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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 19, 2014

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What Do You Think About Open Access Publishing?
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SLAS is interested in your experience and opinions regarding open access publishing of scientific journals.

Please take 5-7 minutes (really, that's all!) before March 28 to complete the multiple choice 2014 SLAS Open Access Publishing Survey, and you could win a full registration to SLAS2015 (Feb. 7-11, 2015, in Washington, DC) or an Amazon gift card.

If you are a JALA SAGEtrack or JBS SAGEtrack user, please access this survey by using the link that was sent to you via e-mail.
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SLAS ELN Reports: Researchers Advance Protein-Protein Interactions as Small Molecule Drug Targets
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Innovators James A. Wells of University of California, San Francisco, Haian Fu of Emory University and Mary Ellen Digan of Novartis are presenters in the Spring 2014 SLAS Webinar Series, Protein-Protein Interactions as Small Molecule Drug Targets.

In this SLAS Electronic Laboratory Neighborhood e-zine article, the three share accomplishments of, and stories behind, their work in this growing area of research.

Wells presented March 18, and his webinar will be available on demand shortly; Fu and Digan will present live April 15 and May 13, respectively.
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JBS Special Issue Call for Papers: Therapeutic Antibody Discovery and Development
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Guest Editors Rob Howes and Joseph G. McGivern are looking for manuscript proposals related to all aspects of the discovery and development of therapeutic antibodies with an emphasis on biochemical, cell-based and analytical assays. Submit abstracts by April 25 for consideration. Invited authors will be notified by May 1 and final manuscripts will be due Aug. 1. More

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It's Time to Submit SLAS2015 Presentation Abstracts
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Abstracts are now being accepted for the 4th Annual SLAS Conference and Exhibition, Feb. 7-11, Washington, DC.

Podium abstracts are due July 28; later deadlines are in place for poster abstracts.

The SLAS2015 scientific program features seven educational tracks: Assay Development and Screening; Automation and High-Throughput Technologies; Bioanalytical Techniques; Biomarker Discovery and Application; Drug Discovery Strategies; Informatics; and Micro/Nano Technologies.
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JBS April Issue Now Online for Members and Subscribers
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Andrew J. deMello and his team from the Institute for Chemical Bioengineering at ETH Zurich and Chungbuk National University published the review article, Droplet-Based Microfluidics: Enabling Impact on Drug Discovery, in this issue.

The team touches on pertinent studies in microfluidic platforms, droplet generation, droplet library creation, probing droplet contents, assays (ligand-binding, PCR-based, proteomics) and chip operations (cell-free protein synthesis, 3D cell culture, organisms), while acknowledging much work remains to be done to bring experimental approaches to market.
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Donald E. Ingber: Aha Moment Defines Career
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The SLAS2015 keynote speaker from Harvard University describes himself as a visual person, who loves art, form and pattern.

Learn of Ingber's aha moment when he tied the shape of a tensegrity sculpture by Kenneth Snelson shown in an undergraduate sculpture class to the work he was doing in the laboratory to culture cells.

"That was the starting point for the rest of my life in science," Ingber states in the Discovery Channel Curiosity series video clip, How Do Art and Architecture Influence Biology. "I felt I had seen something that no one ever had seen."
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Building New Drugs Just Got Easier
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Scientists at The Scripps Research Institute have developed a method for modifying organic molecules that significantly expands the possibilities for developing new pharmaceuticals and improving old ones. "This is a technology that can be applied directly to many medicinally relevant compounds," said Jin-Quan Yu, a professor in TSRI's Department of Chemistry and the senior author of the new report, which appears in Nature. More

Europe Faces Up to Big Pharma Over Clinical Data
New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Next week could see a major step forward in the battle to pass laws compelling drug companies to release all the data from their clinical drugs trials. On March 12, the European Parliament is expected to finalize and give formal approval to much amended draft legislation, with a full vote taking place at the beginning of April. But even as members deliberate, pharmaceutical companies will be fighting back. More

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'Acid Bath' Stem Cell Developments Rapidly Accumulate
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Amid plagiarism claims, the Riken Institute's Haruko Obokata reportedly told a Waseda University professor she plans to withdraw her 2011 thesis, a Waseda spokesperson told Bioscience Technology. Why this matters: days earlier, a global press conference delivered the news that four of 14 co-authors on two controversial Obokata "acid bath" papers — along with the coauthors' boss — wanted the papers retracted mid-investigation. More

China Bans Genetic Testing
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For nearly a half-century, interrupted only by the Cultural Revolution, China promoted the growth of genetic testing to prevent and address birth defects through state-run hospitals, as well as charities and increasingly in recent years, private enterprises. Then last month, China reversed course. The China Food and Drug Administration posted a new regulation that immediately banned genetic testing — even for previously approved services. More


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A Link Between Blood and Plasma Trace Metals in Alzheimer's Disease?
By Dr. Afsaneh Motamed-Khorasani    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Alzheimer's disease, or AD, is the most common type of dementia in the elderly, with a rapidly increasing prevalence. In the past three decades, we have witnessed remarkable advances in our understanding of AD, both in terms of the disease course and its symptoms. About 20 genes have been identified to be associated with an altered risk for late onset AD, which could potentially serve as new therapeutic candidates. However, the risk variability and limited power of allelic risk candidates have led to the conclusion that there must be other factors, such as toxic exposure and environmental factors. More

Fighting Antibiotic Resistance With 'Molecular Drill Bits'
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In response to drug-resistant "superbugs" that send millions of people to hospitals around the world, scientists are building tiny, "molecular drill bits" that kill bacteria by bursting through their protective cell walls. They presented some of the latest developments on these drill bits, better known to scientists as antimicrobial peptides, at the 247th National Meeting & Exposition of the American Chemical Society. More



Reports Make Progress In Transforming C-H Bonds Into Druglike Motifs
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Carbon-hydrogen bonds are ubiquitous, and chemists would love to transform them at will into entry points to materials or drugs. Despite great strides, that goal is far from a reality. A pair of reports now furthers the C–H bond transformation field by taking advantage of weak coordination to palladium catalysts. The chemistry comes from Jin-Quan Yu and coworkers at Scripps Research Institute, La Jolla, Calif. More

Big Data Tackles Tiny Molecular Machines
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Open, feed, cut. Such is the humdrum life of a motor molecule, the subject of new research at Rice University, that eats and excretes damaged proteins and turns them into harmless peptides for disposal. The why is obvious: Without these trash bins, the Escherichia coli bacteria they serve would die. And thanks to Rice, the how is becoming clearer. More

Direction Control of Oriented Self-Assembly for 1D, 2D, and 3D Microarrays of Anisotropic Rectangular Nanoblocks
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Micrometric linear chains (1D arrays), monolayers (2D arrays), and superstructures (3D arrays) of anisotropic Mn3O4 nanocuboids were selectively produced by oriented self-assembly through evaporation of a dispersion. The 1D arrays were basically formed on a substrate via oriented self-assembly of the rectangular crystals in the 100 direction. The 2D and 3D microarrays were obtained by adjusting the particle concentration of the dispersion. More


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