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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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For supporting the unique requirements of bio molecular lab systems, UNIConnect delivers what others can’t.
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13 of 20 top pharma/biotech companies have chosen Titian’s modular Mosaic™ software to control their sample storage/preparation. Find out why.
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The SLAS Market Place offers access to new and existing technology products and services for your laboratory.
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It's new. It's newsy. And it's available now. Check out this interactive e-zine today.
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SLAS makes great strides on global strategy
SLAS Share
   
"We build these new bridges and relationships knowing that as our united scientific community expands its reach and impact, we increase the value of our knowledge network, which benefits members everywhere," states SLAS President Dave Dorsett. Learn more about the steps SLAS is taking to connect the global community to SLAS educational content in Dorsett's new president's message.
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Asia opening speaker addresses new cell death discoveries
SLAS Share
Xiaodong Wang, Ph.D., director and investigator at the National Institute of Biological Sciences in Beijing, China, will present "Biochemical Pathway of Necrosis" at the 2012 SLAS Asia Conference, June 19-21, Shanghai, China. "One form of cell death recently brought to our attention is the tumor necrosis factor receptor induced cell death when caspases are inhibited," according to his NIBS lab webpage. "We discovered that a receptor interactive kinase, Rip3, is a critical downstream mediator for this form of cell death."
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JBS April released
SLAS Share
Original articles include "Hypothesis Testing in High-Throughput Screening for Drug Discovery," "Identification of Novel Compounds That Increase SMN Protein Levels Using an Improved SMN2 Reporter Cell Assay" and "Development of a High-Throughput Screening Method for LIM Kinase 1 Using a Luciferase-Based Assay of ATP Consumption."
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Starfruit Software/Database Service - LTS per Study. You can control who to use a sample. Visit Store – Starfruit Library to see "Starfruit Sample Locator BIMS"
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Pittcon, the world’s largest annual conference and expo for laboratory science, March 17 – 21, 2013, Philadelphia, PA. Pittcon offers innovations from nearly 900 exhibitors, unique networking events, exceptional educational opportunities. Visit www.pittcon.org for more information!
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Robots play a little keyboard, some drums ...
SLAS Share
The GRASP Lab at the University of Pennsylvania and KMel Robotics combined to produce "Flying Robot Quadrotors Perform," the featured video on LabAutopedia. It's a new take on the popular James Bond theme song and includes the debut of the "couch guitar," an instrument built from guitar strings stretched across a couch frame and played by the quadrotor flying over and plucking the strings with a stiff wire.
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Enter by Friday to win $500 Amazon gift card
SLAS Share
The SLAS Electronic Laboratory Neighborhood (ELN) Welcome to the Neighborhood sweepstakes entry period ends Friday, March 30, at 5 p.m. U.S. central time. Sign up for your chance to win this prize! Everyone visiting the SLAS ELN e-zine wins, however, with the timely features sharing experiences and perspectives on science-related topics!
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SLAS2013 call for abstracts opening in April
SLAS Share
Digging deeply into comments provided by SLAS2012 attendees, lining up keynote speakers Mehmet Toner, Sir Harold Kroto and Charles Sabine and recruiting session chairs has been the early work accomplished by the SLAS Scientific Program Advisory Committee preparing for SLAS2013, Jan. 12-16, Orlando, Fla. Next up: opening the SLAS2013 call for abstracts by mid-April.
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Welcome, Molecular Devices!
SLAS Share
Molecular Devices, a division of Danaher Corporation, is now an SLAS sterling corporate member. The company provides high-performance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development including platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics.
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The Nexar® System optimized for Homogeneous ELISA processing is fully automated and modular. The system includes inline random access sample storage, liquid handling, incubation, and detection (< 3 minutes/384 array). Achieve high throughput processing, miniaturized reaction volumes in Array Tape™ and true walk-away operation. Contact Douglas Scientific today! MORE
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The MaxCyte® VLX™ Large Scale Transfection System is specifically designed for extremely large volume transfection and is able to transfect up to 2E11 cells in less than 30 minutes with high cell viability and transfection efficiencies. This system is ideal for rapid, gram scale production of proteins and monoclonal antibodies.
