This message contains images. If you don't see images, click here to view. Advertise in this news brief. Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 09, 2016 SLAS.org    SLAS2017    Moving? New job? Let SLAS know.       Advertisement Advertisement Advertisement Advertisement Expert Advice/Stimulating Conversation Discussions on the engaging field of life sciences discovery and technology.   Advertisement SLAS Europe Compound Management Conference, April 12-13 SLAS    Share    The SLAS Europe Compound Management in Industry and Academia Conference in Berlin, Germany, focuses on technology, process, science and collaboration, and features case studies from leading industry professionals and academics. "Participants will have the opportunity to see the latest innovation from technology vendors, explore breaking science and technology posters and interact with peers from across the compound management community," says Conference Chair Clive Green of AstraZeneca (U.K.). The conference offers relevant content for all compound management and lead discovery professionals from bench scientists to senior leaders in the pharmaceutical, biotechnology and agriscience industries as well as from industry and academic drug discovery. More Advertisement SLAS Webinar: The SmartLab of the Future SLAS    Share    On March 24, Felix Lenk, Ph.D., Technische Universität Dresden, presents "The SmartLab of the Future: Benchtop Lab Automation with the PetriJet and NutriJet Platforms." Lenk describes the PetriJet platform as a compact device for the automated handling of culture dishes in batches of 20 or continuously. Together with exchangeable processing stations, nearly all tasks associated with culture dishes like identification, filling and imaging can be effectively automated. NutriJet provides a fully automated solution for medium composition right from the container of the ingredient manufacturer and is fully GMP compliant. The webinar, presented by JALA and JBS, the official journals of SLAS, is free to SLAS dues-paying members. More Advertisement Tecan booth talks at SLAS2016 are now available! From the LabAutopedia Book List: The Chemistry Book — From Gunpowder to Graphene, 250 Milestones in the History of Chemistry SLAS    Share    In the Pipeline chemistry blogger Derek B. Lowe says, "The story of chemistry is the story of mankind learning to write the missing instruction manuals for the physical world. It has taken perseverance, bravery, all the intelligence we can bring to bear, and no small amount of borderline craziness to get us to where we are today. And I've been very glad, through writing this book, to salute all the people who have made it happen." Lowe highlights milestones as varied as purification, diethyl ether, conservation of mass, caffeine, structural formula, liquid air, hydrogen bonding, molecular disease and PET imaging and provides resources for further study. More Advertisement ACCELERATE YOUR SAMPLE PREP See how researchers are accelerating their research with the Agilent Bravo Automated Sample Prep Platform. On-Demand at SLAS.org: Drug-Target Residence Time — Target Engagement, Target Vulnerability and Predictions of in Vivo Drug Activity SLAS    Share    In his SLAS2016 Drug Target Strategies Track presentation, Peter Tonge, Stony Brook University, USA, proposes that the kinetics of drug-target interactions, and in particular the life-time of the drug-target complex (residence time), should be integrated into predictive models because drug and target are not at equilibrium in vivo. "In particular, drugs that dissociate slowly from their targets will have extended activity at low drug concentration thus mitigating a reduction in the frequency of dosing and hence an increase in therapeutic index," Tonge says. "We have consequently developed a mechanistic PK/PD model that incorporates drug-target kinetics and have used this model to successfully predict efficacy in models of bacterial infection caused by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. We believe that our approach, which is relevant across all disease areas, will have a profound impact on the development of new drugs." It is one of seven presentations recorded at SLAS2016 for on-demand viewing by SLAS dues-paid members and SLAS2016 full conference participants. More Advertisement 5 Reasons to Visit JALA and JBS Online Today SLAS    Share    JALA and JBS offer essential ways to navigate the ever-increasing volume of peer-reviewed research for life sciences discovery and technology professionals. Visit these rich resources regularly to: Find answers, ideas and inspiration by searching the scientific archives of JALA, JBS and other SAGE journals with keywords and author names. Save searches and/or sign up to receive custom search alerts via e-mail. Sign up for citation tracking alerts. Sign up to be alerted when new reports publish online ahead-of-print. See what's trending in the Most Read and Most Cited monitors (located at the bottom/right on the homepages). Get to know the people behind the science by listening to JALA Podcasts. More JALA / More JBS Advertisement Confocal imaging - at the speed of widefield With the ImageXpress® Micro Confocal High-Content Imaging System, capture research-quality images with the widest range of objective lenses, allowing you to work at the resolution appropriate for your biology, including whole organism, thick tissues, 3D spheroid assays, and cellular or intracellular events. Advertisement Welcome to RAD Source Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info. Advertisement Fully automate your genomics workflow The Fragment Analyzer INFINITY is the only parallel capillary electrophoresis instrument capable of complete integration into your robotic automation system. Fully compatible with all the high quality kits developed for the Fragment Analyzer, the Fragment Analyzer INFINITY can run over 2400 samples a day without human intervention. Engineers Grow 3-D Heart, Liver Tissues for Better Drug Testing Phys.org    Share    Researchers at University of Toronto Engineering have developed a new way of growing realistic human tissues outside the body. Their "person-on-a-chip" technology, called AngioChip, is a powerful platform for discovering and testing new drugs, and could eventually be used to repair or replace damaged organs. Professor Milica Radisic, graduate student Boyang Zhang and the rest of the team are among those research groups around the world racing to find ways to grow human tissues in the lab. More Advertisement Important factors to Consider for Thermal Shift Assays Download the Overcoming Technical Challenges in Cell-Based High Throughput Screens Whitepaper It's Time for Positive Action on Negative Results Chemical & Engineering News    Share    Publish or perish. The reality of research is not as brutal as this infamous dictum might suggest. But even though your life may not be at stake, your livelihood probably is if you don't comply with the norms of the scientific world. It is reasonable to expect researchers to produce papers. Yet, as the audit culture that has flooded many areas of human activity soaks into the fabric of academia, researchers are increasingly immersed in the metric tide. More Advertisement Become a Lab Superhero! The Mantis will revolutionize your workflow for applications including NGS sample prep, qPCR, assay development, and cellular assays. Automation made simple. Advertisement Cloud, Consulting, and Custom Services, All In One. Scigilian is a software company specializing in offering solutions to the problems encountered in pharmaceutical research, biotechnology, and contract research. Trusted, from large pharma to small CRO. NAS Urges 'Rapid Learning System' to Accelerate Personalized Medicine Genetic Engineering & Biotechnology News    Share    More rigor, insists the National Academy of Sciences, must be shown by practically everyone who is working on biomarker tests for molecularly targeted therapies. Through a report announced on March 4, "Biomarker Tests for Molecularly Targeted Therapies: Key to Unlocking Precision Medicine," the NAS is calling for "common evidentiary standards" and better coordination of regulatory and reimbursement activities. More Non-Precious-Metal Catalytic Systems Involving Iron or Cobalt Carboxylates and Alkyl Isocyanides for Hydrosilylation of Alkenes with Hydrosiloxanes Journal of the American Chemical Society    Share    A mixture of an iron or a cobalt carboxylate and an isocyanide ligand catalyzed the hydrosilylation of alkenes with hydrosiloxanes with high efficiency (TON >103) and high selectivity. The Fe catalyst showed excellent activity for hydrosilylation of styrene derivatives, whereas the Co catalyst was widely effective in reaction of alkenes. Both of them catalyzed the reaction with allylic ethers. More Advertisement Researchers Identify Drug That Could Treat Melanoma Lab Manager    Share    Less than a year after mapping the genetic landscape of melanoma, a researcher from the University of California, Merced, has identified a drug that could be effective in battling the deadly skin cancer. UC Merced Professor Fabian V. Filipp led a team of researchers on the new project. Filipp's previous study used data from The Cancer Genome Atlas to find patterns of genetic changes that give rise to melanoma tumors. In their new study, Filipp and his team used that same data set to identify a genetic mutation. More Scientists Find Brain Cells with 100+ Unique Mutations Bioscience Technology    Share    In a new study published in the journal Neuron, scientists from The Scripps Research Institute are the first to sequence the complete genomes of individual neurons and to produce live mice carrying neuronal genomes in all of their cells. Use of the technique revealed surprising insights into these cells' genomes — including the findings that each neuron contained an average of more than 100 mutations and that these neurons accumulated more mutations in genes they used frequently. More Advertisement KMC Systems Engineering & Manufacturing KMC Systems provides contract engineering and manufacturing services to leading and emerging OEMs. As a trusted outsourcing partner for 35 years, KMC Systems develops, designs and manufactures cutting-edge, full-system instrumentation for the medical and life science markets. Visit us online and download our brochure to learn more about KMC Systems. Advertisement The Concept Is Simple We work with scientists to design and develop new, innovative tools for biological, chemical, and materials research, both in basic studies and pharmaceutical and industrial applications. We know research, we know assay development, and we know tools development. Learn More Advertisement Sample Screening from your Compound The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and processing modules to enable easy integration into any compound management or screening system. Giant Virus Has CRISPR-like Immune Defense The Scientist    Share    A giant virus known as mimivirus possesses an immune program similar to CRISPR, a defense system evolved by bacteria and archaea and now adapted by scientists for genome editing, researchers reported in Nature. Like CRISPR, the viral version (dubbed MIMIVIRE) includes a stretch of host genome containing repeated sequences matching a pathogen’s along with genes that can destroy the invader's genome. More From Backyard Pool Chemical to Nanomaterial Science Daily    Share    Could a cheap molecule used to disinfect swimming pools provide the key to creating a new form of DNA nanomaterials? Cyanuric acid is commonly used to stabilize chlorine in backyard pools; it binds to free chlorine and releases it slowly in the water. But researchers at McGill University have now discovered that this same small, inexpensive molecule can also be used to coax DNA into forming a brand new structure. More Advertisement Director of Innovation Michelman US – OH – Cincinnati UK/Nordic Sales and Business Development Manager InSphero Switzerland – Schlieren Principal Scientist, Cell Biology & Imaging BioTek Instruments, Inc. US – VT – Burlington Search Jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues March 2, 2016 Feb. 24, 2016 Feb. 17, 2016 Feb. 10, 2016 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063