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SLAS
"SLAS takes seriously its mission to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building," says SLAS President Sabeth Verpoorte, Ph.D. She describes SLAS's new governance structure, which ensures that our dedicated volunteers and subject matter experts around the globe get the tools and support they need to contribute effectively to benefit the varied disciplines and markets SLAS serves. Visit the SLAS Electronic Laboratory Neighborhood e-zine to
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SLAS
Listen and learn: A NEW SLAS Technology Podcast is available featuring author Christian Pylatiuk, Prof. Dr. med., of the Karlsruhe Institute of Technology, Institute for Automation and Applied Informatics (Eggenstein-Leopoldshafen, Germany). Pylatiuk discusses his new article from the April 2018 issue that describes a zebrafish embryo sorting system with two cameras and image processing based on template-matching algorithms.
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SLAS
Join academic and industry scientists and technologists from around the world at the inaugural 2018 SLAS Europe Conference and Exhibition. The program includes 50 scientific presentations addressing emerging and hot topics in biology, technology and discovery, such as that from Benjamin Haibe-Kains, Ph.D., Princess Margaret Cancer Centre, University Health Network (Toronto, Canada), who will present his work into consistency analysis of pharmacogenomic screens. Also on the program will be Maria Francisca Coutinho, Ph.D., National Institute of Health Doutor Ricardo Jorge (Lisbon, Portugal), who will discuss the most recent advances in substrate reduction therapy (SRT) and introduce the concept of genetic SRT (gSRT).
Register now: Two days remain to take advantage of discounted registration rates that expire on Friday, March 30.
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SLAS
Register today for the 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic, Nov. 13-14 in Boston, MA. Save up to $150 when you sign up by October 1. Scientific presentations will focus on implementing new technologies associated with small molecules, managing biologics, new modalities and clinical trials, establishing a biobank and exploring the new frontiers in compound management as they relate to drug discovery. Students: SLAS is pleased to offer discounted registration rates!
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
Register now for an SLAS Webinar, to be held at noon (EDT) on June 7 that describes compound-mediated assay interference and bioassay promiscuity that pose significant burdens in drug and chemical probe discovery. Presented by Jayme L. Dahlin, M.D., Ph.D., chief resident in Clinical Pathology at Brigham and Women's Hospital (Boston, MA), this webinar discusses the fundamental chemical principles of these interferences and introduces technical recommendations to mitigate the incidence of aggregation and nonspecific reactivity in biological assays. This SLAS Webinar, which will be live on June 7 and then available on demand, is free to dues-paying members. For those who perform high-throughput screening (HTS) and triage, drug and chemical probe development, and chemical biology,
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SLAS
WATCH video recaps of SLAS2018, which attracted a record-breaking 6,767 participants from 35 countries to sunny San Diego, CA. Participants enjoyed 144 podium presentations, 350-plus poster presentations, 20 short courses and 300-plus multinational exhibitors in three, action-packed days filled with the latest in life sciences discovery and technology. Plan now for next year's event! Abstract submission open in April. Mark your calendar for SLAS2019, Feb. 2-6 in Washington, DC.
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Genetic Engineering & Biotechnology News
Scientists at the Wyss Institute for Biologically Inspired Engineering have adapted the CRISPR/Cas9 genome-editing system into a genome surveillance tool that acts as a "mutation prevention system" to identify and cut out DNA sequences that carry single point mutations in individual cells. When tested on Escherichia coli strains both in vitro and in the mouse gastrointestinal tract, the system prevented the emergence of antibiotic-resistant bacteria that harbor gain-of-function point mutations.
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Phys.org
Proteins are the worker bees of the cell, mainly ganging up to form macromolecular, multicomponent complexes to perform intricate cellular tasks.
Trying to characterize such protein complexes and all of their functions within organisms is a discipline called "proteomics." Historically, scientists have studied the form and function of proteins by dissolving them with enzymes and sequencing the resulting tiny broken pieces, called peptides.
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Journal of the American Chemical Society
An efficient protocol was developed to construct functionally dense quaternary carbons with concomitant formation of a new Csp3–Csp3 bond via Pd-catalyzed decarboxylative transformation of vinyl cyclic carbonates. This redox-neutral catalytic system features stereocontrolled formation of multisubstituted allylic scaffolds with an aldehyde functionality generated in situ, and it typically can be performed at room temperature without any additives.
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Chemical & Engineering News
Robots have repeatedly demonstrated that they can do the work that humans do. And chemists haven't escaped this automation trend. Food, pharmaceutical and other industries have sped up routine processes by using robots to sample and analyze products. Chemists have designed programs like Chematica to let computers plan synthetic routes. Research groups have even demonstrated nearly autonomous systems that use machine learning to design, carry out and evaluate experiments.
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Lab Manager
A genetic mutation that may protect people from malaria, but was thought to be rare, is surprisingly common, suggest the findings of a new study led by scientists at The Scripps Research Institute. The discovery sheds light on how humans who live in close quarters with malaria-carrying mosquitos may evolve defenses against the disease.
The researchers found that a mutation in the gene PIEZO1, which codes for a pressure-sensing protein, can dehydrate red blood cells.
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The Scientist
People with Alzheimer's have a higher production rate of tau proteins than healthy individuals, according to a study published in Neuron.
While researchers have long known that tau levels are elevated in the brains and cerebrospinal fluid of Alzheimer's patients, "until this study, we didn't know if tau production was increased or if clearance was decreased," said coauthor Chihiro Sato, a researcher in neurologist Randall Bateman's lab at Washington University School of Medicine.
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Science Daily
In materials research, the ability to analyze massive amounts of data — often generated at the nanoscale — in order to compare materials' properties is key to discovery and to achieving industrial use. Jeffrey M. Rickman, a professor of materials science and physics at Lehigh University, likens this process to candy manufacturing:
"If you are looking to create a candy that has, say, the ideal level of sweetness, you have to be able to compare different potential ingredients and their impact on sweetness in order to make the ideal final candy," says Rickman.
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Science Magazine
Twenty-two years ago, microbiologists in Switzerland stumbled on a mystery deep in the muck of Lake Au, an offshoot of Lake Zurich: a bacterium that naturally produced a component of gasoline called toluene. Now, researchers have discovered how some bacteria manage to make the toxic hydrocarbon. Why they do so remains a puzzle, however.
"This is a really nice piece of science," says Alfred Spormann, a chemical engineer at Stanford University who was not involved in the work.
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Automation Engineer
GlaxoSmithKline Pharmaceuticals
US – PA – King of Prussia
Post-doctoral Research Opportunity in Microfluidic Body-on-a-Chip Systems
University of Maryland / NIST CNST Cooperative Agreement
US – MD – Gaithersburg
Staff Scientist Core Managers for the Viral Vector (Neurobiology Laboratory) and the Cryo-electron M
National Institute of Environmental Health Sciences/NIH
US – NC – Research Triangle Park
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