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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit March 29, 2017

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SLAS Discovery Special Collection on Cancer Metabolism
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Four original papers in the April issue from researchers in China, Japan, Spain and the United States focus on recent advances in metabolic assay development, patient tumor metabolomics and the identification of novel inhibitors.

Guest Editor Raymond Gilmour, Ph.D., of Eli Lilly and Company says, "With new tools and technologies in place, cancer metabolism has become an area of renewed focus for both basic research and drug discovery efforts. The ability to link genetics with metabolomics and integrate in vivo biomarker assays offers the opportunity to target cancer metabolism in the era of personalized medicine."
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From the SLAS President: How to Use SLAS to Find People Who Can Help You
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"The life sciences field is incredibly dynamic and for most in the SLAS community it is often difficult to stay current with topics of interest," says SLAS President Scott Atkin in the SLAS Electronic Laboratory Neighborhood e-zine.

"When you want help or information or just somebody who'll toss around ideas with you, one of your most valuable resources can be SLAS. It's a point of pride and a practical fact — SLAS is a portal to thousands of knowledgeable, uniquely experienced and friendly professionals who value their connections to other SLAS members."
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New Technologies for Rapid Bacterial Identification and Antibiotic Resistance Profiling
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A review in the April 2017 issue of SLAS Technology by 2016 SLAS Innovation Award winner Shana O. Kelley of the University of Toronto summarizes recent progress in the development of new devices that can analyze bacterial pathogens and establish their drug resistance profiles.

Devices that use microfluidics and a variety of detection mechanisms are discussed, and their application to this important problem is explained. These devices represent an important alternative to existing methods, which primarily rely on bacterial culture and require two to seven days to reveal the drug susceptible of infectious bacteria. Learn more in a podcast with Kelley.
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Last Call: Abstracts Due April 1 for Two Special Issues of the SLAS Journals
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Submit your manuscript proposals (abstracts) for the opportunity to be published in one of these highly anticipated special issues of the official journals of SLAS.

Quantitative Imaging in Life Sciences and Biomedical Research (SLAS Technology)
Guest Editors: Anand D. Jeyasekharan of National University of Singapore and Jonathan E. Cechetto of PerkinElmer

Statistical Applications in Knowledge and Drug Discovery (SLAS Discovery)
Guest Editors: Robert Nadon of McGill University and Paul Kayne of Bristol-Myers Squibb

SLAS Discovery and SLAS Technology are hallmarks of editorial excellence, popular with readers and highly cited.
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2017 Art of Science Contest: Enter by April 21 to Win a $500 Amazon Gift Card
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This annual contest celebrates how visualization plays an important role in the analysis and presentation of scientific work. In journal articles, images often communicate ideas and information in ways that text, tables, charts, graphs or equations cannot. Scientific images often surpass this purpose with shapes, patterns and designs that capture attention and imagination.

These are the images SLAS Discovery and SLAS Technology seek for the 2017 Art of Science Contest. Pictured here is 2016 finalist Haijiang_Zhang's image of crystals made through a microfluidic process from materials including alginate, calcium, iron and triazole.
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Free Presentation: Case-Study in Consortium-Based Drug Discovery — Allosteric Inhibition of the AAA ATPase p97
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This presentation by Michelle Arkin (University of California, San Francisco) is one of seven carefully selected scientific presentations from SLAS2017 that were recorded and are now available as on-demand webinars free-of-charge to SLAS members always and to non-members through the end of April.

