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SLAS
Next month's SLAS Discovery cover article, "Addressing Antimicrobial Resistance through New Medicinal and Synthetic Chemistry Strategies" by Monika I. Konaklieva, Ph.D., (American University), is now available online. Explore the current medicinal and organic chemistry strategies aimed at addressing the decline of the effectiveness of antibiotics due to the emergence of drug-resistant microorganisms. More specifically, Konaklieva's study focuses on methods of developing diverse libraries of complex scaffolds, including diversity-oriented synthesis, complexity-to-diversity, fragment-based lead generation (FBLG), DNA-encoded chemical libraries and design-to-function strategy. Access will be available until April 20.
READ THE COMPLETE ARTICLE
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SLAS
The call for podium and poster abstract submission has officially opened for the inaugural SLAS 2019 AI in Process Automation Symposium. Podium presentations will be accepted for inclusion in one of four sessions: AI in drug discovery today, AI in screening, AI in chemistry, and data automation. Save the date to attend this brand-new event in Boston, MA, October 3-4. Learn about the tech, tools and potential costs of implementing AI in the workplace while getting a better understanding of its potential with current case studies from companies who have already implemented AI.
SUBMIT A PODIUM OR POSTER ABSTRACT
LEARN MORE ABOUT THE SYMPOSIUM
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SLAS
In the latest update to the On the Road with the SLAS CEO blog, Vicki discusses her important SLAS2019 takeaways and shares a few nuggets of what's current and what's to come for the organization, all while traveling to Berlin for the SLAS 2019 European Sample Management Symposium and to Paris for the Hello-Tomorrow Summit.
CATCH UP WITH VICKI
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SLAS
The deadline to submit a poster abstract for a Tony B. Academic Travel Award is in 4 days. Submit your abstract by Monday, March 25, for the opportunity to attend, present your work with your travel expenses paid by SLAS. Interested applicants are invited to submit research pertaining to the three key themes for the conference: advances in in silico drug discovery, experimental drug discovery and laboratory automation technology. However, all topics related to life sciences discovery and innovation are welcome Tony B. Academic Travel Award winners benefit from covered travel expenses including airfare, train fare or mileage reimbursement within Europe, conference registration and hotel accommodations. The Tony B. Academic Travel Award is open to students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) only.
COMPLETE SUBMISSION DETAILS
VIEW SLAS EUROPE 2019 PROGRAM
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SLAS
Revisit, or experience for the first time, 81 presentations from this year's SLAS2019 International Conference and Exhibition. Review 76 scientific podium presentations, opening and closing keynote addresses, two Career Connections sessions and the Ignite Panel Discussion on entrepreneurship — now available on APPLIED, SLAS's new online learning center. This content is available free to SLAS2019 Full Conference Registrants; $49 for SLAS Premier, Premier Plus, Corporate and Platinum Members; and $99 for SLAS Basic (non-dues paying) Members and non-members. Log in to the SLAS website and learn more.
ACCESS NOW
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
SLAS Journals Special Issues Call for Papers
SLAS Discovery: Membrane Proteins: New Approaches to Probes, Technologies and Drug Design
April 1: Proposals due
July 1: Invited submissions due
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1: Proposals due
Aug. 10: Invited submissions due
Upcoming 2019 Events
SLAS Europe 2019 Conference and Exhibition
June 26 - 28
Barcelona, Spain
Monday, March 25: Tony B. Academic Travel Award Abstract Submission Deadline
Friday, May 3: Innovation AveNEW Exhibitor Submission Deadline
Monday, May 20: Poster Abstract Submission Deadline
Exhibit and sponsorship opportunities available
Save the Dates
SLAS 2019 AI in Process Automation Symposium
October 3 - 4
Boston, MA
Call for Podium and Poster Abstracts Now Open
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium
October 21 - 22
London, UK
SLAS 2019 Americas Sample Management Symposium
November 20 - 21
Boston, MA
SLAS2020 International Conference and Exhibition
January 25 - 29, 2020
San Diego, CA
Abstract submission opens in May.
