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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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For supporting the unique requirements of bio molecular lab systems, UNIConnect delivers what others can’t.
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13 of 20 top pharma/biotech companies have chosen Titian’s modular Mosaic™ software to control their sample storage/preparation. Find out why.
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JALA is a multi-disciplinary international forum devoted to the advancement of technology in the laboratory.
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Boost your career or find the perfect candidate. SLAS Career Connections offers both online and in-person career services.
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2012 SLAS Asia Conference poster submissions due June 4
SLAS Share
  
Abstracts on innovative techniques and technologies for possible poster presentation at the 2012 SLAS Asia Conference, June 19-21, Shanghai, China, are due by June 4, 2012 (May 21 to be included in final program). The conference theme is "Advances in Drug and Life Sciences R&D Through Laboratory Technology." Save with early-bird registration until April 23.
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SLAS2013 keynote speaker publishes again
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Mehmet Toner, Harvard Medical School and Massachusetts General Hospital, has a new manuscript in Physics of Fluids. "Inertial focusing dynamics in spiral microchannels," with co-author Joseph M. Martel, details a comprehensive study of inertial focusing dynamics and particle behavior in low aspect ratio (h/w ∼ 1/1 to 1/8) spiral microchannels.
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Build the SLAS community
SLAS Share
  
Share information about promotions or job changes in the SLAS Electronic Laboratory Neighborhood People Changing Places section. Send your information today to lvalastyan@slas.org.
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New SLAS ELN feature explores expanding role of biomarkers
SLAS Share
  
Leading minds in drug discovery and development recognize that strategic collaboration means more effective outcomes. Read the latest feature in the SLAS Electronic Laboratory Neighborhood.
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Starfruit Software/Database Service - LTS per Study. You can control who to use a sample. Visit Store – Starfruit Library to see "Starfruit Sample Locator BIMS"
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Pittcon, the world’s largest annual conference and expo for laboratory science, March 17 – 21, 2013, Philadelphia, PA. Pittcon offers innovations from nearly 900 exhibitors, unique networking events, exceptional educational opportunities. Visit www.pittcon.org for more information!
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JALA April released
SLAS Share
  
Original reports include "SiLA: Basic Standards for Rapid Integration in Laboratory Automation," "A Practical Method for Patterning Lumens through ECM Hydrogels via Viscous Finger Patterning" and "A Low-Cost Automated Streaming Potential Measurement System."
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New book compiled by SLAS members
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SLAS members Mark Wigglesworth, GlaxoSmithKline and Terry Wood, formerly of Pfizer R&D, are editors of the recently released Management of Chemical and Biological Samples for Screening Applications, which is now featured in the SLAS ELN as the LabAutopedia Book of the Month. SLAS members contribute throughout the book's 19 chapters, beginning with the introduction written by SLAS members William P. Janzen, University of North Carolina, and Andy Zaayenga, HighRes Biosolutions.
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Chemistry's web of data expands
Nature Share
  
Other areas of science feast on free online data, but chemistry has been late to the party. Now it is catching up. In the latest effort to provide free access to chemical information, the London-based company SureChem (owned by Digital Science, a sister company to Nature Publishing Group) said that it would release data on 10 million molecules patented by the pharmaceutical industry since 1976.
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Poster: Technology implementation for analysis of inhaled products
Astech Projects Ltd. Share
  
