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JBS Special Issue Call for Papers: Therapeutic Antibody Discovery and Development
SLAS Share
   
Guest Editors Rob Howes and Joseph G. McGivern are now accepting manuscript proposals related to all aspects of the discovery and development of therapeutic antibodies with an emphasis on biochemical, cell-based and analytical assays. Submit abstracts by April 25 for consideration. Invited authors will be notified by May 1 and final manuscripts will be due August 1.
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From the SLAS President: SLAS Webinars — Practical Value and Shelf Life
SLAS Share
Membership has its privileges, and free access to SLAS Webinars is one excellent example, says SLAS President Daniel G. Sipes in the SLAS Electronic Laboratory Neighborhood e-zine.
The scientific education available in the SLAS Webinars library offers impressive breadth and depth of current interest and importance, like the current SLAS Webinar series, Protein-Protein Interactions as Small Molecule Drug Targets.
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SLAS2015 Program Taking Shape
SLAS Share
The preliminary SLAS2015 Schedule-at-a-Glance is available now and outlines the general flow of activities Feb. 7-11, including short courses, registration, exhibition, scientific sessions, keynote addresses, exhibitor tutorials and evening events. The SLAS2015 scientific planning committee is now accepting abstracts and the due date for podium consideration is July 28. Proposals are being sought for seven educational tracks: Assay Development and Screening, Automation and High-Throughput Technologies, Drug Target Strategies, Micro/Nano Technologies, Bioanalytical Techniques, Informatics and Biomarker Discovery & Application. For SLAS2015 exhibitor and sponsorship information, contact SLAS Exhibits Manager Barry Sacks.
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SLAS Awards Third FIRST Team Grant!
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Congratulations to Code Orange 3476, a high school FIRST team from Irvine, CA, mentored by SLAS member Elliot Hui and the latest recipient of an SLAS FIRST Team Grant. The team earned its way to the FIRST Championship to be held April 23-26 in St. Louis, Mo., with their 2014 robot, Hanalei. SLAS is happy to support the outstanding work being done by FIRST teams by offering a limited number of $500 team grants on a first come, first served basis. Applications must be personally endorsed by a dues-paid SLAS member actively engaged as a coach or mentor in a local FIRST team. Read the SLAS ELN e-zine article on a previous grant recipient, Jody Keck and Puma Robotics.
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Creative Minds: Mapping Molecules in their Cellular Compartments
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SLAS2015 keynote speaker and NIH Director Francis Collins blogs about a "new technique that combines the best spatial capabilities from microscopy with the large-scale protein analysis of mass spectroscopy. The result? A technique with the power to produce a detailed molecular fingerprint of every compartment within the cell."
Read more about this work of Alice Ting, an associate professor at the Massachusetts Institute of Technology.
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SLAS LinkedIn Hits 6,500 Participants!
SLAS Share
If you have not yet joined the discussion on the SLAS LinkedIn forum, you are missing out. Recent posts have included adherent cell culture growth, biobanking, sample management, protein-protein interaction, collaboration in biotech, blood samples in cancer research and JALA and JBS calls for abstracts. What do YOU want to talk about?
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World-to-Digital-Microfluidic Interface Enabling Extraction and Purification of RNA from Human Whole Blood
Analytical Chemistry Share
Digital microfluidics is a powerful technique for simple and precise manipulation of microscale droplets of fluid. This technique enables processing and analysis of a wide variety of samples and reagents and has proven useful in a broad range of chemical, biological and medical applications. Handling of "real-world" samples has been a challenge, however, because typically their volumes are greater than those easily accommodated by DMF devices and contain analytes of interest at low concentration.
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Chemists Achieve Molecular First
Phys.org Share
Chemists from Trinity College Dublin have achieved a long-pursued molecular first by interlocking three molecules through a single point. Developing interlocked molecules is one of the greatest challenges facing researchers, and the Trinity chemists' achievement represents the first time three molecules have been linked in a non-linear "chain-like" form.
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Managing Your Chemical Inventory
Lab Manager Share
While size and complexity differ considerably among laboratories, every lab manager must master a few essential tasks. They fit into two main categories: overseeing physical assets and managing human resources, with the synergistic goal of maximizing efficiency. If you're exploring methods to increase the efficiency and return on investment of your laboratory, your first step should be to update your chemical inventory system.
