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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 08, 2015

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SLAS Webinar Friday, April 10: Improving Success Rates in Drug Discovery
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Edward Scolnick, chief scientist and founding director of the Stanley Center for Psychiatric Research and core faculty member at the Broad Institute, advises: "Invest in as many projects as there is genetic evidence that links the target and pathway to the actual pathophysiology of a disease. Have the discipline to create a high quality molecule, a biologic or a chemical, to perturb this single target and its pathway so that the dose of the potential therapeutic is limited solely by the consequences of perturbation of this target and not off target activity of the molecule. We are in a time where there are, and will be, more such targets than at any time in our history."

Learn more from the expert in the April 10 SLAS Webinar, free to dues-paid SLAS members.
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SLAS ELN Reports: Microengineered Cell- and Tissue-Based Assays Poised to Transform Drug Development
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The integration of engineering techniques with biological research has led to exciting advances in the development of microengineered living systems with the potential to impact "a wide range of communities in pharmaceutical and toxicology research," according to Dan Dongeun Huh, University of Pennsylvania, and Deok-Ho Kim, University of Washington.

Huh and Kim are guest editors of a two-part JALA special issue, Microengineered Cell- and Tissue-Based Assays for Drug Screening and Toxicology Applications, and featured in the SLAS Electronic Laboratory Neighborhood e-zine.
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Last Call: Abstracts for JBS Special Issue on Advances in Mass Spectrometry within Drug Discovery
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SLAS members and nonmembers alike are invited to submit manuscript proposals by April 10 for a special issue that addresses topics such as techniques for reducing sample volumes, new applications for existing mass spectrometry technologies, combination of ion-mobility and mass spectrometry and rapid methods of drug bioanalysis.

Guest Editors Ian Wilson and Jonathan Wingfield will consider all proposals received and issue formal invitations by April 14 (final manuscripts will be due July 1).
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  • 2015 SLAS Innovation Award Winner Among Presentations Now Available at SLAS.org
    SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    To extend the value and accessibility of SLAS2015 scientific sessions, 10 podium presentations were recorded and are now available on demand to SLAS members. In addition, for a limited time, the 2015 SLAS Innovation Award winning presentation, Novel Acoustic Loading of a Mass Spectrometer – Towards Next Generation High-Throughput MS Screening, by Jonathan Wingfield of AstraZeneca is available to members and nonmembers at no cost.

    "The scientific program is a cornerstone of the Society's annual flagship meeting, and showcases some of the important research, innovation and technology utilization that is setting the standard for tomorrow’s scientific discovery," says SLAS President Dean Ho. "We're especially grateful to our presenters — and their organizations — for allowing us to share their expertise in this manner."
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    SAGE Journals Offers Free Trial in April
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    Complete a short form and gain access to more than 800 journals and 1.5 million articles from the publisher of SLAS's two MEDLINE-indexed scientific journals, JALA and JBS.

    SAGE is the world's fifth largest journals publisher and its journal portfolio spans the humanities, social sciences and science, technology and medicine.
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    Principles of Clinical Pharmacology Lecture Series Features SLAS2016 Keynote Speaker
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    Michael Gottesman's P-glycoprotein and drug transport special lecture, Structure and Function of ABC Transporters in Health and Disease, is available for viewing on demand at the National Institutes of Health website. Gottesman discusses efforts to conduct molecular analysis of human cancers to predict response to therapy; use that information to develop novel drugs to treat cancer and new imaging modalities for cancer; and learn more about cellular pharmacology and pharmacokinetics of drugs.

    Gottesman and Adam Diedrich Stelzner of the Jet Propulsion Laboratory are keynote speakers at SLAS2016, Jan. 23-27, 2016 in San Diego, CA.
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    SLAS2016 Podium Abstracts Due Aug. 3, 2015
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    Conference Chairs Doug Auld, Novartis Institutes for Biomedical Research, and Dino Di Carlo, University of California, Los Angeles, invite abstract submissions to be considered for podium presentations at SLAS2016, Jan. 23-27, 2016, San Diego, CA.

