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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 12, 2017    SLAS2018    Moving? New job? Let SLAS know.      






SLAS ELN Reports: Liquid Biopsy — New Technology Uses a Microfluidic Vortex to Isolate Circulating Tumor Cells (CTCs) from Blood Samples
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Elodie Sollier-Christen earned the 2017 SLAS Innovation Award for her captivating work at Vortex Biosciences that allows clinicians to obtain meaningful results with liquid biopsies utilizing a technology that is low cost, simple to use, reproducible and fast.

"Circulating tumor cells (CTCs) are cancer cells that have been shed from a tumor into the bloodstream and play a major role in metastasis," she says in a recent publication. "The relative number of CTCs is predictive of patient prognosis and treatment efficacy." Learn more in the SLAS Electronic Laboratory Neighborhood e-zine.


One Week Left to Enter the 2017 SLAS Art of Science Contest
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Capture our attention with your stunning scientific lab imagery and you may win a $500 Amazon gift card! Review the 2017 SLAS Discovery and SLAS Technology Art of Science Contest details, and submit before April 21.

Pictured here is 2016 finalist Carrie Lovitt's image of breast cancer cells after applying texture mapping.

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Now at HTS Tumor — Stroma Co-Culture Spheroid Platform Reveals CAF-Specific Chemotherapeutic Targets
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Shane R. Horman, Genomics Institute of the Novartis Research Foundation, digs deep into his work with cancer associated fibroblasts (CAFs).

"CAFs are actually very important in recruiting and programming immune cells and they also stimulate neoangiogenesis," Horman explains. "The genes that are turned on in stroma in response to tumor cell crosstalk might make attractive drug targets."

Learn more in this on-demand webinar, one of seven carefully selected scientific presentations from SLAS2017, which are free-of-charge to SLAS members always and to non-members through the end of April. Presentations by the opening keynote speaker and 2017 SLAS Innovation Award winner are included in the seven selections.

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SLAS Video: Learn More about the SLAS Discovery Journal
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"One of the pieces of data that I think people should be aware of," says Editor-in-Chief Robert M. Campbell, Ph.D., of Eli Lilly and Company, "... is that we have more than a million online accesses per year, and over 300,000 papers are downloaded per year. Think about that. I'd say that's quite impressive."

Campbell talks about the SLAS Discovery focus on quantitative biology, including basic screening and automation together with basic and applied biology.


SLAS Technology: Metabolic Pathway Inhibition in Liver Cancer
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This review by Ali Zarrinpar, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, now is available ahead-of-print for SLAS members and SLAS Technology subscribers.

Zarrinpar is a guest editor of the June 2017 SLAS Technology Special Issue on Personalized and Precision Medicine, which features a diligently peer-reviewed complement of 11 reports that explore innovation from a cross section of the disciplines driving major advances in personalized and precision medicine.

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A Protein's 'Dance Steps' Affect Its Biological Function, Study Shows
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A new microspectroscopy technique can track changes in the overall direction of complex protein vibrations. The method could enable researchers to determine how an enzyme responds when an inhibitor binds to it, for instance, or when the enzyme develops a mutation. "Global vibrations" can be thought of as intricate dance steps performed by proteins. The new technique provides an unprecedented up-close look at how those dance steps shift when a protein's conformation changes, a process that underpins important biological functions. More

CRISPR Mines Bacterial Genome for Hidden Pharmaceutical Treasure    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In the fight against disease, many weapons in the medicinal arsenal have been plundered from bacteria themselves. Using CRISPR-Cas9 gene-editing technology, researchers have now uncovered even more potential treasure hidden in silent genes. A new study from researchers at the University of Illinois and colleagues at the Agency for Science, Technology and Research in Singapore used CRISPR technology to turn on unexpressed, or "silent," gene clusters in Streptomyces, a common class of bacteria. More


Molecules in the Body More Visible in New Detection System, Say Scientists
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Scientists at the University of York have developed a technique that will enhance the performance of magnetic resonance imaging in identifying disease. MRI and Nuclear Magnetic Resonance are two of the most important techniques used in identifying simple molecules and complex materials and provide valuable information about how they behave. Applications in the diagnosis of a range of diseases, from cancerous tumors to heart disease are particularly important. More

Method for Capturing Secreted Cancer Markers Developed
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If we were able to actively watch cells at the nanoscale level, an entirely new world of molecules and processes would provide us with as many new questions, as well as answers to long-standing hypotheses. Yet, if our attention were focused on the cell membrane, we would see active secretion of extracellular vesicles, ranging in size from 30 to 50 nanometers in diameter. These tiny lipid sacks were once thought of as cellular garbage dumps; but in recent years, scientists have discovered that these nanoparticles contain valuable information. More

Turning Spinach Into Human Heart Tissue
By Dorothy L. Tengler    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Like Popeye, we have all grown up knowing the health benefits of eating leafy green spinach. Belonging to the chenopodiaceae family, spinach is part of a family of nutritional powerhouses. As for its benefits, dark green spinach leaves contain high levels of chlorophyll, folate and health-promoting carotenoids. But spinach is more than a superfood. Scientists are now able to convert spinach leaves into heart tissue, according to new research in the journal Biomaterials. More

Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry
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In recent years, the direct coupling of solid phase microextraction and mass spectrometry has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential matrix effects when compared to direct injection to MS. In this study, we introduce the open port probe as a robust interface to couple biocompatible SPME fibers to MS systems for direct electrospray ionization. More

Mutations Linked to Secondary Cancers
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Sequencing the whole genomes and exomes of more than 3,000 childhood cancer survivors, Zhaoming Wang of the St. Jude Children's Research Hospital in Memphis, Tennessee, and colleagues identified 365 pathogenic or likely pathogenic mutations in 84 genes. In total, 12 percent of the patients studied carried one of these mutations, which pose an increased risk of secondary cancer, Wang noted in his presentation at the American Association for Cancer Research annual meeting. More

Why We Need a Culture of International Collaboration to Fight Antibiotic Resistance
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Antimicrobial resistance poses one of the biggest threats to public health faced in modern times. If left unchecked, it's thought that by 2050 the global number of deaths from antimicrobial resistance may be as high as 10 million per year — costing $100 trillion annually just to manage the effects, according to the 2016 Review on Antimicrobial Resistance. In this article, we look at the scale of the challenge, and consider the ways in which all international stakeholders need to work together in order to avoid these statistics becoming reality. More


Regenerative Medicine – Faculty Position
The Houston Methodist Research Institute
US – TX – Houston

Clinical Research Coordinator and Pre-Clinical Research Scientist
Field Neurosciences Institute, St. Mary’s of Michigan/Ascension
US – MI – Saginaw

Sr. Clinical Research Associate
Avanir Pharmaceuticals
US – CA – Aliso Viejo

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