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The xCELLigence RTCA Cardio System monitors cardiomyocyte beating functions in a 96-well format under physiological conditions, using a noninvasive label-free impedance-based technology. Rule out both acute and long-term cardiotoxicity in a single experiment. For more information, please visit www.aceabio.com.
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Molecular-Level Understanding of Protein Adsorption at the Interface Between Water and a Strongly Interacting Uncharged Solid Surface
Journal of the American Chemical Society Share
Although protein adsorption on solids is of immense relevance, experimental limitations mean there is still a remarkable lack of understanding of the adsorption mechanism, particularly at a molecular level. By subjecting 240+ molecular dynamics simulations of two peptide/water/solid surface systems to statistical analysis, a generalized molecular level mechanism for peptide adsorption has been identified for uncharged surfaces that interact strongly with the solution phase.
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How a Silly Putty Ingredient Could Advance Stem Cell Therapies
Bioscience Technology Share
The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a University of Michigan study shows. The researchers coaxed human embryonic stem cells to turn into working spinal cord cells more efficiently by growing the cells on a soft, ultrafine carpet made of a key ingredient in Silly Putty. Their study is published online at Nature Materials.
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Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule
Cell Share
Glioblastoma multiforme is the most aggressive form of brain cancer with marginal life expectancy. Based on the assumption that GBM cells gain functions not necessarily involved in the cancerous process, patient-derived glioblastoma cells were screened to identify cellular processes amenable for development of targeted treatments. The quinine-derivative NSC13316 reliably and selectively compromised viability.
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Transport Regulations Impact You.
Saf-T-Pak provides certified shipping systems and compliance training to help ensure public safety in the transportation of Class 6.2 Infectious Substances and related materials. Contact us today! www.Saftpak.com
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An Integrated Approach to Clinical Genetics Research
Oxford Gene Technology Share
A free, downloadable whitepaper from Oxford Gene Technology provides researchers the opportunity to explore the latest strategies in the genomic characterization of complex disorders and to discover how, when used alongside sequencing, microarrays play a vital role in delivering accurate detection of point mutations and single exon copy number aberrations. The new whitepaper features the approach of Professor Madhuri Hegde from Emory Genetics Laboratory and explains his use of a range of available tools to build a more complete picture of inherently complex genetic disorders, providing the insights necessary to drive novel discoveries and research into potential therapeutic strategies.
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Physiologically Relevant Cell Culture Handbook
AMSBIO Share
Drawing upon a wealth of experience of working with a wide range of 3-D cell culture procedures and formats, AMSBIO has produced an extensive 48-page handbook for research scientists looking to culture cells in more physiologically relevant environments. Over the past two decades, many researchers have actively sought ways to culture cells in 3-D. The conclusion reached by many researchers is that there is no single optimal solution; each cell type needs a different environment and many biological processes may need specific methods to study them.
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Manganese Dioxide Nanoparticles Increase Tumor Vulnerability To Radiation Therapy
Chemical & Engineering News Share
Pretreating tumors with manganese dioxide nanoparticles may increase the efficacy of radiation therapy, according to a new study in mice. Tumors injected with the particles grew less after irradiation than untreated tumors did. The nanoparticles react with hydrogen peroxide in the tumors to correct chemical conditions that make tumors aggressive and thwart the effects of radiation.
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25 Grants for Young Researchers
Genetic Engineering & Biotechnology News Share
Finding funds for research is among the steepest hurdles that young investigators must surmount as they grow from grad school students to postdocs to finally running their own laboratories. Years of yo-yo budgeting has reduced the confidence young researchers once had of obtaining funding through NIH, and over the past 20 years, lowered the amount of money available. The success rate for all research project grants dipped to 15.3 percent in the sequestration-stymied federal fiscal year that ended Sept. 30, 2013.
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3-D Tumors Are Printed in the Lab
Live Science Share
Using 3-D printing, researchers have made a tumor-like lump of cancer cells in the lab, and they say this lump shows a greater resemblance to natural cancer than do the two-dimensional cultured cells grown in a lab dish. This more realistic representation of a tumor could aid studies on cancer and drug treatments, the researchers said.
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Nanostructures With Applications in Infrared and Terahertz Ranges
Science Daily Share
Scientists have created a compound semiconductor of nearly perfect quality with embedded nanostructures containing ordered lines of atoms that can manipulate light energy in the mid-infrared range. More efficient solar cells, less risky and higher resolution biological imaging, and the ability to transmit massive amounts of data at higher speeds are only a few applications that this unique semiconductor will be able to support.
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SLAS Point-to-Point
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