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2017 Art of Science Contest: Enter to Win a $500 Amazon Gift Card
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Visualization plays an important role in the analysis and presentation of scientific work. In journal articles, images often communicate ideas and information in ways that text, tables, charts, graphs or equations cannot. Sometimes scientific images surpass this purpose and create shapes, patterns and designs that capture attention and imagination. These are the images SLAS Discovery and SLAS Technology seek for the 2017 Art of Science Contest.

Share your mesmerizing original scientific images with SLAS by April 21, and you might win a $500 Amazon Gift Card or 60 Days Free Online Access to the SAGE Pharmacology and Biomedical Collection.
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SLAS ELN Reports: Redefining Drug Development with Digital Health and Nanomedicine
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As the first SLAS Endowed Fellowship draws to a close, SLAS Innovation Award finalist Dean Ho and his team of researchers at UCLA introduce a landmark advance in personalized and precision medicine in the challenging area of combination drug therapy.

"Pinpointing the right drug and dose for each person at any given time is like finding a needle in 10 galaxies," says Dean Ho, Ph.D., professor of oral biology and medicine, and bioengineering, as well as the co-director of the Jane and Jerry Weintraub Center for Reconstructive Biotechnology at the University of California, Los Angeles (UCLA) School of Dentistry. "In a situation as complex as designing a novel combination therapy for cancer or infectious diseases, the number of possible drugs and dosages is almost infinite."

Learn more about this exciting work in the SLAS Electronic Laboratory Neighborhood e-zine.
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Statistical Applications and Quantitative Imaging: Journals Special Issue Abstracts Due April 1
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Special issues of SLAS Discovery and SLAS Technology are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs continue to be accepted until April 1 for:

Statistical Applications in Knowledge and Drug Discovery (SLAS Discovery)
Topics may include traditional and high-throughput applications used in drug discovery, including biomarker discovery, assay development, screening, target validation, chemical biology, personalized medicine, image analysis, high-throughput and high-content screening, robotics and automation, kinetic profiling, library generation, ‘omics technologies, flow cytometry and immunocytochemistry.

Quantitative Imaging in Life Sciences and Biomedical Research (SLAS Technology)
Topics may include novel technologies for quantitative and high-content imaging, high-throughput applications of advanced microscopy, advances in image analysis and processing of high-content data, novel biological and chemical reagents to facilitate quantitative imaging, and standardization and benchmarking in imaging.
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SLAS2018: Marc Abrahams is Improbable Closing Keynote Speaker
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Marc Abrahams is co-founder and editor of the enjoyable yet thought-provoking Annals of Improbable Research, a magazine about unusual research. He also founded the Ig Nobel Prize Ceremony, hosts the Improbable Research weekly podcast and wrote several books including This is Improbable and The Ig Nobel Prizes.

Abrahams' SLAS2018 address takes place Wednesday afternoon, Feb. 7, 2018. Listen to many of Abrahams' fascinating stories in a 2014 TEDMED Talk.
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2017 SLAS Europe Nordic Chemical Biology Meeting
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The June 6-7 meeting highlights recent discoveries in the field, including open innovation, selection and quality of screening libraries, and chemoproteomics, and will be held at the University of Copenhagen, Denmark.

The scientific program is still forming, and poster abstracts are being accepted until May 1. May 1 also is the deadline for registration discounts.

Prepare your taste buds for a traditional Danish hot dog, as pictured here (photo credit: Nan Hallock).
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Free Access through April 30: Seven SLAS2017 Presentations
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Keynote speaker Jennifer Lippincott-Schwartz's SLAS2017 presentation, "Emerging Fluorescence Technology to Study the Spatial and Temporal Dynamics of Organelles within Cells," discusses emerging visualization technologies that allow cell biologists to capture processes from whole organisms down to single molecules.

