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SLAS2016 Call for Abstracts is Open
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Conference Chairs Doug Auld, Ph.D., Novartis Institutes for Biomedical Research and Dino Di Carlo, Ph.D., University of California, Los Angeles announce that abstracts received by Aug. 3, 2015 will be considered for presentation in the following tracks: Advances in Bioanalytics, Biomarkers and Diagnostics; Assay Development and Screening; Automation and High Throughput Technologies; Cellular Technologies; Drug Target Strategies; Informatics; and Micro/Nano Technologies.
SLAS2016 is set for Jan. 23-27, 2016, San Diego, CA.
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SLAS Asia Conference News
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- Xin Xie, Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese National Center for Drug Screening, has been added to the speaker lineup for the April 9-10, 2015 SLAS Asia Conference and Exhibition at the Crowne Plaza Century Park in Shanghai. She presents "Discovery of GPR119 Agonist from Hoodia."
- In collaboration with WuXi AppTec, "Developing an Open Platform for Compound Management and In Vitro Screening," a free pre-conference workshop on April 8 has been added.
- The poster deadline has been extended to March 27.
Learn more about the event and register today.
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SLAS Webinar March 31: HELM — Setting the Standard for Biomolecular Data Exchange
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Tianhong Zhang, Ph.D., manager, Research Business Technology at Pfizer, leads the March 31 SLAS Webinar. HELM (Hierarchical Editing Language for Macromolecules) allows biotherapeutics researchers to define complex biologic entities without ambiguity, the same way as chemists have long been able to do for small molecules.
Zhang, technical lead for the Pistoia Alliance HELM project, presents the HELM open standard and the reference implementation, its origin and use at Pfizer and the emerging HELM ecosystem.
SLAS Webinars are free to dues-paid SLAS members. Not yet a member? Join today.
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From the LabAutopedia Book List — The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution
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According to publisher Simon & Schuster, Walter Isaacson approaches his story of the people who created the computer and the Internet by seeking answers to questions such as "What were the talents that allowed certain inventors and entrepreneurs to turn their visionary ideas into disruptive realities? What led to their creative leaps? Why did some succeed and others fail?"
He shares stories of Ada Lovelace, Vannevar Bush, Alan Turing, John von Neumann, J.C.R. Licklider, Doug Engelbart, Robert Noyce, Bill Gates, Steve Wozniak, Steve Jobs, Tim Berners-Lee and Larry Page in this Publishers Weekly bestseller.
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Registration Open: Cutting-Edge Technologies for Drug Target Validation
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SLAS and the Scottish Universities Life Science Alliance (SULSA) invite academics and industry professionals to the University of Ediburgh, UK, May 18-19.
Speakers include Chas Bountra of the University of Oxford, Lars Hammarström of the Karolinska Institutet, William Janzen of Epizyme, Lorenz Mayr of AstraZeneca, Saskia Otto of Bayer Health Care and 2015 SLAS Innovation Award winner Jonathan Wingfield of AstraZeneca.
Topics include Imaging Techniques and their Application to Drug Discovery Screening; Application of Precise Genome Editing for Target Validation; and Target Engagement and Deconvolution. Share your latest discoveries with the community by submitting your poster for consideration by April 24.
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Sign Up for FREE E-Mail Alerts from JALA & JBS
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Be the first to know when new scientific reports publish ahead-of-print and when new issues of JALA and JBS become available by signing up for free e-mail alerts at JALA Online and JBS Online.
Sign up for keyword alerts to be the first to know when new material about a particular topic becomes available.
Plus, authors whose work has been published in JALA and JBS can sign up for citation tracking alerts.
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SLAS2015 in Pictures
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Enjoy a photo review of SLAS2015, which attracted 4,700 attendees and 296 exhibitors to Washington, DC in February.
This select and diverse collection of scientists, academicians, business leaders and students from around the globe (34 countries represented) benefitted from an extensive lineup of education, new product information, and opportunities to collaborate, interact and enjoy time with peers interested in charting the future of laboratory science and technology.
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Ribosome Assembly Process Validated as Anticancer Drug Target
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Scientists at the Florida campus of The Scripps Research Institute say they have reinforced the idea that the ribosome assembly process is a potentially fertile new target for anticancer drugs by detailing the essential function of a key component in that process.
"This study confirms that ribosome assembly is a good therapeutic target in cancer," said Katrin Karbstein, Ph.D., a TSRI associate professor.
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Bond and Bond Alike: Unlikely Hydrogen Bond Discovered
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As with magnets and alternating current, positively charged molecules never aim for one another. Indeed, similarly charged poles are repelled. Nevertheless, scientists have managed to bond positively charged phosphorus atoms with positively charged hydrogen ones. Their insight may prove pivotal to understanding how biologically important molecules such as DNA and proteins form properly.
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Stereo- and Chemoselective Cross-Coupling between Two Electron-Deficient Acrylates: An Efficient Route to (Z,E)-Muconate Derivatives
Journal of the American Chemical Society Share
  
A Ru-catalyzed direct oxidative cross-coupling reaction of acrylates was developed. It offers a straightforward and atom-economical protocol for the synthesis of functionalized (Z,E)-muconate derivatives in moderate to good yields with good stereo- and chemoselectivities. The conjugated muconates bearing differentiable terminal functionality can be selectively transformed into versatile synthetic intermediates widely used in organic synthesis.
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Scientists Make Surprise Finding in Stroke Research
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Inflammation is activated in the brain after a stroke, but rather than aiding recovery it actually causes and worsens damage. That damage can be devastating. In fact, stroke is responsible for 10 percent of deaths worldwide and is the leading cause of disability.
Therefore, understanding how inflammation is regulated in the brain is vital for the development of drugs to limit the damage triggered by a stroke.
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Chemists Develop New Way to Make Cost-Effective Material for Electricity Storage
Lab Manager Share
  
The researchers wanted to find a better way to make coatings that can be painted onto surfaces to conduct electricity or convert electricity into hydrogen fuels. Typically these coatings are developed in extreme conditions with expensive tools and materials. But the researchers developed a technique that allows them to use a consumer grade heat lamp to get the same results. A solution is painted onto a surface and once heated up, it transforms into a catalytic coating.
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