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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 7, 2018    SLAS2018    Moving? New job? Let SLAS know.      






SLAS ELN Reports: The People Powering the 2018 SLAS Technology Ten
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"We are pleased to recognize the innovators behind the 2018 SLAS Technology Ten," says Editor-in-Chief Edward Kai-Hua Chow, Ph.D., (National University of Singapore) in a new article in the SLAS Electronic Laboratory Neighborhood e-zine. Learn more about the hard-working individuals who are contributing to a wide range of applications in life sciences research, biomedical innovations, drug development, and clinical and field diagnostics. More


Speakers, Innovation AveNEW Highlight the 2018 SLAS Europe Conference and Exhibition
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The scientific program for the inaugural 2018 SLAS Europe Conference and Exhibition, June 27-29, 2018, in Brussels, Belgium, features 24 inspiring and innovative speakers, such as Louise Berg, Ph.D., senior lab manager at the Karolinska Institute (Stockholm, Sweden). Berg will describe the experimental platforms in her lab that utilize primary cells from patients with chronic inflammatory diseases. Also on the program are keynote speakers Peter Hinssen of nexxworks (Ghent, Belgium), Mathias Uhlén, also of the Karolinska Institute, and Max Lemke of the European Commission (Brussels, Belgium). Poster abstract submission deadline extended to May 25.

Innovation AveNEW comes to Europe! ATTENTION Life Sciences Discovery and Technology Startups: Apply today for an opportunity to get your company on SLAS Innovation AveNEW at the 2018 SLAS Europe Conference and Exhibition. This special area of the exhibit floor provides a venue for positive, collaborative interaction and exposure for your product and/or service concept. Grow and scale your startup by directly connecting with decision-makers from across Europe. The application submission deadline extended to April 26.

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SLAS Journal Achievement Awards Triple Play: TEER Measurement Techniques for In Vitro Barrier Model Systems
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Being honored with the 2018 SLAS Technology Authors Choice Award after earning both the 2017 SLAS Technology Authors and Readers Choice Awards made this popular SLAS Technology article a three-time winner. The article presents a review of transepithelial/transendothelial electrical resistance (TEER), a widely accepted quantitative technique to measure the integrity of tight junction dynamics in cell culture models of endothelial and epithelial monolayers. TEER values are strong indicators of the integrity of the cellular barriers before they are evaluated for transport of drugs or chemicals. The review analyzes the strengths and weaknesses of different TEER measurement techniques, determines the significance of TEER in drug toxicity studies, examines in vitro models and microfluidic organs-on-chip implementations using TEER measurements in widely-studied barrier models (BBB, GI tract and pulmonary) and discusses factors that can affect TEER measurements. More

Gain Some Sample Savvy at the NEW 2018 SLAS Americas Sample Management Symposium
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Planned and presented by experienced experts, the 2018 SLAS Americas Sample Management Symposium, November 13-14, 2018, in Boston, provides in-depth presentations that address how ever-growing collaborations demand increased emphasis on best practices for sharing samples.

Network with sample management experts from academia, biotech, pharma and vendor communities to learn more about how your organization should navigate this changing landscape. Registration begins in March!

Essential Steps to Better Collaboration

Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.

SLAS2019 Sets the Stage for Innovation and Application
Feb. 2-6 in Washington, DC

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Armed with input from SLAS2018 participants, the SLAS2019 Scientific Program Committee is forging the early program details for the 2019 SLAS International Conference and Exhibition. Keynote presenters Teresa Woodruff, Ph.D., Northwestern University, Chicago, and Eran Segal, Ph.D., Weizmann Institute of Science, Israel, share their expertise while 10 educational tracks frame the scientific program. These tracks include:

  • Assay Development and Screening
  • Automation and High-Throughput Technologies
  • Advances in Bioanalytics and Biomarkers
  • Biologics Discovery
  • Cellular Technologies
  • Chemical Biology
  • High Definition Biotechnology
  • Data Analysis and Informatics
  • Drug Target Strategies
  • Micro- and Nanotechnologies

  • The committee will begin accepting research abstracts for podium and poster consideration beginning in April.

