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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 02, 2014

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SLAS Webinar April 15: Protein-Protein Interactions as an Anticancer Strategy
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The emergence and convergence of cancer genomics, targeted therapies and network oncology have significantly expanded the landscape of protein-protein interaction (PPI) networks in cancer for therapeutic discovery. On April 15, innovator Haian Fu, Ph.D., of the Emory University Chemical Biology Discovery Center will present a webinar overview of the current status of PPI interrogation in cancer and highlight some widely employed high-throughput screening technologies for monitoring PPIs.

Read more about the Spring 2014 SLAS Webinar Series, Protein-Protein Interactions as Small Molecule Drug Targets, in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS2015 Call for Abstracts Now Open
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Please consider submitting a podium or poster abstract for consideration toward the SLAS2015 scientific program at the Fourth Annual SLAS Conference and Exhibition, taking place next Feb. 7-11 in Washington, D.C.

See key dates, requirements, track descriptions, general instructions, a sample abstract and an abstract submission on the SLAS2015 website.

Scientific podium abstract submissions are due July 28, 2014. Poster abstracts are due October 13 (Student Poster Competition deadline) or January 26, 2015 (final submission deadline).
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April JALA Podcast: LCAT DNA Shearing
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JALA Podcast Editor David Pechter speaks with JALA authors Yuka Okabe and Abraham P. Lee about an easy-to-use, low-cost, low-energy way to fragment DNA: lateral cavity acoustic transducers (LCATs) in a microfluidic device.

The LCATs cause microstreaming, which fragments DNA within the solution without any need for purification or downstream processing.

The original report is published in JALA April 2014, now available to SLAS LAS members and JALA subscribers.
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SLAS ELN Reports: Sample Management — Are You Paying Attention to All the Variables?
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"Advances in precision medicine, outcomes management and genetic classification require high quality biospecimens, yet standard procedures for collecting, storing and handling such samples are lacking," says Katheryn Shea, vice president of Bioservices at Precision Bioservices in Frederick, MD, and immediate past president of the International Society for Biological and Environmental Repositories, an SLAS strategic alliance partner. "Inconsistency in these processes can lead to inconsistent, irreproducible results," she warns.

Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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New JBS Special Issue Call for Papers: Screening by RNAi and Precise Genome Editing Technologies
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Guest Editors Marc Bickle, Hakim Djaballah and Lorenz M. Mayr request manuscript proposals (abstracts) by September 1, 2014 for this 2015 special issue. Topics of interest include all aspects of commercially available RNAi libraries and related platforms, process development and validation for RNAi screening, screening data analysis and bioinformatics filtering, use of genome editing tools for hit validation and phenotype confirmation in multiple cell models, and target validation for drug discovery. Additional JALA and JBS special issue publishing opportunities are noted on the SLAS website. More

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Laurie Garrett Calls for Increased Response on Global Health Problems
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In a recent BBC interview video, SLAS2015 keynote presenter Laurie Garrett expresses her concerns that global health institutions and governments are not taking threats seriously enough.

"The things that I personally deal with the most and that cause me the greatest concern are issues related to the possibility of a pandemic, either manmade or natural. I think we're at a point now where we have to rethink what is a government, and what is global governance."

Garrett, journalist and global health authority, speaks at SLAS2015, Feb. 7-11, Washington, DC.
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Erasing a Genetic Mutation
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Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation. The findings, described in the March 30 issue of Nature Biotechnology, offer the first evidence that this gene-editing technique, known as CRISPR, can reverse disease symptoms in living animals. More

Radical Method Uses Cells to Fight Brain Tumors
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The American Brain Tumor Association says this year nearly 70,000 people in the United States will be diagnosed with tumors that form in blood vessels, cranial nerves, lymphatic tissue and other parts of the brain. Of those, nearly 12,000 people will be diagnosed with a particularly deadly form of brain cancer called glioblastoma multiforme. More

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Zapping Rocks on Mars
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"It's been a good year on Mars," said Roger C. Wiens, speaking at a symposium at Pittcon, held in Chicago. Wiens, a scientist at Los Alamos National Laboratory, is principal investigator for ChemCam, an instrument on the Curiosity rover, the latest vehicle to explore the surface of Earth's next-door neighbor. During the past 18 months, ChemCam has acquired more than 120,000 spectra, which are helping to elucidate the geologic history of Mars. More

Researchers Discover Ancient Virus DNA Remnants Necessary for Pluripotency in Humans
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A team of Canadian and Singaporean researchers has discovered that remnants of ancient viral DNA in human DNA must be present for pluripotency to occur in human stem cells. In their paper published in the journal Nature Structural and Molecular Biology, the team describes how they disabled a viral remnant in stem cell samples and discovered that doing so prevented the stem cell from being able to grow into all but one type of human cell. More


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Deja Vu All Over Again for Stem Cell Research
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We said it had a distinctly "too good to be true" feel about it. Now research describing a simple way of producing embryonic-like stem cells is being investigated over "inconsistencies." It is too soon to say whether two papers reporting the results will have to be retracted. But for stem cell research there is a sense of déjà vu. This is far from the first time that promising results have fallen under a cloud of suspicion. More

Researchers Engineer Resistance to Ionic Liquids in Biofuel Microbes
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Researchers with the U.S. Department of Energy's Joint BioEnergy Institute, a multi-institutional partnership led by Berkeley Lab, have identified the genetic origins of a microbial resistance to ionic liquids and successfully introduced this resistance into astrain of E. coli bacteria for the production of advanced biofuels. The ionic liquid resistance is based on a pair of genes discovered in a bacterium native to a tropical rainforest in Puerto Rico. More



Proton Clouds to Measure Long-Range Contacts between Nonexchangeable Side Chain Protons in Solid-State NMR
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
We show that selective labeling of proteins with protonated amino acids embedded in a perdeuterated matrix, dubbed "proton clouds," provides general access to long-range contacts between nonexchangeable side chain protons in proton-detected solid-state NMR, which is important to study protein tertiary structure. More

New Research Shows Promise in Blood Cancer Treatment
By Rosemary Sparacio    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Blood cancers pose many challenges for healthcare professionals engaged in clinical research, patient care and treatment. Several new approaches published recently show promise for the future in this field of medicine. One approach for treating leukemia, discovered by a team in Montreal, disarms a gene that is responsible for tumor progression. By targeting the gene, known as Brg1, in leukemia stem cells, researchers think this may offer new therapeutic opportunities by preventing the disease from coming back. Several new drugs are also on the horizon. More

Evaluation of 3D Printing and Its Potential Impact on Biotechnology and the Chemical Sciences
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Nearing 30 years since its introduction, 3D printing technology is set to revolutionize research and teaching laboratories. This feature encompasses the history of 3D printing, reviews various printing methods, and presents current applications. The authors offer an appraisal of the future direction and impact this technology will have on laboratory settings as 3D printers become more accessible. More


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