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SLAS.org    SLAS2013   Moving? New job? Let SLAS know.    Mar. 7, 2012


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SLAS2013 keynote speaker publishes in Biophysical Journal
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Mehmet Toner, Ph.D., and colleagues explore a new microfluidic device that can isolate target cells much faster than existing devices, offering valuable information for diagnosing and treating disease, in the Feb. 22 issue of Biophysical Journal. Toner is the Helen Andrus Benedict Professor of Surgery (Biomedical Engineering), Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School and Massachusetts General Hospital. More

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Last call: JALA special issue on novel drug development and delivery
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JALA Editor-in-Chief Dean Ho, Ph.D., of Northwestern University and Co-Guest Editor Edward Chow, Ph.D., of University of California, San Francisco invite you to submit your abstract by Thursday, March 15. Following abstract selection, final manuscripts must be completed and submitted by Friday, June 1. More



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SLAS president shares forward focus
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With a highly successful SLAS2012 just passed, 2012 SLAS President Dave Dorsett talks about next steps toward realizing the SLAS strategic plan, including the formation of the SLAS International Advisory Committee. The focus of this important new leadership group is to provide strategic insight and ensure balanced representation globally. More

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Congratulations, young scientists!
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SLAS welcomed stellar young scientists from around the world to SLAS2012 in San Diego. This year's winners were Lauren Drowley, AstraZeneca, European Laboratory Robotics Interest Group, United Kingdom; Zafer Gezgin, Rutgers University, Institute of Food Technologists, United States; Brian Cox, University of Toronto, International Society for Stem Cell Research, United States; and Jonas Kühn, EPFL-SV-BSF, MipTec, Switzerland. More

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Special interest groups offer targeted networking
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From Academic Drug Discovery to Women Professionals in Science and Technology and Automation Quality Control to Stem Cells, SLAS offers an organized way to discuss challenges and share solutions with other SLAS members through free membership in one or more SLAS special interest groups (SIG). Browse descriptions of the 14 current SIGs to find where you might plug in — or learn how to start a new one! More
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NMR detection of pH-dependent histidine—water proton exchange reveals conduction mechanism of transmembrane proton channel
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The acid-activated proton channel formed by the influenza M2 protein is important for the life cycle of the virus. A single histidine, His37, in the M2 transmembrane domain (M2TM) is responsible for pH activation and proton selectivity of the channel. Recent studies suggested three models for how His37 mediates proton transport: a shuttle mechanism involving His37 protonation and deprotonation, a H-bonded imidazole–imidazolium dimer model and a transporter model involving large protein conformational changes in synchrony with proton conduction. More



Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
Nature Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The ability to redesign enzymes to catalyze noncognate chemical transformations would have wide-ranging applications. We developed a computational method for repurposing the reactivity of metalloenzyme active site functional groups to catalyze new reactions. Using this method, we engineered a zinc-containing mouse adenosine deaminase to catalyze the hydrolysis of a model organophosphate with a catalytic efficiency (kcat/Km) of ∼104 M−1 s−1 after directed evolution. More

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Get Connected to Laboratory Science at Pittcon 2012
If you are a scientist or researcher looking for the latest innovations in laboratory equipment–then Pittcon 2012, the world’s largest annual conference and expo for lab science, is a must attend event. Register now at www.pittcon.org
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Squeezing polymers produces chemical energy but raises doubts about implant safety
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In a new study, Northwestern University scientists turned to squeezed polymers and free radicals in a search for new energy sources. They found incredible promise but also some real problems. Their report is published by the journal Angewandte Chemie. The researchers demonstrated that radicals from compressed polymers generate significant amounts of energy that can be used to power chemical reactions in water. More

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Washington U. to offer free exome sequencing for rare diseases
GenomeWeb    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Washington University School of Medicine in St. Louis plans to provide free exome sequencing for 99 patients suffering from rare disorders in an effort to discover genetic factors that may be causing these diseases. The Rare99X Clinical Exome Challenge project will work with patient groups to study patients with some of the nearly 7,000 rare diseases that affect an estimated 25 million Americans. More


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Innovation³ from TTP Labtech

3 innovative products launched at SLAS Booth 914:

• arktic: compact automated biobanking
• aequus: non-contact liquid level monitoring
• mosquito HV: cost-saving serial dilutions.


