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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 5, 2017

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SLAS ELN Reports: Cancer Metabolism — It's a Brave New World
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Recent advances in metabolic assay development, patient tumor metabolomics and the identification of novel inhibitors paint a promising future for cancer metabolism research, says Raymond Gilmour, Ph.D. Gilmour, Eli Lilly and Company, is co-author of the editorial introduction to the April 2017 SLAS Discovery special collection on cancer metabolism. He offers further insight to the four featured papers in the SLAS Electronic Laboratory Neighborhood e-zine.

"There's still a lot to be understood within cancer metabolism and many opportunities to modulate cancer metabolism for therapeutic benefit," he says. "I think it's going to be an exciting field for the foreseeable future."
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SLAS Video: Learn More about the SLAS Technology Journal
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"There is no other journal out there like SLAS Technology," says Editor-in-Chief Edward Kai-Hua Chow, Ph.D., of National University of Singapore. "We fill a very important niche."

Chow talks about how SLAS Technology highlights emerging technologies, particularly for academic researchers seeking commercialization or early start-up companies looking to publish rigorous peer-reviewed manuscripts that demonstrate the importance of their technology and the important advancements that they've made in their respective fields.
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Whose Responsibility is Research Reproducibility? A Conversation Focused on Solutions
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"There is a tendency to point fingers when discussing reproducibility," says Lenny Teytelman of protocols.io and SLAS2017 Data Analysis and Informatics Track chair. In a report he posted about a special session on research reproducibility that he organized and moderated at SLAS2017, Teytelman adds that "Academics say that it's just a problem for pharmaceuticals. Industry blames sloppy academics. Journals and funders are often scapegoated as the ones who could wave a magic wand and solve it all. The reality is that it is everyone's problem and everyone has a responsibility and a role to play in improving reproducibility."

Read about highlights of the dynamic two-hour SLAS2017 panel discussion in Teytelman's post.
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SLAS Discovery: Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation
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Authors from Imperial College London and the Institute of Cancer Research (London) report a mobility shift assay (MSA) format that "does not employ radiolabeled substrates or require multiple liquid-handling steps and allows direct, real-time and automated measurement of 12 samples in parallel. Addition of nonfluorescent substrate peptide provides a generic means to achieve stopped-assay conditions for application to screening of larger sample numbers. Both kinetic and dose-response analysis can be rapidly performed through this method, thus expanding the applications of MSA as a powerful tool in the analysis of amine posttranslational modification."

The report is available to all readers free of charge.
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A Video Review of the Excitement and Community Spirit at SLAS2017
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Get ready for SLAS2018, Feb. 3-7 in San Diego, by watching this short recap of the SLAS2017 community in the Exhibition, scientific sessions, networking and celebratory night at the Newseum in Washington, DC. Maybe you will even see yourself in the video! Scroll to SLAS2017 Recap section of webpage to view video.

SLAS2017 drew 5,050 participants from 42 countries to Washington, DC.
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Two Weeks Left to Enter the 2017 Art of Science Contest
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Capture our attention with your stunning scientific lab imagery, and you may win a $500 Amazon gift card! Review the 2017 SLAS Discovery and SLAS Technology Art of Science Contest details, and submit before April 21.

Pictured here is 2016 finalist Jing Yan's image of a community of bacteria, Vibrio cholerae, the pathogen for cholera.
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Free Presentation: Precision Immunology Through Deeper, Single Cell Profiling
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Pratip Chattopadhya, Precision Medicine Incubator, Vaccine Research Center, National Institutes of Health, demonstrates the value of new technologies for comprehensive and complete cellular analysis and provides examples of how deep knowledge about immune responses can be attained. He uses examples from HIV vaccine settings, immunotherapy and fundamental immunology and highlights NIH work developing 30 parameter flow cytometry, single cell RNA sequencing and new bioinformatic tools including how microfluidics and nanotechnologies can fit into a pipeline that includes the above technologies.

This is one of seven carefully selected scientific presentations from SLAS2017 that were recorded and are now available as on-demand webinars free-of-charge to SLAS members always and to non-members through the end of April. Presentations by the opening keynote speaker and 2017 SLAS Innovation Award winner are included in the seven selections.
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New Method to 'Fingerprint' HIV Developed
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HIV is a master of disguise. The virus uses a shield of sugar molecules, called glycans, to hide from the immune system and block antibodies from attacking it. Now scientists at The Scripps Research Institute have developed a method to analyze the glycan shield on HIV's protective outer glycoprotein, developed as a potential HIV vaccine candidate. More


Evaluating Epigenome-Targeting Cancer Therapies
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Cancer is primarily a disease of aberrant cell identity, and cell identity is largely controlled by epigenetics. Thus, it's no surprise that "many cancers appear to be epigenetic diseases or have a very prominent epigenetic component," said Jean-Pierre Issa, director of the Fels Institute for Cancer Research & Molecular Biology at Temple University in Philadelphia. More




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The Carpenter Enzyme Gives DNA the Snip
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Microscopes that reveal the hidden complexities of life down to the nanoscale level have shown in exquisite detail how an enzyme involved in DNA repair works its molecular magic. This enzyme — known as Flap endonuclease 1, or FEN1 — is often highly overexpressed or faulty in cancer and other types of diseases. Now that researchers know how it operates, they plan to use the information to design an inhibitor against it. More


New Stem Cell Screening Platform Opens Door to Novel Ways to Treat Neuro Diseases
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Scientists at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause similar symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. More


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Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The deployment of nonaqueous redox flow batteries for grid-scale energy storage has been impeded by a lack of electrolytes that undergo redox events at as low (anolyte) or high (catholyte) potentials as possible while exhibiting the stability and cycling lifetimes necessary for a battery device. Herein, we report a new approach to electrolyte design that uses physical organic tools for the predictive targeting of electrolytes that possess this combination of properties. More


Chemists Get Better Acquainted With Palladium Catalysts
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A team of chemists from industry and academia has taken a step back from the normal hustle and bustle of synthesizing new molecules to investigate what happens to workhorse palladium catalysts when they go catalyzing. The traditional thinking has been that a precursor Pd(II) salt is reduced to a catalytically active Pd(0) species when a ligand is introduced. Yet chemists have never had a complete picture of this reduction mechanism. More




Researcher Creates Chemical System That Mimics Early Cell Behavior
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A Harvard researcher seeking a model for the earliest cells has created a system that self-assembles from a chemical soup into cell-like structures that grow, move in response to light, replicate when destroyed, and exhibit signs of rudimentary evolutionary selection. While the system, developed by senior research fellow Juan Pérez-Mercader, mimics what one might conceive of as early cell behavior, a major caveat is that its main component is a molecule not typically found in living things. More


Gold Standards for Nanoparticles
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Expanding the potential of gold nanoparticles for a range of uses requires methods to stabilize the clusters and control their size. Researchers at KAUST reveal how simple organic citrate ions, derived from readily available citric acid, can interact with the gold atoms to yield the stable nanoparticles needed for further research. Such clusters of gold atoms are proving increasingly useful as catalysts, drug delivery systems, anti-cancer agents and components of solar cells among other applications. More


Career


Director, Pritzker Institute of Biomedical Science and Engineering
Illinois Institute of Technology
US – IL – Chicago

Sr. Clinical Research Associate
Avanir Pharmaceuticals
US – CA – Aliso Viejo

Senior Technical Service Chemist/Engineer – Composites
Scott Bader
US – OH – Stow

Search Jobs at SLAS Career Connections


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