SLAS 2012 exhibitor Astech Projects Ltd. released a poster detailing how bespoke analytical technology platforms in support of Dry Powder Inhaler testing have been implemented within the GlaxoSmithKline inhaled testing laboratories using a Quality by Design approach. In comparison to the manual procedures previously employed, Astech reports that the newly developed platforms increase throughput by substantially reducing the time taken to perform 100 samples and minimize analytical variability.
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The Nexar® System optimized for Homogeneous ELISA processing is fully automated and modular. The system includes inline random access sample storage, liquid handling, incubation, and detection (< 3 minutes/384 array). Achieve high throughput processing, miniaturized reaction volumes in Array Tape™ and true walk-away operation. Contact Douglas Scientific today! MORE
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The MaxCyte® VLX™ Large Scale Transfection System is specifically designed for extremely large volume transfection and is able to transfect up to 2E11 cells in less than 30 minutes with high cell viability and transfection efficiencies. This system is ideal for rapid, gram scale production of proteins and monoclonal antibodies.
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ALPAQUA® offers 24-well, 96-well & 384-well magnet plates with integrated spring technology for touch-off dispensing and complete supernatant removal while eliminating costly tip crashes and occlusions. Strong NdFeB magnets enable rapid, reliable bead capture and retention. Alpaqua magnet plates are SBS compliant and compatible with many liquid handlers, plate hotels & stackers.
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Reliable method for characterizing polyfluorinated compounds
Exeter Analytical Share
  
Exeter Analytical has developed a reliable analytical method for accurately determining the percentage carbon, hydrogen and nitrogen content of polyfluorinated compounds (PFCs). PFCs are thermally and chemically stable and have soil, water and fat-repellent properties. A copy of application note 217 detailing the method is available from the company.
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Orientation-independent charge transport in single spherulites from solution-processed organic semiconductors
Journal of the American Chemical Society Share
  
Due to the rapidity of morphological development during deposition, solution-processed organic semiconductor thin films exist in semicrystalline or polycrystalline states, incorporating a high degree of local variations in molecular orientation compared to their single-crystal counterparts. Spherulites, a common crystalline superstructure found in these systems, for example, incorporate a large distribution of molecular orientations about the radial axis to maintain their space-filling growth habit.
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Whole-genome sequencing of healthy individuals provides limited risk prediction for common diseases
GenomeWeb Share
  
Whole-genome sequencing of healthy individuals will likely only provide limited information about the risk of developing common diseases, and will not become a substitute for traditional medicine, according to a new study published in Science Translational Medicine. Researchers from Johns Hopkins University developed an algorithm to assess the ability of whole-genome sequencing of healthy individuals to provide clinically relevant information on 24 common diseases.
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Chemists for hire
Chemical & Engineering News Share
  
As of March 1, 4.6 percent of American Chemical Society members were unemployed, the highest level recorded since ACS began tracking employment in 1972, according to the society's Membership & Scientific Advancement Division. What's more, unemployment for ACS member chemists in 2011 climbed from 3.8 percent in 2010, whereas overall unemployment in the U.S. fell from 9.7 percent in 2010 to 8.8 percent in 2011, according to the U.S. Bureau of Labor Statistics.
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In only 8 minutes, TTP Labtech’s acumen eX3 screens:
• Whole wells at 20x
• 96-3456 well plates
• 4 fluorescent colours
• AND gives your results immediately!
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Whether your lab is manual, semi-automated or fully automated, FlexLink has flexible conveyor systems and solutions that fit perfectly where space is limited and close machine interface is required.
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Researcher finds connections between math, molecules and materials
PhysOrg Share
  
If anyone were going to discover the connections between molecular structures, mathematical concepts and musical scores, it's not surprising that Markus Buehler would be the one. He has built his career on bridging the connections between disparate disciplines, asking simple questions as an approach to understanding the world. Buehler grew up around engineering.
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Commonly used diabetes drug may help to prevent primary liver cancer
eBio News Share
  
Metformin, a drug widely used to treat Type II diabetes, may help to prevent primary liver cancer, researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer Center report in the April 2012 issue of Cancer Prevention Research. Primary liver cancer, or hepatocellular carcinoma, is an often-deadly form of cancer that is on the rise worldwide and is the fastest-growing cause of cancer-related deaths among American men.
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Cancer stem cell vaccine in development shows antitumor effect
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Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. "This is a major breakthrough in immunotherapy research because we were able to use purified cancer stem cells to generate a vaccine, which strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells," said Qiao Li, Ph.D.
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Search for new analgesics worth the pain given side effects of opioids
Genetic Engineering & Biotechnology News Share
  
