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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 19, 2017

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SLAS ELN Reports: Beyond the Bench — Translating Life Sciences Innovation
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If you want to commercialize new scientific technologies, SLAS is a fertile starting point. Positioned at the intersection of life sciences discovery and technology, the Society and its diverse membership offer unparalleled opportunities to spark creative cross-disciplinary collaborations.

SLAS members Dino Di Carlo, Marcie Glicksman, Dean Ho and Sumita Pennathur share their experiences on how to best innovate, collaborate, experiment, adapt and validate constantly en route to launching companies to meet market needs. Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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LAST CALL: 2017 SLAS Art of Science Content Entries Due April 21
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Submit your interesting scientific images by Friday to be considered for the $500 Amazon gift card grand prize and, of course, overwhelming adoration from your colleagues! Online voting commences May 1 at SLAS.org.

Pictured here is 2016 finalist Tomasz Koprowski's creative image of caenorhabditis elegans worms in a drop of M9 buffer captured during a microfluidic experiment.
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Free at SLAS.org: Droplet Microfluidic 3D Tumor Models for Cancer Screening
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Pooja Sabhachandani, Northeastern University, says that cancer models "to evaluate the efficacy of drugs at preclinical stage, 2D monolayers, fail to mimic the in-vivo human tumor biology and do not consider the effect of tumor microenvironment when testing therapeutic efficacy of new drug candidates. As a result, 90 percent of the promising preclinical drugs fail to transform into efficacious treatment options."

The work described in her SLAS2017 presentation provides a simple, novel, high-throughput in vitro platform to generate, image and analyze 3D monodisperse alginate hydrogel tumors for various omic studies and therapeutic efficiency screening. It is one of seven selected scientific presentations from SLAS2017, which are free-of-charge to SLAS members always and to non-members through the end of April.
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SLAS Members and Exhibitors Highlighted in Science
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Richard Eglen, Robin Felder, Timothy Spicer and several SLAS2017 exhibitors were interviewed for the Science Technology Feature, "Adding Depth to Cell Culture."

Watch for more on the topic in June when SLAS Discovery publishes a special issue on 3D Cell Culture, Drug Screening and Optimization, including Spicer and team's Science-cited, open access paper, "A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids" (which is now available at SLAS Discovery Online First ahead-of-print).
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SLAS Video: SLAS Journals Global Reach and Impact
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"We publish papers from many different countries, on many different topics," says SLAS Discovery Associate Editor Lorenz Mayr, Ph.D., of AstraZeneca. "The authors in our journal come from about 40 different countries ... about one-third from North America, one-third from Europe, and one-third from Asia."

Mayr invites YOU to join this elite group by authoring a paper for SLAS Discovery and/or SLAS Technology.
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SLAS Reviews Five SLAS ANSI Microplate Standards
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The SLAS Microplate Standard Advisory Committee is in the process of voting to reaffirm the five SLAS ANSI standards, per the established process for ANSI compliance.

The committee is balanced among four interest categories: manufacturers of microplates; manufacturers of instruments that utilize microplates; industrial and academic users of microplates; those with a general interest in the topic that do not fit the previous categories.
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Special Issue Calls for Papers: SLAS Discovery and SLAS Technology
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Special issues of SLAS Discovery and SLAS Technology are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs are being accepted through June 1 for special issues on these important topics: More


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Method Improves Single-Cell Genome Analysis
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Genomic changes in individual cells can eventually lead to cancer or other diseases. So scientists would like to be able to sequence the genome in a single cell. But the methods to do so can be plagued by the preferential amplification of some regions of the genome over others, leading to incomplete sequence coverage. More


Controlling Photorelaxation in Uracil with Shaped Laser Pulses: A Theoretical Assessment
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The RNA nucleobase uracil can suffer from photodamage when exposed to UV light, which may lead to severe biological defects. To prevent this from happening in most cases, uracil exhibits an ultrafast relaxation mechanism from the electronically excited state back to the ground state. In our theoretical work, we demonstrate how this process can be significantly influenced using shaped laser pulses. More




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Negative Pressure Induced Droplet Generation in a Microfluidic Flow-Focusing Device
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We introduce an effective method to actively induce droplet generation using negative pressure. Droplets can be generated on demand using a series of periodic negative pressure pulses. Fluidic network models were developed using the analogy to electric networks to relate the pressure conditions for different flow regimes. Experimental results show that the droplet volume is correlated to the pressure ratio with a power law of 1.3. More


New Plant Gene Network Could Significantly Improve Drug Discovery
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The contribution that plants make to the drug discovery process is indispensable. Yet, identifying the networks of genes that plants use to make these biologically active compounds has vexed scientists for years, hindering efforts to tap this vast pharmacopeia to produce new and improved therapeutics. Now, a team of geneticists led by investigators at Vanderbilt University believes they may have developed an effective and powerful new way for identifying these elusive gene networks. More


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Overcoming Opioids: The Quest for Less Addictive Drugs
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Tummy tucks really hurt. Doctors carve from hip to hip, slicing off skin, tightening muscles, tugging at innards. Patients often need strong painkillers for days or even weeks, but Mary Hernandez went home on just over-the-counter ibuprofen. The reason may be the yellowish goo smeared on her 18-inch wound as she lay on the operating table. The Houston woman was helping test a novel medicine aimed at avoiding opioids. More


Rapid Screening Machine Can Read and Separate Protein Sequences
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The structural properties of proteins that could eventually become important materials for manufacturing and medicine are revealed by a novel optical technique that works rapidly to sort through amino acid sequences even inside living bacteria, according to a team of engineers. "There remains an urgent need for fast and efficient techniques that can screen the properties of large numbers of protein sequences with minimal sample volume or in living cells," the researchers report. More




Chemists Devise Simple Method for Making Sought-After Boronic Acid-Based Drugs and Other Products
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Chemists at The Scripps Research Institute have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals. The difficulty of preparing these compounds — boronic acids and closely related molecules known as boronate esters — has greatly limited their use in the pharmaceutical industry. More


Career


Scientific Manager, Sample Management - Biomolecular Engineering Group
Genentech
US – CA – South San Francisco

Sr. Clinical Research Associate
Avanir Pharmaceuticals
US – CA – Aliso Viejo

Technical Platform Manager – Hematology / Laboratory Automation Specialist
IDEXX Laboratories Inc.
US – Virtual

Search Jobs at SLAS Career Connections


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