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SLAS Webinar March 18: Challenging Targets for Drug Discovery (free for members!)
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"Protein-protein targets are challenging but they are doable," says webinar presenter James A. Wells from University of California, San Francisco. Among the topics Wells plans to cover is a site-directed fragment-based discovery approach, disulfide-trapping, that is well suited to probing these challenging surfaces. His presentation is the first of three one-hour sessions in the Spring 2014 SLAS Webinar Series, Protein-Protein Interactions as Small Molecule Drug Targets, FREE to dues-paid SLAS members. Join or renew today for your chance to participate in these webinars.
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Exclusive EndNote Discount for SLAS Members
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Collect. Collaborate. Create. From Anywhere!
EndNote is regarded as the industry standard software tool for publishing and managing bibliographies, citations and references.
JBS SAGEtrack and JALA SAGEtrack users know the EndNote Fast Pass submission shortcut saves them time and effort by automatically populating many of the required fields.
For a limited time, SLAS dues-paid members can purchase Endnote X7 for the deeply discounted price of $95.45 (retail price: $249.95).
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From the SLAS President: SLAS LabAutopedia — A Stockpile of Information
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"SLAS LabAutopedia publishes an international encyclopedic repository of how-to information; a global reference resource; another example of how SLAS members worldwide unite and collaborate to advance laboratory science and technology through education about scientific research, and to serve as a public forum for the exchange of information related to laboratory science and technology," states SLAS President Daniel G. Sipes in his latest message in the SLAS Electronic Laboratory Neighborhood e-zine.
LabAutopedia passed the five million views mark last month.
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JALA Special Issue Call for Papers: Microengineered Cell- and Tissue-Based Assays for Drug Screening and Toxicology Applications
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JALA Special Issue Guest Editors Dan Dongeun Huh and Deok-Ho Kim are looking for manuscript proposals (abstracts) by April 20 on novel biological assay systems that synergistically combine microengineering technologies, such as microfabrication and microfluidics with cultured living cells or tissues to enable screening and analysis of drugs, chemicals, toxins, and other stimuli relevant to pharmaceutical and environmental applications.
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Did You Receive Your March Copy of JBS?
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If not, it may be because you have not yet renewed your SLAS membership.
Renew — or join — today to enjoy free access to the JALA and/or JBS Online archives; live and on-demand webinars like that by Jim Wells on March 18; SLAS Membership Directories; 2014 Laboratory Products Trends Report; conference registration discounts; FIRST Team Grants; members-only EndNote discounts; and more.
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Inline liquid handling system for sample and reagent processing in 384-well Array Tape™. Flexible inline modular options include dispensing, plate storage, incubation and dehydration. Check it out!
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SLAS2015 Headquarters Hotel: Looking Grand!
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Construction on the Marriott Marquis Washington DC, SLAS2015 Headquarters Hotel, is on schedule for its May 1 opening and looking grand, says SLAS CEO Greg Dummer following a professional team visit last week.
"We were very excited to see great progress and know this hotel will be well received by SLAS2015 participants." See a recent video from DC television.
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SpectraMax® i3 Multi-Mode Detection Platform is a flexible plate reader that evolves to fit your application needs. This system offers one-of-a kind ScanLater™ Western Blot Detection, SpectraMax® MiniMax™ Imaging Cytometer, as well as built in absorbance, fluorescence, and luminescence detection modes while the patented cartridge design allows FP, HTRF, and AlphaScreen® field upgrades – all on a single detection platform. View video and learn more →
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New in 2014! MultiCyt™ QBeads enable multiplexed assays for secreted proteins, including cytokines and growth factors, at the pace and price of screening. Choose up to 30 analytes, assemble with a no-wash protocol, and read a 384-well plate in < 15 minutes using IntelliCyt's iQue™ Screener. Learn More
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Study of Proteins in Space Could Yield New Drug Development
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Innovative methods of drug discovery do not always take place in an academic laboratory. They may start there, but they can also happen in orbit aboard the International Space Station, as protein crystallization research from the University of Alabama at Birmingham is about to demonstrate once again. "The human body contains many proteins known to be involved in a number of diseases," said Lawrence DeLucas, O.D., Ph.D., director of the Center for Biophysical Sciences and Engineering.
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Chemists Discover New Class of Antibiotics
Lab Manager Share
A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity."
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Stem Cell Study Opens Door to Protein Synthesis Studies
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For the first time, researchers have shown that an essential biological process known as protein synthesis can be studied in adult stem cells — something scientists have long struggled to accomplish. The findings from the Children's Medical Center Research Institute at UT Southwestern also demonstrate that the precise amount of protein produced by blood-forming stem cells is crucial to their function.
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Gene Editing Technique Boosts Patients' HIV Resistance
Genetic Engineering & Biotechnology News Share
A clinical trial has not only established the safety of genetically engineered T cells in HIV patients, it has also demonstrated that gene therapy can boost resistance to HIV. These heartening outcomes emerged from a study of 12 HIV-positive patients. In some of these patients, viral loads remained decreased even after retroviral drug therapy had been suspended.
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Is Pharmaceutical Biotech Investment at Risk?
By Mike Wokasch Share
 High profitability, strong cash positions, large global healthcare market opportunities, reliable dividends, and perceived security and stability have provided Big Pharma Biotech investors a solid basis for investment rationale. On the other hand, increasing cost of R&D, prolonged time to market, pricing pressures, marketing constraints, and regulatory uncertainty and challenges are now eroding investor confidence and interest.
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Turing's Theory of Chemical Morphogenesis Validated 60 Years After His Death
Science Daily Share
Sixty years after Alan Turing's death, researchers have provided the first experimental evidence that validates Turing's theory of chemical morphogenesis in cell-like structures. This research could impact not only the study of biological development, and how similar patterns form in nature, but materials science as well. Turing's model could help grow soft robots with certain patterns and shapes.
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High-Resolution Structures and Orientations of Antimicrobial Peptides Piscidin 1 and Piscidin 3 in Fluid Bilayers Reveal Tilting, Kinking and Bilayer Immersion
Journal of the American Chemical Society Share
While antimicrobial peptides (AMPs) have been widely investigated as potential therapeutics, high-resolution structures obtained under biologically relevant conditions are lacking. Here, the high-resolution structures of the homologous 22-residue long AMPs piscidin 1 (p1) and piscidin 3 (p3) are determined in fluid-phase 3:1 phosphatidylcholine/phosphatidylglycerol (PC/PG) and 1:1 phosphatidylethanolamine/phosphatidylglycerol (PE/PG) bilayers to identify molecular features important for membrane destabilization in bacterial cell membrane mimics.
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Ingredients Derived from Nature Challenge Synthetic Colors, Preservatives and Flavors
Chemical & Engineering News Share
Fans of M&M's, the popular candy-coated chocolate treats, can be divided into two generations: those who grew up with tan M&M's in the mix and younger folks who enjoy the bright-blue ones introduced in 1995. Now another change may be afoot — instead of synthetic dye, the blue color could come from spirulina algae.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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