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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 13, 2016

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New SLAS Webinars Available On-Demand
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Now at SLAS.org: Fully Automated 3D Cell Culture Provides Standardized, Biologically Relevant, and High Production for Human Cells by Robin Felder, Ph.D. of the University of Virginia; and The SmartLab of the Future: Bench-top Lab-Automation with the PetriJet and NutriJet Platforms by Felix Lenk, Ph.D. of the Technische Universität in Dresden, Germany.

Dues-paying SLAS members can access both of these presentations and all the other SLAS Webinars at SLAS.org for free.
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2016 SLAS Leadership Forum: Genome-Based Therapeutics — Are We Finally There?
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An expert panel and invested audience of senior-level executives and key opinion leaders in life sciences discovery and technology wrestled with this topic at the 2016 SLAS Leadership Forum held at SLAS2016 in San Diego earlier this year. Moderator and SLAS Past President Daniel Sipes of the Genomics Institute of the Novartis Research Foundation indicated lively discussion continued far beyond the end of the forum.

"This is surely a sign, as the panelists suggested and Dr. Gottesman emphasized, that the use of patient sequencing information to guide genome-based therapies is still developing and the impact will be profound," Sipes concludes. The SLAS Electronic Laboratory Neighborhood e-zine recaps the SLAS Leadership Forum discussion.
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Stellar Results from the SLAS Endowed Fellowship at UCLA
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SLAS Past President Dean Ho and a team of researchers from the UCLA schools of dentistry, engineering and medicine, have developed a revolutionary technology platform called phenotypic personalized medicine, or PPM, which can accurately identify a person's optimal drug and dose combinations throughout an entire course of treatment.

The results of the team's first in-human/pilot clinical trial can be read in the April 6 issue of Science Translational Medicine. Ho is the recipient of a 2012 SLAS Endowed Fellowship.
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Save the Date: May 17 SLAS Webinar on Challenges of 1536-Well Cell-Based Screening
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Join SLAS and Helen Plant of AstraZeneca (U.K.) to explore the practical intricacies of doing small volume, 1536-well cell-based assays. Dues-paying SLAS members may participate at no cost.

SLAS Webinars are presented by JALA and JBS, the official journals of SLAS.
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The JALA Podcast Series: Conversations with Authors
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With each new issue of JALA, Podcast Editor David Pechter talks with an author to add perspective and background to the work presented. The most recent podcast features Joanne Young of CYTOO (France) discussing her team's manuscript, "Fully Automated One-Step Production of Functional 3D Tumor Spheroids for High-Content Screening," featured on the front cover of the April 2016 Special Issue on High-Throughput Imaging Technologies. More


FREE to All at SLAS.org: 'Analyzing the Complexity of Drug Resistance in Cancer' by Michael M. Gottesman
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Recorded live at SLAS2016 and now freely accessible to everyone, this keynote presentation by Michael Gottesman, Ph.D., chief of the U.S. National Cancer Institute's Laboratory of Cell Biology, discusses the daunting complexity of resistance mechanisms in cancer cells, the Institute's approach to cell-based research and recent discoveries related to oncology. More



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CRISPR Debate Fueled by Publication of Second Human Embryo-Editing Paper
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Chinese researchers report that they have used the CRISPR gene-editing technique to modify the genome of a human embryo in an effort to make it resistant to HIV infection. The paper, reported on by Nature News, is only the second-ever publication on the ethically fraught use of gene editing in human embryos. According to the report in the Journal of Assisted Reproduction and Genetics, researchers at Guangzhou Medical University in China attempted — with limited success — to modify the CCR5 gene, which codes for a cell receptor that the HIV virus uses to enter T cells. More


Report: University Leaders Should Be Responsible for Lab Safety
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Presidents and chancellors of U.S. universities must take personal responsibility for changing the lab safety culture in academia, a new report says. The document, published by the Association of Public & Land-Grant Universities, challenges top university officials to create high-level committees responsible for lab safety, to modify tenure and promotion requirements to include safety, and to promote open commutation about accidents and near-misses on campuses. More


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San Diego to Be Research Hub for New Human Vaccines Project
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Four scientific institutions–University of California, San Diego, J. Craig Venter Institute, La Jolla Institute for Allergy and Immunology, and The Scripps Research Institute–have teamed up to create the "Mesa Consortium," a new scientific hub for the Human Vaccines Project. Under a collaborative agreement, the Mesa Consortium and the Human Vaccine Project aim to transform current understanding of the human immune system and expedite development of vaccines and biologics to prevent and treat many global diseases. More


Exotic Quantum Effects Can Govern the Chemistry Around Us
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Objects of the quantum world are of a concealed and cold-blooded nature: they usually behave in a quantum manner only when they are significantly cooled and isolated from the environment. Experiments carried out by chemists and physicists have destroyed this simple picture. It turns out that not only does one of the most interesting quantum effects occur at room temperature and higher, but it plays a dominant role in the course of chemical reactions in solutions. More




Sequence and Epigenetic Factors Determine Overall DNA Structure
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The traditionally held hypothesis about the highly ordered organization of DNA describes the interaction of various proteins with DNA sequences to mediate the dynamic structure of the molecule. However, recent evidence has emerged that stretches of homologous DNA sequences can associate preferentially with one another, even in the absence of proteins. Researchers found that DNA molecules interact directly with one another in ways that are dependent on the sequence of the DNA and epigenetic factors, such as methylation. More


Immunoassay Blocking Reagents Guide
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AMSBIO has released a new 16-page practical guide that provides a detailed overview on how blockers can be used to reduce non-specific binding in immunoassays. Immunoassay Blocking Reagents (Blockers) are typically applied to ELISA and Lateral Flow-based assays, specifically paired monoclonal sandwich assays, competitive assays and antigen capture (IgG/IgM) assays. They work by removing interfering proteins in patient samples that could produce false results and an incorrect diagnosis. More


Methods Used to Create Textiles Also Could Help Manufacture Human Tissues
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Tissue engineering is a process that uses novel biomaterials seeded with stem cells to grow and replace missing tissues. When certain types of materials are used, the "scaffolds" that are created to hold stem cells eventually degrade, leaving natural tissue in its place. The challenge is creating enough of the material on a scale that clinicians need to treat patients. Elizabeth Loboa, dean of the University of Missouri College of Engineering, and her team recently tested new methods to make the process of tissue engineering more cost effective and producible in larger quantities. More


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Postdoctoral Position in Bionanotechnology
University of Washington
US – WA – Seattle

Phase 1 Experimental Therapeutics Program Director
Children's Mercy Hospital
US – MO – Kansas City

Scientist III
BASF
US – NC – Research Triangle Park

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