Six SLAS2017 scientific podium presentations also are available, including 2017 SLAS Innovation Award winner Elodie Sollier-Christen's overview of Vortex Bioscience's new VTX-1 platform to isolate and collect intact circulating tumor cells directly from whole blood in less than 1.5 hours. SLAS members can access the presentations (synched audio and slides) at any time; non-members have access until April 30.
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Say Hello to SLAS at the LRIG Midwest Annual Spring Meeting
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Learn more about SLAS Discovery and SLAS Technology, enter to win prizes (including a full conference registration for SLAS2018) and meet SLAS Senior Manager of Communications Lynn Valastyan on April 26 in Madison, WI.

The LRIG Midwest "Biotechnology and Automation: What Makes Sense?" chapter meeting focuses on the use of laboratory robotics to automate workflows as well as laboratory information technology to integrate data collection and information flow for assays and processes used in academia, biotech, ag-biotech and pharma. LRIG meeting participation is free.
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New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules
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Chemists at The Scripps Research Institute (TSRI) have devised a versatile molecule-building tool for creating new drugs and other chemical products. The tool is a small molecule known as a template. It has a long, curved structure and functions like a crane and wrecking-ball, anchoring itself temporarily to one part of a target molecule and swinging an atom of palladium to break a chemical bond at a distant part of the molecule. More


Computer Models Could Allow Researchers to Better Understand, Predict Adverse Drug Reactions
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New computer models from North Carolina State University show how a variant of a common protein involved in human immune response binds to the antiviral drug abacavir, causing a severe life-threatening reaction known as the abacavir hypersensitivity syndrome. The work has implications for predicting severe adverse reactions caused by existing drugs and future drug candidates in subpopulations of patients. Abacavir is a common anti-HIV drug. More


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Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle—Polymer Conjugates
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Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals. The most common and long-standing polymer modification is the attachment of methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led to several clinically approved pharmaceuticals. Recent data indicate that brush-type polymers significantly enhance in vitro and in vivo properties. More


New Research Shows Promise in Disabling Cancer's Defenses
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Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others. Part of what makes cancer cells so devastating is their ability to fight back against treatments — sometimes they work, sometimes they don't. But what if we could take away cancer cells' defenses altogether? Researchers from the University of Ottawa have taken an important step forward to doing just that. More




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Quantum Effect Could Explain How Chiral Molecules Interact
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Biomolecules from small amino acids to large DNA helices are chiral, and how they interact depends on their chirality. A newly identified quantum effect could help explain how biomolecules' chirality persists. When two molecules interact, their electron clouds reorganize. In chiral molecules, that reorganization is accompanied by electron spin polarization that enables molecules of the same chirality to interact more strongly than molecules of opposite chirality, reports a research team. More


Building on Nature's Design
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In 1996, a breakthrough was achieved when the sequence of ∼12 million base pairs, divided among 16 chromosomes, was reported for baker's yeast (Saccharomyces cerevisiae). Now, some 20 years later, the Synthetic Yeast Genome Project (Sc2.0) reports on five newly constructed synthetic yeast chromosomes, advancing efforts to substantially reengineer all 16 yeast chromosomes with the goal of creating a fully synthetic eukaryotic genome. More




Team Develops More Effective Therapeutic Antibodies
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Researchers from the University of Maryland (UMD) and The Rockefeller University, who previously developed a method to modify an antibody's sugar group structure, which opened the door for biochemists to create antibodies with consistent sugar groups, report that they have taken their method a step further by determining which specific sugar combinations enhance — or suppress — an antibody's ability to signal the immune system to attack an invader. More


Potential Approach to How Radioactive Elements Could Be 'Fished Out' of Nuclear Waste
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Manchester scientists have revealed how arsenic molecules might be used to "fish out" the most toxic elements from radioactive nuclear waste — a breakthrough that could make the decommissioning industry even safer and more effective. Elizabeth Wildman, a PhD student, has reported the first examples of thorium with multiple bonds to arsenic to exist under ambient conditions on multi-gram scales where before they had only been prepared on very small scales at temperatures approaching that of interstellar space (3-10 Kelvin). More


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Research Chemist
Michelman
US

Sr. Statistician, Research & Development
E. and J. Gallo Winery
US – CA – Modesto

Associate Scientist/Scientist/Principal Scientist
Janssen Research & Development, LLC
US – PA – Spring House

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