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SLAS
Submissions for an upcoming 2020 special issue of SLAS Technology are being accepted through Wednesday, May 1. Guest Editors Parastoo Azadi, Ph.D. and Christian Heiss, Ph.D., of the Complex Carbohydrate Research Center at the University of Georgia (USA), invite manuscript proposals on topics related to Carbohydrate Structure Analysis: Methods and Applications for publication next year. Proposals will be used to select and invite manuscript submissions for review and publication consideration. First-time as well as seasoned authors are encouraged to submit for a chance for their research to be featured.
VIEW SUBMISSION DETAILS
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SLAS
Several important SLAS Europe 2019 Conference and Exhibition deadlines are approaching. Keep these dates in mind as you plan your trip to Barcelona, June 26-28:
While you're building your schedule, make sure to check out the first-ever, pre-conference short course program. Short courses are deep-dive, highly-relevant educational experiences that will take place on Tuesday, June 25. This year's topics are:
- Introduction to Laboratory Automation Technology
- Assay Guidance Workshop for High-Throughput Screening
- Lead Discovery and 3D Culture Models and Organoids for Drug Discovery
Courses require an additional registration fee and seating is limited.
VIEW SHORT COURSE PROGRAM DETAILS
VISIT SLAS EUROPE 2019 PROGRAM
SLAS EUROPE 2019 REGISTRATION INFORMATION
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SLAS
There's a little less than a week to submit podium abstract submissions for the inaugural SLAS 2019 AI in Process Automation Symposium. Research will be accepted for a chance to present within four different session topics: AI in Drug Discovery Today, AI in Screening, AI in Chemistry, and Data Automation. The SLAS AI in Process Automation Symposium will take place in Boston, MA, USA, October 3-4, and include discussions about the tech, tools and potential costs of embedding AI into workplace drug discovery processes. Registration opens soon!
SUBMIT A PODIUM ABSTRACT
LEARN MORE ABOUT THE SYMPOSIUM
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SLAS
Access to March's SLAS 2019 European Sample Management Symposium session content is now available in SLAS APPLIED. The content is free for 2019 SLAS European Sample Management Symposium attendees; $10 for SLAS Premier, Premier Plus, Corporate and Platinum Members; and $20 for SLAS Basic (non-dues paying) Members and non-members. In addition, access is also available for 81 recorded sessions from the SLAS2019 International Conference & Exhibition. All available files are compatible with your desktop or preferred mobile device.
ACCESS NOW
SLAS
Submit your ideas for solving the opioid crisis for a chance to win cash. The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) created the ASPIRE Design Challenges as a catalyst for individuals or teams to use novel chemistries, data-mining and analysis tools, and technologies or biological assays to produce safer and non-addictive treatments and overdose solutions. Submissions are due to challenge.gov by May 31, 2019.
FULL ASPIRE DESIGN CHALLENGE DETAILS
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
SLAS Journals Special Issues Call for Papers
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1: Proposals due
Aug. 10: Invited submissions due
Upcoming 2019 Events
LRIG San Diego Exhibition and Rapid Fire
April 25
Green Acres, 10300 Campus Point Drive, San Diego, CA
Stop at the SLAS booth to pick up an SLAS journal and enter to win a registration for SLAS2020 (also in San Diego next January!)
SLAS Europe 2019 Conference and Exhibition
June 26 - 28
Barcelona, Spain
Friday, May 3: Innovation AveNEW Exhibitor Submission Deadline
Monday, May 6: Early-Bird Registration Discount Deadline
Monday, May 20: Poster Abstract Submission Deadline
Exhibit and sponsorship opportunities available
Save the Dates
SLAS 2019 AI in Process Automation Symposium - Registration Opens in May
October 3 - 4
Boston, MA
Call for Podium and Poster Abstracts Now Open
Exhibit and Sponsorship Opportunities Available: Contact Karen Layser
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium
October 21 - 22
London, UK
SLAS 2019 Americas Sample Management Symposium — Registration Opening Soon
November 20 - 21
Boston, MA
Sponsorship Opportunities Available: Contact Karen Layser
SLAS2020 International Conference and Exhibition — Call for Abstracts Opens in May
January 25 - 29, 2020
San Diego, CA
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Journal of the American Chemical Society
While cryo-EM is revolutionizing structural biology, its impact on enzymology is yet to be fully demonstrated. The ketol-acid reductoisomerase catalyzes conversion of (2S)-acetolactate or (2S)-aceto-2-hydroxybutyrate to 2,3-dihydroxy-3-alkylbutyrate. We found that KARI from archaea Sulfolobus solfataricus is unusual in being a dodecamer, bispecific to NADH and NADPH, and losing activity above pH 7.8.
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Laboratory Equipment
A Massachusetts General Hospital research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, extending beyond the targeted DNA. Their report receiving advance online publication in Nature also describes engineering variant base editors that significantly reduced the incidence of RNA edits while also increasing the precision of on-target DNA editing.
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Lab Manager
The advance of science is something like the wandering of an explorer through an uncharted jungle. Often, the dense undergrowth can seem impenetrable, but at certain privileged moments, a clearing opens and an entirely new landscape emerges.
Something like this is occurring in the field of biology with the recent discovery of powerful techniques for intervening in the genetic code of life.
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Genetic Engineering & Biotechnology News
A concern that has plagued CRISPR-Cas9 technology from the beginning is the possibility, and unknown effect, of off-target effects—DNA mutations that result from CRISPR-Cas9 editing that are not in the targeted area. In order to understand the effect of off-target changes, they must first be detected. A new universally applicable approach for unbiased off-target identification has been developed.
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The Scientist
Sequencing can identify mutations linked to autism even before a child's birth — especially in cases where doctors suspect problems, two new studies suggest.
In the studies, scientists sequenced fetal DNA only when ultrasounds revealed atypical development of limbs or other organs, and they gave families only the results that seemed to explain those problems.
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Science Daily
Discovering new biological targets is a critical part of our ongoing battle against diseases. Over the years, scientists have made impressive progress towards the understanding of biological systems, constantly identifying novel targets. The structural diversity of these targets requires a broad range of different therapeutic agents.
"Small synthetic molecules are still key players, but biomolecules such as peptides, proteins and oligonucleotides have become an important area of research," says Professor Jérôme Waser.
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Chemical & Engineering News
Polymers have previously been made in the presence of living cells, for such purposes as encapsulating the cells or engineering their surfaces. But people haven't known whether synthetic polymers could be made inside cells, given the presence of free-radical scavengers. Mark Bradley and coworkers at the University of Edinburgh now show that radical polymerization can indeed happen inside living cells.
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Phys.org
Cryogenic-Electron Microscopy has been a game changer in the field of medical research, but the substrate, used to freeze and view samples under a microscope, has not advanced much in decades. Now, thanks to a collaboration between Penn State researchers and the applied science company Protochips, Inc., this is no longer the case.
"The traditional type of grid hasn't changed much since the inception of cryo-EM, while materials science has changed vastly," said Deb Kelly, a professor of biomedical engineering at Penn State.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Lead Engineer – Process Engineering
Eli Lilly & Company
US – NJ – Branchburg
Postdoctoral Fellow
UC Irvine School of Medicine
US – CA – Irvine
Microbial Automation Expert
AgBiome
US – NC – Durham
Search Jobs at SLAS Career Connections
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