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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit Apr. 3, 2013

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SLAS Electronic Laboratory Neighborhood e-zine: Managing Collaborative Science for Improved Patient Care
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Spring 2013 SLAS Webinar Series presenters discuss working effectively in emerging markets, with contract research organizations and for transferring biological assays in the latest feature article in the SLAS Electronic Laboratory Neighborhood e-zine. Ajay Gautam of AstraZeneca, Jonathan Connick of Merck and Liming Shi of Eli Lilly help readers learn to formulate strategy, employ best practices and establish successful long-term collaborations. The three-part webinar series, "Effectively Managing Collaborative Science," upcoming live webinars will be held April 17 and May 15. The first webinar in the series from March is available on demand. More

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SLAS2014 keynote speaker on The Colbert Report
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Eric J. Topol, M.D., appeared on The Colbert Report to talk about his book, The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care. Topol succeeded in describing for the popular comedian's audience how new tools support a doctor's efforts. More

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JBS Online features new manuscripts ahead-of-print
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"Development of a Novel β-Secretase Binding Assay Using the AlphaScreen Platform," "A Generic, Whole-Cell–Based Screening Method for Baeyer-Villiger Monooxygenases" and "Discovering New Medicines Targeting Helicases: Challenges and Recent Progress" are among the new manuscripts available only to SLAS Biomolecular Sciences Section members ahead-of-print. More


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JALA scientific advisor named AACR inaugural fellow
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Leroy E. Hood, M.D., Ph.D., president and co-founder of the Institute for Systems Biology, is among an elite group announced as the first class of fellows of the American Association for Cancer Research Academy. According to the March 25 news release, "The AACR Academy has been created to recognize and honor distinguished scientists whose major scientific contributions have propelled significant innovation and progress against cancer. These Fellows have been selected through a rigorous peer review process that evaluates individuals on the basis of their stellar scientific achievements in cancer research." Earlier this year, Hood received a National Medal of Science from President Barack Obama for his pioneering work in the systems approach to biology and medicine. More

2013 SLAS Asia Conference and Exhibition session spotlight: Drug Discovery Science; early-bird registration rates end April 9
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Danyi Wen, M.D., M.B.A., Shanghai ChemPartner and Xiaoming Guan, Ph.D., GlaxoSmithKline (China) R&D, are the co-chairs for this session, which will address: "Novel Human Ig Transgenic Mouse Technology for the Development of Fully Human Therapeutic Antibodies," "Non-human Primates as an Animal Model in Drug Discovery," "The Road from Discovery to Clinic: A Story of Horizant" and "Innovative and Practical Approaches to New Drug Discovery at Hansoh Pharmaceutical." Register by Tuesday, April 9, and save! More


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Biomarkers for autism discovered
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An important step towards developing a rapid, inexpensive diagnostic method for autism has been taken by Uppsala University, among other universities. Through advanced mass spectrometry the researchers managed to capture promising biomarkers from a tiny blood sample. The study has just been published in the journal Nature Translational Psychiatry. More

Medical science may be answer to budget woes
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"Sequestration" has forced the National Institutes of Health — the leading funder of biomedical research — to halt or cut funding to thousands of potentially groundbreaking research projects. On the 10th Anniversary of the completion of the Human Genome Project, we can't let the ongoing tug-of-war in Congress over spending priorities threaten the revolutionary work that is taking place in medical science," says JALA Scientific Advisor Leroy E. Hood, M.D., Ph.D., in The Hill's Congress Blog. More

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Crystal-free crystallography
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Crystals are the preferred material chemists use to determine molecular structure via X-ray crystallography. But when scientists can't crystallize a substance, or not enough exists to get good crystals, they face a roadblock. Now, researchers have found a way to solve this problem using nanoscale scaffolds to capture the molecules they want to visualize. More

Researchers find surprising similarities between genetic and computer codes
Brookhaven National Laboratory    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The term "survival of the fittest" refers to natural selection in biological systems, but Darwin's theory may apply more broadly than that. New research from the U.S. Department of Energy's Brookhaven National Laboratory shows that this evolutionary theory also applies to technological systems. More



Best practices to optimize your cell-based assays
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Cell-based assays are routinely performed throughout the drug discovery process. However, there are issues that need to be overcome, including the edge effect, where cells in wells on the edge of an assay plate behave differently from those in the center. More

Crucial step in human DNA replication observed for first time
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For the first time, an elusive step in the process of human DNA replication has been demystified by scientists at Penn State University. According to senior author Stephen J. Benkovic, an Evan Pugh Professor of Chemistry and Holder of the Eberly Family Chair in Chemistry at Penn State, the scientists "discovered how a key step in human DNA replication is performed." More

Short Guide to 3-D Cell Culture
AMSBIO     Share    Share on FacebookTwitterShare on LinkedinE-mail article
AMSBIO has released a guide to assist research scientists looking to culture cells in more physiologically relevant environments. Traditional monolayer cell culture on plastic dishes or in flasks rarely recreates the conditions cells experience in vivo. This guide provides background information describing a 3-D cell culture and why researchers are increasingly switching to it. Many types of 3-D cell culture matrices for spheroid, organotypic and directional cultures are described in addition to natural hydrogels, scaffold-free cell culturing, artificial scaffolds and synthetic biomimetics. More


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Selective inhibition of extracellular thioredoxin by asymmetric disulfides
Journal of Medicinal Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Whereas the role of mammalian thioredoxin as an intracellular protein cofactor is widely appreciated, its function in the extracellular environment is not well-understood. Only few extracellular targets of Trx-mediated thiol–disulfide exchange are known. For example, Trx activates extracellular transglutaminase 2 via reduction of an intramolecular disulfide bond. More

SCOTUS weighs pay-for-delay
eBio News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The U.S. Supreme Court recently heard arguments in a case that could put an end to so-called pay-for-delay settlements between branded pharmaceutical makers and their generic competitors. Critics of these agreements argue that they are anticompetitive, costing consumers billions of dollars by delaying competition from entering the market. More

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Italy pushes on with controversial stem cell therapy
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Italian health officials are allowing a handful of patients to continue with a controversial stem cell therapy amid protests from scientists that the treatments are unproven and unsafe. The Stamina Foundation has been administering the therapy at a public hospital to people with a range of degenerative diseases. Their approach is based on mesenchymal stem cells, derived from bone marrow, which can become mature bone and connective tissue. More

Reaction pathways for Maillard degradation of vitamin C
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Vitamin C is found in many foods, and, among other things, is used to prolong shelf life. However, it is not stable in air or at room temperature. Cut fruits turn brown and the tastes of foods change. In the journal Angewandte Chemie, German researchers have now presented a systematic study of the processes that occur during the degradation of vitamin C. More

X-ray free electron lasers motivate bioanalytical characterization of protein nanocrystals: Serial femtosecond crystallography
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Atomic resolution structures of large biomacromolecular complexes can now be recorded at room temperature from crystals with submicrometer dimensions using intense femtosecond pulses delivered by the world's largest and most powerful X-ray machine, a laser called the Linac Coherent Light Source. More


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Science Director, Clinical Biomarkers
CHDI Foundation/CHDI Management
USA – NJ – Princeton

QC Senior Scientist – Commercial
Genentech
USA – CA – South San Francisco

Technical Sales Specialist
Ziath
United Kingdom – Cambridge

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