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SLAS
Conference news: Alexey Rak, Ph.D., of Sanofi (Paris), is one of 29 inspiring and innovative speakers to present their work at the inaugural 2018 SLAS Europe Conference and Exhibition, June 27-29 in Brussels, Belgium. Register today to learn how Rak integrates novel biophysical approaches in the early discovery pipeline and reveals how fragment-based lead discovery is an effective alternative to high-throughput screening to identify chemical matter that can be developed into robust lead compounds.
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SLAS
There's still time for life sciences discovery and technology start-up companies to earn the opportunity to exhibit in this special area of the 2018 SLAS Europe Exhibition, June 27-29. SLAS Europe Innovation AveNEW helps promising new companies grow their businesses by directly connecting them with decision-makers from across Europe. Selected applicants receive complimentary exhibit space and a travel grant.
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SLAS
SLAS Discovery Associate Editor Marc Bickle of the Max Planck Institute of Molecular Cell Biology and Genetics (Dresden, Germany) seeks original research papers, technical notes or reviews for a special issue that focuses on science in the context of academic screening and drug discovery endeavors. Plus, laboratories that publish papers in this issue will be described in an in-depth editorial.
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
SLAS Membership expands your access to the life sciences discovery and technology community. Join the accomplished researchers, scientists, engineers, innovators and entrepreneurs of SLAS who freely share their wisdom, experiences and best practices delivered through formal education and informal peer networking opportunities. Tangible benefits of SLAS Premier (dues-paying) Membership include:
- Print and online subscriptions to either SLAS Technology OR SLAS Discovery. (Become a Premier Plus member and receive both!)
- Registration discounts for SLAS conferences, events, products and services.
- Free access to SLAS Live Webinars (including SLAS2018 presentations, such as Keynote Speaker Benjamin Cravatt's "Activity-Based Proteomics — Protein and Ligand Discovery on a Global Scale").
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SLAS
Wonder who's sharing, discussing, rating, recommending, reviewing and reading published research? Discussion and use of research that was previously hidden (because it was conducted offline or in print) is now discoverable and reported via Altmetrics. Data-sourced from online discussions, Altmetrics complement citations in understanding the potential impact of published research. To benefit SLAS journal authors, Altmetrics are built into SLAS Discovery and SLAS Technology online functionality.
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SLAS
Mark your calendar and prepare an abstract of your work for consideration! The 2018 SLAS Europe Advanced 3D Human Models and High-Content Analysis Conference, Oct. 17-19 in Leiden, Netherlands, is accepting podium or poster abstracts for consideration. Podium abstract deadline: May 2. Poster abstracts due: Sept. 20.
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Chemical & Engineering News
Researchers have discovered a new class of potential antibiotics that work against methicillin-resistant Staphylococcus aureus and against so-called persisters, dormant bacteria associated with chronic infections. The team, led by Eleftherios Mylonakis of Brown University, Rhode Island Hospital, and Miriam Hospital, screened a library of small molecules to find ones that decrease MRSA's ability to kill Caenorhabditis elegans, a model organism.
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Analytical Chemistry
Dielectric spectroscopy is a noninvasive technique for real-time measurements of the impedance spectra of biological cells. DS enables characterization of cellular dielectric properties such as membrane capacitance and cytoplasmic conductivity. We have developed a lab-on-a-chip device that uses an electro-activated microwells array for capturing, DS measurements, and unloading of biological cells.
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Bioscience Technology
Gene therapy has shown promise in treating inherited genetic diseases, but a major issue that has frustrated scientists remains: Replacing a "bad" gene with a healthy one often is a short-lived fix. Typically, the healthy replacement gene works for just a few weeks. Now, scientists at Washington University School of Medicine in St. Louis have combined the gene-editing tool CRISPR with a deactivated virus to deliver a healthy gene to a precise location in the bodies of living mice.
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Journal of the American Chemical Society
We report on the theoretical prediction and experimental realization of new ternary zinc molybdenum nitride compounds. We used theory to identify previously unknown ternary compounds in the Zn–Mo–N systems, Zn3MoN4 and ZnMoN2, and to analyze their bonding environment. Experiments show that Zn–Mo–N alloys can form in broad composition range from Zn3MoN4 to ZnMoN2 in the wurtzite-derived structure, accommodating very large off-stoichiometry.
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Lab Services integrates and develops innovative systems to automate standardized processes in Laboratories. For this integration we are brand independent and use our own software, PlateButler! Together with our customers we will find the best solution possible, matching their application. We Simply Accomplish!
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Science Daily
Making a giant leap in the "tiny" field of nanoscience, a multi-institutional team of researchers is the first to create nanoscale particles composed of up to eight distinct elements generally known to be immiscible, or incapable of being mixed or blended together. The blending of multiple, unmixable elements into a unified, homogenous nanostructure, called a high entropy alloy nanoparticle, greatly expands the landscape of nanomaterials — and what we can do with them.
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Phys.org
Not only can synthetic molecules mimic the structures of their biological models, they can also take on their functions and may even successfully compete with them, as an artificial DNA sequence designed by Ludwig-Maximilians-Universitaet in Munich chemist Ivan Huc now shows.
Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems.
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Genetic Engineering & Biotechnology News
Scientists in Australia have solved a 50-year-old mystery that could lead to the development of new gene therapies for blood disorders such as sickle cell anemia and β-thalassemia. The team, led by University of New South Wales professor Merlin Crossley, Ph.D., has identified the gene-control mechanism that allows some individuals with these blood disorders to keep producing a fetal form of human hemoglobin.
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Lab Manager
Researchers have developed a process for creating ultrathin, self-assembling sheets of synthetic materials that can function like designer flypaper in selectively binding with viruses, bacteria, and other pathogens.
In this way the new platform, developed by a team led by scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory, could potentially be used to inactivate or detect pathogens.
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Senior Scientific Engineering Associate/Automation Engineer
Lawrence Berkeley National Laboratory
US – CA – Emeryville
Research Scientist Biochemistry
Altria
US – VA – Richmond
Automation Engineer
GlaxoSmithKline Pharmaceuticals
US – PA – King of Prussia
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