A hundred years have passed "without having really a major new pain drug," according to Thomas Schnitzer, M.D., Ph.D., a professor of medicine at Northwestern University. Dr. Schnitzer made those comments to Nature Biotechnology in commenting on FDA's December 2010 decision to place a hold on most clinical trials involving therapies targeting nerve growth factor.
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A nanomechanical mass sensor with yoctogram resolution
Nature Nanotechnology Share
  
Nanomechanical resonators have been used to weigh cells, biomolecules and gas molecules, and to study basic phenomena in surface science, such as phase transitions and diffusion. These experiments all rely on the ability of nanomechanical mass sensors to resolve small masses. Here, we report mass sensing experiments with a resolution of 1.7 yg (1 yg = 10−24 g), which corresponds to the mass of one proton.
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Antibiotics may make you fat
New Scientist Share
  
The trillions of bacteria that colonize our guts are in jeopardy. Overusing antibiotics has not only led to the development of dangerous superbugs, but has changed the bacteria that live inside us. Now evidence suggests that new gut floras may be responsible for our expanding waistlines. Antibiotic use has been rising for the past 70 years. They are now often prescribed as a precaution for illnesses when the cause has not been confirmed as a bacterial infection.
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Major taste loss in carnivorous mammals
National Academy of Sciences Share
  
Mammalian sweet taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act as the principal umami taste receptor. Bitter taste is mediated by a different group of G protein-coupled receptors, the Tas2rs, numbering 3 to ∼66, depending on the species. We showed previously that the behavioral indifference of cats toward sweet-tasting compounds can be explained by the pseudogenization of the Tas1r2 gene, which encodes the Tas1r2 receptor.
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Effective use of mass spectrometry for glycan and glycopeptide structural analysis
Analytical Chemistry Share
  
Most proteins are glycosylated. Mass spectrometry methods are used for mapping glycoprotein glycosylation and detailed glycan structural determination. This technology enables precise characterization of recombinant glycoproteins in the pharmaceutical industry and academic biomedicine.
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Scientists: Humans used fire 1 million years ago
Live Science Share
  
Ash and charred bone, the earliest known evidence of controlled use of fire, reveal that human ancestors may have used fire a million years ago, a discovery that researchers say will shed light on this major turning point in human evolution. Scientists analyzed material from Wonderwerk Cave in South Africa, a massive cavern located near the edge of the Kalahari Desert. Previous excavations there had uncovered an extensive record of human occupation.
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Agilent Technologies’ RapidFire is an SPE-based solution that enables detection of native compounds by mass spec. Requiring no labels or surrogates, it enables the screening of intractable or challenging targets which are not amenable to fluorescence or luminescence. Sample throughput is 10x faster than conventional MS screening methods. MORE
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How do you like straightforward integration and adaptation of systems at lower costs?
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Labcyte has introduced a new consumables website designed to be a one stop solution for Labcyte® consumables, from product research to purchase and fulfillment. The new website will allow you to:
• Review product specifications
• Request product samples
• Order consumables (US currently, EU soon)
Visit microplates.labcyte.com for the latest product information.
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Focused on Outsourced Materials Management and Sample Preparation Services, FSSI supports Compound Management, Research and Discovery Screening, and Chemistry. FSSI performs Sample Reformatting and Full Repository Services with on-demand 24-48 hour delivery. FSSI offers diversity screening libraries, pre-weighed building blocks in custom aliquots, full preparative purification, and high-throughput analysis.
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EasyHandling makes Mechatronics easier and faster than ever, with high-performance mechanical technologies and our new EasyWizard programming tool. Cut engineering time, effort & cost by up to 80%. EasyHandling is perfect for Lab applications—ranging from test tube pick-and-place and medical product packaging to hands-off inspection of hazardous materials.
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Astech Projects launch new turnkey approach to automation at SLAS! Composed of four key steps – consultation & proposal, concept design study, proof of concept, and detailed design, manufacture and testing – Astech currently offers the initial consultation & proposal free of charge. Apply for yours today.
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