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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 09, 2014

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April 15: Protein-Protein Interaction in Cancer

Featuring Haian Fu Ph.D., of the Emory University Chemical Biology Discovery Center; FREE to dues-paid SLAS members. Register today!


 

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JALA Special Issue Call for Papers: Microengineered Cell- and Tissue-Based Assays for Drug Screening and Toxicology Applications
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JALA Special Issue Guest Editors Dan Dongeun Huh and Deok-Ho Kim seek manuscript proposals (abstracts) by April 20 on novel biological assay systems that synergistically combine microengineering technologies, such as microfabrication and microfluidics with cultured living cells or tissues to enable screening and analysis of drugs, chemicals, toxins, and other stimuli relevant to pharmaceutical and environmental applications. More

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The Lab Man Talks with SLAS2014 Student Poster Winners
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Three new podcasts are available now featuring The Lab Man’s discussions with Garrett Mosley, Tim Ruckh and Kris Wilson, whose posters were judged as the top three by students at the SLAS Annual Conference earlier this year.

The students represent the University of California, Los Angeles; Northeastern University; and the University of Edinburgh, respectively.

Learn about each student’s exciting work.
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April 15 SLAS Webinar FREE to Dues-Paid SLAS Members
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Haian Fu Ph.D., of the Emory University Chemical Biology Discovery Center will present an overview of the current status of PPI interrogation in cancer and highlight some widely employed high-throughput screening technologies for monitoring PPIs.

Read more about the Spring 2014 SLAS Webinar Series, Protein-Protein Interactions as Small Molecule Drug Targets, in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS Asia Seminar: Introduction to Lab Automation
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Three speakers addressed 105 participants on Mar. 31 in Shanghai at this SLAS Seminar, organized jointly with SIAIS of Shanghai Tech University. Jianwei Liu of AstraZeneca, Justin Gu of Novartis China and Steve Hamilton of SLAS shared the basics of laboratory automation system architectures, focusing on the application of laboratory automation in industrial and academic laboratories in China.

Attendees also learned about high-throughput screening and profiling systems at the Novartis Institute of Biomedical Research.

See photos on Facebook and contact Kitty Yang for information on future SLAS Asia events.
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Did You Receive Your April Issues of JALA and/or JBS?
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If your copy was not delivered in the mail, it may be because you forgot to renew your membership. Renew or join today to enjoy full access to the JALA or JBS Online archives; live and on-demand webinars; SLAS Membership Directories; the 2014 North American Laboratory Products Purchasing Trends Report; conference registration discounts; FIRST Team Grants; members-only EndNote discounts; and more. More

Donald Ingber Reports on New Microdevice to Detect Fungal Pathogens
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The SLAS2015 keynote speaker and his team published "A Microdevice for Rapid Optical Detection of Magnetically Captured Rare Blood Pathogens" in Lab on a Chip, issue 1, 2014.

From the abstract: "Using this device, we have been able to detect fungal pathogens in less than three hours after sample collection compared to days with current technology, and with an extremely high sensitivity (<1 cell="">−1 of human blood)."

Ingber speaks Monday, Feb. 9, during the Feb. 7-11 event in Washington, DC.
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Chemists' Work With Small Peptide Chains May Revolutionize Study of Enzymes and Diseases
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Chemists in Syracuse University's College of Arts and Sciences have, for the first time, created enzyme-like activity using peptides that are only seven amino acids long. Their breakthrough, which is the subject a recent article in Nature Chemistry magazine, may revolutionize the study of modern-day enzymes, whose chains of amino acids usually number in the hundreds, and of neurological diseases, such as Alzheimer's, which are usually characterized by small clumps of misshaped proteins called amyloids. More

New Data Show Short-term Value of Scientific Research
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Using new data available to examine the short-term economic activity generated by science funding, researchers have for the first time been able to illuminate the breadth of the scientific workforce and the national impact of the research supply chain that is funded by federal grants. Most of the workers supported by federal research funding are not university faculty members. In fact, fewer than one in five workers supported by federal funding are faculty researchers. More

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New Anticancer Target Identified
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A novel strategy for fighting cancer with potentially minimal side effects could spark a new round of drug discovery efforts. In two new papers, researchers confirm earlier hints that an enzyme called MTH1 is critical for cancer cell proliferation. They identified inhibitors of the enzyme and showed that the compounds suppress tumor growth in cancerous mice. In addition, they found that an anticancer agent of previously unknown mechanism works by inhibiting MTH1 and also identified another inhibitor with better drug properties. More

DNA Nanobots Deliver Drugs in Living Cockroaches
New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It's a computer — inside a cockroach. Nano-sized entities made of DNA that are able to perform the same kind of logic operations as a silicon-based computer have been introduced into a living animal. The DNA computers — known as origami robots because they work by folding and unfolding strands of DNA — travel around the insect's body and interact with each other, as well as the insect's cells. When they uncurl, they can dispense drugs carried in their folds. More


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Can Pharma R&D Satisfy the New Healthcare Market?
By Mike Wokasch    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A more attentive FDA and a more demanding healthcare market are forcing pharmaceutical companies to change the way they have done business for decades. Research and development is perhaps the most impacted by both of these market dynamics. After all, without new products you don't have to worry about marketing and sales or manufacturing. The new market mandate is that you have to discover truly-innovative new products that are better than what is currently available. To meet this new market expectation, drug companies have two options. More

Messenger of Pain Identified
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In their pursuit of understanding how pain works at the molecular level, a research team lead by Ru-Rong Ji of anesthesiology and neurobiology has found a new function for MicroRNAs, short stretches of genetic material that signal genes to turn on or off. In a paper appearing online in the journal Neuron, Ji and his colleagues in the Pain Signaling and Plasticity Lab describe one MicroRNA called "let-7b" that is found floating outside cells and can bind specifically to pain-sensing neurons. More



How Electrodes Charge and Discharge: Analysis Probes Charge Transfer in Porous Battery Electrodes for First Time
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A new analysis probes charge transfer in porous battery electrodes for the first time. The electrochemical reactions inside the porous electrodes of batteries and fuel cells have been described by theorists, but never measured directly. Now, scientists have figured out a way to measure the fundamental charge transfer rate — finding some significant surprises. More

AACR Panel Discusses Challenges of Reporting Incidental Findings
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Reporting incidental or secondary findings may pose a challenge for the cancer field, a panel at this year's American Association for Cancer Research meeting said. The panelists particularly focused their discussion on recommendations the American College of Medical Genetics and Genomics issued last year and updated about a week ago. Those guidelines list a set of some 56 genes for which variants should be reported back to patients undergoing clinical sequencing. Many of the genes on that list are linked to increased cancer risk, as well as susceptibility to cardiac conditions. More

NIH Funding Opportunity Focuses on Diagnostics for Hospital-Based Antibacterial-Resistant Infections
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NIAID recently announced a research funding opportunity to develop and/or produce diagnostics to quickly detect the key bacteria responsible for antibacterial-resistant infections in hospital settings. The request for applications (RFA) will support diagnostics research related to one or more of the following types of bacteria: Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and extra-intestinal pathogenic Eschericihia coli. NIAID expects to fund 10-15 awards for a total of up to $12 million in 2015, and the maximum length of each award is 5 years. NIAID will accept applications through June 19, 2014. More


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