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April 12-13: SLAS Europe Compound Management in Industry and Academia Conference
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Focusing on technology, process, science and collaboration, this conference at the Wyndam Garden Berlin Mitte Hotel in Berlin, Germany, features case studies from leading industry professionals and academics. It is appropriate for all compound management and lead discovery professionals from bench scientists to senior leaders in the pharmaceutical, biotechnology and agri-science industries as well as from academic drug discovery.

The keynote presentation, "A Hit Discovery Strategy for 2020 and Beyond," will be delivered by Steve Rees, VP discovery sciences at AstraZeneca.
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SLAS ELN Reports: SLAS2016 Student Poster Winners — At the Top of the Science Class
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Information drawn from research into drug resistance mechanisms in breast cancer led Carrie Lovitt, Ph.D., to further explore the tumor microenvironment. Innovation helped Joohun Kang, Ph.D., take one successful platform and turn it into an award-winning adaptation. Inspiration guided Masturah Bte Mohd Abdul Rashid’s tireless pursuit for answers to fill the gap left in multidrug regimens for multiple myeloma.

Read more about these SLAS Student Poster Competition winners and their exciting work in the SLAS Electronic Laboratory Neighborhood e-zine.
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New and FREE at JBS: Characterization of Early Cortical Neural Network Development in Multiwell Microelectrode Array Plates
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A collaborative team from the University of Cambridge (U.K.) and U.S. Environmental Protection Agency describe the early development of neural networks grown in 48-well mwMEA (multiwell microelectrode array) plates, finding that it is qualitatively equivalent to the development of network activity in single-well MEAs.

Furthermore, the research shows that multiparametric evaluation of the network activity parameters provide an accurate method of classifying networks by age and indicate that neural networks cultured on mwMEAs will be a useful tool to study the ontogeny of network activity, as well as the potential for drugs, chemicals and diseases to disrupt that activity. This is a SAGE Choice article, allowing all readers immediate free access to the full manuscript.
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SLAS Community Video: Where Science and Technology Unite
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Enjoy the unique spirit and enthusiasm of SLAS members in this upbeat two-minute video.

"It really illustrates the core values of the SLAS family," says SLAS CEO Gregory F. Dummer. "It does a great job of expressing who we are, what we do and how we do it."

Share it with your co-workers and colleagues!
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JBS Special Issue Call for Papers: 3D Cell Culture, Drug Screening and Optimization
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Guest Editors Richard Eglen, Ph.D., of Corning Life Sciences and Jean-Louis Klein, Ph.D., of GlaxoSmithKline, invite proposals (abstracts) of original, high-quality research and review papers by June 1, 2016. Areas of interest include comparative gene expression, protein function and physiology of immortalized and primary cells in 2D vs. 3D cell culture; optimizing matrices and scaffolds for 3D culture and screening; use of 3D cell culture in phenotypic screening, and comparison with 2D approaches; and organ-on-a-chip microfluidic technologies to evaluate drug toxicity and metabolic liability.

JALA also is accepting manuscript proposals for two additional special issues:
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On-Demand at SLAS.org: Identifying Druggable Cells — Automated Methods for High-Content Single-Cell Screening
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In her SLAS2016 Informatics Track presentation, Tiffany Chen, Cytobank, Inc. and Stanford University, USA, describes an automated pipeline leveraging robotics, as well as algorithmic and machine learning methods to process and computationally identify cancer cell subsets in response to therapeutic perturbations. Chen discusses initial applications of this workflow to cells treated with 89 therapeutics currently approved for cancer therapy, creating a new landscape for classification of cancer therapeutics, from canonical checkpoint to kinase inhibitors. In addition, she highlights newer applications of the pipeline to high-content mass cytometry analysis, as well as extensions of machine learning methods for identification of rare and differential cell subsets.