Arkin demonstrates the value of new technologies for comprehensive and complete cellular analysis, providing examples of how deep knowledge about immune responses can be attained in HIV vaccine settings, immunotherapy and fundamental immunology. She highlights her lab's work developing 30 parameter flow cytometry, single cell RNA sequencing and new bioinformatic tools and shows how microfluidics and nanotechnologies can fit into the pipeline. The opening keynote and 2017 SLAS Innovation Award winning presentations are included in the seven selections.
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Debilities of Aging Reversed by Protein That Targets Senescent Cells
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Relieved of the burden of senescent cells, we may enjoy extended healthspans — or even lifespans. This notion was put to the test by a team of scientists based at Erasmus University Medical Center. They selectively eliminated senescent cells in aging mice, which responded by showing a reversal of age-related loss of fur, poor kidney function and frailty. When cells become damaged, they resort to senescence — cell cycle arrest — to avoid contributing to the proliferation of flawed cells, which can give rise to diseases such as cancer. More


Decasilahexahydrotriquinacene and Decasilaisotwistane: σ Conjugation on a Bowl Surface
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first bowl-shaped oligosilane, hexadecamethyldecasilahexahydrotriquinacene, and a related oligosilane, hexadecamethyldecasilaisotwistane, were synthesized, and their structures and properties were studied. The results revealed importance of σ conjugation on a bowl surface: the HOMOs of 1 are σ orbitals delocalized on the bowl surface, whereas the LUMO is a pseudo π* orbital on the convex and concave sides of the bowl surface. More




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Drug Development: Subtle Steric Differences Reveal a Model for Ni Cross-Coupling Success
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A new strategy for ligand design may enable challenging metal-catalyzed cross couplings reactions that are indispensable to drug development, according to a study published in Nature Chemistry. Based on subtle differences between ligand parameters, Princeton researchers have developed a predictive model for the success of a novel Ni-catalyzed cross-coupling reaction. The widespread adoption of Pd-catalyzed cross-couplings has been driven in large part by the extensive development of ligands, supporting molecules attached to the Pd center. More


Laser Activated Gold Pyramids Could Deliver Drugs, DNA Into Cells Without Harm
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The ability to deliver cargo like drugs or DNA into cells is essential for biological research and disease therapy but cell membranes are very good at defending their territory. Researchers have developed various methods to trick or force open the cell membrane but these methods are limited in the type of cargo they can deliver and aren't particularly efficient. Now, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences have developed a new method using gold microstructures to deliver a variety of molecules into cells with high efficiency and no lasting damage. More


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New Study Finds That Most Cancer Mutations are Due to Random DNA Copying 'Mistakes'
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Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying "mistakes" account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world. "It is well-known that we must avoid environmental factors such as smoking to decrease our risk of getting cancer. But it is not as well-known that each time a normal cell divides and copies its DNA to produce two new cells, it makes multiple mistakes," says Cristian Tomasetti, PhD. More


New Twist on an Old Method Sorts Neurons From Preserved Brain Tissue
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Researchers who study the brain routinely preserve tissue from their patients in brain banks all over the world for future analysis. However, tissue samples that have been fixed with preservatives and then frozen are difficult to analyze with powerful cell-sorting techniques such as flow cytometry. Now, scientists have developed new methods to overcome these previous limitations. So far these new methods have only been validated for brain tissue, but they could also be applied to other tissue types that have been fixed, frozen, and need to be analyzed, the developers say. More




Chemists ID Catalytic 'Key' for Converting CO2 to Methanol
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Capturing carbon dioxide (CO2) and converting it to useful chemicals such as methanol could reduce both pollution and our dependence on petroleum products. So scientists are intensely interested in the catalysts that facilitate such chemical conversions. Like molecular dealmakers, catalysts bring the reacting chemicals together in a way that makes it easier for them to break and rearrange their chemical bonds. Understanding details of these molecular interactions could point to strategies to improve the catalysts for more energy-efficient reactions. More


Qualities Tied to Potential Scientific Bias
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Looking for patterns of potential bias in scientific studies, a Stanford University–based research team found a number of risk factors. Among more than 3,000 meta-analyses, small studies that were highly cited were more likely to contain bias, as were studies authored by scientists with a history of misconduct or by small but global research teams. On the other hand, the study, published in PNAS, found no association between bias and the authors' country of origin giving incentives to individuals for performance, refuting the idea of a "publish or perish" environment. More


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