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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit April 27, 2016

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May 17 SLAS Webinar on Challenges of 1536-Well Cell-Based Screening
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Join SLAS and Helen Plant of AstraZeneca (U.K.) to explore the practical intricacies of doing small volume, 1536-well cell-based assays.

"Successful conversion of complex phenotypic assays to 1536-well formats results in up to a 50 percent reduction in cell number requirements and approximately a four-fold reduction in time taken to perform a full HTS screening campaign," she says.

Plant explains how the BlueCatBio centrifugal plate washer integrates centrifugal emptying with the individual addition of up to four separate solutions for complex phenotypic assays. Dues-paying SLAS members may participate at no cost. SLAS Webinars are presented by JALA and JBS, the official journals of SLAS.
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Publish Your Achievements in 3D Cell Culture
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Guest Editors Richard Eglen and Jean-Louis Klein invite proposals (abstracts) of original research and review papers for a JBS Special Issue on "3D Cell Culture, Drug Screening and Optimization."

Proposals are due by June 1. Topics of interest include comparative gene expression, protein function and physiology of immortalized and primary cells in 2D vs. 3D cell culture; optimizing matrices and scaffolds for 3D culture and screening; applications of gene editing technologies to 3D cell culture; use of 3D cell culture in cellular imaging and high-content screening; in vivo 3D models of cellular metabolism, particularly cancer cells, neuronal cells, hepatocytes and cardiomyocytes; and organ-on-a-chip microfluidic technologies to evaluate drug toxicity and metabolic liability.
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SLAS ELN Reports: SLAS Goes Forward with Confidence and a Tidal Wave of Positive Momentum
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SLAS President Richard M. Eglen, Ph.D., reflects on the resignation of SLAS CEO Greg Dummer, effective June 30.

"SLAS's high-functioning professional team is the envy of many other societies, and its infrastructure includes a thoughtful succession plan that ensures continued stability and success through a transition such as this. And so ... we go forward with confidence," Eglen notes in the SLAS Electronic Laboratory Neighborhood e-zine.

A search committee has been created by the SLAS Board of Directors to oversee the process of identifying and selecting a new CEO. For anyone interested in being considered for the SLAS CEO position, more information is available at SLAS.org. CVs will be accepted through May 31.
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SLAS Europe High-Content Screening Conference, June 27-29
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Novel organisms, novel markers, new essays, novel microscopy techniques, image analysis and statistics — each of these hot topics is addressed at the June 27-29 SLAS Europe High-Content Screening Conference at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.

Scientific program speakers represent industry-leading institutions like AstraZeneca, Broad Institute, European Molecular Biology Laboratory, GlaxoSmithKline, Hungarian Academy of Sciences, King's College of London, Mimetas, Mount Sinai Hospital, Novartis, OcellO and the University of Tübingen. Share your latest discoveries by submitting a poster abstract by Friday, May 13.
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Five Reasons to Visit JALA and JBS Online Today
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JALA and JBS offer essential ways to navigate the ever-increasing volume of peer-reviewed research for life sciences discovery and technology professionals. Visit these rich resources regularly to:
  1. Find answers, ideas and inspiration by searching the scientific archives of JALA, JBS and other SAGE journals with keywords and author names. Save searches and/or sign up to receive custom search alerts via e-mail.
  2. Sign up for citation tracking alerts.
  3. Sign up to be alerted when new reports publish online ahead-of-print.
  4. See what's trending in the Most Read and Most Cited monitors (located at the bottom/right on the homepages).
  5. Get to know the people behind the science by listening to JALA Podcasts.
More JALA / More JBS


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New Understanding of Enzymes Could Help to Develop New Drugs
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer's, according to research led by the University of Leicester. The team, working under Professor John Schwabe from the University of Leicester's Department of Molecular and Cell Biology, focuses on understanding the structure and function of large protein complexes in the body that are involved in the regulation of gene expression called co-repressor complexes. More


2-(Naphthalen-1-yl)thiophene as a New Motif for Porphyrinoids: Meso-Fused Carbaporphyrin
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The first synthesis of meso-fused carbaporphyrin via a premodification method was accomplished by substituting two pyrrole moieties and one meso-carbon with 2-(naphthalen-1-yl)thiophene. The obtained global π-conjugation pathway of the macrocycle noticeably disturbs the 10π local aromaticity of naphthalene, and its aromatic nature was supported by NMR spectroscopy together with nucleus-independent chemical shift, anisotropy of the induced current density, and harmonic oscillator stabilization energy calculations. More


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New CRISPR System Targets Both DNA and RNA
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
With a staggering number of papers published in the past several years involving the characterization and use of the CRISPR/Cas9 gene editing system, it is surprising that researchers are still finding new features of the versatile molecular scissor enzyme. Now, a collaborative team of scientists led by researchers at the Max Planck Institute and a co-discoverer of CRISPR's genome editing capabilities has uncovered a feature of the CRISPR-associated protein Cpf1 that has previously not been observed in this family of enzymes — dual RNA and DNA cleavage activity. More


New Protein-Making Factory Promises Better Medicines
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A Yale research team has created a mutant protein-making factory in bacteria that churns out proteins containing beta-amino acids, molecules not normally found in nature but capable of creating longer-lasting and life-saving medicines. The research findings, published in the Journal of the American Chemical Society, are the first to report creation of beta-amino acid-containing proteins in a living organism. More




Single Molecule Electronic DNA Sequencing Advanced
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
DNA sequencing is the key technology for personalized and precision medicine initiatives, enabling rapid discoveries in biomedical science. An individual's complete genome sequence provides important markers and guidelines for medical diagnostics, healthcare, and maintaining a healthy life. To date, the cost and speed involved in obtaining highly accurate DNA sequences has been a major challenge. More


New Study Questions Ghrelin-Appetite Link
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In what could be a game changer for research on ghrelin, the so-called hunger hormone, scientists report that the biomolecule may actually be a mediator of fat storage, rather than an appetite driver. Researchers previously thought ghrelin regulated appetite because stomach cells produce the hormone when the gut is empty and cease production when the stomach is full. More


First Data from Anti-Aging Gene Therapy
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Last year, Elizabeth Parrish, the CEO of Seattle-based biotech firm BioViva, hopped a plane to Colombia, where she received multiple injections of two experimental gene therapies her company had developed. One is intended to lengthen the caps of her chromosomes (called telomeres) while the other aims to increase muscle mass. The idea is that together these treatments would "compress mortality," Parrish told The Scientist, by staving off the diseases of aging — enabling people to live healthier, longer. More


Researchers Discover New State of Water Molecule
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid, or solid states. In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of water molecules confined in hexagonal ultra-small channels — 5 angstrom across — of the mineral beryl. More


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Bristol-Myers Squibb
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Product Manager – Automation
Labcyte, Inc.
US – CA – Sunnyvale

Discovery BioAssets Global Lead
GlaxoSmithKline
UK – Stevenage, Hertfordshire and US – PA – Collegeville

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