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Analytical Chemistry
Developing new nanomaterials with strong and distinctive Raman vibrations in the biological Raman-silent region (1800–2800 cm) were highly desirable for Raman hyperspectral detection and imaging in living cells and animals. Herein, polymeric nanoparticles with monomers containing alkyne, cyanide, azide, and carbon-deuterate were prepared as Raman-active nanomaterials (Raman beads) for bioimaging applications.
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The FlowMarker™  uses non-toxic, bacteria-free fog, and unlike smoke sticks, which contain particulates, disperse inconsistent smoke, and the potential for contaminants to migrate to equipment and walls, breaks down into carbon dioxide and water. With 100% tamper-proof fluid, using certified propylene glycol dispensed via pressurized canisters, provides contamination-free testing assurance. For USP testing of Pharmaceutical isolators, the FlowMarker™  is the tool of choice.
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Journal of the American Chemical Society
Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃siRNA) for the purpose of realizing siRNA delivery into deep tissues and RNA interference (RNAi) subsequently. For obtaining TfNC⊃siRNA, a macromonomer (AzGu) bearing multiple guanidinium (Gu+) ion units, azide (N3) groups, and trityl (Trt)-protected thiol groups in the main chain, side chains, and termini, respectively, was newly designed.
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"Small Molecule screening with assays for calcium, sodium and potassium that are convenient and easy from ION. To view the latest technology visit us at IonIndicators.com MORE
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Lab Manager
One of Matthew Liao's most popular papers proposes that humans could genetically engineer themselves to collectively reduce our species' carbon footprint.
The piece, "Human Engineering and Climate Change," offers ideas such as stimulating an aversion to red meat (thereby reducing greenhouse gasses from livestock farming); making people physically smaller (and thus likely to consume less food); lowering birth rates through cognitive enhancement (based on the idea that birth rates are negatively correlated with access to education for women); and enhancing our altruistic and empathetic responses in the hopes that, if people are more aware of the suffering climate change causes, they will be more likely to take positive steps.
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Laboratory Equipment
Fruit flies make for stingy mothers, imparting only a portion of the genetic building blocks their offspring need to survive. The rest must be produced by the fertilized egg in its first few steps of growth.
Scientists puzzled for two decades over this seemingly unnecessary withholding. Now researchers at Princeton University have shown that the inhibiting mechanism, controlled by an enzyme known as RNR, is actually key to the embryo's survival.
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Genetic Engineering & Biotechnology News
Acute myeloid leukemia is an aggressive cancer that led to over 10,000 deaths in the United States last year. While AML is the most type of leukemia in adults, thankfully, overall, this disease is relatively rare accounting for only about 1% of all cancers. Though there are therapeutics available to treat AML, a new study by a team of researchers led by investigators at Cambridge Institute for Medical Research in the U.K. has identified a potentially interesting new therapeutic target that could also be an underlying factor in the disease development.
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Phys.org
Exposure to potentially harmful chemicals is a reality of life. Our ancestors, faced with naturally occurring toxins, evolved mechanisms to detoxify and expel damaging substances. In the modern world, our bodies regularly process chemicals, from medicines and food additives to agricultural and industrial chemicals, to protect our tissues from harm.
As the organs responsible for metabolizing and excreting toxic chemicals, the liver and kidneys bear the brunt of this exposure and are at the highest risk for toxin-induced damage.
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Chemical & Engineering News
U.S. consumers will not be able to purchase paint and coating removers that contain methylene chloride by the end of the year, under a rule finalized by the U.S. Environmental Protection Agency on March 15. Environmental and health advocacy groups welcome the ban but say it does not go far enough because it fails to protect workers who use such products.
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Science Daily
Seven of the 10 most frequent medications contain chiral agents. These are molecules that occur in right- or left-handed forms. During chemical synthesis both forms usually occur in equal parts and have to be separated afterward, because chirality determines the agent's effect in the body. Physicists have now succeeded in using laser light for the purpose of creating either right- or left-handed molecules.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
SLAS Administrative Coordinator
SLAS
US – Illinois – Oak Brook
Director of the Early Translation Branch, Division of Preclinical Innovation (DPI)
NIH/NCATS
US – MD – Rockville
Senior Research Scientist - Cell Biology
Syngenta
EU – UK – Bracknell
Search Jobs at SLAS Career Connections
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