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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 16, 2016    SLAS2017    Moving? New job? Let SLAS know.      








JBS Special Issue Call for Papers: Cancer Metabolism
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Guest Editors Raymond Gilmour, Ph.D., of Eli Lilly and Company (USA) and Susana Velasco-Miguel, Ph.D., of CNIO (Spain) invite proposals (abstracts) of original, high-quality, research and review papers for a special issue of JBS on cancer metabolism. Areas of interest include enzyme assay development and validations for cancer metabolism targets, synthetic lethality in targeting cancer metabolism, immunotherapies and immune-metabolism, metabolic changes in response to chemotherapeutic treatment and new technologies to interrogate metabolic activity of cancer in vitro and in vivo. Abstracts for this special issue are due April 1, 2016.

JALA and JBS also are accepting manuscript proposals for four additional special issues:


March 21: Early-Bird Deadline for SLAS Compound Management Conference
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Obtain a discount up to €119 if you register for the April 12-13 conference to be held in Berlin, Germany by Monday, March 21. You can also obtain the lowest rate available if you book a room at the Wyndam Garden Berlin Mitte Hotel, which is where the conference is being held. The conference focuses on technology, process, science and collaboration and features case studies from leading industry professionals and academics. It is appropriate for all compound management and lead discovery professionals from bench scientists to senior leaders in the pharmaceutical, biotechnology and agri-science industries as well as from academic drug discovery. More

JALA & JBS Global Spotlights are on Germany
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The SLAS journal archives comprise 21 years of achievements from around the world, reflecting the breadth, depth and diversity of the SLAS life sciences discovery and technology community.

In focus this quarter are recently published reports from Germany in JALA and JBS, including two of the three 2016 SLAS Journal Achievement Award Honorees.

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Share the SLAS Story
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Do you have colleagues who could benefit from the opportunities offered by SLAS membership?

Tell them why you belong and share this link so they can learn first-hand how others have advanced their careers through SLAS membership.

SLAS ELN Reports: The Lab Man — JALA and JBS Guest Editors Add Value/Gain Value
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Serving as a guest editor for JALA or JBS expands a scientist’s areas of expertise, builds upon innate curiosity and develops a professional network that is built on knowledge exchange and mutual respect.

Joe Olechno and Jonathan Wingfield found their recent guest editor experiences personally rewarding. Read more in the SLAS Electronic Laboratory Neighborhood e-zine article and listen to their podcasts with The Lab Man.


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On-Demand at Genome Engineering with Zinc Finger Nucleases
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In his SLAS2016 Cellular Technologies Track presentation, Edward Rebar, Sangamo BioSciences, USA, believes proteins that can be designed to cleave user-chosen sites in a living genome provide powerful tools for engineering eukaryotic cells with new and useful properties.

"By provoking break repair of the targeted locus, such proteins can mediate highly efficient rates of gene disruption, gene editing or gene addition at levels that allow ready isolation of cells or organisms bearing a desired genetic change," he says. "These capabilities can enable diverse applications in research, medicine and biotechnology, including the creation of customized cell and animal models for drug development. Realizing the full potential of these technologies, however, requires methods for generating sufficiently active nucleases for the widest range of sequence targets while minimizing off-target effects."

It is one of seven presentations recorded at SLAS2016 for on-demand viewing by SLAS dues-paid members and SLAS2016 full conference participants.


Welcome to the Neighborhood!
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If you haven't been to the SLAS Electronic Laboratory Neighborhood e-zine lately, here's what you've been missing:
  • Michelle Arkin: All Things are One Thing
  • Exploring the Potential of Mass Spectrometry in Drug Discovery: A JBS Special Issue
  • Acoustic Droplet Ejection: Bringing Liquid Handling to a New Level
  • The Lab Man Podcasts

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FREE to All at 'Analyzing the Complexity of Drug Resistance in Cancer' by Michael M. Gottesman
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Recorded live at SLAS2016 and now freely accessible to everyone, this keynote presentation by Michael Gottesman, Ph.D., chief of the U.S. National Cancer Institute's Laboratory of Cell Biology, discusses the daunting complexity of resistance mechanisms in cancer cells, the Institute's approach to cell-based research and recent discoveries related to oncology. More


CRISPRi-Controlled Gene Expression
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A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent stem cells (iPSCs) and derivative T cells and heart cells, according to a study published in Cell Stem Cell. More

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We present a new methodology for efficient and high-quality patterning of biological reagents for surface-based biological assays. The method relies on hydrodynamically confined nanoliter volumes of reagents to interact with the substrate at the micrometer-length scale. We study the interplay between diffusion, advection, and surface chemistry and present the design of a noncontact scanning microfluidic device to efficiently present reagents on surfaces. More

Engineered Tissue Goes Bigger, Lives Longer
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Engineered, living tissue could help scientists and doctors test for drug safety or even repair injured tissue. Researchers have already used cells and biocompatible polymers to build materials that look and behave like living tissue in many ways. But they have struggled to create tissue that is thicker than about 1 mm and can survive for more than a couple weeks, says Jennifer A. Lewis of Harvard University. More

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Large Genomic Study Finds New Kidney Cancer Subtypes and Drug Targets
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A new collaborative study led by researchers at Baylor College of Medicine has not only helped to restructure the taxonomy of kidney cancer, it has also uncovered some new actionable therapeutic targets. The new study was a comprehensive molecular analysis of almost 900 kidney cancer cases that found substantial molecular diversity within each major histological type that pathologists typically use to categorize cancer. More

Tracking the Social Networks of Genes Disrupted in Complex Diseases
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Innovative software tools allowed scientists to construct accurate "maps" of gene networks for about 400 different human cell and tissue types, ranging from immune cells to brain tissues, whereas previous studies were limited to just one or few tissues. Each of these networks describes hundreds of thousands of regulatory interactions among thousands of genes, giving the first global view of the "control system" of diverse cells and tissues. More


Sweet 'Quantum Dots' Light the Way for New HIV and Ebola Treatment    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A research team led by the University of Leeds has observed for the first time how HIV and Ebola viruses attach to cells to spread infection. The findings, published in the journal Angewandte Chemie, offer a new way of treating such viruses: instead of destroying the pathogens, introduce a block on how they interact with cells. More

Red Wonder: Chemists Pave Way for Phosphorus Revolution
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Florida State University researchers have discovered a way to safely activate red phosphorus, an element that will be critical in the creation of new electronics and the materials of the future. The discovery details the process to activate red phosphorus using inexpensive and widely available potassium ethoxide dissolved in ethanol. More

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Scientists Closer to Finding Key to Converting Algae to Biofuel
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University of Florida Institute of Food and Agricultural Sciences researchers may have found a key to converting algae to fuel. The scientists have found what researchers call a "transcription factor," called ROC40. Bala Rathinasabapathi, a UF/IFAS professor of horticultural sciences, likened a transcription factor's role in controlling the expression of many genes inside the algae cells to a policeman controlling a large crowd. More

How to Dominate any Networking Event in 9 Minutes or Less
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Talking to strangers used to be super hard for me. I used to look at people and wonder what I should say for what seemed like an eternity. By the time I thought of something cool or witty to say, the other person was already long gone having a seemingly awesome conversation with someone else. There had to be a better way. More



Automation Engineer
US – MA – Worcester

Principal Scientist, Cell Biology & Imaging
BioTek Instruments, Inc.
US – VT – Burlington

Senior Automation Specialist (Robotics), Antibody Engineering
US – CA – South San Francisco

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