This presentation is one of seven recorded at SLAS2016 for convenient, on-demand viewing by SLAS dues-paid members.
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New Tools Allow Rapid ID of CRISPR-Cas System PAMs
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CRISPR-Cas systems are widely heralded as a new generation of genetic tools. But development of these tools requires researchers to identify the protospacer-adjacent motifs (PAMs) that unlock each system's functionality. A new set of techniques expedites PAM identification — and early testing finds that many CRISPR-Cas systems actually have multiple PAMs of varying strength. More


Researchers Use Sunlight to Produce Chemicals and Energy
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Researchers at the University of Copenhagen have discovered a natural process they describe as "reverse photosynthesis," by which the energy in solar rays breaks down plant biomass rather than building it, as is the case with photosynthesis. The sunlight is collected by chlorophyll, the same molecule used in photosynthesis. Combined with a specific enzyme, the energy of sunlight breaks down plant biomass, with possible applications in chemicals, biofuels or other products that take a long time to produce. More


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Mass Spectrometry in Plant-omics
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Plant-omics is rapidly becoming an important field of study in the scientific community due to the urgent need to address many of the most important questions facing humanity today with regard to agriculture, medicine, biofuels, environmental decontamination, ecological sustainability, etc. High-performance mass spectrometry is a dominant tool for interrogating the metabolomes, peptidomes, and proteomes of a diversity of plant species under various conditions, revealing key insights into the functions and mechanisms of plant biochemistry. More


Using the Human Genome to Repurpose Medicine for Zika Virus
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The Zika virus, transmitted by Aedes mosquitoes, is spreading rapidly across the globe and threatens to become a global pandemic. A strong link to neurological disorders including Guillain-Barré syndrome, and microcephaly is suspected, but not yet proven. Furthermore, the sexual transmission of the Zika virus and the presence of the virus in the mother's milk are a cause for major concern. Currently, no treatment options, diagnostic kits, or biomarkers are available for the Zika virus. More


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Three Stories of Pharmaceutical Outsourcing
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The U.S. Food & Drug Administration approved 45 new drugs in 2015, a 20-year high. Thirty-three of them are small molecules — the products of chemical synthesis. One of the new drugs is Xuriden, a small molecule from Wellstat Therapeutics that treats an ultrarare disease called hereditary orotic aciduria. By the time Xuriden was approved last September, Wellstat had been working with its active ingredient, uridine triacetate, for close to 15 years. More


Chemists Create Mimic of Key Vision Protein
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An artificial mimic of a key light-sensitive molecule has been made by scientists at the University of Bristol. The work, published in Science, could lead to new ways of building light-sensitive artificial cells. Professor Jonathan Clayden and colleagues in Bristol's School of Chemistry, along with collaborators at the Universities of Manchester and Hull, created an artificial mimic of rhodopsin, a protein that resides in cell membranes in the retina. More


Lab-Grown Skin Shows Off Follicles, Glands
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It's enough to give members of the transplant community goose bumps — and other features of the skin's integumentary system. According to a new study, lab-grown skin needn't be limited to plain, featureless sheets. This study, from scientists based at the RIKEN Center for Developmental Biology, indicates that lab-grown skin can be studded with hair follicles and sebaceous glands. More


Alzheimer's May Be Caused by Haywire Immune System Eating Brain Connections
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More than 99% of clinical trials for Alzheimer's drugs have failed, leading many to wonder whether pharmaceutical companies have gone after the wrong targets. Now, research in mice points to a potential new target: a developmental process gone awry, which causes some immune cells to feast on the connections between neurons. "It is beautiful new work," which "brings into light what's happening in the early stage of the disease," says Jonathan Kipnis, a neuroscientist at the University of Virginia School of Medicine in Charlottesville. More




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Senior Automation Specialist (Robotics), Antibody Engineering
Genentech Research
US – CA – South San Francisco

Automation Engineer
Abbvie
US – MA - Worcester

R&D Chemist
Enzymatic Deinking Technologies LLC
US – GA – Norcross

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