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SLAS
Congratulations to Santosh Paidi, a graduate research assistant in the Department of Mechanical Engineering at Johns Hopkins University (Baltimore, MD)! Paidi earned the SLAS grant that will provide $100,000 over two years to further his research in the Barman Lab. Spurred by implementation of surface-enhanced Raman spectroscopy (SERS) assays for protein biomarkers detection in sera and development of single cell analysis platforms for live cell imaging, Paidi envisions that his current project will open new photonic routes for quantification of circulating cancer biomarkers as well as for high definition visualization of cell-surface glycosylation. Read about last year's winner in the SLAS Electronic Laboratory Neighborhood e-zine. SLAS will begin accepting applications for the 2019 SLAS Graduate Education Fellowship Grant in the fall of 2018. Graduate students may also be interested in applying for the SLAS Visiting Graduate Researcher Grant Program. READ MORE
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SLAS
A new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity. This robotic platform uses standard manual pipettors and an optically guided arm to facilitate the automation of manual procedures, reducing the time researchers spend at the lab bench, and mimicking, as closely as possible, the results obtained when using the manual GlycoWorks RFMS protocol. Image: Total N-Glycan Recovery from Cetuximab / Image Credit: Corey Reed.
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SLAS
Chosen from a diverse pool of innovative research, Xiao Wang, Ph.D., Sri Teja Mullapudi, M.Tech., and John Hickey, B.Sc., took top honors out of 50 undergraduate, graduate and post-doctoral students who participated in the SLAS2018 Student Poster Competition. "Winning the SLAS poster competition was a fantastic opportunity for me. It allowed me to present my research to a cadre of expert panelists and get their feedback, enabled potential collaboration with a panelist who is also working on immunotherapy and introduced me to the other amazing student poster finalists," says Hickey.
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Because drug discovery involves scientists from multiple disciplines and often organizations, it is critical to have an efficient mechanism for researchers to collaborate and realize the collective value of their specialized knowledge, assets, and capabilities. This free white paper details the essential keys to effective collaboration.
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SLAS
There's still time to gain significant visibility for your research and organization by presenting a poster to academic and industry scientists and technologists from across Europe. The deadline for poster abstract submissions is now May 25. APPLY TODAY: Students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) may apply for SLAS Tony B. Academic Travel Awards. Applications are due with poster abstracts on May 25.
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SLAS
Save up to $150 when you sign up by Oct. 1 for the new 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic. Planned and presented by experienced experts, the symposium will examine advances in traditional compound management and how research organizations evolve by partnering with biological and clinical groups to support and reinvent modern drug discovery processes. Learn more and advance your career Nov. 13-14 in Boston, MA. Students: register for just $75!
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SLAS
Meet Teresa K. Woodruff, Ph.D., dean and associate provost for graduate education in The Graduate School at Northwestern University (Chicago), who studies aspects of reproductive health, including ovarian follicle development, determinants of egg quality and translation to patient care. Learn more about Eran Segal, Ph.D., Weizmann Institute of Science (Rehovot, Israel), who uses an algorithm to accurately predict post-meal blood sugar levels based on a person's individual biological makeup and lifestyle. These intriguing innovators will share their unique insight and experiences at the 2019 SLAS International Conference and Exhibition, Feb. 2-6, Washington, D.C.
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Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Chemical & Engineering News
Chemists and computer scientists are working hard to make quantum computers work for them. In the wake of IBM publishing the quantum computational calculation of beryllium hydride's ground state in September, chemists are upping the complexity of their simulations and, they hope, putting quantum computers to use in fields like catalysis, materials science, and drug discovery. Our latest episode of Speaking of Chemistry looks into how they're going about doing that.
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Genetic Engineering & Biotechnology News
Scientists at Harvard Medical School, the University of California-San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and packaged.
Their study ("Unraveling the sequence of cytosolic reactions in the export of GspB adhesion from Streptococcus gordonii"), which could facilitate the development of new antibiotics, appears in the Journal of Biological Chemistry.
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In 25 years of Lab Services, we know when software is needed, flexibility, simplicity, and speed are of the essence. Therefore, we developed our own flexible software: PlateButler®. Taking your needs and changes in the market as our guidelines, we have continued to develop the PlateButler® software ever since.
We simply accomplish: www.lab-services.nl/eng/
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Journal of the American Chemical Society
Resolving the structure and composition of supported nanoparticles under reaction conditions remains a challenge in heterogeneous catalysis. Advanced configurational sampling methods at the density functional theory level are used to identify stable structures of a Pd8 cluster on ceria (CeO2) in the absence and presence of O2. A Monte Carlo method in the Gibbs ensemble predicts Pd-oxide particles to be stable on CeO2 during CO oxidation.
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Lab Manager
Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies.
The drug may not become available to patients for a number of years yet, but researchers believe that if clinical trials are successful, it could be used to tackle a variety of treatment-resistant cancers.
Patients with breast cancer, for example, frequently become resistant to existing hormone-based treatments, leading to the disease becoming fatal.
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Bioscience Technology
In collaboration with a number of American colleagues, researchers from Uppsala University have found an Achilles' heel for the most common form of malignant child brain tumors. By combining two kinds of medicines, it is possible to simultaneously attack the cancer cell’s division and its reinforcement system, which is necessary in order for treatment to be sufficiently effective.
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Phys.org
A trio of researchers at the University of Cambridge has come up with a new way to control adding chirality to nitrogen rings without first installing reactive groups on them. In their paper published in the journal Science, Robert Phipps and two grad students describe the new reaction process and possible uses for it.
As the researchers note, nitrogen rings with associated chiral groups are common in agricultural, pharmaceutical and bioactive products.
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Science Daily
Most of us don't think about our teeth and bones until one aches or breaks. A team of engineers at Washington University in St. Louis looked deep within collagen fibers to see how the body forms new bone and teeth, seeking insights into faster bone healing and new biomaterials. Young-Shin Jun, professor of energy, environmental & chemical engineering in the School of Engineering & Applied Science and director of the Environmental NanoChemistry Lab, leads a team of experts in nucleation.
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Science Magazine
The hunt for wispy particles called axions, which might make up the dark matter whose gravity keeps galaxies from falling apart, is heating up. The Axion Dark Matter Experiment at the University of Washington in Seattle has finally reached the sensitivity needed to detect axions if they make up dark matter, physicists report in Physical Review Letters. However, researchers don't know exactly how much axions should weigh, and it may take them years to scan the range of possible masses.
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Director of the Drug Analysis and Toxicology Section of the Chemical Pathology Laboratory
University of Michigan
US – MI – Ann Arbor
Basic Scientist - Pain Research
University of Minnesota
US – MN – Minneapolis
Basic Scientist - Pain Focus
University of Minnesota
US – MN – Minnespolis
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