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SLAS
Register now for the inaugural 2018 SLAS Europe Conference and Exhibition, June 27-29, 2018, in Brussels, Belgium. Two weeks remain to take advantage of the early bird discounted registration rates that save participants €140 and expire on Friday, March 30. Interact with top experts and learn what they’ve done to achieve success. Benefit from interactive and solution-focused scientific presentations from speakers such as Massimo Alessio, Ph.D., head of the Proteome Biochemistry Unit at IRCCS-San Raffaele Scientific Institute (Milano, Italy). Alessio will discuss how ceruloplasmin replacement therapy ameliorates neurological symptoms in a preclinical model of aceruloplasminemia.
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SLAS
Discover the research of SLAS2019 Opening Keynote Speaker Teresa K. Woodruff, Ph.D., a reproductive scientist and director of the Women’s Health Research Institute at Northwestern University's Feinberg School of Medicine. Among her many accomplishments, Woodruff developed a 3D-printed, bioprosthetic ovary to restore ovarian function in sterilized mice, and she created Evatar, a microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Woodruff shares details of her work in a recent Nerdette podcast, "Sex, Drugs and Singing Ovaries," that includes her thoughts on equal representation of the sexes in life sciences research. She reports that more than 80 percent of basic science papers feature research conducted only on males. "We talk about time, temperature and dose, we just don’t talk about sex," says Woodruff in the interview. She also talks about her new project, which is set to music and helps kids sing through anatomy and puberty.
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SLAS
New! SLAS Discovery and SLAS Technology invite proposals from interested guest editors for collections of five to seven original scientific reports that collectively explore the different dimensions, recent achievements and existing challenges related to a timely topic of interest and importance to SLAS journal readers.
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SLAS
Discover what drives Annika Jenmalm Jensen, Ph.D., to solve complex research puzzles in a call to foster collaboration, improve research reproducibility and nurture breakthrough discoveries. "This is the aspect of science I embrace–the challenges that make research more intriguing," says Jensen, who is infrastructure director for the Science for Life Laboratory (SciLifeLab, Stockholm, Sweden). Read more about Jensen, SciLifeLab and her work as co-chair of the inaugural 2018 SLAS Europe Conference and Exhibition in an SLAS Electronic Laboratory Neighborhood e-zine feature article.
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Protect your scholarly identity by registering for an ORCID unique identifier today! ORCID provides a persistent digital identifier that distinguishes you from every other researcher so editors, funding agencies, publishers and institutions can reliably recognize you in the same way that ISBNs and DOIs identify books and articles. Through integration into key research workflows, such as manuscript and grant submissions, ORCID supports automated links between you and your professional activities to ensure that your work is recognized. Simply 1) Register, 2) Add Your Info (including past publications), and 3) Use Your ORCID ID.
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SLAS
SLAS Europe invites research scientists, engineers, academics and business leaders to submit abstracts for presentation at the 2018 SLAS Europe Advanced 3D Human Models and High-Content Analysis Conference, Oct. 17-19, in Leiden, Netherlands. Submit your podium or poster abstract for consideration in one of four sessions:
- 3D Culture Enabling Technologies
- High-Content Screening
- Advances in Imaging and Analysis
- Stem Cells and Organoids
Podium abstract deadline: May 2. Poster abstracts due: Sept. 20.
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Phys.org
Researchers say they can now produce a vast library of unique cyclic compounds, some with the capacity to interrupt specific protein-protein interactions that play a role in disease. The new compounds have cyclic structures that give them stability and enhance their ability to bind to their targets.
The study, reported in the journal Nature Chemical Biology, also revealed that one of the newly generated compounds interferes with the binding of an HIV protein to a human protein, an interaction vital to the virus' life cycle.
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Genetic Engineering & Biotechnology News
While much of the genetics surrounding amyotrophic lateral sclerosis and frontotemporal dementia has been enigmatic for decades, new gene-editing techniques — such as CRISPR/Cas9 — are beginning to help uncover genes in the human genome that may modify the severity of these neurological disorders. Researchers at Stanford University just published their recent findings in Nature Genetics in an article entitled "CRISPR-Cas9 Screens in Human Cells and Primary Neurons Identify Modifiers of C9ORF72 Dipeptide-Repeat-Protein Toxicity."
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Chemical & Engineering News
The single carbon-carbon bond is among the most familiar covalent connections in organic compounds. But a new study suggests that chemists have yet to fully explore the limits of this basic bond.
Scientists have previously found that these ubiquitous bonds, which typically measure about 1.54 Å in length, can be elongated through the use of bulky substituents to endow molecules with special properties.
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Science Daily
Researchers at The Scripps Research Institute have designed a new molecule-building method that uses sulfones as partners for cross-coupling reactions, or the joining of two distinct chemical entities in a programmed fashion aided by a catalyst. The technique, described recently in the journal Science, paves the way toward other new chemical reactions and facilitates the synthesis of pharmaceutically relevant molecules.
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Science Magazine
Despite enormous efforts over more than 30 years, HIV/AIDS researchers have yet to develop either a vaccine or cure for the disease. But they have made progress in monkey experiments, and two studies reported at the largest annual U.S. HIV/AIDS conference created serious buzz.
Several AIDS vaccines have had some success in monkey models, which typically use SIV, a simian cousin of HIV that causes AIDS in rhesus macaques.
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Lab Manager
A team of researchers has developed a light-activated switch that can turn genes on and off in mammalian cells. This is the most efficient so-called "optogenetic switch" activated by red and far-red light that has been successfully designed and tested in animal cells — and it doesn't require the addition of sensing molecules from outside the cells.
The light-activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.
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The Scientist
The European Patent Office granted a patent for CRISPR-Cas9 applications to Emmanuelle Charpentier, a co-discoverer of CRISPR and the cofounder of ERS Genomics, the University of California, and the University of Vienna. The patent has very broad claims covering the use of the technology and is directed to applications that use a modified version of the Cas9 protein.
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Bioscience Technology
With an average lifespan of 78 years and rising, Europeans can look forward to longer lives. But these lives may not necessarily be healthy, since the onset of age-related diseases has failed to follow this upward trend.
To gain a better understanding of the ageing process, an international team of researchers conducted a study of different bat species. The results were recently published in the journal Science Advances.
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Post-doctoral Research Opportunity in Microfluidic Body-on-a-Chip Systems
University of Maryland / NIST CNST Cooperative Agreement
US – MD – Gaithersburg
Staff Scientist Core Managers for the Viral Vector (Neurobiology Laboratory) and the Cryo-electron M
National Institute of Environmental Health Sciences/NIH
US – NC – Research Triangle Park
Chair, Department of Epidemiology and Health Services Research
Geisinger Health System
US - PA - Danville
Search Jobs at SLAS Career Connections
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