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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 26, 2014    SLAS2015    Moving? New job? Let SLAS know.    





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SLAS ELN Reports: SLAS Member Influences FIRST Experiences in Science
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A sense of awe, a gasp or even five minutes of concentrated silence; these are the reactions SLAS member Jody Keck seeks as he works with elementary students to spark an early interest in science and technology.

Even for the kids who don't grow up to be scientists, Keck hopes to plant a sense of curiosity and determination to find answers in the face of a challenge.

Read more about this Abbott R&D engineer in the SLAS Electronic Laboratory Neighborhood e-zine.


JALA April Issue Now Online for Members and Subscribers
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In the April cover article, Yuka Okabe and Abraham P. Lee from the University of California, Irvine present a novel method to fragment DNA by using lateral cavity acoustic transducers (LCATs).

"The LCATs cause microstreaming, which fragments DNA within the solution without any need for purification or downstream processing," say the authors in the abstract.

Read this full manuscript, eight other original reports, technology brief, literature highlights and world news in the April issue.

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Francis Collins on Accelerating Medicines Partnership
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The SLAS2015 keynote speaker and other key members of the Accelerating Medicines Partnership (AMP) discuss on BioCentury TV how this collaboration will transform the way drugs are developed.

"The good news is we have this remarkable proliferation of new information about human biology, human disease, human genetics, all kinds of omics, imaging, other things," Collins states. "We ought to have a chance to do something fairly radical here ... to put all that together and really identify those targets that are most likely to work."

The AMP collaboration involves 10 companies, NIH, academics and patient organizations focused on Alzheimer’s disease, type 2 diabetes, rheumatoid arthritis and lupus.


Open Access Publishing Survey Closes March 28
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Just a few days remain to share your thoughts regarding open access publishing of scientific journals.

The survey is short, multiple choice and should only require 5-7 minutes to complete. Do so, and you could win a full registration to SLAS2015 (Feb. 7-11, 2015, in Washington, DC) or an Amazon gift card.

If you are a JALA SAGEtrack or JBS SAGEtrack user, please access this survey using the link sent to you via e-mail.

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Challenging Targets for Drug Discovery On Demand
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James A. Wells presented an informative SLAS Webinar last week, which is now available on demand at no charge for dues-paid SLAS members.

In the webinar, Wells reviewed a site-directed fragment-based discovery approach (disulfide-trapping), dug into exploring allosteric sites and discussed some compounds discovered by high-throughput screening that activate capsases.

Learn more about his work, and that of the two other presenters in this Protein-Protein Interactions as Small Molecule Drug Targets SLAS Webinar Series, in the SLAS Electronic Laboratory Neighborhood e-zine article. The next webinars in the series are April 15 and May 13 — mark your calendar!


LabAutopedia Includes Recipes?
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Well, just once in awhile. Following the wonderful SLAStronomy evening at SLAS2014, dueling chefs Carissa Giacalone and Patrick Dahms shared their delicious recipes. Wow your family and friends by making Fruit-Stuffed Crepes with Dulce de Leche or Tamarind Crepes! More

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Multiplexed Capture of Secreted Proteins for Screening
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Shifting Evolution Into Reverse Promises Cheaper, Greener Way to Make New Drugs
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By shifting evolution into reverse, it may be possible to use "green chemistry" to make a number of costly synthetic drugs as easily and cheaply as brewing beer. Normally, both evolution and synthetic chemistry proceed from the simple to the complex. Small molecules are combined and modified to make larger and more complex molecules that perform specific functions. Bioretrosynthesis works in the opposite direction. More

Nature Rejects Challenge to 'Acid Stem Cells'; Scientists Try New Tips
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Nature has rejected the paper of a top Hong Kong stem cell researcher whose lab several times failed to replicate the results of the journal's famous "acid bath" stem cell papers — and an additional protocol posted by Riken Institute co-authors weeks later. That researcher, Chinese University of Hong Kong's Kenneth Ka Ho Lee, is trying to reproduce the work as it appears in yet another new updated protocol. More


Mass Spectrometry Method Provides Insights into Insecticide Resistance
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When pests gain resistance to insecticides, they can threaten food crops across the globe. But researchers have struggled to understand some of the mechanisms insect cells use to withstand these chemicals, which makes it difficult for scientists to design ways to combat resistance. Now, using a mass spectrometry technique, researchers in Australia have explained how fruit flies express a single gene at high levels to rid themselves of a common insecticide. More

Observation of Complete Pressure-Jump Protein Refolding in Molecular Dynamics Simulation and Experiment
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Density is an easily adjusted variable in molecular dynamics (MD) simulations. Thus, pressure-jump (P-jump)-induced protein refolding, if it could be made fast enough, would be ideally suited for comparison with MD. Although pressure denaturation perturbs secondary structure less than temperature denaturation, protein refolding after a fast P-jump is not necessarily faster than that after a temperature jump. More

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Hacked Bacteria Keep Tabs on Health of Gut
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Think of them as tiny environmental health officers. Bacteria have been engineered to monitor the state of a live animal's gut. The work is a first step towards developing genetically modified bacteria that non-invasively diagnose problems such as gut infections or inflammation. Synthetic biologists have made similar systems before in the lab, but never one designed to stand up to the harsh conditions in the gut of living mammals, says Jeffrey Way at Harvard Medical School. More

Cholesterol Transporter Structure Decoded    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The word "cholesterol" is directly linked in most people's minds with high-fat foods, worrying blood test results, and cardiovascular diseases. However, despite its bad reputation, cholesterol is essential to our wellbeing: It stabilizes cell membranes and is a raw material for the production of different hormones in the cell's power plants — the mitochondria. Now, for the first time, scientists have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. More

The Challenging Market Environment for Drug Companies
By Mike Wokasch    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The traditional pharmaceutical industry is going through perhaps its biggest transformation since The Pure Food and Drug Act of 1906. Unfortunately, the entrenched "we have always done it this way" leadership mentality has been slow to react to the magnitude of changes taking place over the past two decades. Every aspect of how drug companies have done business in the past is being re-evaluated, evolved, restructured or even dismantled. More importantly, companies are now realizing they have to come up with new ways to remain viable in this ever-changing market. More

Cracking Bacteria's Playbook
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A new map drawn by a team of biophysicists could point the way to better antibiotics. Rather than chart Earth's geography, the scientists mapped how fast bacteria with different genetic mutations reproduce and how they respond to varying doses of a drug. Such a map could help drugmakers develop treatments that block bacteria's ability to evolve antibiotic resistance, said Terence Hwa, a biological physicist at the University of California, San Diego. More

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