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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 22, 2017    SLAS2018    Moving? New job? Let SLAS know.      






SLAS ELN Reports: A Look at Last Year's Art of Science Contest Winner
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"The win was unexpected and surprising for me," Fernanda Ricci says about "Beautiful Cell Colonies," her 2016 SLAS Art of Science Contest winning entry. "When I stitched the images together, I was fascinated with their mosaic appearance — very simply the art of science. However, to be able to show obscure scientific questions to a general audience by means of imagery is a powerful way to embed science into daily life. People can see the science in action."

Read more about last year's winners and submit your mesmerizing scientific images to the 2017 SLAS Technology & SLAS Discovery Art of Science Contest before April 21 — you could win a $500 Amazon gift card.


FREE at SLAS Discovery Online: High-Throughput Patch Clamp Screening in Human α6-Containing Nicotinic Acetylcholine Receptors
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A collaborative team from Charles River Discovery and the U.S. Food and Drug Administration (FDA) Center for Tobacco Products describes the development and validation of a recombinant cell line expressing human α6/3β2β3V273S nAChR for screening and profiling assays in an automated patch clamp platform. The cell line is pharmacologically characterized by subtype-selective and nonselective reference agonists, pore blockers and competitive antagonists.

Agonist and antagonist effects detected by the automated patch clamp approach are comparable to those obtained by conventional electrophysiological assays. A pilot screen of a library of FDA-approved drugs identifies compounds, previously not known to modulate nAChRs, which selectively inhibit the α6/3β2β3V273SK subtype. These assays provide new tools for screening and subtype-selective profiling of compounds that act at α6β2β3 nicotinic receptors.

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Free Until April 30: Seven SLAS2017 Top Presentations
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Learn from the experts! Carefully selected scientific presentations from SLAS2017 were recorded and are now available as on-demand webinars free-of-charge to SLAS members always and to non-members through the end of April:

Case-Study in Consortium-Based Drug Discovery: Allosteric Inhibition of the AAA ATPase p97
Michelle Arkin, University of California, San Francisco

Precision Immunology Through Deeper, Single Cell Profiling
Pratip Chattopadhya, NIH

HTS Tumor: Stroma Co-Culture Spheroid Platform Reveals CAF-Specific Chemotherapeutic Targets
Shane Horman, Genomics Institute of the Novartis Research Foundation

Emerging Fluorescence Technology to Study the Spatial and Temporal Dynamics of Organelles within Cells
Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus

Droplet Microfluidic 3D Tumor Models for Cancer Screening
Pooja Sabhachandani, Northeastern University

Vortex Biosciences Technology for Fast and Label-Free Isolation of Circulating Tumor Cells from Blood Samples
Elodie Sollier-Christen, Vortex Biosciences, Inc. (2017 SLAS Innovation Award Winner pictured here)

High-Throughput Acoustic Mass Spectrometry: Development and Delivery of a Biochemical Screen
Jonathan Wingfield, AstraZeneca

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SLAS2017 Compound Combination Screening SIG Meeting Presentations Now Online
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"We had a great meeting in Washington — about 20 participants, two talks and interesting discussions," says Oliver Leven, SLAS Compound Combination Screening SIG chair. Leven posted the slides from both speakers and invites follow-up comments and questions on the SIG's LinkedIn forum:

Combination Screening: A Necessity or Stamp-Collecting in Drug Discovery by Eric Tang, managing director at Phoenix Biomedical Ltd.

Combination Studies: A Mixtures Approach by William Markland, director of cell & molecular biology at Vertex Pharmaceuticals.


Special Issue Calls for Papers: SLAS Discovery and SLAS Technology
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Special issues of SLAS Discovery (formerly JBS) and SLAS Technology (formerly JALA) are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs are now being accepted for special issues on these important topics: More

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Tell them why you belong, and share this link so they can learn first-hand how others have advanced their careers and enhanced their personal lives through SLAS membership.

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3D Single-Cell Genome Structures Compared, Contrasted
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The cell's nucleus is like a densely packed but busy archive, one that resorts to the use of mobile shelving, which consists of wheeled shelving units that run along tracks — pushed together to save space, then separated to facilitate access, when needed. In the nucleus, where the mobile shelving units consist of chromosomal structures and genomic DNA domains, some order is maintained despite the constant shuttling of information, not to mention the occasional copying project, necessary for cell division. More

Cellular Manipulation Could Advance Biomedical Research, Robotic Actuation and Even the Cleaning of Industrial Surfaces    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cells in developing tissues respond to local mechanical forces by adjusting their growth, differentiation and migration patterns. Being able to mimic these changes accurately outside the body could lead to a better understanding of the underlying molecular mechanisms and create new opportunities for tissue engineering and drug development. Current cell manipulation methods, however, either investigate the behavior of single cells taken out of their natural tissue context, or they deform entire cell sheets without control over individual cells. More


Gene Editing Technique Helps Find Cancer's Weak Spots
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Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells. This concept is called "synthetic lethality" because the drug is only lethal to mutated (synthetic) cells. Researchers at UC San Diego School of Medicine and Jacobs School of Engineering developed a new method to search for synthetic-lethal gene combinations. More

Groundbreaking Process for Creating Ultra-Selective Separation Membranes
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A team of researchers, led by the University of Minnesota, has developed a groundbreaking one-step, crystal growth process for making ultra-thin layers of material with molecular-sized pores. Researchers demonstrated the use of the material, called zeolite nanosheets, by making ultra-selective membranes for chemical separations. More

Native State Volume Fluctuations in Proteins as a Mechanism for Dynamic Allostery
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Allostery enables tight regulation of protein function in the cellular environment. Although existing models of allostery are firmly rooted in the current structure–function paradigm, the mechanistic basis for allostery in the absence of structural change remains unclear. In this study, we show that a typical globular protein is able to undergo significant changes in volume under native conditions while exhibiting no additional changes in protein structure. More

Scientists Develop New Drug Delivery Method for Cancer Therapy
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Scientists from the Florida campus of The Scripps Research Institute have developed a new drug delivery method that produces strong results in treating cancers in animal models, including some hard-to-treat solid and liquid tumors. The study, led by TSRI Associate Professor Christoph Rader, was published online ahead of print in the journal Cell Chemical Biology. More

Light-Generating Reporter Molecules Ease Cell Monitoring
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To detect the goings-on inside cells without an external light source, scientists can genetically engineer cells to produce chemiluminescent reporter molecules. A new class of small molecules, however, can penetrate cells and monitor their biological processes by chemiluminescence, avoiding genetic modification. Chemiluminescence, the process that lights up glow sticks, occurs when a chemical reaction generates light. More

Rapid Blood-Type Test
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
While existing tests can take anywhere from 5 to 20 minutes and require two steps to complete, a new paper-based diagnostic method, described in a paper published in Science Translational Medicine, takes just 30 seconds to reveal whether a person is type A, B, or O, and a total of two minutes to reveal a whether the person is "positive" or "negative" for Rh factor, all with just one step. More


Henry Rutgers Professorship and Director of Rutgers Addiction Research Center
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