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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 09, 2016

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Expert Advice/Stimulating Conversation

Discussions on the engaging field of life sciences discovery and technology.


 

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SLAS Europe Compound Management Conference, April 12-13
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The SLAS Europe Compound Management in Industry and Academia Conference in Berlin, Germany, focuses on technology, process, science and collaboration, and features case studies from leading industry professionals and academics.

"Participants will have the opportunity to see the latest innovation from technology vendors, explore breaking science and technology posters and interact with peers from across the compound management community," says Conference Chair Clive Green of AstraZeneca (U.K.).

The conference offers relevant content for all compound management and lead discovery professionals from bench scientists to senior leaders in the pharmaceutical, biotechnology and agriscience industries as well as from industry and academic drug discovery.
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SLAS Webinar: The SmartLab of the Future
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On March 24, Felix Lenk, Ph.D., Technische Universität Dresden, presents "The SmartLab of the Future: Benchtop Lab Automation with the PetriJet and NutriJet Platforms." Lenk describes the PetriJet platform as a compact device for the automated handling of culture dishes in batches of 20 or continuously. Together with exchangeable processing stations, nearly all tasks associated with culture dishes like identification, filling and imaging can be effectively automated.

NutriJet provides a fully automated solution for medium composition right from the container of the ingredient manufacturer and is fully GMP compliant. The webinar, presented by JALA and JBS, the official journals of SLAS, is free to SLAS dues-paying members.
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From the LabAutopedia Book List: The Chemistry Book — From Gunpowder to Graphene, 250 Milestones in the History of Chemistry
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In the Pipeline chemistry blogger Derek B. Lowe says, "The story of chemistry is the story of mankind learning to write the missing instruction manuals for the physical world. It has taken perseverance, bravery, all the intelligence we can bring to bear, and no small amount of borderline craziness to get us to where we are today. And I've been very glad, through writing this book, to salute all the people who have made it happen."

Lowe highlights milestones as varied as purification, diethyl ether, conservation of mass, caffeine, structural formula, liquid air, hydrogen bonding, molecular disease and PET imaging and provides resources for further study.
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On-Demand at SLAS.org: Drug-Target Residence Time — Target Engagement, Target Vulnerability and Predictions of in Vivo Drug Activity
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In his SLAS2016 Drug Target Strategies Track presentation, Peter Tonge, Stony Brook University, USA, proposes that the kinetics of drug-target interactions, and in particular the life-time of the drug-target complex (residence time), should be integrated into predictive models because drug and target are not at equilibrium in vivo.

"In particular, drugs that dissociate slowly from their targets will have extended activity at low drug concentration thus mitigating a reduction in the frequency of dosing and hence an increase in therapeutic index," Tonge says. "We have consequently developed a mechanistic PK/PD model that incorporates drug-target kinetics and have used this model to successfully predict efficacy in models of bacterial infection caused by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. We believe that our approach, which is relevant across all disease areas, will have a profound impact on the development of new drugs."

It is one of seven presentations recorded at SLAS2016 for on-demand viewing by SLAS dues-paid members and SLAS2016 full conference participants.
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5 Reasons to Visit JALA and JBS Online Today
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JALA and JBS offer essential ways to navigate the ever-increasing volume of peer-reviewed research for life sciences discovery and technology professionals. Visit these rich resources regularly to:
  1. Find answers, ideas and inspiration by searching the scientific archives of JALA, JBS and other SAGE journals with keywords and author names. Save searches and/or sign up to receive custom search alerts via e-mail.
  2. Sign up for citation tracking alerts.
  3. Sign up to be alerted when new reports publish online ahead-of-print.
  4. See what's trending in the Most Read and Most Cited monitors (located at the bottom/right on the homepages).
  5. Get to know the people behind the science by listening to JALA Podcasts.
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Engineers Grow 3-D Heart, Liver Tissues for Better Drug Testing
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers at University of Toronto Engineering have developed a new way of growing realistic human tissues outside the body. Their "person-on-a-chip" technology, called AngioChip, is a powerful platform for discovering and testing new drugs, and could eventually be used to repair or replace damaged organs. Professor Milica Radisic, graduate student Boyang Zhang and the rest of the team are among those research groups around the world racing to find ways to grow human tissues in the lab. More


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It's Time for Positive Action on Negative Results
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Publish or perish. The reality of research is not as brutal as this infamous dictum might suggest. But even though your life may not be at stake, your livelihood probably is if you don't comply with the norms of the scientific world. It is reasonable to expect researchers to produce papers. Yet, as the audit culture that has flooded many areas of human activity soaks into the fabric of academia, researchers are increasingly immersed in the metric tide. More


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NAS Urges 'Rapid Learning System' to Accelerate Personalized Medicine
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
More rigor, insists the National Academy of Sciences, must be shown by practically everyone who is working on biomarker tests for molecularly targeted therapies. Through a report announced on March 4, "Biomarker Tests for Molecularly Targeted Therapies: Key to Unlocking Precision Medicine," the NAS is calling for "common evidentiary standards" and better coordination of regulatory and reimbursement activities. More


Non-Precious-Metal Catalytic Systems Involving Iron or Cobalt Carboxylates and Alkyl Isocyanides for Hydrosilylation of Alkenes with Hydrosiloxanes
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A mixture of an iron or a cobalt carboxylate and an isocyanide ligand catalyzed the hydrosilylation of alkenes with hydrosiloxanes with high efficiency (TON >103) and high selectivity. The Fe catalyst showed excellent activity for hydrosilylation of styrene derivatives, whereas the Co catalyst was widely effective in reaction of alkenes. Both of them catalyzed the reaction with allylic ethers. More


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Researchers Identify Drug That Could Treat Melanoma
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Less than a year after mapping the genetic landscape of melanoma, a researcher from the University of California, Merced, has identified a drug that could be effective in battling the deadly skin cancer. UC Merced Professor Fabian V. Filipp led a team of researchers on the new project. Filipp's previous study used data from The Cancer Genome Atlas to find patterns of genetic changes that give rise to melanoma tumors. In their new study, Filipp and his team used that same data set to identify a genetic mutation. More


Scientists Find Brain Cells with 100+ Unique Mutations
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In a new study published in the journal Neuron, scientists from The Scripps Research Institute are the first to sequence the complete genomes of individual neurons and to produce live mice carrying neuronal genomes in all of their cells. Use of the technique revealed surprising insights into these cells' genomes — including the findings that each neuron contained an average of more than 100 mutations and that these neurons accumulated more mutations in genes they used frequently. More


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Giant Virus Has CRISPR-like Immune Defense
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A giant virus known as mimivirus possesses an immune program similar to CRISPR, a defense system evolved by bacteria and archaea and now adapted by scientists for genome editing, researchers reported in Nature. Like CRISPR, the viral version (dubbed MIMIVIRE) includes a stretch of host genome containing repeated sequences matching a pathogen’s along with genes that can destroy the invader's genome. More


From Backyard Pool Chemical to Nanomaterial
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Could a cheap molecule used to disinfect swimming pools provide the key to creating a new form of DNA nanomaterials? Cyanuric acid is commonly used to stabilize chlorine in backyard pools; it binds to free chlorine and releases it slowly in the water. But researchers at McGill University have now discovered that this same small, inexpensive molecule can also be used to coax DNA into forming a brand new structure. More


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