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ALPAQUA® offers 24-well, 96-well & 384-well magnet plates with integrated spring technology for touch-off dispensing and complete supernatant removal while eliminating costly tip crashes and occlusions. Strong NdFeB magnets enable rapid, reliable bead capture and retention. Alpaqua magnet plates are SBS compliant and compatible with many liquid handlers, plate hotels & stackers.
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GE Healthcare increases training opportunities in China
GE Life Sciences Share
SLAS2012 exhibitor and SLAS 2012 Asia Conference and Exhibition sponsor and exhibitor GE Healthcare expanded its Fast Trak Training Center in Shanghai to meet the needs of the rapidly growing biopharmaceutical industry in China. Fast Trak courses provide hands-on practical training in the latest technologies and strategies for start-to-finish bioprocessing, and are specifically designed to help manufacturers of biopharmaceuticals increase their process productivity and bring their product to market faster.
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Memorial Sloan-Kettering Cancer Center, IBM to collaborate in applying Watson technology to help oncologists
Memorial Sloan-Kettering Cancer Center Share
Memorial Sloan-Kettering Cancer Center and IBM have agreed to collaborate on the development of a powerful tool built upon IBM Watson in order to provide medical professionals with improved access to current and comprehensive cancer data and practices. The resulting decision support tool will help doctors everywhere create individualized cancer diagnostic and treatment and recommendations for their patients based on current evidence.
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Dye-loaded porous nanocapsules immobilized in a permeable polyvinyl alcohol matrix: A versatile optical sensor platform
Analytical Chemistry Share
In this work, we report on a versatile sensor platform based on encapsulated indicator dyes. Dyes are entrapped in hollow nanocapsules with nanometer-thin walls of controlled porosity. The porous nanocapsules retain molecules larger than the pore size but provide ultrafast access to their interior for molecules and ions smaller than the pore size. Dye-loaded nanocapsules are immobilized in a polyvinyl alcohol matrix with high solvent permeability and rapid analyte diffusion.
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The holes in whole genome sequencing
Genetic Engineering & Biotechnology News Share
The Supreme Court recently handed down a unanimous decision overturning Prometheus Laboratories' dosage calibration patent. Where Prometheus saw a solid contribution to the technological arts, the Court saw an attempt to patent a formula. The amicus briefs were fascinating: Mayo Clinic, the ACLU, Cato Institute, AARP, LabCorp and Verizon on one side; and Prometheus, BIO, Novartis, Myriad, the National Venture Capital Association, several intellectual property associations and the Association of University Technology Managers on the other.
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3 innovative products launched at SLAS Booth 914:
• arktic: compact automated biobanking
• aequus: non-contact liquid level monitoring
• mosquito HV: cost-saving serial dilutions.
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Whether your lab is manual, semi-automated or fully automated, FlexLink has flexible conveyor systems and solutions that fit perfectly where space is limited and close machine interface is required.
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Oxadiazoles in medicinal chemistry
Journal of Medicinal Chemistry Share
Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are frequently occurring motifs in druglike molecules, and they are often used with the intention of being bioisosteric replacements for ester and amide functionalities. The current study presents a systematic comparison of 1,2,4- and 1,3,4-oxadiazole matched pairs in the AstraZeneca compound collection.
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Big motivation
Lab Manager Magazine Share
Are you motivated? Is everyone motivated? Yes or no? Take a look around your lab. The truth is, you and everyone around you are motivated in one way or another. Even someone frozen in place, not doing one single solitary thing, is motivated to do just that — absolutely nothing.
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Studies: Surgery can put diabetes into remission
Bioscience Technology Share
New research gives clear proof that weight-loss surgery can reverse and possibly cure diabetes, and doctors say it should be offered sooner to more people with the disease — not just as a last resort. The two studies are the first to compare stomach-reducing operations to medicines alone for "diabesity" — Type 2 diabetes brought on by obesity. Millions of Americans have this and can't make enough insulin or use what they do make to process sugar from food.
