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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit Mar. 6, 2013

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JALA special issue on global health technologies: proposals due March 15
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SLAS is still accepting proposals for the Journal of Laboratory Automation special issue, "New Developments in Global Health Technologies." Guest Editor Peter B. Lillehoj of Michigan State University seeks high-quality proposals for papers on novel technologies and systems for the advancement of global health, particularly those focused on infectious diseases (e.g. HIV/AIDS, malaria, tuberculosis, diarrheal and tropical diseases, polio, pneumonia) and neonatal/maternal health. More

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NEW on SLAS Electronic Laboratory Neighborhood e-zine: The stories behind the 2013 Art of Science Contest winning images
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"On the silent, black background, the fluorescent GPCR extensions appeared to have their own sublime conversation," Carolina Haass-Koffler says in awe of her image that earned an honorable mention in the contest. "The connection between the 'reach of two cells' and the 'near-touching hands' in the Creation of Adam by Michelangelo in the Sistine Chapel was pretty much immediate." Thoughts from the grand prize and 10 honorable mention winners are shared. More

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JBS announces special issue on Knowledge from Small-Molecule Screening & Profiling
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Abstract proposals are now being accepted by the Journal of Biomolecular Screening related to the production, integration, analysis and mining of large datasets relevant to biological discovery, including chemical genomics, network biology and phenotypic drug discovery. Submission due date is May 1. More

NEW on the LabAutopedia Book List: Hallucinations
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Andy Zaayenga reviews Oliver Sacks' treatise exploring mind-altering experiences affecting the normal and the insane — those naturally occurring as well as self-imposed. "One of the most interesting parts for me was the hallucinations of body image coupled with migraines, and the fact that Lewis Carroll is known to have suffered from classical migraines." More

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SLAS welcomes new corporate member: Festo
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With more than 40 years of innovation in the United States and over 80 years globally, Festo products, services and engineering support span the full needs of the laboratory automation community, from piece parts to custom value-add solutions. The company's aim is to maximize productivity and competitiveness for its customers. Festo was an exhibitor at SLAS2013 in Orlando, Fla. More

2013 SLAS Innovation Award winner and two SLAS members present webinar
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Andrea Weston of Bristol-Myers Squibb, Patrick Faloon of the Broad Institute of MIT and Harvard and Daniel G. Sipes of the Genomics Institute of the Novartis Research Foundation are featured speakers for the March 20 American Association for the Advancement of Science webinar, "The Future of High Throughput Assays: From Reporter Genes to qPCR." Weston received the prestigious SLAS Innovation Award for her SLAS2013 presentation, "Making a Quantum Leap in Mass Spectrometry Throughput: Applying the NextVal MassInsight Technology to Monitor Cytochrome P450 Enzyme Inhibition in Human Liver Microsomes." Sipes is SLAS vice president. More


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Turning ideas into drugs
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The journey of a pharmaceutical from gleam in a scientist's eye to indispensable medicine on the pharmacy shelf is a multiyear odyssey, practically Homeric in scope, filled with victories and defeats, detours and delays, and many surprises. Big pharmaceutical firms usually have the tools and the skills to make the journey on their own. Smaller biotech firms aren't so well equipped. More

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
Nature Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
We describe the discovery of UNC1215, a potent and selective chemical probe for the methyllysine reading function of L3MBTL3, a member of the malignant brain tumor family of chromatin-interacting transcriptional repressors. UNC1215 binds L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family. More


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Turbulence in a crystal
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When a crystal is hit by an intense ultrashort light pulse, its atomic structure is set in motion. A team of scientists can now observe how the configuration of electrons and atoms in titanium dioxide, a semiconductor, changes under the impact of an ultraviolet laser pulse, confirming that even subtle changes in the electron distribution caused by the excitation can have a considerable impact on the whole crystal structure. More

