincing evidence that the amino acid methionine plays a role in catalysis in an enzyme has been uncovered by researchers from the University of Bristol. Previously, it was thought that methionine was only involved in structure and binding, not in making reactions happen in enzymes. Using molecular simulations, Dr. Kara Ranaghan and Professor Adrian Mulholland from Bristol's School of Chemistry found an interesting interaction involving a particular methionine residue in the enzyme phosphite dehydrogenase. More

Malignant Melanoma: Diagnosis and Treatment Progress
By Rosemary Sparacio    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Immunology has been in the forefront and progress in the area of skin cancer — particularly malignant melanoma — and has shown great promise. Melanoma is the sixth-most common cancer in the U.S., and the most common fatal malignancy in young adults. Currently, about 1 in 50 people will be diagnosed with melanoma. In the 1960s, it was 1 in 600. Two independent studies are being conducted using two different kinds of vaccines developed to treat malignant melanoma. More


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  • Career


    R&D Engineer 4
    Los Alamos National Laboratory
    US – NM – Los Alamos

    Faculty
    Center for Combustion Energy, Tsinghua University
    China – Beijing

    Cell Biologist
    GlaxoSmithKline Pharmaceuticals
    US – PA – Collegeville

    More jobs at SLAS Career Connections


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