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International team detects gene variant influencing flu susceptibility
GenomeWeb Share
A variant in a gene called IFITM3 appears to mediate at least some variability in human influenza virus susceptibility, according to a study online in Nature by investigators from the U.K., U.S. and Italy. Motivated by past genomic screening and cell line experiments showing that the IFITM3 gene product affects the ability of influenza A and some other viruses to enter and replicate in host cells, the researchers did a series of experiments in mouse models before turning their attention to hospital patients.
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Foundation Medicine: Personalizing cancer drugs
Technology Review Share
Starting this spring, for about $5,000, any oncologist will be able to ship a sliver of tumor in a bar-coded package to Foundation Medicine's lab. Foundation will extract the DNA, sequence scores of cancer genes and prepare a report to steer doctors and patients toward drugs, most still in early testing, that are known to target the cellular defects caused by the DNA errors the analysis turns up.
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How to write like a scientist
Science Magazine Share
From Adam Ruben, Ph.D.: I didn't know whether to take my Ph.D. adviser's remark as a compliment. "You don’t write like a scientist," he said, handing me back the progress report for a grant that I had written for him. In my dream world, tears would have come to his eyes, and he would have squealed, "You write like a poet!"
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False memories generated in lab mice
New Scientist Share
In the 1940s, neurosurgeon Wilder Penfield found his patients would recall seemingly random information — the smell of cookies for instance — when he stimulated different brain areas with electric shocks. Two studies have now found evidence to support the memory storage theory that Penfield stumbled across. The research, in mice, even demonstrates that it is possible to manipulate brain cells to create false memories.
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Fatty diet may cause new brain cells to sprout
Live Science Share
Eating too many burgers and fries? Your brain might show the effects, if new mouse research holds true in humans. Researchers have discovered that a high-fat diet causes new brain cells to sprout in an area of the brain that seems to regulate eating. Interestingly, if the researchers stopped new brain-cell growth, mice gained less weight and stayed more active.
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Chemical sensor is all wires, no battery
Science & Technology Review Share
Sensor technology keeps advancing with the development of smaller and smaller sensors that have higher and higher sensitivities. However, when it comes to conventional chemical detectors, most (if not all) still require a power source, that is, a battery, and therein lies a challenge. Battery-powered sensors require regular maintenance and replacement, making them problematic for field use.
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Petite particle accelerator: A proton gun for killing tumors
Popular Science Share
Since 1990, doctors have been regularly treating cancer patients using proton beams, which work similarly to radiation. Proton therapy is more precise, however, causing less harm to healthy surrounding tissues. Unfortunately, generating a proton beam requires a particle-accelerator facility that's the size of an airplane hangar and costs more than $100 million to build.
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Agilent Technologies’ RapidFire is an SPE-based solution that enables detection of native compounds by mass spec. Requiring no labels or surrogates, it enables the screening of intractable or challenging targets which are not amenable to fluorescence or luminescence. Sample throughput is 10x faster than conventional MS screening methods. MORE
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Labcyte has introduced a new consumables website designed to be a one stop solution for Labcyte® consumables, from product research to purchase and fulfillment. The new website will allow you to:
• Review product specifications
• Request product samples
• Order consumables (US currently, EU soon)
Visit microplates.labcyte.com for the latest product information.
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Focused on Outsourced Materials Management and Sample Preparation Services, FSSI supports Compound Management, Research and Discovery Screening, and Chemistry. FSSI performs Sample Reformatting and Full Repository Services with on-demand 24-48 hour delivery. FSSI offers diversity screening libraries, pre-weighed building blocks in custom aliquots, full preparative purification, and high-throughput analysis.
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EasyHandling makes Mechatronics easier and faster than ever, with high-performance mechanical technologies and our new EasyWizard programming tool. Cut engineering time, effort & cost by up to 80%. EasyHandling is perfect for Lab applications—ranging from test tube pick-and-place and medical product packaging to hands-off inspection of hazardous materials.
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Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.
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