    SLAS2016 is organized in seven scientific tracks: Advances in Bioanalytics, Biomarkers and Diagnostics; Assay Development and Screening; Automation and High Throughput Technologies; Cellular Technologies; Drug Target Strategies; Informatics; and Micro/Nano Technologies.
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    Who Owns CRISPR?
    The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    On April 15, 2014, the U.S. Patent and Trademark Office awarded the first patent for use the CRISPR/Cas system to edit eukaryotic genomes to Feng Zhang of the Broad Institute and MIT. Originally a bacterial or archaeal defense system that uses viral DNA inserted into the genome (CRISPR) as a guide to cut the genomic material of invading viruses with a CRISPR-associated enzyme, researchers have found many ways to turn the system into a potent and quick way to edit specific genetic sequences. More

    RNA as an Anticancer Drug Target
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The traditional paradigm in cancer drug development is to target the aberrant protein or stretch of DNA that is wreaking havoc within the cell. Now, a team of University of California, Berkeley scientists is looking past the traditional molecules at an entirely new set of potential targets: RNA. Specifically, the researchers focused on messenger RNA, which is generated within the cell's nucleus and shuttled to the cytoplasm to link up with the protein generation machinery that resides there. More

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    How Can Chemometrics Improve Microfluidic Research?
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    Chemometrics has the potential to embolden microfluidics to become that enabling technology for so long sought after. In this feature article, we describe a historical perspective on microfluidics and its current challenges, a perspective on chemometric methods including response surface methodology (RSM), and how a combination of artificial neural network with experimental design (ANN-ED) have demonstrated promise in addressing basic microfluidic problems. More

    New Study Hints at Spontaneous Appearance of Primordial DNA
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The self-organization properties of DNA-like molecular fragments four billion years ago may have guided their own growth into repeating chemical chains long enough to act as a basis for primitive life, says a new study by the University of Colorado Boulder and the University of Milan. While studies of ancient mineral formations contain evidence for the evolution of bacteria from 3.5 to 3.8 billion years ago, what might have preceded the formation of such unicellular organisms is still a mystery. More

    U.S. Scientists Celebrate the Restart of the Large Hadron Collider
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    With the collider back in action, the more than 1,700 U.S. scientists who work on LHC experiments are prepared to join thousands of their international colleagues to study the highest-energy particle collisions ever achieved in the laboratory. These collisions — hundreds of millions of them every second — will lead scientists to new and unexplored realms of physics and could yield extraordinary insights into the nature of the physical universe. More


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    Chiral Molecular Tweezers: Synthesis and Reactivity in Asymmetric Hydrogenation
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    We report the synthesis and reactivity of a chiral aminoborane displaying both rapid and reversible H2 activation. The catalyst shows exceptional reactivity in asymmetric hydrogenation of enamines and unhindered imines with stereoselectivities of up to 99% ee. DFT analysis of the reaction mechanism pointed to the importance of both repulsive steric and stabilizing intermolecular non-covalent forces in the stereodetermining hydride transfer step of the catalytic cycle. More

    EPA Halts New Uses of Pesticides Linked to Bee Decline
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The Environmental Protection Agency is drawing fire from all sides after it announced restrictions on any new uses of neonicotinoid pesticides, chemicals linked to a decline in bee populations. Requests from pesticide makers to use any of four neonicotinoids on additional crops or in new products or to apply them in new ways, such as by aerial spraying, are on hold until EPA can evaluate new data. More



    From the Heart
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Growing up near Springfield, Mass., Laurie Boyer was always interested in science but didn't have many opportunities to satisfy her curiosity. She was unsure how to pursue a career in science and was instead encouraged to put her energy into working after school. However, Boyer persevered and became the first person in her family to attend college, eventually earning a Ph.D. and joining the faculty of MIT's Department of Biology, where she recently earned tenure. More

    Computers That Mimic the Function of the Brain
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A team of researchers used a promising new material to build more functional memristors, bringing us closer to brain-like computing. Both academic and industrial laboratories are working to develop computers that operate more like the human brain. Instead of operating like a conventional, digital system, these new devices could potentially function more like a network of neurons. More

    Career


    Sr. External Pharmacology Manager
    Pfizer
    China

    Assistant Professor Biomedical Sciences
    Texas Tech University Health Sciences Center 
    US – TX – El Paso

    Laboratory Manager
    New York Blood Center
    US – NY – New York City

    More jobs at SLAS Career Connections


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