The stealth sodium revolution
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers with the U.S. Departments of Agriculture and Health and Human Services have teamed up for HHS's sodium surveillance efforts. The National Institute of Medicine, part of the National Academies, is also involved and has called on the Food and Drug Administration to set mandatory national standards for the sodium content in foods. More

Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types
National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonistic coevolution, postulates a never-ending molecular arms race where pathogens evolve to evade immune recognition by common MHC alleles, which in turn provides a selective advantage to hosts carrying rare MHC alleles. More

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Making memories: How 1 protein does it
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Studying tiny bits of genetic material that control protein formation in the brain, Johns Hopkins scientists say they have new clues to how memories are made and how drugs might someday be used to stop disruptions in the process that lead to mental illness and brain wasting diseases. The report was published in the March 2 issue of Cell. More

A wirelessly controlled pharmacy dispenses drugs from within your abdomen
Popular Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In the future, implantable computerized dispensaries will replace trips to the pharmacy or doctor's office, automatically leaching drugs into the blood from medical devices embedded in our bodies. These small wireless chips promise to reduce pain and inconvenience, and they'll ensure that patients get exactly the amount of drugs they need, all at the push of a button. More

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Dental pulp stem cells transformed by 'bad breath' chemical
eBio News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Japanese scientists have found that the odorous compound responsible for halitosis — otherwise known as bad breath — is ideal for harvesting stem cells taken from human dental pulp. In a study published in the Journal of Breath Research, researchers showed that hydrogen sulphide increased the ability of adult stem cells to differentiate into hepatic (liver) cells, furthering their reputation as a reliable source for future liver-cell therapy. More

A little mass spec goes a long way
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Transition metal complexes catalyze many important reactions that are employed in medicine, materials science and energy production. Although high-throughput methods for the discovery of catalysts that would mirror related approaches for the discovery of medicinally active compounds have been the focus of much attention, these methods have not been sufficiently general or accessible to typical synthetic laboratories to be adopted widely. More

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Shale boom in full swing for North American petrochemical industry
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Shale is forcing North American petrochemical executives to unlearn much of what they thought they knew about their industry. And given that they are near the beginning of what is likely to be a long, prosperous period, they are more than happy to change their outlook. Experiences early in the previous decade taught executives that their reliance on raw materials derived from natural gas to make ethylene put them at a cost disadvantage to the areas of the world that use petroleum-derived naphtha. More

Even mild concussions can cause lingering symptoms
The Associated Press via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Children with even relatively mild concussions can have persistent attention and memory problems a year after their injuries, according to a study that helps identify which kids may be most at risk for lingering symptoms. In most kids with these injuries, symptoms resolve within a few months but the study results suggest that problems may linger for up to about 20 percent, said study author Keith Owen Yeates. More


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Labcyte Introduces Dynamic Fluid Analysis™
Labcyte released a novel software algorithm that enables a greater range of fluid types to be automatically transferred with acoustic energy. Dynamic Fluid Analysis™ enables the Echo® liquid handling systems to adapt to fluid properties changes such as surface tension and viscosity, and adjusts sound energy in real time with no operator intervention required.
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Career

Application Engineer II
Broad Institute
USA – MA – Cambridge

Drug Development Scientist
Cedars-Sinai Medical Center
USA – CA – Los Angeles

Robotic Integration Specialist
Labcyte
USA – CA – Sunnyvale

More jobs at SLAS Career Connections


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Get your free automation consultation
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JALA: Leading Peer-Reviewed Journal

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The SLAS Electronic Laboratory Neighborhood

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SLAS Point-to-Point
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