    Tell Them Why: Share the SLAS Story
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    Do you know colleagues who could benefit from SLAS membership opportunities?

    Tell them why you belong and share this link so they can learn first-hand how others have advanced their careers and enhanced their professional knowledge through SLAS and its programs.

    AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.

    Contact us to put our Discovery expertise to work for you, contact:


    New CRISPR Discovery Could Ward Off Dangerous Mistakes
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    Even as CRISPR gene-editing technology is offering insights into genetic diseases, researchers are discovering new things about how it actually works. In the first of two papers published in the Journal of the American Chemical Society, researchers at The Ohio State University report that they've figured out the mechanism by which the CRISPR gene-editing enzyme Cas9 determines where and when to cut DNA strands — a discovery that could help prevent gene-cutting errors. More

    Chemists Test Computer-Planned Syntheses for the First Time
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    Planning efficient synthetic routes can seem like a dark art or feel like a Herculean labor of literature review. Chemists, for the first time, have tested a computer program's ability to plan complete syntheses without human help, following the proposed routes in the lab. The idea of a computer planning chemical syntheses isn't new. Elias J. Corey of Harvard University developed the first version of such a program, called Logic and Heuristics Applied to Synthetic Analysis, in the 1970s, but it never lived up to its promise. More

    Method to Predict Drug Stability Could Lead to More Effective Medicines    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers from the U.K. and Denmark have developed a new method to predict the physical stability of drug candidates, which could help with the development of new and more effective medicines for patients. The technology has been licensed to Cambridge spin-out company TeraView, who are developing it for use in the pharmaceutical industry in order to make medicines that are more easily released in the body. More

    Dual Frequency Comb Generated on a Single Chip Using a Single Laser
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    In a new paper published in Science Advances, researchers under the direction of Columbia Engineering Professors Michal Lipson and Alexander Gaeta (Applied Physics and Applied Mathematics) have miniaturized dual-frequency combs by putting two frequency comb generators on a single millimeter-sized chip. "This is the first time a dual comb has been generated on a single chip using a single laser," says Lipson, Higgins Professor of Electrical Engineering. More

    Conical Torch: The Next-Generation Inductively Coupled Plasma Source for Spectrochemical Analysis
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    A completely new ICP torch for optical/mass spectrometry is introduced with a conical geometry leading to significant reduction in gas and power consumption. As a new holistic methodology, the torch has been designed on the basis of fluid flow patterns, heat transfer, plasma physics, and analytical performance. Computer simulations, capable of accounting for magneto-hydrodynamic effects, have been used to optimize torch geometry. More

    New Enzyme Makes CRISPR More Powerful
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    An enzyme dubbed xCas9 enables researchers to target more sites in the genome than with traditional CRISPR-Cas9 editing, while reducing off-target effects. The technique was reported in Nature by Broad Institute chemical biologist David Liu and his colleagues. "This is very impressive and important work," University of Massachusetts Medical School molecular biologist Erik Sontheimer tells Science. More

    Gene-Therapy Trials for Inherited Form of Blindness Could Start in Two Years
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists in the U.S. say human trials of gene therapy for an inherited form of blindness known as vitelliform macular degeneration, or Best disease, could be less than two years away, following successful use of the treatment in a canine model of the disease. Developed through a longstanding collaboration between scientists at the University of Pennsylvania's School of Veterinary Medicine and Penn’s Perelman School of Medicine, the canine therapy corrected both mild and more severe lesions in animals with early- and mid-stage disease. More

    Calcium Sensor for Photoacoustic Imaging
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    We introduce a selective and cell-permeable calcium sensor for photoacoustics (CaSPA), a versatile imaging technique that allows for fast volumetric mapping of photoabsorbing molecules with deep tissue penetration. To optimize for Ca2+-dependent photoacoustic signal changes, we synthesized a selective metallochromic sensor with high extinction coefficient, low quantum yield, and high photobleaching resistance. More


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    University of Connecticut Health School of Medicine
    US – CT – Farmington

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    ENANTA Pharmaceuticals, Inc.
    US – MA – Watertown

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