Mapping molecular perturbations by a new form of two-dimensional spectroscopy
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
We propose a new general form of two-dimensional spectroscopy where the indirect "evolution" dimension is derived using the Radon transform. This idea is applicable to several types of spectroscopy but is illustrated here for the case of NMR spectroscopy. This "projection spectroscopy" displays characteristic correlation peaks that highlight perturbations of chemical shifts. More

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Physical chemistry could answer many questions on fracking
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By some estimates, continued growth in hydraulic fracturing (or "fracking") could put the U.S. on the path to self-sufficiency in energy over the next few decades. Yet despite the potential economic benefits, fracking has also generated controversy due to the unknown long-term consequences of all the drilling, pumping, fracturing and extracting processes involved. More

Man-made material pushes the bounds of superconductivity
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A multi-university team of researchers has artificially engineered a unique multilayer material that could lead to breakthroughs in both superconductivity research and in real-world applications. The researchers can tailor the material, which seamlessly alternates between metal and oxide layers, to achieve extraordinary superconducting properties — in particular, the ability to transport much more electrical current than non-engineered materials. More



White paper: 'Video' enables fast, cost-effective chemistry
METTLER TOLEDO     Share    Share on FacebookTwitterShare on LinkedinE-mail article
METTLER TOLEDO offers a free download, "In Situ Monitoring of Chemical Reactions — A Molecular Video," that reviews four recent case studies where sophisticated in-line monitoring techniques provided helpful chemical reaction insight. The information gained helped researchers to accurately characterize reactions, optimize processes and speed results, essentially helping them to "do more with less" — a common theme in today's competitive chemical development laboratories. More

Vision scientists: Experienced and accomplished in brain activity mapping
By Denise A. Valenti     Share    Share on FacebookTwitterShare on LinkedinE-mail article
President George H. W. Bush declared the 1990s to be the “decade of the brain.” More recently President Barack Obama mentioned in his inaugural address what is expected to be a decade-long, nationwide initiative to fully map the brain. Vision scientists are already far along with such an endeavor. The “decade of the brain” saw substantial gains in our ability to map neural processing, and neuroscientists in the field of vision achieved groundbreaking results in our understanding of retinal neural circuitry. With current and emerging technologies, we are now in position to achieve mapping retinal cells, axonal pathways and brain interface. More


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5 things you should know about the baby cured of HIV
Popular Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
1. The baby girl was cured with standard anti-retroviral drugs. When the baby was born in a Mississippi hospital in 2010, pediatric specialist Hannah Gay began treating her with three anti-retroviral drugs just 31 hours after she was born. This combination treatment has been around since the mid-1990s, and remains the biggest breakthrough in the fight against a disease that has claimed tens of millions of lives. More

Integral membrane proteins and bilayer proteomics
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Integral membrane proteins reside within the bilayer membranes that surround cells and organelles, playing critical roles in movement of molecules across them and the transduction of energy and signals. While their extreme amphipathicity presents technical challenges, biological mass spectrometry has been applied to all aspects of membrane protein chemistry and biology. More

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Life Tech gains rights to Harvard's stem cell assays
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Life Technologies signed a research and license agreement with Harvard University under which the firm has acquired exclusive rights to develop a panel of characterization assays designed to rapidly evaluate human pluripotent stem cells for their utility in a variety of discovery and translational research applications. The panel will be offered on the company's semiconductor sequencing and PCR-based genetic analysis platforms. More

Tumors deliberately create conditions that inhibit body's best immune response
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New research in the Journal of Clinical Investigation reveals that tumors in melanoma patients deliberately create conditions that knock out the body's "premier" immune defense and instead attract a weaker immune response unable to kill off the tumor's cancerous cells. The study also highlights a potential antibody biomarker that could help predict prognosis and identify which patients are most likely to respond to specific treatments. More


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Career


Assistant Director, Infectious Disease Diagnostic
North Shore-LIJ Health System
USA – NY – Lake Success

Research Soil Scientist
USDA-ARS Salinity LaboratoryLLC
USA – CA – Riverside

Supplier Quality Evaluation Service
Bristol-Myers Squibb
USA – NJ – Princeton

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